公开(公告)号：US20060160787A1

公开(公告)日：2006-07-20

申请号：US11374814

申请日：2006-03-14

申请人： Q. Dou ,  Edward Turos ,  David Smith

发明人： Q. Dou ,  Edward Turos ,  David Smith

IPC分类号： A61K31/397 ,  C07D205/08

CPC分类号： C07D491/04 ,  C07D205/08

摘要： The subject invention concerns N-thiolated β-lactam compounds of formula A, wherein R1is a hydrocarbon group having 1-8 carbon atoms; R3 is an organothio group; and R4 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, and analogs and pharmaceutically acceptable salts, esters and amides thereof. The subject invention also concerns methods for inducing tumor cell death or inhibiting tumor cell proliferation, and methods for inducing DNA damage, inhibiting DNA replication, activating p38 MAP kinase, or activating caspase cascade activation, or releasing cytochrome C from mitochondria into the cytoplasm in a tumor cell. Methods for treating cancer using N-thiolated β-lactam compounds, as well as pharmaceutical compositions comprising the same are further disclosed.

摘要翻译： 本发明涉及式A的N-硫醇化β-内酰胺化合物，其中R 1是具有1-8个碳原子的烃基; R 3是有机硫基; 和R 4是烷基，烯基，炔基，芳基，杂芳基，环烷基，杂环烷基，环烯基或杂环烯基，以及其类似物和药学上可接受的盐，酯和酰胺。 本发明还涉及诱导肿瘤细胞死亡或抑制肿瘤细胞增殖的方法，以及用于诱导DNA损伤，抑制DNA复制，激活p38 MAP激酶或激活胱天蛋白酶级联活化或将细胞色素C从线粒体释放到细胞质中的方法 肿瘤细胞。 使用N-硫醇化β-内酰胺化合物治疗癌症的方法以及包含其的药物组合物进一步公开。

公开(公告)号：US20060110016A1

公开(公告)日：2006-05-25

申请号：US11320472

申请日：2005-12-29

申请人： David Smith

发明人： David Smith

IPC分类号： G06K9/00

CPC分类号： G06K9/036 ,  G06K9/00013

摘要： A system and method of capturing an acceptable fingerprint image is disclosed herein. The method includes a step of capturing an initial fingerprint image at a nominal image integration time. Once this initial fingerprint image is captured, a first intermediate fingerprint image at a first intermediate image integration time is captured. Next, an image darkness test is performed followed by an image definition test. If one or more of these tests indicates that the first intermediate fingerprint image is unacceptable, a subsequent intermediate fingerprint image at a subsequent intermediate image integration time is captured. This subsequent intermediate fingerprint image can be captured before the image definition test is performed. Additional intermediate fingerprint images can be captured until an image that has an acceptable darkness level as a well as an acceptable definition level is captured. Also disclosed is a fingerprint scanner that performs this method.

公开(公告)号：US20060102347A1

公开(公告)日：2006-05-18

申请号：US10525550

申请日：2003-08-29

申请人： David Smith

发明人： David Smith

IPC分类号： E21B47/00

CPC分类号： E21B47/065 ,  E21B23/00 ,  E21B47/123 ,  G01K11/32

摘要： The invention is a system and method to log a wellbore, comprising a logging tool including a downhole power source to power the data transmission and logging tool, the logging tool adapted to be deployed in a wellbore environment, the logging tool taking at least one measurement of the wellbore environment, a fiber optic line in optical communication with the logging tool, and the logging tool transmitting the measurements on a real time basis through the fiber optic line to surface and converting the data at surface back into electrical data and processing the data at surface into a real time display of the data. In one embodiment, a continuous tube with one end at the earth's surface and the other end in the wellbore is attached to the logging tool and includes the fiber optic line disposed therein.

摘要翻译： 本发明是一种用于记录井眼的系统和方法，包括测井工具，其包括用于为数据传输和测井工具提供动力的井下电源，所述测井工具适于部署在井眼环境中，所述测井工具采取至少一个测量 的井眼环境，与测井工具光学通信的光纤线路，测井工具通过光纤线路实时传输测量结果，并将表面上的数据转换成电气数据并处理数据 在表面上实时显示数据。 在一个实施例中，在地球表面具有一端并且在井筒中的另一端的连续管连接到测井工具，并且包括布置在其中的光纤线。

