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61.发明申请Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia 有权杂环作为治疗血脂异常的烟酸受体激动剂公开(公告)号：US20060264489A1
公开(公告)日：2006-11-23
申请号：US11432133
申请日：2006-05-11
申请人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying Huang , Robert Aslanian , Brian McKittrick
发明人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying Huang , Robert Aslanian , Brian McKittrick
IPC分类号： A01N43/50
CPC分类号： C07D471/04 , C07D491/04 , C07D491/052
摘要： A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome and dyslipidemia.
摘要翻译： 具有式（I）的通式结构的化合物或其药学上可接受的盐，溶剂化物，酯或互变异构体，其中：Q选自：和L选自：或其药学上可接受的盐 可接受的盐，溶剂合物，酯或互变异构体，可用于治疗疾病，病症或病症如代谢综合征和血脂异常。
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公开(公告)号：US20060258665A1
公开(公告)日：2006-11-16
申请号：US11291363
申请日：2005-12-01
申请人： Dong Xiao , Anandan Palani , Cheng Wang , Hon-Chung Tsui , Xianhai Huang , Sapna Shah , Ashwin Rao , Xiao Chen , Sunil Paliwal , Neng-Yang Shih
发明人： Dong Xiao , Anandan Palani , Cheng Wang , Hon-Chung Tsui , Xianhai Huang , Sapna Shah , Ashwin Rao , Xiao Chen , Sunil Paliwal , Neng-Yang Shih
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D471/08
摘要： A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式（I）所示的一般结构的化合物或其药学上可接受的盐和/或溶剂化物可用于治疗由NK 1受体介导的疾病或病症，例如各种生理紊乱，症状或 疾病包括呕吐，抑郁，焦虑和咳嗽。
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公开(公告)号：US08754216B2
公开(公告)日：2014-06-17
申请号：US13245403
申请日：2011-09-26
申请人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
发明人： Sapna S. Shah , Anandan Palani , Xianhai Huang , Dong Xiao , Sunil Paliwal , Hon-Chung Tsui , Michelle Laci Wrobleski , Ashwin U. Rao , Cheng Wang , Neng-Yang Shih
IPC分类号： C07F7/02 , C07D215/12 , C07D215/16 , C07D213/02 , C07D405/00
CPC分类号： C07D401/04 , A61K31/4178 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/573 , A61K45/06 , C07D211/56 , C07D211/60 , C07D211/66 , C07D211/76 , C07D413/04 , C07D417/04 , C07D498/20
摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.
摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。
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公开(公告)号：US08518975B2
公开(公告)日：2013-08-27
申请号：US12673858
申请日：2008-09-04
申请人： Robert G. Aslanian , Xianhai Huang , Anandan Palani , Jun Qin , Wei Zhou , Xiaohong Zhu , Robert D. Mazzola, Jr. , Pawan Dhondi , William J. Greenlee
发明人： Robert G. Aslanian , Xianhai Huang , Anandan Palani , Jun Qin , Wei Zhou , Xiaohong Zhu , Robert D. Mazzola, Jr. , Pawan Dhondi , William J. Greenlee
IPC分类号： C07D403/12 , C07D401/12 , C07D237/14 , A61K31/501 , A61K31/50 , A61K31/4439
CPC分类号： C07D403/12 , C07D237/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).
摘要翻译： 本发明提供了作为γ分泌酶调节剂的新型化合物。 所述化合物具有式还公开了使用式（I）化合物调节γ-分泌酶活性的方法和治疗阿尔茨海默氏病的方法。
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公开(公告)号：US08450343B2
公开(公告)日：2013-05-28
申请号：US12746041
申请日：2008-12-04
申请人： Xianhai Huang , Anandan Palani , Jun Qin , Robert G. Aslanian , Zhaoning Zhu , William Greenlee , Hubert Josien , Wei Zhou , Xiaohong Zhu , Chad E. Bennett , Dmitri Pissarnitski , Mihirbaran Mandal , Pawan Dhondi , Troy McCracken , Thomas Bara , Zhiqiang Zhao , Duane Burnett , John Clader
发明人： Xianhai Huang , Anandan Palani , Jun Qin , Robert G. Aslanian , Zhaoning Zhu , William Greenlee , Hubert Josien , Wei Zhou , Xiaohong Zhu , Chad E. Bennett , Dmitri Pissarnitski , Mihirbaran Mandal , Pawan Dhondi , Troy McCracken , Thomas Bara , Zhiqiang Zhao , Duane Burnett , John Clader
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04 , C07D403/10 , C07D487/04 , C07D498/04 , C07D513/04
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
摘要翻译： 本发明提供了作为γ分泌酶调节剂的新型化合物。 所述化合物具有式（I），其中R 2是式（II）的稠合双环。 还公开了使用式（I）的化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法的方法。
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公开(公告)号：US20120316154A1
公开(公告)日：2012-12-13
申请号：US13515638
申请日：2010-12-09
申请人： Dong Xiao , Anandan Palani , Robert G Aslanian , Sylvia Degrado , Xianhai Huang , Wei Zhou , Michael Sofolarides , Xiao Chen
发明人： Dong Xiao , Anandan Palani , Robert G Aslanian , Sylvia Degrado , Xianhai Huang , Wei Zhou , Michael Sofolarides , Xiao Chen
IPC分类号： A61K31/55 , C07D495/04 , A61P11/06 , A61P1/00 , A61P17/06 , C07D491/048 , A61P29/00
CPC分类号： A61K31/55 , C07D491/048 , C07D495/04
摘要： The present invention relates to certain lactam ring-containing compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein D, E, X1, R1, R2, R3, R4, R9, and R10 are as herein described. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, and chronic obstructive pulmonary disorder.
