公开(公告)号：US07235067B2

公开(公告)日：2007-06-26

申请号：US10382757

申请日：2003-03-06

申请人： Mary M. Morris ,  Timothy G. Laske ,  Kenneth T. Heruth ,  Michael R. Ujhelyi ,  Jesus W. Casas-Bejar ,  David S. Olson

发明人： Mary M. Morris ,  Timothy G. Laske ,  Kenneth T. Heruth ,  Michael R. Ujhelyi ,  Jesus W. Casas-Bejar ,  David S. Olson

IPC分类号： A61M25/16

CPC分类号： A61M25/0075

摘要： A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body. In another embodiment the sleeve includes a tapered edge.

摘要翻译： 导管主体包括出口，在该出口处形成压力响应套筒，其允许材料在给定压力下离开导管体的内腔。 在一个实施例中，套筒的表面与导管主体的表面大致齐平。 在另一个实施例中，套筒包括锥形边缘。

公开(公告)号：US07191009B2

公开(公告)日：2007-03-13

申请号：US10914303

申请日：2004-08-09

申请人： Timothy G. Laske ,  Gonzalo Martinez ,  Lea A. Nygren

发明人： Timothy G. Laske ,  Gonzalo Martinez ,  Lea A. Nygren

IPC分类号： A61N1/00

CPC分类号： A61N1/375 ,  A61N1/3756

摘要： A surface area of an IMD electrode is increased by forming a conductive layer over an external portion of a sidewall of an IMD connector header and electrically coupling the conductive layer of the connector header to a conductive mounting surface of a hermetically sealed IMD housing; wherein the conductive mounting surface is an extension of an external conductive surface of the IMD, which external conductive surface forms the IMD electrode that is increased in surface area by the conductive layer formed over the connector header.

摘要翻译： 通过在IMD连接器集管的侧壁的外部部分上形成导电层并将连接器集管的导电层电耦合到密封的IMD壳体的导电安装表面来增加IMD电极的表面积; 其中所述导电安装表面是所述IMD的外部导电表面的延伸部，所述外部导电表面形成所述IMD电极，所述IMD电极通过形成在所述连接器插头上的导电层而在表面积上增加。

公开(公告)号：US07177704B2

公开(公告)日：2007-02-13

申请号：US10135909

申请日：2002-04-29

申请人： Timothy G. Laske ,  Terrell M. Williams

发明人： Timothy G. Laske ,  Terrell M. Williams

IPC分类号： A61N1/00

CPC分类号： A61N1/057

摘要： The present invention provides for a method and apparatus providing pacing to improve the hemodynamics of the heart for patients with AV nodal block, right/left bundle branch block, and heart failure. A lead body having at least one conductor with an insulative sleeve is introduced into the right atrium of a heart. A partially masked helical electrode connected to the conductor is then secured preferably into the atrial aspect of the atrioventricular septum. The electrical conductor is then rotated such that an unmasked portion of the electrode is moved to a depth within the heart tissue substantially near the heart's intrinsic conduction system. This method and apparatus allow pacing in a natural manner via low power stimulation of the heart's intrinsic conduction system.

摘要翻译： 本发明提供了一种提供起搏以改善AV结节块，右/左束支传导阻滞和心力衰竭患者的心脏血流动力学的方法和装置。 具有至少一个具有绝缘套管的导体的引线体引入心脏的右心房。 然后将连接到导体的部分掩蔽的螺旋电极优选地固定在房室隔膜的心房方面。 然后旋转电导体，使得电极的未屏蔽部分基本上靠近心脏的本征传导系统移动到心脏组织内的深度。 该方法和装置可以通过心脏内在传导系统的低功率刺激以自然的方式起搏。

公开(公告)号：US07162309B2

公开(公告)日：2007-01-09

申请号：US10408426

申请日：2003-04-07

申请人： Timothy G. Laske ,  James F. Kelley

发明人： Timothy G. Laske ,  James F. Kelley

IPC分类号： A61N1/05 ,  A61B5/042

CPC分类号： A61N1/0587 ,  A61N2001/0578

摘要： A manipulator joined to a distal end of a delivery system shaft includes a plurality of arms and a collar. A proximal portion of each of the arms is joined to the shaft and a distal portion of each of the arms is joined to the collar such that the collar is substantially aligned with a lumen of the shaft. The lumen and the collar slideably and rotatably engage a medical electrical lead while a plurality of control wires, adapted to manipulate the manipulator, join to each of the plurality of manipulator arms in proximity to the distal end of the shaft.

