公开(公告)号：US20060040890A1

公开(公告)日：2006-02-23

申请号：US11208510

申请日：2005-08-22

申请人： Joseph Martin ,  Keshab Sarma ,  David Smith

发明人： Joseph Martin ,  Keshab Sarma ,  David Smith

IPC分类号： A61K31/7072 ,  C07H19/12

CPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/12

摘要： 4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

摘要翻译： 4-氨基-1 - （（2R，3S，4S，5R）-5-叠氮基-3,4-二羟基-5-羟甲基 - 四氢 - 呋喃-2-基）-1H-嘧啶-2-酮（I ：R 1 = R 2 = R 3 = R 4 = H），其前药是丙型肝炎（C） HCV）聚合酶抑制剂。 还公开了用于抑制HCV和治疗HCV介导的疾病的组合物和方法，用于制备该方法中使用的化合物和合成中间体的方法。

公开(公告)号：US20070042988A1

公开(公告)日：2007-02-22

申请号：US11503558

申请日：2006-08-11

申请人： Klaus Klumpp ,  Joseph Martin ,  Christopher McGuigan ,  David Smith

发明人： Klaus Klumpp ,  Joseph Martin ,  Christopher McGuigan ,  David Smith

IPC分类号： A61K31/7076 ,  A61K31/7072 ,  C07H19/04

CPC分类号： C07H19/10 ,  C07H19/04

摘要： The invention provides novel nucleoside compounds of formula I wherein R1, R2a, R2b, R3, R4, R5, R6, R8a, R9 and R10 are as defined herein which are useful for the treatment of Hepatitis C Virus (HCV) mediated diseases. The invention further provides methods for treatment or prophylaxis of HCV mediated diseases with compounds of formula I and pharmaceutical compositions comprising these compounds,

摘要翻译： 本发明提供了式I的新型核苷化合物，其中R 1，R 2，R 2，R 2b，R 3， R 4，R 5，R 6，R 8a，R 9和R 9，和 R 10如本文所定义，其可用于治疗丙型肝炎病毒（HCV）介导的疾病。 本发明还提供了用式I化合物治疗或预防HCV介导的疾病的方法和包含这些化合物的药物组合物，

公开(公告)号：US10196155B2

公开(公告)日：2019-02-05

申请号：US14481456

申请日：2014-09-09

申请人： Joseph Martin

发明人： Joseph Martin

IPC分类号： B64C39/02 ,  B64F1/00 ,  A47G29/14

摘要： An unmanned aerial vehicle delivery system utilizes an unmanned aerial vehicle (UAV) to deliver packages between an initiation point and multiple delivery points at a raised elevation. The UAV flies between points in an organized manner, using logistical, maintenance and safety software, commands from a delivery organization, and guidance tools to coordinate deliveries. One advantage of the system is that the UAV engages the delivery points at a raised elevation, rather than the ground level. The UAV docks through an elevated structure at the delivery point for delivering the package and replenishing a power source. The package is conveyed from a docking end and through a central shaft of the elevated structure by means of an elevator. The package then travels to a lower structure, such as a house or office, for pickup. After completion of the delivery, the UAV replenishes its power source and/or continues on the delivery route.

公开(公告)号：US20070156434A1

公开(公告)日：2007-07-05

申请号：US11325830

申请日：2006-01-04

申请人： Joseph Martin ,  Venkatachary Srinivasan ,  Jerald Singh ,  Marco Boerries ,  Torsten Schulz

发明人： Joseph Martin ,  Venkatachary Srinivasan ,  Jerald Singh ,  Marco Boerries ,  Torsten Schulz

IPC分类号： G06Q99/00

CPC分类号： G06Q10/10 ,  G06F17/3028 ,  G06Q10/06 ,  G06Q50/01

摘要： For providing synchronization of image data among diverse devices and applications, exemplary systems include a direct client application providing a user interface operable to allow a user to organize image data according to albums, and to select one or more albums for synchronization with one or more server interfaces that provide various image data manipulation, sharing, and features related thereto. Systems also include an intermediary system to assist in synchronization of select albums with handheld devices, and a notification server to provide scalable notifications of album updates made at server interfaces by users. Exemplary methods include steps providing for selection, from direct client applications, of albums to synchronize with devices, including handheld devices, and various steps of providing updates and notifications among appropriate system components.

