Process for the preparation of atorvastatin and intermediates
    63.
    发明授权
    Process for the preparation of atorvastatin and intermediates 失效
    制备阿托伐他汀和中间体的方法

    公开(公告)号:US07812179B2

    公开(公告)日:2010-10-12

    申请号:US12222690

    申请日:2008-08-14

    IPC分类号: C07D207/333

    CPC分类号: C07D207/34

    摘要: A process is provided for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 comprising: (a) reacting the aldehyde 1 with the enolate form of (S)-2-hydroxy-1,2,2-triphenylethyl acetate substituent in a chelating co-solvent; (b) hydrolysis of (R,S)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (S)-2-hydroxy-1,2,2-triphenylethyl ester (2a and 2b) using a base, preferably an alkali metal base, preferably in a solvent to form the carboxylic acid 7; (c) treating the acid 7 with a chiral base to form a salt and purifying the salt to obtain enantiomerically enriched (R)-7 chiral base salt; (d) alkylation of the (R)-7 chiral base salt or the free base derived from (R)-7, forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 and atorvastatin calcium 6, wherein R is a C1 to C6 alkyl, C6 to C9 aryl or C7 to C10 aralkyl.

    摘要翻译: 提供了制备(R)-5- [2-(4-氟苯基)-5-(1-甲基乙基)-3-苯基-4 - [(苯基氨基)羰基] -1H-吡咯-1-基] -5-羟基-3-氧代-1-庚酸,R-取代的酯9,其包含:(a)使醛1与烯醇化形式的(S)-2-羟基-1,2,2-三苯基乙基乙酸酯取代基 在螯合助溶剂中; (b)(R,S)-5- [2-(4-氟苯基)-5-(1-甲基乙基)-3-苯基-4 - [(苯基氨基)羰基] -1H-吡咯-1-基 ] -3-羟基-1-戊酸,(S)-2-羟基-1,2,2-三苯基乙酯(2a和2b),使用碱,优选碱金属碱,优选在溶剂中形成羧酸 酸7; (c)用手性碱处理酸7以形成盐并纯化该盐以获得对映体富集的(R)-7手性碱盐; (d)(R)-7手性碱盐或衍生自(R)-7的游离碱的烷基化,形成(R)-5- [2-(4-氟苯基)-5-(1-甲基乙基) 3-苯基-4 - [(苯基氨基)羰基] -1H-吡咯-1-基] -5-羟基-3-氧代-1-庚酸,R-取代的酯9和阿托伐他汀钙6,其中R是C1 C6烷基,C6〜C9芳基或C7〜C10芳烷基。

    Method and apparatus for binding redundancy versions with a system frame number and subframe numbers
    64.
    发明授权
    Method and apparatus for binding redundancy versions with a system frame number and subframe numbers 有权
    用于将冗余版本与系统帧号和子帧号绑定的方法和装置

    公开(公告)号:US07801037B2

    公开(公告)日:2010-09-21

    申请号:US12771972

    申请日:2010-04-30

    申请人: Fan Wang

    发明人: Fan Wang

    IPC分类号: H04L12/56 H04J1/16

    CPC分类号: H04L1/1819 H04L1/1887

    摘要: A method and apparatus for binding Redundancy Versions (RVs) with a System Frame Number (SFN) and subframe numbers are disclosed. The method includes: choosing any five (5) continuous subframes within a transmission window of a System Information (SI-x) message according to the subframe numbers of an SFN; and binding the SFN and subframe numbers of the five (5) continuous subframes with RVs of the SI-x message. Because RVs are bound with an SFN and subframe numbers, when a transmission window of an SI-x message is longer than or equal to 5 ms, system frames and subframes are bound with RVs of the SI-x message so that the RV retransmission of the SI-x message is guaranteed.

    摘要翻译: 公开了一种用于将冗余版本(RV)与系统帧号(SFN)和子帧号绑定的方法和装置。 该方法包括:根据SFN的子帧号,选择系统信息(SI-x)消息的传输窗口内的五(5)个连续子帧; 并将五(5)连续子帧的SFN和子帧号与SI-x消息的RV绑定。 由于RV与SFN和子帧号绑定,当SI-x消息的传输窗口长于或等于5ms时,系统帧和子帧与SI-x消息的RV绑定,使得RV重传 SI-x消息得到保证。

    Process for the preparation of esomeprazole and salts thereof
    65.
    发明授权
    Process for the preparation of esomeprazole and salts thereof 失效
    艾美拉唑及其盐的制备方法

    公开(公告)号:US07786309B2

    公开(公告)日:2010-08-31

    申请号:US11797921

    申请日:2007-05-09

    IPC分类号: C07D401/12

    CPC分类号: C07D401/12 Y02P20/55

    摘要: A novel process for the preparation of omeprazole and its enantiomers, such as esomeprazole, as well as the preparation of related 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles, including pantoprazole, lansoprazole and rabeprazole, as recemates or single enantiomers, and their alkali or alkaline salts has been developed. The novel process involves the surprising discovery that protection of the free-base benzimidazole sulfoxide (e.g. omeprazole or esomeprazole), by reaction with an alkyl, aryl or aralkyl chloroformate following oxidation of the corresponding sulfide, eliminates the need for its direct isolation. Subsequent removal of the protecting group with a solution of alkali or alkaline earth alkoxide in a C1-C4 alcohol directly provides the corresponding salt. By eliminating the need to handle the free-base benzimidazole sulfoxide, this advantageous procedure provides increased chemical yields over processes described in the art.