摘要翻译： 接合到输送系统轴的远端的操纵器包括多个臂和一个套环。 每个臂的近端部分连接到轴，并且每个臂的远端部分连接到轴环，使得轴环基本上与轴的内腔对准。 内腔和套管可滑动地和可旋转地接合医疗电引线，而适于操纵操纵器的多个控制线连接到靠近轴的远端的多个操纵臂中的每一个。

公开(公告)号：US07141017B2

公开(公告)日：2006-11-28

申请号：US10821451

申请日：2004-04-09

申请人： Timothy G. Laske ,  Thomas S. Ahern

发明人： Timothy G. Laske ,  Thomas S. Ahern

IPC分类号： A61B5/00 ,  A61B5/04

CPC分类号： A61N1/08 ,  A61N2001/083

摘要： An IMD includes a variable sense amplifier that can be adjusted to counteract the variability created in EGM's due to lead maturation. The effects of lead maturation are either predictively assumed or individually assessed on a given patient. The sense amplifier is then adjusted to assure positive identification of desired events and eliminate unwanted events.

摘要翻译： IMD包括可调节的可变感测放大器，以抵消由于铅成熟引起的EGM中产生的变异性。 铅成熟的影响可以在给定的患者中被预测地假定或单独评估。 然后调整读出放大器以确保所需事件的正确识别并消除不需要的事件。

公开(公告)号：US07082335B2

公开(公告)日：2006-07-25

申请号：US10260815

申请日：2002-09-30

申请人： George J. Klein ,  Timothy G. Laske

发明人： George J. Klein ,  Timothy G. Laske

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0573

摘要： A physiological pacing system including a physiological pacing lead having an electrode array and a means for fixation, including a collar for securing the fixation means to a lead body of the pacing lead, is inserted into a bore within a heart wall at a physiological pacing site. The system further includes a means to create the bore, the means being a piercing tip, which is either coupled to a piercing tool or the pacing lead. The piercing tool may be an elongated hollow shaft into which the pacing lead is slideably insertable or a stylet wire, which is slideably insertable within a lumen of the pacing lead. Once the electrode array is implanted within the bore, a first pair of electrodes is selected for sensing and a second pair of electrodes is selected for pacing.

摘要翻译： 生理起搏系统包括具有电极阵列的生理起搏引线和用于固定的装置，包括用于将固定装置固定到起搏引线的引线本体的套环，在生理起搏部位插入心壁内的孔中 。 该系统还包括用于产生孔的装置，所述装置是穿刺尖端，其被连接到穿刺工具或起搏引线。 穿刺工具可以是细长空心轴，起搏引线可滑动插入其中，或者可以可滑动地插入到起搏引导管的内腔内的探针线。 一旦将电极阵列植入孔内，则选择第一对电极进行感测，并选择第二对电极进行起搏。

公开(公告)号：US06379346B1

公开(公告)日：2002-04-30

申请号：US09552250

申请日：2000-04-18

申请人： Michael E. McIvor ,  Kenneth C. Gardeski ,  Pedro A. Meregotte ,  Matthew D. Bonner ,  Timothy G. Laske ,  Linda L. Lach

发明人： Michael E. McIvor ,  Kenneth C. Gardeski ,  Pedro A. Meregotte ,  Matthew D. Bonner ,  Timothy G. Laske ,  Linda L. Lach

IPC分类号： A61M2500

CPC分类号： A61M25/0668 ,  A61M25/01 ,  A61M2025/0675

摘要： An introducer is structured with an elongated tube having first and second lumens. A molded handle is coupled to the proximal end of the tube with an opening aligned with the first lumen. Further, a wall adjacent the opening of the handle defines a slot and is located diametrically opposite the second lumen. A tubular reinforcement member is located within the second lumen and the handle is provided with a second opening, thereby having a communication with the second lumen. In another embodiment a lead/catheter introducer includes an implantable lead or catheter having an elongated first lumen through which the lead or catheter passes and a second lumen extends parallel to the first lumen along at least a distal portion thereof. A tubular reinforcement member is disposed within the second lumen. The tubular reinforcement member further includes an internal lumen and a curvable stylet disposed in the lumen.

摘要翻译： 导引器构造有具有第一和第二腔的细长管。 模制手柄与管的近端连接，开口与第一内腔对准。 此外，与手柄的开口相邻的壁限定了狭槽，并且位于与第二内腔完全相对的位置。 管状加强构件位于第二内腔内，手柄设置有第二开口，从而与第二腔相连通。 在另一个实施例中，引导/导管导引器包括具有细长的第一内腔的可植入引线或导管，所述引导件或导管通过所述细长的第一内腔，并且沿其至少其远端部分平行于所述第一内腔延伸的第二腔。 管状加强构件设置在第二内腔内。 管状加强构件还包括内腔和设置在内腔中的可调节探针。

公开(公告)号：US06289251B1

公开(公告)日：2001-09-11

申请号：US09430890

申请日：1999-11-01

申请人： George M. Huepenbecker ,  Timothy G. Laske

发明人： George M. Huepenbecker ,  Timothy G. Laske

IPC分类号： A61N105

CPC分类号： A61N1/056

摘要： An implantable electrical lead having at least two mutually insulated electrical components that are separated by a portion of the lead's body fabricated of a plant, extensible biocompatible insulated material. An extensible conductor extends from the proximal end of the lead body to a first one of the electrical components, and a second, inextensible conductor extends from the proximal end of the lead body to a second one of the electrical components. An inextensible reinforcement member is coupled to the inextensible conductor and extends distally from the second electrical component to the first electrical component and is coupled mechanically to the first electrical component.

