Method of manufacturing a nicotine delivery product
    61.
    发明申请
    Method of manufacturing a nicotine delivery product 有权
    制造尼古丁递送产品的方法

    公开(公告)号:US20090092573A1

    公开(公告)日:2009-04-09

    申请号:US11921199

    申请日:2006-06-01

    申请人: Carsten Andersen

    发明人: Carsten Andersen

    IPC分类号: A61K31/74 A61P25/34

    摘要: A method of manufacturing a nicotine delivery product comprising nicotine and a cation exchange resin. More precisely, to a method for preparing a nicotine delivery product said method comprising (a) mixing nicotine, a cation exchange resin, an organic polyol and water to form a mixture wherein the total amount of water is from 26 to 45% by weight of the total mixture, and (b) removing water from the mixture to produce said nicotine delivery product.

    摘要翻译: 一种制造尼古丁和阳离子交换树脂的尼古丁递送产品的方法。 更准确地说,涉及一种制备尼古丁递送产品的方法,所述方法包括(a)将尼古丁,阳离子交换树脂,有机多元醇和水混合以形成混合物,其中水的总量为26-45重量% 总混合物,和(b)从混合物中除去水以产生所述尼古丁递送产物。

    Distributed test equipment system for testing analog communications systems
    63.
    发明授权
    Distributed test equipment system for testing analog communications systems 有权
    用于测试模拟通信系统的分布式测试设备系统

    公开(公告)号:US07457712B1

    公开(公告)日:2008-11-25

    申请号:US10770298

    申请日:2004-02-02

    IPC分类号: G06F19/00

    CPC分类号: H04L43/50

    摘要: A distributed test equipment system for testing analog communications systems. One or more analog signal receivers and one or more computers are connected via a packet-switched network such that each computer can remotely control and receive signal data from each receiver. Analog signal data measured by each receiver is available for relaying to each computer where it is processed for analysis in conformance with respective user commands.

    摘要翻译: 用于测试模拟通信系统的分布式测试设备系统。 一个或多个模拟信号接收器和一个或多个计算机经由分组交换网络连接,使得每个计算机可以远程控制和接收来自每个接收机的信号数据。 由每个接收器测量的模拟信号数据可用于中继到每个计算机,其中它们根据相应的用户命令进行处理以进行分析。

    Polypeptides Having Phytase Activity and Polynucleotides Encoding Same
    65.
    发明申请
    Polypeptides Having Phytase Activity and Polynucleotides Encoding Same 有权
    具有植酸酶活性的多肽和编码相同的多核苷酸

    公开(公告)号:US20080016584A1

    公开(公告)日:2008-01-17

    申请号:US11574715

    申请日:2005-10-04

    CPC分类号: C12N9/16 A23K20/189

    摘要: The invention relates to a phytase derived from Citrobacter gillenii and related phytases. The phytases belong to the acid histidine phosphatase family, are acid-stable, and expectedly of a high specific activity. The invention also relates to the corresponding DNA, the recombinant and wild-type production of the phytases, as well as the use thereof, in particular in animal feed, for example in combination with phytases having a higher pH-optimum.

    摘要翻译: 本发明涉及源自吉利吉列丝杆菌和相关植酸酶的植酸酶。 植酸酶属于酸性组氨酸磷酸酶家族,具有酸稳定性,预期具有较高的比活性。 本发明还涉及相应的DNA,植酸酶的重组和野生型产生,以及其用途,特别是动物饲料中的用途,例如与具有较高pH最佳值的植酸酶组合。

    Cell-wall degrading enzyme variants
    68.
    发明授权
    Cell-wall degrading enzyme variants 失效
    细胞壁降解酶变体

    公开(公告)号:US06808915B2

    公开(公告)日:2004-10-26

    申请号:US10403192

    申请日:2003-03-31

    IPC分类号: C12N988

    CPC分类号: C11D3/38636 C12N9/88

    摘要: The present invention relates to variants of a cell-wall degrading enzyme having a beta-helix structure, which variant has at least one substituent in a position determined by identifying all residues potentially belonging to a stack; characterizing the stack as interior or exterior; characterizing the stack as polar, hydrophobic or aromatic/heteroaromatic based on the dominating characteristics of the parent or wild-type enzyme stack residues and/or its orientation relative to the beta-helix (interior or exterior); optimizing all stack positions of a stack either to hydrophobic aliphatic amino acids, hydrophobic aromatic or polar amino acids by allowing mutations within one or all positions to amino acids belonging to one of these groups; measuring thermostability of the variants by DSC or an application-related assay such as a Pad-Steam application test; and selecting the stabilized variants. Variant of a wild-type parent pectate lyase (EC 4.2.2.2) having the conserved amino acid residues D111, D141 or E141, D145, K165, R194 and R199 when aligned with the pectate lyase comprising the amino acid sequence of SEQ ID NO: 2 are preferred.

    摘要翻译: 本发明涉及具有β-螺旋结构的细胞壁降解酶的变体,该变体具有至少一个取代基,其位置通过鉴定潜在属于堆叠的所有残基而确定; 将堆栈表征为内部或外部; 基于母体或野生型酶堆残基的主导特征和/或其相对于β-螺旋(内部或外部)的取向,将所述叠层表征为极性,疏水性或芳族/杂芳族化合物; 通过在属于这些基团之一的氨基酸的一个或所有位置内允许突变将堆叠的所有堆叠位置优化为疏水性脂族氨基酸,疏水性芳族或极性氨基酸; 通过DSC测量变体的热稳定性或应用相关测定,例如Pad-Steam应用测试; 并选择稳定的变体。 当与包含SEQ ID NO:1的氨基酸序列的果胶酸裂解酶比对时,具有保守氨基酸残基D111,D141或E141,D145,K165,R194和R199的野生型亲本果胶酸裂合酶(EC 4.2.2.2) 2是优选的。

    Method Of Providing Fast Relief To A User Of A Nicotine Chewing Gum
    70.
    发明申请
    Method Of Providing Fast Relief To A User Of A Nicotine Chewing Gum 有权
    为尼古丁口香糖使用者提供快速救济的方法

    公开(公告)号:US20130323184A1

    公开(公告)日:2013-12-05

    申请号:US13963480

    申请日:2013-08-09

    申请人: Carsten Andersen

    发明人: Carsten Andersen

    IPC分类号: A61K31/465 A61K9/68

    CPC分类号: A61K31/465 A61K9/0058

    摘要: The invention relates to a method of relieving nicotine craving comprising the steps of providing at least one chewing gum comprising tobacco alkaloid to a user, providing relief of nicotine craving to said user by transferring of tobacco alkaloid from the chewing gum to the human body of said user by chewing of said chewing gum, said chewing of said chewing gum comprising a chewing process involving a transfer of tobacco alkaloid from said chewing gum above a threshold transfer rate in the period of about ½ minute to about 2½ minutes from initiation of said chewing process.

    摘要翻译: 本发明涉及一种减轻尼古丁渴望的方法,包括以下步骤:向使用者提供包含烟草生物碱的至少一种口香糖,通过将烟草生物碱从口香糖转移到所述口腔内的人体,使所述使用者缓解尼古丁渴望 所述咀嚼口咀嚼所述口香糖,所述咀嚼口香糖包括咀嚼方法,所述咀嚼方法涉及在所述咀嚼过程开始之后约1/2分钟至约2.5分钟的时间内从所述口香糖转移烟草生物碱高于阈值转移速率 。