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公开(公告)号：US07514533B2
公开(公告)日：2009-04-07
申请号：US10557400
申请日：2003-05-21
申请人： Stephen Noel Fitzgerald , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Mark Ibberson , Melanie Yorke
发明人： Stephen Noel Fitzgerald , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Mark Ibberson , Melanie Yorke
CPC分类号： A01K2217/075 , A61K38/00 , C07K14/472 , C07K14/525
摘要： This invention relates to novel protein INSP058, herein identified as TNF-like secreted protein, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及本文鉴定为TNF-样分泌蛋白的新型蛋白质INSP058，以及该蛋白质和来自编码基因的核酸序列在疾病的诊断，预防和治疗中的用途。
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公开(公告)号：US20080213286A1
公开(公告)日：2008-09-04
申请号：US11577443
申请日：2005-10-18
IPC分类号： A61K39/395 , C07K14/00 , C12N15/11 , C12N9/00 , A61K31/70 , A61K38/00 , A61K39/00 , A61P43/00 , C12Q1/68 , G01N33/53 , A01K67/027 , C12N15/00 , C12N5/06 , C07K16/18
CPC分类号： C12N9/6489 , C12N9/16
摘要： This invention relates to a novel protein, termed INSP152, herein identified as a secreted protein, in particular, as a MAM domain containing protein and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment.
摘要翻译： 本发明涉及一种称为INSP152的新型蛋白质，在本文中鉴定为分泌蛋白，特别是含有MAM结构域的蛋白质，以及在诊断，预防和治疗中使用该蛋白质和编码基因的核酸序列。
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公开(公告)号：US20080025951A1
公开(公告)日：2008-01-31
申请号：US10579113
申请日：2004-11-12
申请人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
发明人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
IPC分类号： A61K38/16 , A01K67/00 , A61K48/00 , A61P31/12 , C07H21/00 , C12N1/00 , C12N15/63 , C07K14/00 , A61P37/00 , A61P17/00 , A61K31/7088
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/10 , C07K2319/30 , Y02A50/401
摘要： This invention relates to novel uses of a protein sequence (INSP052EC), herein identified as an immunoglobulin domain-containing cell surface recognition, in the diagnosis, prevention and treatment of diseases, in particular those related to the excessive expression and/or secretion of cytokines.
摘要翻译： 本发明涉及本文鉴定为含有免疫球蛋白结构域的细胞表面识别的蛋白质序列（INSP052EC）在疾病的诊断，预防和治疗中的新用途，特别是与细胞因子的过度表达和/或分泌相关的那些 。
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公开(公告)号：US20070274992A1
公开(公告)日：2007-11-29
申请号：US10554816
申请日：2004-04-30
CPC分类号： C07K14/47 , A61K38/00 , Y02A90/26 , Y10T436/143333
摘要： This invention relates to a new family of secreted proteins, termed the SECFAM3 family, its family members including the novel human proteins INSP123, INSP124, and INSP125, herein identified as secreted proteins containing a von Willebrand Factor type C (vWFC) domain, and to the use to these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及称为SECFAM3家族的新型分泌蛋白家族，其家族成员包括新型人蛋白质INSP123，INSP124和INSP125，其鉴定为含有von Willebrand因子C型（vWFC）结构域的分泌蛋白质，以及 用于这些蛋白质和核酸序列的编码基因的诊断，预防和治疗疾病。
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公开(公告)号：US20070141569A1
公开(公告)日：2007-06-21
申请号：US10539962
申请日：2003-12-19
IPC分类号： C12Q1/68 , A61K38/18 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号： C07K14/61
摘要： This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种称为INSP105的蛋白质，在本文中被鉴定为人胎盘生长激素的剪接变体，以及来自编码基因的该蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。
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公开(公告)号：US20070021588A1
公开(公告)日：2007-01-25
申请号：US10531751
申请日：2003-10-16
CPC分类号： C07K14/8107
摘要： This invention relates to two proteins, termed INSP087, herein identified as members of the alpha macroglobulin family, in particular as alpha-2-macroglobulin-like proteinase inhibitors, and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及称为INSP087的两种蛋白质，在本文中被鉴定为α巨球蛋白家族的成员，特别是作为α-2-巨球蛋白样蛋白酶抑制剂，以及来自编码基因的这些蛋白质和核酸序列的使用 诊断，预防和治疗疾病。
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公开(公告)号：US20060121475A1
公开(公告)日：2006-06-08
申请号：US10526722
申请日：2003-09-05
CPC分类号： C12N9/1205 , A01K2217/05 , A01K2217/075
摘要： The present invention relates to novel proteins, termed INSP081, INSP082, and INSP091, herein identified as members of the Germinal Center Kinase (GCK) subfamily of the STE20 family of protein kinases, preferably as NCK-interacting kinases (NIKs) and more preferably as NIK-like embryo specific kinases (NESKs), and to the use of these and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及称为INSP081，INSP082和INSP091的新蛋白质，其在本文中被鉴定为STE20家族蛋白激酶的生发中心激酶（GCK）亚家族的成员，优选作为NCK相互作用的激酶（NIK），更优选为 NIK样胚胎特异性激酶（NESKs），以及来自编码基因的这些和核酸序列在疾病的诊断，预防和治疗中的应用。
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68.发明申请Uses of a chemokine receptor able to bind to MCP-1, MIP-1 alpha and/or rantes 失效使用能够结合MCP-1，MIP-1α和/或细胞的趋化因子受体公开(公告)号：US20050014695A1
公开(公告)日：2005-01-20
申请号：US10933356
申请日：2004-09-03
申请人： Timothy Wells , Christine Power
发明人： Timothy Wells , Christine Power
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/10 , A61P11/06 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P31/12 , A61P31/18 , A61P37/00 , A61P37/08 , A61P43/00 , C07K14/52 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , A61K38/17
CPC分类号： C07K14/7158
摘要： A chemokine receptor binds to MCP-1, MIP-1α and/or RANTES. It can be used in screening for agents which act as antagonists to MCP-1, MIP-1α and/or RANTES. Such agents may be useful in treating various disorders, including allergies, atheromas and diseases mediated by viruses. They may also be useful in preventing graft rejection and in protecting stem cells from potentially damaging effects of chemotherapy.
摘要翻译： 趋化因子受体结合MCP-1，MIP-1α和/或RANTES。 它可用于筛选作为MCP-1，MIP-1α和/或RANTES拮抗剂的药剂。 这样的药剂可用于治疗各种疾病，包括过敏，动脉粥样化和由病毒介导的疾病。 它们也可用于预防移植物排斥和保护干细胞免受化学疗法的潜在破坏性影响。
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