摘要翻译： 本发明涉及式（I）的某些含内酰胺环的化合物及其药学上可接受的盐，其中D，E，X 1，R 1，R 2，R 3，R 4，R 9和R 10如本文所述。 此外，本发明涉及包含至少一种这样的化合物的药学上可接受的组合物，以及使用该化合物治疗或预防各种炎性疾病如类风湿性关节炎，炎性肠病，牛皮癣，哮喘和慢性阻塞性肺病的方法。
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公开(公告)号：US20120245158A1
公开(公告)日：2012-09-27
申请号：US13377885
申请日：2010-06-15
IPC分类号： A61K31/519 , A61K31/53 , A61P25/28 , C07D487/04 , C07D498/04 , A61K31/5395
CPC分类号： C07D471/04 , C07D498/04
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the Formula I: Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of Formula I.
摘要翻译： 本发明提供了作为γ分泌酶调节剂的新型化合物。 化合物具有式I：还公开了使用式I化合物调节γ-分泌酶活性的方法和治疗阿尔茨海默病的方法。
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公开(公告)号：US20120107328A1
公开(公告)日：2012-05-03
申请号：US12739315
申请日：2008-11-03
IPC分类号： A61K39/395 , C07D498/20 , C07F7/10 , C07F9/6574 , C07D498/22 , A61K31/438 , A61K31/5386 , A61K31/695 , A61K31/675 , A61K31/5395 , A61K31/53 , A61P29/00 , A61P25/28 , A61P27/06 , A61P25/00 , A61P9/00 , C07D498/10
CPC分类号： C07D498/10 , C07D487/10 , C07D487/20 , C07D493/20 , C07D495/20 , C07D498/20 , C07D498/22 , C07F7/0812 , C07F9/657181
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).
摘要翻译： 本发明提供了作为γ分泌酶调节剂的新型化合物。 化合物具有式（I）。 还公开了使用式（I）化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法的方法。
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公开(公告)号：US20110257156A1
公开(公告)日：2011-10-20
申请号：US13126056
申请日：2009-11-05
申请人： Zhaoning Zhu , William J. Greenlee , David James Cole , Dmitri A. Pissarnitski , Gioconda V. Gallo , Hongmei Li , Hubert B. Josien , Jun Qin , Chad E. Knutson , Mihirbaran Mandal , Monica L. Vicarel , Murali Rajagopalan , Pawan Kumar Dhondi , Ruo Xu , Zhong-Yue Sun , Thomas A. Bara , Xianhai Huang , Xiaohong Zhu , Zhiqiang Zhao , John W. Clader , Anandan Palani , Theodros Asberom , Troy McCracken , Chad E. Bennett
发明人： Zhaoning Zhu , William J. Greenlee , David James Cole , Dmitri A. Pissarnitski , Gioconda V. Gallo , Hongmei Li , Hubert B. Josien , Jun Qin , Chad E. Knutson , Mihirbaran Mandal , Monica L. Vicarel , Murali Rajagopalan , Pawan Kumar Dhondi , Ruo Xu , Zhong-Yue Sun , Thomas A. Bara , Xianhai Huang , Xiaohong Zhu , Zhiqiang Zhao , John W. Clader , Anandan Palani , Theodros Asberom , Troy McCracken , Chad E. Bennett
IPC分类号： A61K31/55 , A61K31/5383 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/438 , A61K31/437 , C07D413/10 , C07D498/20 , C07D498/04 , A61P25/00 , A61P25/28 , A61K31/4245 , A61K31/5386
CPC分类号： C07D471/04 , C07D413/10 , C07D498/04 , C07D498/20 , C07F7/0812
摘要： In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明提供了新颖的杂环化合物作为γ-分泌酶的调节剂，制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及治疗方法， 使用这种化合物或药物组合物预防，抑制或改善与中枢神经系统相关的一种或多种疾病。
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公开(公告)号：US20110082153A1
公开(公告)日：2011-04-07
申请号：US12673858
申请日：2008-09-04
申请人： Robert G. Aslanian , Xianhai Huang , Anandan Palani , JUn Qin , Wei Zhou , Xiaohong Zhu , Robert Mazzola , Pawan Dhondi , William J. Greenlee
发明人： Robert G. Aslanian , Xianhai Huang , Anandan Palani , JUn Qin , Wei Zhou , Xiaohong Zhu , Robert Mazzola , Pawan Dhondi , William J. Greenlee
IPC分类号： A61K31/501 , C07D403/12 , C07D237/14 , A61K31/50 , C07D401/12 , A61K31/4439 , C07D403/14 , A61P25/28 , A61P27/06 , A61P9/00 , A61P29/00
CPC分类号： C07D403/12 , C07D237/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).
摘要翻译： 本发明提供了作为γ分泌酶调节剂的新型化合物。 化合物具有式（I）。 还公开了使用式（I）化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法的方法。
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