公开(公告)号：US20060084677A1

公开(公告)日：2006-04-20

申请号：US11291867

申请日：2005-11-30

申请人： Chris Broka ,  Woongki Kim ,  David Smith ,  Kevin McLaren

发明人： Chris Broka ,  Woongki Kim ,  David Smith ,  Kevin McLaren

IPC分类号： A61K31/47 ,  C07D215/60

CPC分类号： C07D215/36

摘要： This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH2, CH(OH), C(O), C═NOR4, NR5, O, S, S(O), or S(O)2, and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

摘要翻译： 本发明涉及通常为抗炎和止痛化合物的化合物，其由式I表示：其中A是CH 2，CH（OH），C（O），C- NOR 4，NR 5，O，S，S（O）或S（O）2，其它取代基如所定义 在规范中; 或前药，各异构体，异构体的混合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法

公开(公告)号：US20060040890A1

公开(公告)日：2006-02-23

申请号：US11208510

申请日：2005-08-22

申请人： Joseph Martin ,  Keshab Sarma ,  David Smith

发明人： Joseph Martin ,  Keshab Sarma ,  David Smith

IPC分类号： A61K31/7072 ,  C07H19/12

CPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/12

摘要： 4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

摘要翻译： 4-氨基-1 - （（2R，3S，4S，5R）-5-叠氮基-3,4-二羟基-5-羟甲基 - 四氢 - 呋喃-2-基）-1H-嘧啶-2-酮（I ：R 1 = R 2 = R 3 = R 4 = H），其前药是丙型肝炎（C） HCV）聚合酶抑制剂。 还公开了用于抑制HCV和治疗HCV介导的疾病的组合物和方法，用于制备该方法中使用的化合物和合成中间体的方法。

公开(公告)号：US20060001681A1

公开(公告)日：2006-01-05

申请号：US11156626

申请日：2005-06-21

申请人： David Smith

发明人： David Smith

IPC分类号： G09G5/00

CPC分类号： G06T15/503 ,  G06T11/60 ,  G06T15/30

摘要： Methods of rendering an object-based image are described. The methods receive a list of objects (951-955) in the image (950), the list ordering the objects in priority order from a lowest-priority object (951) to a highest-priority object (955). The objects are assigned to a first set of objects (951, 952) and/or a second set of objects (953-955). The first set of objects is rendered to an image store using a first rendering method that only renders a portion of an object if the portion is visible in the first set of objects and the second set of objects is rendered to the image store using a second rendering method that renders each object independently of the other objects in the second set. The assignment may be based on a priority order of a highest-compositing object (952). The assignment may be based on a group of overlapping objects (1101, 1102, 1103, 1105), where an object (1105) in the group requires compositing.

摘要翻译： 描述呈现基于对象的图像的方法。 该方法在图像（950）中接收对象（951-955）的列表，该列表以优先顺序从最低优先级对象（951）到最高优先级对象（955）排序对象。 对象被分配给第一组对象（951,952）和/或第二组对象（953-955）。 使用第一渲染方法将第一组对象呈现到图像存储器，该第一渲染方法仅在第一组对象中显示该部分时呈现对象的一部分，并且使用第二渲染方法将第二组对象渲染到图像存储器 渲染方法，使每个对象独立于第二个集合中的其他对象。 分配可以基于最高合成对象的优先顺序（952）。 分配可以基于一组重叠对象（1101,1102,1103,1105），其中该组中的对象（1105）需要合成。

公开(公告)号：US20060000701A1

公开(公告)日：2006-01-05

申请号：US10884336

申请日：2004-07-01

申请人： David Smith ,  Allen Ferrell

发明人： David Smith ,  Allen Ferrell

IPC分类号： C10B7/10

CPC分类号： C10B7/10 ,  C10B53/02 ,  C10B57/02 ,  C10J3/32 ,  C10J2300/0909 ,  C10J2300/092 ,  Y02E50/14

摘要： A wood gasification apparatus in which cellulosic material is transported by an auger through a housing and heated to vaporize at least a portion of the cellulosic material by frictional heating. The auger and housing define a spiral void through which the cellulosic material is propelled from the inlet to the outlet, and which continually decreases in volume from the inlet to the outlet. The ever decreasing volume of the void increases the pressure on the cellulosic material and maximizes the frictional heating until the material reaches a vaporization temperature.

