公开(公告)号：US07066875B2

公开(公告)日：2006-06-27

申请号：US10165396

申请日：2002-06-07

Applicant: David R. Knighton ,  Vance D. Fiegel

Inventor： David R. Knighton ,  Vance D. Fiegel

IPC: A61F2/04

CPC classification number: A61B17/00008

Abstract: A device and method for removing a generally cylindrical tissue structure such as a blood vessel from the body of a human or animal. The device includes a body portion having distal and proximal ends with at least one lumen extending longitudinally through the body portion. The lumen is sized to accommodate the vessel and at least one tool used in removing the vessel. Means is provided for isolating the vessel from the tools used in the removal procedure.

公开(公告)号：US5772576A

公开(公告)日：1998-06-30

申请号：US570229

申请日：1995-12-11

Applicant: David R. Knighton ,  Vance D. Fiegel

Inventor： David R. Knighton ,  Vance D. Fiegel

IPC: A61B17/00 ,  A61F2/04

CPC classification number: A61B17/00008

Abstract: A device and method for removing a generally cylindrical tissue structure such as a blood vessel from the body of a human or animal. The device includes a body portion having distal and proximal ends with at least one lumen extending longitudinally through the body portion. The lumen is sized to accommodate the vessel and at least one tool used in removing the vessel. The lumen is provided for isolating the vessel from the tools used in the removal procedure.

Abstract translation: 一种用于从人或动物身体移除大致圆柱形的组织结构（例如血管）的装置和方法。 该装置包括主体部分，该主体部分具有远端和近端，其具有沿主体部分纵向延伸的至少一个内腔。 管腔的尺寸适于容纳容器和用于移除容器的至少一个工具。 提供内腔以将容器与用于移除过程中的工具隔离。

公开(公告)号：US5178883A

公开(公告)日：1993-01-12

申请号：US525891

申请日：1990-05-18

Applicant: David R. Knighton

Inventor： David R. Knighton

IPC: A61K8/64 ,  A61K35/14 ,  A61K35/16 ,  A61K47/42 ,  A61L26/00 ,  A61Q7/00

CPC classification number: A61K38/1858 ,  A61K47/42 ,  A61K8/64 ,  A61L26/0033 ,  A61L26/0066 ,  A61Q7/00 ,  A61K2800/412 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/18

Abstract: Platelet enriched plasma is produced from blood. The platelets are activated by thrombine which causes therelease of platelet-derived growth and angiogenesis factors. A carrier such as a microcrystalline collagen is added to produce a wound-treating salve. The composition is applied directly to wounds and initiates healing in nonhealing wounds as well as accelerating normal wound-healing by increasing vascularization, stimulating fibroblast mitrosis and migration, and increasing collagen synthesis by fibroblasts. The composition is also applied to tissue to facilitate the growth of hair.

Abstract translation: 富血小板血浆由血液产生。 血小板由血栓素活化，引起血小板衍生生长和血管生成因子的释放。 加入诸如微晶胶原的载体以产生伤口治疗药膏。 该组合物直接施用于伤口并且在非愈合伤口中引发愈合，并通过增加血管形成，刺激成纤维细胞的细胞增殖和迁移以及增加成纤维细胞的胶原合成来加速正常的伤口愈合。 组合物也可用于组织以促进头发的生长。

公开(公告)号：US4512349A

公开(公告)日：1985-04-23

申请号：US494173

申请日：1983-05-13

Applicant: Thomas K. Hunt ,  William H. Goodson, III ,  Ning Chang ,  David R. Knighton ,  Finn Gottrup ,  Richard Firmin

Inventor： Thomas K. Hunt ,  William H. Goodson, III ,  Ning Chang ,  David R. Knighton ,  Finn Gottrup ,  Richard Firmin

IPC: A61B5/00 ,  A61B5/07

CPC classification number: A61B5/14542 ,  A61B5/076 ,  A61B5/1468

Abstract: A new method of tissue oxygen tension measurement which is suitable for human use utilizes an implanted Silastic tube which is inserted through four to five cm of subcutaneous tissue leaving the ends exposed. With the tube filled, for example, with a saline solution, reference and oxygen electrodes are inserted at the exposed ends and by the use of a polarographic potential the amount of oxygen which permeates through the tube from the tissue into the saline solution may be measured on a continuous real-time basis.

Abstract translation: 一种适合人类使用的组织氧张力测量的新方法利用一种植入的硅橡胶管，其通过四至五厘米的皮下组织插入，使两端露出。 例如，在管子填充的情况下，用盐水溶液，参考和氧气电极插入暴露的末端，并且通过使用极谱势，可以测量从组织渗透到盐溶液中的穿过管的氧量 在连续实时的基础上。

公开(公告)号：US4503038A

公开(公告)日：1985-03-05

申请号：US469935

申请日：1983-02-25

Applicant: Michael J. Banda ,  Zena Werb ,  David R. Knighton ,  Thomas K. Hunt

Inventor： Michael J. Banda ,  Zena Werb ,  David R. Knighton ,  Thomas K. Hunt

IPC: A61K38/00 ,  C07K14/515 ,  A61K35/12 ,  A61K37/02

CPC classification number: C07K14/515 ,  A61K38/00

Abstract: A nonmitogenic angiogenesis factor is isolated from wound fluid by dialysis to include materials in the molecular size range of 2,000 to 14,000, lyophilization, and chromatography. The nonmitogenic angiogenesis factor is identified by activity by corneal implant assay and by cell migration assay. The angiogenesis factor is also characterized by inactivity by mitogenesis assay.

Abstract translation: 通过透析从伤口液中分离非血液生成血管生成因子，以包括分子大小范围为2,000至14,000的物质，冻干和色谱法。 通过角膜植入物测定和细胞迁移测定的活性鉴定非血液生成血管生成因子。 血管生成因子的特征还在于通过有丝分裂测定不活动。