公开(公告)号：US20050283895A1

公开(公告)日：2005-12-29

申请号：US10875363

申请日：2004-06-23

Applicant: Alexander Tilson ,  David Knight ,  Mitchell Barham

Inventor： Alexander Tilson ,  David Knight ,  Mitchell Barham

IPC: E03D1/14 ,  E03D1/30 ,  E03D1/34

CPC classification number: E03D1/304 ,  E03D1/142 ,  E03D1/34

Abstract: Described here are flush valves for delivering a selected amount of water from a toilet tank into a toilet bowl, particularly collapsible flush valves having substantial durability and resistance to wear and deleterious chemicals. These flush valves have a collapsible member extending from above the surface of the water in the toilet tank to the tank outlet in the normal (closed flush valve) state. Collapsing the flush valve allows water to flow into the toilet bowl through the flush valve until the toilet tank is drained to the level of the collapsed flush valve and buoyancy is restored. Flush valves may be made of a material that does not substantially deteriorate in the presence of halogen-containing toilet disinfectants, and the outer surface (the water contacting surface) of the flush valves may be a single continuous piece.

Abstract translation: 这里描述的是用于将选定量的水从马桶罐输送到马桶的冲洗阀，特别是具有显着的耐久性和耐磨性和有害化学品的可折叠的冲洗阀。 这些冲洗阀具有在正常（关闭的冲洗阀）状态下从马桶水箱中的水表面上方延伸到罐出口的可折叠构件。 使冲洗阀塌缩，水可以通过冲洗阀流入马桶，直到马桶水箱排放到塌陷的冲洗阀的水平面并恢复浮力。 冲洗阀可以由在含卤素马桶消毒剂的存在下基本上不劣化的材料制成，并且冲洗阀的外表面（水接触表面）可以是单个连续件。

公开(公告)号：US20050260201A1

公开(公告)日：2005-11-24

申请号：US11053749

申请日：2005-02-07

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  Bernard Scallon

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  Bernard Scallon

IPC: A61K38/17 ,  A61K39/395 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US20050123541A1

公开(公告)日：2005-06-09

申请号：US10954900

申请日：2004-09-30

Applicant: George Heavner ,  David Knight ,  Jill Giles-Komar ,  Bernard Scallon ,  David Shealy

Inventor： George Heavner ,  David Knight ,  Jill Giles-Komar ,  Bernard Scallon ,  David Shealy

IPC: C12N15/09 ,  A61K20060101 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P20060101 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07K20060101 ,  C07K16/24 ,  C07K16/42 ,  C12N20060101 ,  C12N5/10 ,  C12N15/13 ,  C12P21/08 ,  G01N20060101 ,  A61K31/573 ,  A61K31/473 ,  A61K31/137

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  Y02A50/412

Abstract: The present invention relates to methods for treating carcinomas or adenocarcinomas using at least one anti-TNF antibody.

Abstract translation: 本发明涉及使用至少一种抗TNF抗体治疗癌或腺癌的方法。

公开(公告)号：US06179165B2

公开(公告)日：2001-01-30

申请号：US09338374

申请日：1999-06-23

Applicant: David Knight ,  Joanne Knight

Inventor： David Knight ,  Joanne Knight

IPC: B65D3500

CPC classification number: A23G3/28 ,  A21C15/005 ,  A23G3/203 ,  B65D31/18 ,  B65D85/36

Abstract: A pastry bag construction 10 comprising a generally elongated pastry bag member 20 fabricated from a generally flexible material 21 and having an upper end provided with an enlarged opening 23 and a lower end provided with a relatively small outlet opening 22 wherein the exterior periphery of the bag member 20 is provided with a plurality of finger engaging loop units 12 which include an elongated horizontally disposed strap member 30 and a plurality of relatively short vertically disposed strap members 40 wherein the strap members 30 and 40 define loop openings 32 and 41 which are dimensioned to receive the fingers of the users hands for manipulating the bag member 20.