摘要翻译： 木材气化装置，其中纤维素材料通过螺旋钻通过壳体输送并通过摩擦加热被加热以蒸发至少一部分纤维素材料。 螺旋推运器和壳体限定了螺旋空隙，纤维素材料从入口到出口被推进，并且从入口到出口不断地减小体积。 空隙的不断减小的体积增加了纤维素材料上的压力，并使摩擦加热最大化直到材料达到蒸发温度。

公开(公告)号：US06957789B2

公开(公告)日：2005-10-25

申请号：US10683705

申请日：2003-10-14

申请人： Paul Bowman ,  Alan George Smithson ,  George Brotherson Routledge ,  David Smith ,  Terry Nichol

发明人： Paul Bowman ,  Alan George Smithson ,  George Brotherson Routledge ,  David Smith ,  Terry Nichol

IPC分类号： B60R22/36 ,  B60R22/28

CPC分类号： B60R22/36

摘要： A U-shaped frame for a seat belt retractor has two spaced arms made from a material of a predetermined thickness and having a cutout in the material of each arm for receiving a lockbar. Each cutout has an edge comprising a land portion for supporting the lockbar, which land portion is of a reduced thickness compared to the thickness of the material of the arms, to present a reduced surface area to the lockbar. The frame may be of pressed steel and the lockbar of die-cast non-ferrous material.

摘要翻译： 用于安全带卷收器的U形框架具有由预定厚度的材料制成的两个间隔开的臂，并且在每个臂的材料中具有用于接收锁定杆的切口。 每个切口具有包括用于支撑锁定杆的陆部部分的边缘，所述陆部部分与臂的材料的厚度相比具有减小的厚度，以将减小的表面面积提供给锁定杆。 框架可以是压制钢和压铸有色金属材料的锁定杆。

公开(公告)号：US20050226584A1

公开(公告)日：2005-10-13

申请号：US10430058

申请日：2003-05-05

申请人： Jerry Williams ,  David Smith ,  Jeffrey Muhs

发明人： Jerry Williams ,  David Smith ,  Jeffrey Muhs

IPC分类号： G01D5/353 ,  G01L5/10 ,  G02B6/10

CPC分类号： D04C1/02 ,  D07B1/145 ,  D07B2201/2096 ,  D07B2301/5577 ,  D07B2501/2061 ,  G01D5/35316 ,  G01D5/35354 ,  G01L5/105

摘要： A method for the direct measurement of large strains in ropes in situ using a plastic optical fiber, for example, perfluorocarbon or polymethyl methacrylate and Optical Time-Domain Reflectometer or other light time-of-flight measurement instrumentation. Protective sheaths and guides are incorporated to protect the plastic optical fiber. In one embodiment, a small rope is braided around the plastic optical fiber to impose lateral compressive forces to restrain the plastic optical fiber from slipping and thus experience the same strain as the rope. Methods are described for making reflective interfaces along the length of the plastic optical fiber and to provide the capability to measure strain within discrete segments of the rope. Interpretation of the data allows one to calculate the accumulated strain at any point in time and to determine if the rope has experienced local damage.

摘要翻译： 使用塑料光纤例如全氟化碳或聚甲基丙烯酸甲酯和光时域反射计或其他轻型飞行时间测量仪器直接测量原位绳索中的大应变的方法。 整合护套和引导件以保护塑料光纤。 在一个实施例中，围绕塑料光纤编织小绳索以施加横向压缩力以限制塑料光纤滑动，并因此经历与绳索相同的应变。 描述了用于沿着塑料光纤的长度制造反射界面的方法，并提供测量绳索的离散段内的应变的能力。 数据解释可以计算任何时间点的累积应变，并确定绳索是否遭受局部损坏。

公开(公告)号：US20050174946A1

公开(公告)日：2005-08-11

申请号：US11025298

申请日：2004-12-29

申请人： David Smith

发明人： David Smith

IPC分类号： H04L12/26

CPC分类号： H04L43/00

摘要： The present invention is a system and method of providing a GR303 interface to a digital central office. A virtual line group is installed within a line frame holding a plurality of line groups for communicating with analog subscriber telephones. The digital central office utilizes internal proprietary signals to operate the line groups and route calls to a public switched telecommunications network. The virtual line group emulates a line group within the digital central office and provides an GR303 interface for communicating with remote digital loop carriers. The virtual line group provides the GR303 interface without modifying or adding software or hardware to the digital central office.

摘要翻译： 本发明是向数字中心局提供GR303接口的系统和方法。 虚拟线路组安装在保持多个线路组的线路框架内，以与模拟用户电话进行通信。 数字中心局利用内部专有信号来操作线路组并将呼叫路由到公共交换电信网络。 虚拟线路组模拟数字中心局内的一个线路组，并提供一个用于与远程数字环路载波进行通信的GR303接口。 虚拟线路组提供GR303接口，无需修改或添加软件或硬件到数字中心局。