摘要翻译： 为了提供不同设备和应用之间的图像数据的同步，示例性系统包括提供可操作以允许用户根据相册组织图像数据的用户界面的直接客户端应用，并且选择一个或多个相册以与一个或多个服务器同步 提供各种图像数据操作，共享和与其相关的特征的接口。 系统还包括协助选择专辑与手持设备同步的中介系统，以及通知服务器，以提供在用户在服务器接口处制作的相册更新的可伸缩通知。 示例性方法包括提供从直接客户端应用程序选择要与包括手持设备在内的设备同步的相册以及在适当的系统组件之间提供更新和通知的各种步骤的步骤。

公开(公告)号：US5928815A

公开(公告)日：1999-07-27

申请号：US971054

申请日：1997-11-14

申请人： Joseph Martin

发明人： Joseph Martin

IPC分类号： G03F1/00 ,  G03F9/00

CPC分类号： G03F1/50

摘要： A masking device for performing high-resolution photoresist-based lithography in the fabrication of integrated circuits. The heart of the device is a cylindrical block made of material transparent to, and manifesting a relatively high index of refraction for, the wavelengths of light to be used in conjunction with it. The mask end of the block is imprinted with a pattern of ridges corresponding to the pattern to be illuminated on the photoresist. The mask end, including the inter-ridge troughs, is covered with a metal film several tens of .ANG. thick. The troughs are filled in with a material such as carbon black strongly absorptive of the wavelengths that will emerge from the mask. The sides of the block are covered with a metal cladding sufficiently thick to prevent any light from escaping from the block. The top end of the block, opposite the mask end, is left uncovered. In operation, the block is used in conjunction with a precise positioning mechanism for locating the block in the horizontal plane and for maintaining a very small, but non-zero, distance between the mask ridges and the photoresist layer, such that the photoresist layer is in the near-field of the mask. In this manner, the photoresist can be illuminated with the pattern desired, with a resolution sufficient to produce circuit elements with dimensions much less than the wavelength of light entering the top end of the mask block.

摘要翻译： 一种用于在集成电路的制造中执行高分辨率光致抗蚀剂的光刻的掩模装置。 器件的心脏是由与其结合使用的光的波长透明的材料制成的圆柱形块，并且表现出相对较高的折射率。 块的掩模端部印有对应于要在光致抗蚀剂上照射的图案的脊的图案。 包括脊间槽的掩模端被几十个厚度的ANGSTROM的金属膜覆盖。 槽中填充有诸如炭黑的材料，其强烈吸收将从掩模中出现的波长。 块的侧面被足够厚的金属覆层覆盖，以防止任何光从块中逸出。 块的顶端与掩模端相对，未被覆盖。 在操作中，块与精确的定位机构一起使用，用于将块定位在水平面中并且用于在掩模脊和光致抗蚀剂层之间保持非常小但非零的距离，使得光致抗蚀剂层为 在面具的近场。 以这种方式，可以以期望的图案照射光致抗蚀剂，其分辨率足以产生尺寸远小于进入掩模块顶端的光的波长的电路元件。

公开(公告)号：US5164559A

公开(公告)日：1992-11-17

申请号：US692421

申请日：1991-04-29

申请人： Van Doan Pham ,  Edmond Thuries ,  Joseph Martin

发明人： Van Doan Pham ,  Edmond Thuries ,  Joseph Martin

IPC分类号： H01H33/16 ,  H01H33/70

CPC分类号： H01H33/161

摘要： An SF.sub.6 circuit breaker having a varistor incorporated in line with its interrupting chamber in which insertion of the varistor on opening and closing is performed by coaxial translation of two electrodes outside and around the main contacts.

摘要翻译： 具有与其中断室一致的可变阻器的SF6断路器，其中通过在主触点外部和周围的两个电极的同轴平移来执行非线性阻尼器在打开和关闭中的插入。

公开(公告)号：US5124872A

公开(公告)日：1992-06-23

申请号：US618206

申请日：1990-11-21

申请人： Van Doan Pham ,  Joseph Martin ,  Robert Deville

发明人： Van Doan Pham ,  Joseph Martin ,  Robert Deville

IPC分类号： H01C7/12 ,  H01H33/16

CPC分类号： H01H33/161 ,  H01H2033/146

摘要： A high tension circuit breaker comprising at least one circuit-breaking chamber and, in parallel with the circuit-breaking chamber, firstly a varistor in series with an interrupter, and secondly a tension-distributing capacitor. The circuit breaker has a linear resistor having a resistance lying in the range range 30 ohms to 300 ohms inserted in series with the varistor. The invention is particularly suitable for reactance circuit breakers.