    摘要翻译: 一种用于制备奥美拉唑及其对映异构体的新方法,例如艾美拉唑,以及相关的2-(2-吡啶基甲基 - 亚磺酰基)-1H-苯并咪唑(包括泮托拉唑,兰索拉唑和雷贝拉唑)作为受体或单一对映异构体的制备, 并开发了它们的碱金属盐或碱金属盐。 该新方法涉及令人惊奇的发现:在相应的硫化物氧化后,通过与烷基,芳基或氯甲酸烷基酯反应来保护游离碱性苯并咪唑亚砜(例如奥美拉唑或埃索美拉唑)消除了对其直接分离的需要。 随后用碱金属或碱土金属醇溶液在C1-C4醇中除去保护基团直接提供相应的盐。 通过消除处理游离碱性苯并咪唑亚砜的需要,与本领域中描述的方法相比,该有利的方法提供了增加的化学产率。

    FRAME ALLOCATION TO SUPPORT LEGACY WIRELESS COMMUNICATION PROTOCOLS ON UPLINK TRANSMISSION
    66.
    发明申请
    FRAME ALLOCATION TO SUPPORT LEGACY WIRELESS COMMUNICATION PROTOCOLS ON UPLINK TRANSMISSION 有权
    框架分配支持上传传输中的无线通信协议(LEGACY WIRELESS COMMUNICATION PROTOCOLS ON UPLINK TRANSMISSION)

    公开(公告)号:US20090323614A1

    公开(公告)日:2009-12-31

    申请号:US12487171

    申请日:2009-06-18

    IPC分类号: H04W72/00

    摘要: A frame (200) and a method for allocating resources that is used in a wireless communication network is provided. The frame includes a first subframe (202) concatenated to a second subframe (204). A first portion (206) of the first subframe allocated for a control channel of a first protocol. A second portion (208) of the first subframe and the second subframe are allocated for a data channel for the first protocol. In an embodiment second portion of the first subframe and the second subframe are allocated for a data channel of the second protocol that are multiplexed with the data channel of the first protocol using frequency division multiplexing (FDM).

    摘要翻译: 提供了一种帧(200)和用于分配在无线通信网络中使用的资源的方法。 帧包括级联到第二子帧(204)的第一子帧(202)。 分配给第一协议的控制信道的第一子帧的第一部分(206)。 第一子帧和第二子帧的第二部分(208)被分配用于第一协议的数据信道。 在一个实施例中,第一子帧和第二子帧的第二部分被分配用于使用频分复用(FDM)与第一协议的数据信道复用的第二协议的数据信道。

    METHOD AND APPARATUS FOR PROVIDING CHANNEL QUALITY FEEDBACK IN AN ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING COMMUNICATION SYSTEM
    67.
    发明申请
    METHOD AND APPARATUS FOR PROVIDING CHANNEL QUALITY FEEDBACK IN AN ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING COMMUNICATION SYSTEM 有权
    在正交频分复用通信系统中提供通道质量反馈的方法和装置

    公开(公告)号:US20090274204A1

    公开(公告)日:2009-11-05

    申请号:US12427187

    申请日:2009-04-21

    IPC分类号: H04Q1/20 H04B7/02

    摘要: In an OFDM communication system, a mobile station provides a radio access network (RAN) a channel quality metric second order statistic, in one embodiment a signal to noise plus interference power ratio (SINR) second order statistic and in particular an SINR standard deviation and/or variance, along with a mean channel quality metric, that is, a mean SINR. By providing both a mean channel quality metric and a channel quality metric second order statistic, the communication system permits the RAN to create a more accurate fading profile of an associated air interface, and in particular a downlink of the air interface, thereby facilitating an improved scheduling decision over the prior art and assuring that a packet has a higher probability to go through a downlink channel without too many retransmissions.

    摘要翻译: 在OFDM通信系统中,移动站提供无线电接入网络(RAN)信道质量度量二阶统计量,在一个实施例中,信噪比加干扰功率比(SINR)二阶统计量,特别是SINR标准偏差, /或方差,以及平均信道质量度量,即平均SINR。 通过提供平均信道质量度量和信道质量度量二阶统计量,通信系统允许RAN创建相关联的空中接口,特别是空中接口的下行链路的更准确的衰落简档,从而有助于改进 对现有技术进行调度决定,并且确保分组具有更高的通过下行链路信道的可能性,而不需要太多的重传。

    SYSTEM AND METHOD FOR NON-STANDARD WIRELESS BANDWIDTH COMMUNICATIONS
    68.
    发明申请
    SYSTEM AND METHOD FOR NON-STANDARD WIRELESS BANDWIDTH COMMUNICATIONS 审中-公开
    非标准无线带宽通信的系统和方法

