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77 条记录 (耗时 0.031 秒)

    TREATMENT OF PEDIATRIC TUMORS
    66.
    发明申请
    TREATMENT OF PEDIATRIC TUMORS 有权
    治疗小儿肿瘤

    公开(公告)号：US20100197718A1

    公开(公告)日：2010-08-05

    申请号：US12669134

    申请日：2008-07-03

    申请人： Claudio Pisano ,  Loredana Vesci ,  Paolo Carminati

    发明人： Claudio Pisano ,  Loredana Vesci ,  Paolo Carminati

    IPC分类号： A61K31/4375 ,  A61P35/00

    CPC分类号： A61K31/4745

    摘要： A subclass of camptothecin derivatives is disclosed to be useful for the preparation of a medicament for the treatment of pediatric tumors such as for examplerhabdomyosarcoma, primitive neuroectodermal tumors (PNET) and neuroblastoma.

    摘要翻译： 喜树碱衍生物的亚类被公开用于制备用于治疗儿科肿瘤的药物，例如示例性腹膜肉瘤，原始神经外胚层肿瘤（PNET）和神经母细胞瘤。

    Method for preventing and/or treating peripheral Neuropathies induced by the administration of an anticancer agent
    67.
    发明申请
    Method for preventing and/or treating peripheral Neuropathies induced by the administration of an anticancer agent 审中-公开
    用于预防和/或治疗通过施用抗癌剂诱导的周围神经病变的方法

    公开(公告)号：US20090143464A1

    公开(公告)日：2009-06-04

    申请号：US12320430

    申请日：2009-01-26

    申请人： Claudio Cavazza ,  Claudio Pisano ,  Loredana Vesci

    发明人： Claudio Cavazza ,  Claudio Pisano ,  Loredana Vesci

    IPC分类号： A61K31/282 ,  A61K31/205 ,  A61P35/00 ,  A61P25/02

    CPC分类号： A61K45/06 ,  A61K31/205 ,  A61K31/221 ,  A61K31/28 ,  A61K31/335 ,  A61K31/475 ,  A61K31/555 ,  A61K33/24 ,  A61K38/14 ,  A61K2300/00

    摘要： A method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent of the family of platin compounds, taxanes, epothilone class, vinca alkaloids, said method comprising the administration in a co-ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies, an effective amount of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof. In case of prevention, acetyl L-carnitine is administered to a subject, in view of the need of a treatment with an anticancer agent, immediately before or immediately after surgical removal of the tumor, but in any case before the administration of the anticancer agent. Acetyl L-carnitine can enhance the supportive effect of physiological NGF during chemotherapy-induced neuropathy, thus avoiding the problem of the local and general side effects of the exogenous administration of NGF which are a major problem of this neuroprotective strategy.

    摘要翻译： 一种预防和/或治疗通过施用铂类化合物，紫杉烷类，埃坡霉素类，长春花生物碱类的抗癌剂诱导的周围神经病变的方法，所述方法包括以协调的方式向患有所述 周围神经病变，或预期患有所述周围神经病，有效量的乙酰左旋肉碱或其药学上可接受的盐。 在预防的情况下，考虑到在手术切除肿瘤之前或之后立即用抗癌剂治疗的需要，向受试者施用乙酰左旋肉碱，但是在施用抗癌剂之前的任何情况下 。 乙酰左旋肉碱可以增强生理NGF在化疗诱发的神经病变过程中的支持作用，从而避免外源性施用NGF的局部和一般副作用的问题，这是神经保护策略的主要问题。

    Method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent
    68.
    发明申请
    Method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent 审中-公开
    用于预防和/或治疗通过施用抗癌剂诱导的周围神经病变的方法

    公开(公告)号：US20090137619A1

    公开(公告)日：2009-05-28

    申请号：US12320422

    申请日：2009-01-26

    申请人： Claudio Cavazza ,  Claudio Pisano ,  Loredana Vesci

    发明人： Claudio Cavazza ,  Claudio Pisano ,  Loredana Vesci

    IPC分类号： A61K31/437 ,  A61P25/00

    CPC分类号： A61K45/06 ,  A61K31/205 ,  A61K31/221 ,  A61K31/28 ,  A61K31/335 ,  A61K31/475 ,  A61K31/555 ,  A61K33/24 ,  A61K38/14 ,  A61K2300/00

    摘要： A method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent of the family of platin compounds, taxanes, epothilone class, vinca alkaloids, said method comprising the administration in a co-ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies, an effective amount of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof. In case of prevention, acetyl L-carnitine is administered to a subject, in view of the need of a treatment with an anticancer agent, immediately before or immediately after surgical removal of the tumor, but in any case before the administration of the anticancer agent. Acetyl L-carnitine can enhance the supportive effect of physiological NGF during chemotherapy-induced neuropathy, thus avoiding the problem of the local and general side effects of the exogenous administration of NGF which are a major problem of this neuroprotective strategy.

    摘要翻译： 一种预防和/或治疗通过施用铂类化合物，紫杉烷类，埃坡霉素类，长春花生物碱类的抗癌剂诱导的周围神经病变的方法，所述方法包括以协调的方式向患有所述 周围神经病变，或预期患有所述周围神经病，有效量的乙酰左旋肉碱或其药学上可接受的盐。 在预防的情况下，考虑到在手术切除肿瘤之前或之后立即用抗癌剂治疗的需要，向受试者施用乙酰左旋肉碱，但是在施用抗癌剂之前的任何情况下 。 乙酰左旋肉碱可以增强生理NGF在化疗诱发的神经病变过程中的支持作用，从而避免外源性施用NGF的局部和一般副作用的问题，这是神经保护策略的主要问题。