摘要翻译： 一种高压断路器，包括至少一个断路室，并且与断路室并联，首先是与断路器串联的变阻器，其次是张力分配电容器。 断路器具有线性电阻器，其电阻位于与压敏电阻串联插入的30欧姆至300欧姆的范围内。 本发明特别适用于电抗断路器。

公开(公告)号：US20120328776A1

公开(公告)日：2012-12-27

申请号：US13490520

申请日：2012-06-07

申请人： Pierre-Jean CALBA ,  Joseph Martin ,  Karin Scherer ,  Alain Thuillier ,  Gérard Willemin

发明人： Pierre-Jean CALBA ,  Joseph Martin ,  Karin Scherer ,  Alain Thuillier ,  Gérard Willemin

IPC分类号： B05D5/06

CPC分类号： B29D11/00865

摘要： Process for manufacturing of an optical article which comprises:making available an organic substrate based on an organic polymer having a degree of water uptake of greater than or equal to 0.6% by weight, with respect to the total weight of the substrate, the degree of water uptake being equal to the weight of water absorbed by the material after drying and then storing for 800 hours in a chamber at 50° C. under a relative humidity of 100% and at atmospheric pressure;forming a hard abrasion-resistant coating on the substrate by heating the substrate at a temperature of greater than or equal to 90° C. for a period of time of at least 20 minutes;exposing the substrate covered with the hard abrasion-resistant coating to a humid atmosphere, so as to restore, to the organic substrate, the water evaporated during stage; anddepositing of a water-impermeable inorganic coating by vacuum evaporation.

摘要翻译： 一种光学制品的制造方法，其特征在于：使基于有机聚合物获得有机基材，所述有机聚合物的吸水度大于或等于0.6重量％，相对于所述基材的总重量， 吸水量等于干燥后材料吸收的水的重量，然后在相对湿度100％和大气压下在50℃的室中储存800小时; 通过在大于或等于90℃的温度下加热基底至少20分钟的时间，在基底上形成硬的耐磨涂层; 将被硬质耐磨涂层覆盖的基材暴露于潮湿气氛中，以使在阶段中蒸发的水回收到有机基材; 并通过真空蒸发沉积不透水的无机涂层。

公开(公告)号：US07313848B2

公开(公告)日：2008-01-01

申请号：US10784096

申请日：2004-02-23

申请人： Mark Forster ,  Joseph Martin

发明人： Mark Forster ,  Joseph Martin

IPC分类号： A44B11/25

CPC分类号： B64D17/38 ,  Y10T24/45644 ,  Y10T24/45686

摘要： A dual action canopy release for releasably holding a parachute harness securement strap in a buckle. The canopy release may be activated by a forward movement of a lever arm or a rearward movement of the lever arm. The lever arm cooperates with an actuating lever having a first position, wherein the actuating lever holds a latch in a locked position, and a second position, wherein the actuating lever releases the latch thereby allowing the latch to move to an unlocked position. Either the forward movement or the rearward movement of the lever arm causes the actuating lever to move to the second position. In the unlocked position, the latch allows parachute harness securement strap to be withdrawn from the buckle.

摘要翻译： 双作用罩盖释放，用于可拆卸地将降落伞束固定带固定在扣环中。 可以通过杠杆臂的向前运动或杠杆臂的向后运动来激活冠层释放。 杠杆臂与具有第一位置的致动杠杆配合，其中所述致动杆将闩锁保持在锁定位置和第二位置，其中所述致动杆释放所述闩锁，从而允许所述闩锁移动到解锁位置。 杠杆臂的向前运动或向后运动使致动杆移动到第二位置。 在解锁位置，闩锁允许降落伞线束固定带从带扣中取出。

公开(公告)号：US20070235843A1

公开(公告)日：2007-10-11

申请号：US11399542

申请日：2006-04-07

申请人： Joseph Martin ,  King Fu ,  Hoi Phen

发明人： Joseph Martin ,  King Fu ,  Hoi Phen

IPC分类号： H01L23/495

CPC分类号： H01L23/3107 ,  H01L23/49582 ,  H01L24/48 ,  H01L2224/05155 ,  H01L2224/05644 ,  H01L2224/05664 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/484 ,  H01L2224/85444 ,  H01L2224/85455 ,  H01L2224/85464 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01046 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/181 ,  H01L2224/45099 ,  H01L2924/00012

摘要： An electronic device comprises a leadframe attached to a die and embedded in a mold packaging with enhanced adhesion property. The leadframe comprises a bonding surface, a soldering surface, a mold adhesion surface, and a die attachment surface wherein the soldering surface and bonding surface are selectively plated with nickel/palladium/gold. The mold adhesion surface and the die attachment surface are roughened for better attachment to a mold and a die respectively.

摘要翻译： 一种电子设备包括一个连接在一个模具上的引线框，并嵌入一个具有增强的粘合性能的模具包装中。 引线框架包括接合表面，焊接表面，模具粘合表面和模具附接表面，其中焊接表面和接合表面选择性地镀有镍/钯/金。 模具附着表面和模具附接表面被粗糙化，以分别更好地附接到模具和模具。