    公开(公告)号:US20090147735A1

    公开(公告)日:2009-06-11

    申请号:US11950435

    申请日:2007-12-05

    IPC分类号: H04Q7/00

    CPC分类号: H04W8/30

    摘要: A wireless communications method and device including a transmitter (130) configured to transmit according to an Orthogonal Frequency Division Multiplexing transmission standard (300), such as the WiMAX standard. The wireless communications device (120) includes a transmission bandwidth controller (136) adapted to configure the transmitter (130) to adjust a transmitted bandwidth (312) by at least one of 1) configuring at least one of a first set of punctured subcarriers (324) and a second set of punctured subcarriers (326) to not be used for data transmission. The first set of punctured subcarriers and the second set of punctured subcarriers are located within opposite edges of the transmission bandwidth (340); and 2) configuring at least a first set of guardband subcarriers (322) and a second set of guardband subcarriers (330), which are located on opposite edges of the transmission bandwidth, to be used for data transmission.

    摘要翻译: 一种无线通信方法和装置,包括被配置为根据诸如WiMAX标准的正交频分复用传输标准(300)发送的发射机(130)。 无线通信设备(120)包括适于配置发射机(130)以通过以下至少之一来调整发射带宽(312)的传输带宽控制器(136):1)配置第一组穿孔子载波中的至少一个( 324)和第二组穿孔子载波(326),不用于数据传输。 第一组穿孔子载波和第二组穿孔子载波位于传输带宽(340)的相对边缘内; 以及2)配置位于所述传输带宽的相对边缘上的至少第一组保护带子载波(322)和第二组保护带子载波(330),用于数据传输。

    METHOD AND APPARATUS FOR A FREQUENCY DIVISION DUPLEX COMMUNICATION USING A TIME DIVISION DUPLEX MODEM
    69.
    发明申请
    METHOD AND APPARATUS FOR A FREQUENCY DIVISION DUPLEX COMMUNICATION USING A TIME DIVISION DUPLEX MODEM 审中-公开
    使用时分双工调制解调器进行频分双工通信的方法和装置

    公开(公告)号:US20090067383A1

    公开(公告)日:2009-03-12

    申请号:US11853998

    申请日:2007-09-12

    IPC分类号: H04Q7/00

    CPC分类号: H04B1/52

    摘要: The present invention is directed to an communication unit an antenna and at least two modem cards. The first modem card is coupled to the antenna so that the first modem card transmits a first transmit signal at a first frequency during a first period and receives a first received signal at a second frequency during a second time period. The second modem card couple to the antenna so that the second modem card transmits a second transmit signal at the first frequency during the second time period and receives a second receive signal at the second frequency during the first time period. The communication unit can also include a synchronizer that is coupled to the first and second modem cards to generate a signal to synchronize the transmit and receive signals transmitted and received by the antenna.

    摘要翻译: 本发明涉及通信单元天线和至少两个调制解调器卡。 第一调制解调器卡耦合到天线,使得第一调制解调器卡在第一时段期间以第一频率发送第一发射信号,并且在第二时间段期间以第二频率接收第一接收信号。 第二调制解调器卡耦合到天线,使得第二调制解调器卡在第二时间段期间以第一频率发送第二发送信号,并且在第一时间段期间以第二频率接收第二接收信号。 通信单元还可以包括耦合到第一和第二调制解调器卡以产生信号以同步天线发送和接收的发送和接收信号的同步器。

    PREAMBLE SEQUENCING FOR RANDOM ACCESS CHANNEL IN A COMMUNICATION SYSTEM
    70.
    发明申请
    PREAMBLE SEQUENCING FOR RANDOM ACCESS CHANNEL IN A COMMUNICATION SYSTEM 有权
    通信系统中随机访问通道的前导序列

    公开(公告)号:US20070165567A1

    公开(公告)日:2007-07-19

    申请号:US11621587

    申请日:2007-01-10

    IPC分类号: H04Q7/00

    摘要: A system and method for initializing a system communication without previous reservations for random access channel (RACH) access includes a first step of defining at least one spread sequence derived from at least one constant amplitude zero autocorrelation sequence. A next step includes combining the spread sequence with a Walsh code to form an extended spread sequence. A next step includes using the extended spread sequence in a preamble for a RACH. A next step includes sending the preamble to a BTS for acquisition. A next step includes monitoring for a positive acquisition indicator from the BTS. A next step includes scheduling the sending of a RACH message. A next step includes sending the RACH message.

    摘要翻译: 用于初始化系统通信而没有对随机接入信道(RACH)接入的先前保留的系统和方法包括定义从至少一个恒定幅度零自相关序列导出的至少一个扩展序列的第一步骤。 下一步包括将扩展序列与沃尔什码组合以形成扩展扩展序列。 下一步包括在RACH的前同步码中使用扩展扩展序列。 下一步包括将前导码发送到BTS进行采集。 下一步包括监测来自BTS的正采集指示符。 下一步包括调度RACH消息的发送。 下一步包括发送RACH消息。