摘要翻译： 一种可植入电导线，其具有至少两个相互绝缘的电气部件，所述电气部件由由植物可延展的生物相容绝缘材料制成的引线主体的一部分分开。 可伸长的导体从引线体的近端延伸到电气部件中的第一个，并且第二不可伸长的导体从引线本体的近端延伸到电部件的第二个。 不可伸展的加强构件联接到不可伸展的导体并且从第二电气部件向远侧延伸到第一电气部件并且机械地耦合到第一电气部件。

公开(公告)号：US06178355B1

公开(公告)日：2001-01-23

申请号：US09216293

申请日：1998-12-18

申请人： Terrell M. Williams ,  Peter M. J. Mulier ,  John G. Keimel ,  Timothy G. Laske ,  Gregory A. Boser ,  Mary M. Morris ,  Xiaoyi Min

发明人： Terrell M. Williams ,  Peter M. J. Mulier ,  John G. Keimel ,  Timothy G. Laske ,  Gregory A. Boser ,  Mary M. Morris ,  Xiaoyi Min

IPC分类号： A61N105

CPC分类号： A61N1/0565 ,  A61N1/0563

摘要： A lead and a lead system for dispersion of a cardioversion/defibrillation electrode formed of one or more small diameter defibrillation electrodes in a heart chamber and for attaching a pace/sense electrode in contact with the heart. The small diameter defibrillation electrode or electrodes extend distally from the distal end of the lead body. If multiple electrodes are employed, they are preferably biased to spread apart when unrestrained and have a cross-section size small enough to be inserted into interstices of trabeculae in the ventricular chamber. The distal ends of the defibrillation electrodes may be free of attachment to the lead body or may be attached by a weak bond to the distal portion of the lead.

摘要翻译： 一种用于在心室中由一个或多个小直径除颤电极形成的复律/除颤电极的分散的引线和引导系统，并且用于附接与心脏接触的步调/感测电极。 小直径除颤电极或电极从引线体的远端向远端延伸。 如果使用多个电极，则它们优选地被偏置以在不受限制的情况下展开，并且具有足够小的横截面尺寸以插入心室中的小梁的间隙中。 除颤电极的远端可以没有附着到引线体，或者可以通过弱接合附着到引线的远端部分。

公开(公告)号：US5957970A

公开(公告)日：1999-09-28

申请号：US25485

申请日：1998-02-18

申请人： Bret R. Shoberg ,  Matthew D. Bonner ,  Timothy G. Laske

发明人： Bret R. Shoberg ,  Matthew D. Bonner ,  Timothy G. Laske

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0563

摘要： A method of producing a lead which is isodiametric or nearly so over the region in which an elongated coiled electrode is located and which can optionally be manufactured starting from a single extruded tubular lead body of constant diameter and the lead so produced. Rather than molding the electrode into the surface of the lead or machining the electrode so that it is flush with the surface of the lead, the present invention instead employs an extruded, multiple lumen lead body of circular cross-section which has material cut away or otherwise removed in one or more regions spaced from one another around the lead body and extending longitudinally along the region of the lead body where the coil electrode is to be located or a lead body which is so molded. The areas in which material is removed or is absent are preferably located in regions where the lead body wall is thickest, for example between adjacent lumens. The removal of material may result in one or more elongated, generally planar surfaces spaced from one another around the circumference of the lead body or may result in elongated indentations spaced from one another around the circumference of the lead body. The removal or absence of material renders the lead body more compressible in the region the electrode is to be located.

摘要翻译： 一种制造在其中设置有细长卷绕电极的区域上是等距或接近的引线的方法，其可以任选地从具有恒定直径的单个挤出管状引线体和由此产生的引线开始制造。 不是将电极模制到引线的表面或加工电极以使其与引线的表面齐平，而是本发明使用具有圆形横截面的挤出的多腔引线体，其具有切除的材料或 否则在围绕引线主体彼此间隔开的一个或多个区域中移除，并沿着线体电极要被定位的引线体的区域或者如此模制的引线体纵向延伸。 材料被去除或不存在的区域优选地位于引线体壁最厚的区域中，例如在相邻流明之间。 去除材料可能导致一个或多个细长的，大致平坦的表面围绕引线主体的圆周彼此间隔开，或者可能导致围绕引线主体的圆周彼此间隔开的细长的凹陷。 材料的去除或不存在使得引线体在电极将被定位的区域中更加可压缩。