Abstract translation: 包括由通常柔性材料21制成并具有设置有扩大开口23的上端的大致细长的糕点袋构件20的糕点袋构造10以及设置有较小出口22的下端，其中袋的外周边 构件20设置有多个手指接合环单元12，其包括细长的水平设置的带构件30和多个相对短的垂直设置的带构件40，其中带构件30和40限定环开口32和41，其限定为 接收用户手的手指以操纵袋构件20。

公开(公告)号：US5919452A

公开(公告)日：1999-07-06

申请号：US192861

申请日：1994-02-04

Applicant: Junming Le ,  Jan Vilcek ,  Peter Dadonna ,  John Ghrayeb ,  David Knight ,  Scott Seigal

Inventor： Junming Le ,  Jan Vilcek ,  Peter Dadonna ,  John Ghrayeb ,  David Knight ,  Scott Seigal

IPC: A61K38/00 ,  C07K14/525 ,  C07K16/24 ,  A61K39/395

CPC classification number: C07K14/525 ,  C07K16/241 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00

Abstract: Treatment of tumor necrosis factor, TNF, mediated pathologies is provided by administering anti-TNF compounds, such as anti-TNF antibodies and anti-TNF peptides, which compounds are specific for tumor necrosis factor-.alpha. (TNF.alpha.) or tumor necrosis factor-.beta. (TNF.beta.) and which are useful for in vivo therapy or diagnosis of TNF.alpha.-mediated pathologies and conditions, wherein the anti-TNF compound is selected from the group consisting of at least one of an immunoglobulin variable region, a fragment of a TNF receptor and an anti-TNF peptide, such as a structural analog of a anti-TNF antibody fragment or a TNF receptor fragment.

Abstract translation: 肿瘤坏死因子，肿瘤坏死因子介导的病理学的治疗是通过施用抗TNF化合物，例如抗TNF抗体和抗TNF肽来提供的，该化合物对肿瘤坏死因子-α（TNFα）或肿瘤坏死因子-α β（TNFβ），其可用于TNFα介导的病理学和病症的体内治疗或诊断，其中所述抗TNF化合物选自免疫球蛋白可变区， TNF受体和抗TNF肽，例如抗TNF抗体片段或TNF受体片段的结构类似物。

公开(公告)号：US5808244A

公开(公告)日：1998-09-15

申请号：US900140

申请日：1997-07-28

Applicant: David Knight ,  Leslie M. O'Farrell

Inventor： David Knight ,  Leslie M. O'Farrell

IPC: A61B1/00 ,  A61B7/02

CPC classification number: A61B7/02 ,  A61B1/00142

Abstract: A protective cover for a contact surface of a stethoscope having a planar section of film material with a static charge placed therein. The planar section of film material has a top surface and a bottom surface. The section of film material has an area greater than the contact surface of the stethoscope. The top and bottom surfaces are non-adhesive surfaces. The static charge acts on the bottom surface so as to allow the bottom surface to removably cling to the contact surface of the stethoscope. The planar section of film material is applied to a backing surface having an area greater no less than the area of the section of film material.

Abstract translation: 一种用于听诊器的接触表面的保护罩，其具有放置在其中的具有静电荷的薄膜材料的平面部分。 薄膜材料的平面部分具有顶表面和底表面。 薄膜材料的部分面积大于听诊器的接触表面。 顶部和底部表面是非粘合剂表面。 静电荷作用在底面上，以便允许底表面可移除地粘附到听诊器的接触表面。 膜材料的平面部分被施加到具有不小于膜材料部分的面积的面积的背衬表面。

公开(公告)号：US4409529A

公开(公告)日：1983-10-11

申请号：US247117

申请日：1981-03-24

Applicant: Robert Basford ,  David Hart ,  David Hawkins ,  David Knight ,  Roger Sidey

Inventor： Robert Basford ,  David Hart ,  David Hawkins ,  David Knight ,  Roger Sidey

IPC: A61F2/00 ,  A61F2/58 ,  A61F2/68 ,  A61F2/70 ,  A61F2/72 ,  B25J15/08 ,  G05B1/06

CPC classification number: B25J15/08 ,  A61F2/583 ,  A61F2/68 ,  A61F2/70 ,  A61F2/72 ,  A61F2002/5001 ,  A61F2002/701

Abstract: A prosthesis comprising:(a) a gripping member;(b) an operating lever mounted to pivot about a pivot axis and operatively connected to the gripping member;(c) a power unit including an electric motor, and a drive shaft rotatable by said electric motor;(d) means connecting the drive shaft to the operating lever at a region spaced from the said pivot axis of the operating lever, said connecting means being constructed so that when the drive shaft rotates the connecting means (and also the region of the operating lever connected to the shaft) travels axially along the shaft thereby causing the operating lever to pivot about its pivot axis; and(e) means pivotally mounting said power unit to allow the connecting means to move along an arcuate path about the pivot axis during pivoting of the operating lever.

