摘要:
Methods for synthesizing chain molecules on particles in a multi-stream laminar flow, microfluidic reaction cells in which the methods can be carried out, and microfluidic systems incorporating the microfluidic reaction cells are provided. The methods, cells and systems are well suited for the rapid, large-scale production of chain biomolecules, such as oligonucleotides, in parallel.
摘要:
An cable assembly (100) includes an insulated housing (1) extending along a front-to-back direction; a plurality of contacts (2) arranged in a row and supported by the insulated housing, said contacts including three grounding contact members spaced by two pair of signal contact members; a cable (4) including two juxtaposed differential wire pairs (41) respectively enclosed by conductive shielding portions (43); a grounding member (3) including a main portion (31), three finger portions (33) extending forwardly from a front side of the main portion and two arm portions (32) formed at lateral sides of a rear segment of the main portion, said grounding member (3) securely engaged with the cable via the two arm portions thereof griping the conductive shielding portions; and the finger portions soldered to the grounding contact members, and inner conductors of the differential pairs soldered to the signal contact members, respectively.
摘要:
This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
摘要:
A method for reducing dislocation density between an AlGaN layer and a sapphire substrate involving the step of forming a self-organizing porous AlN layer of non-coalescing column-like islands with flat tops on the substrate.
摘要:
The present invention relates to compounds of Formula (I) and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.
摘要:
Architecture that includes a batch framework engine incorporated into the server and that supports a rich set of dependencies between tasks in a single batch job. A bottom-up approach is employed where analysis is performed if a task can run based on the parent tasks. The framework runs batch jobs without the need of a client, and provides the ability to create dependencies between tasks, which allow the execution of tasks in parallel or in sequence. Using an AND/OR relationship engine, a task can require that all parent tasks (logical AND) meet requirements to run, or that only one parent (logical OR) is required to meet its requirements in order to run. Clean-up or non-important tasks can have the a flag set where even if such tasks fail when executing, the batch job will ignore these tasks when defining the final status of the job.
摘要:
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
摘要:
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
摘要:
This invention relates to a method of inhibiting the expression of TNFα or IL-1β with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.
摘要:
This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.