Abstract translation: 一种假体，包括：（a）夹持构件; （b）安装成围绕枢转轴线枢转并可操作地连接到所述夹持构件的操作杆; （c）包括电动机的动力单元和由所述电动机可旋转的驱动轴; （d）将所述驱动轴连接到所述操作杆的区域与所述操作杆的所述枢转轴线隔开的区域，所述连接装置构造成使得当所述驱动轴旋转所述连接装置（以及所述操作杆的区域）时， 连接到轴）沿着轴线轴向移动，从而使操作杆绕其枢转轴线枢转; 以及（e）装置，用于枢转地安装所述动力单元，以允许所述连接装置在所述操作杆的枢转期间沿着围绕所述枢转轴线的弧形路径移动。

公开(公告)号：US08645906B2

公开(公告)日：2014-02-04

申请号：US11852952

申请日：2007-09-10

Applicant: Sandeep Jain ,  David Knight

Inventor： Sandeep Jain ,  David Knight

IPC: G06F9/44

CPC classification number: G06F21/6218 ,  G06F8/70 ,  G06F8/71 ,  G06F17/50 ,  G06Q10/06

Abstract: A set of tools and other mechanisms automatically enforce software development change policies by providing a way to map physical source control system codelines to projects and by providing a way to maintain current project and codeline state information. The set of tools and other mechanisms also provide ways to define change management rules and policies, as well as, ways to evaluate and allow or deny each proposed change against the defined change policy.

Abstract translation: 一套工具和其他机制通过提供一种将物理源控制系统代码线映射到项目并通过提供一种维护当前项目和代码状态信息的方法来自动实施软件开发变更策略。 一套工具和其他机制还提供了确定变更管理规则和政策的方法，以及如何评估和允许或拒绝每项拟议的变更与定义的变更政策。

公开(公告)号：US08645463B2

公开(公告)日：2014-02-04

申请号：US11549562

申请日：2006-10-13

Applicant: David Knight ,  Christopher Daniels ,  Steffen Matt

Inventor： David Knight ,  Christopher Daniels ,  Steffen Matt

IPC: G06F15/16

CPC classification number: H04L12/1822 ,  H04L51/04

Abstract: In one embodiment, the methods and apparatuses display a list configured to represent a plurality of virtual rooms; identify a selected participant device associated with a selected virtual room from the plurality of virtual rooms wherein the selected participant device is a member of the selected virtual room; selectively display content associated with the selected virtual room to the selected participant device; and notify the selected participant device of a change to the content associated with the selected virtual room.

Abstract translation: 在一个实施例中，方法和装置显示配置为表示多个虚拟房间的列表; 从所述多个虚拟房间中识别与所选择的虚拟房间相关联的所选参与者设备，其中所选择的参与者设备是所选虚拟房间的成员; 选择性地将与所选虚拟房间相关联的内容显示给所选择的参与者设备; 并通知所选择的参与者设备对与所选虚拟房间相关联的内容的改变。

公开(公告)号：US20130333026A1

公开(公告)日：2013-12-12

申请号：US13491494

申请日：2012-06-07

Applicant: Angelo Starink ,  David Knight

Inventor： Angelo Starink ,  David Knight

IPC: G06F21/00 ,  G06F15/16

CPC classification number: H04L63/0281 ,  G06F17/30882 ,  G06F21/554 ,  G06F21/567 ,  G06F2221/2115 ,  G06F2221/2119 ,  H04L51/12 ,  H04L63/1466 ,  H04L67/02

Abstract: Malicious message detection and processing systems and methods are provided herein. According to some embodiments, the messages are emails and the method for processing emails may be facilitated by way of an intermediary node which may be cloud-based. The intermediary node may be communicatively couplable with an email client and an email server. The intermediary node may execute a method that includes analyzing a link included in an email to determine if the link is associated with a potentially malicious resource, and replacing the link with an alternate link to a trusted resource if the link is associated with a potentially malicious resource.

Abstract translation: 本文提供了恶意的消息检测和处理系统和方法。 根据一些实施例，消息是电子邮件，并且用于处理电子邮件的方法可以通过可能基于云的中间节点来实现。 中间节点可以与电子邮件客户端和电子邮件服务器通信地耦合。 中间节点可以执行一种方法，该方法包括分析电子邮件中包括的链接以确定链接是否与潜在的恶意资源相关联，并且如果该链接与潜在的恶意文件相关联，则将替换链接替换为可信资源的替代链接 资源。