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公开(公告)号：US09724459B2
公开(公告)日：2017-08-08
申请号：US14238434
申请日：2012-08-15
CPC分类号： A61M1/3656 , A61M1/367 , A61M2205/15 , G01M3/04 , Y10T137/5762
摘要： Features for protecting against leaks in a fluid circuit are disclosed. In a first embodiment, a fluid circuit is housed by another fluid circuit that is configured to capture and convey leaks to leak detector. In a second embodiment, a first indicator of a leak is used to trigger confirmation by blood flow reversal and air detection in the blood circuit.
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公开(公告)号：US08585096B2
公开(公告)日：2013-11-19
申请号：US13503734
申请日：2010-10-26
IPC分类号： F16L13/04
CPC分类号： F16L15/08 , A61M39/1011 , A61M2205/273
摘要： A restraining device for a tubing connector assembly can include a resilient member having a generally U-shape with forked ends that curve toward each other. Each forked end can have a recess between tines thereof. Each recess can have a blind end. The resilient member can have a bend provided with an engagement bump. The engagement bump and forked ends can be aligned such that the engagement bump coincides with a line joining the blind ends. When a cylindrical connector assembly tube is placed in the recesses, the engagement bump is urged against a side of the connector assembly to thereby prevent inadvertent disconnection.
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公开(公告)号：US20130180339A1
公开(公告)日：2013-07-18
申请号：US13825310
申请日：2011-09-23
申请人： James M. Brugger
发明人： James M. Brugger
IPC分类号： A61B5/02
CPC分类号： A61B5/02 , A61B5/0215
摘要： A pressure measuring device has tubing with an inline “pillow” portion that is more flexible than the tubing portion. The pillow portion may be created by heating a portion of a length of medical tubing and forcing air into the heated portion to expand, and thin, its walls. The tubing and pillow portion may be used in a negatively pressurized portion of a blood circuit such as an arterial return line. An assembly of interleaved support members adhesively bonded to the pillow portion holds the pillow portion in an expanded state even under negative pressure. Further, when the pillow portion tries to collapse, the interleaved support members compress a strain gauge to provide a pressure signal corresponding to the negative pressure exerted by the fluid therewithin.
摘要翻译： 压力测量装置具有管道，其具有比管部分更柔性的在线“枕头”部分。 枕头部分可以通过加热一段长度的医疗管道并迫使空气进入加热部分而膨胀并使其壁变薄而产生。 管路和枕头部分可以用在诸如动脉返回线的血液回路的负压部分中。 粘合到枕头部分的插入支撑构件的组件即使在负压下也将枕头部分保持在膨胀状态。 此外，当枕头部分试图折叠时，交错的支撑构件压缩应变计以提供对应于由其中的流体施加的负压的压力信号。
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64.发明授权Batch filtration system for preparation of sterile fluid for renal replacement therapy 有权用于制备用于肾替代治疗的无菌液体的分批过滤系统公开(公告)号：US08460558B2
公开(公告)日：2013-06-11
申请号：US13526145
申请日：2012-06-18
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A first connector of a connector assembly of a sterile batch container can be unsealed. The connector assembly can be attached to a filling port of the sterile batch container and can have a sterile filter arranged between the filling port and the first connector. The first connector can be coupled so as to receive produced purified water. A transmembrane pressure can be monitored across the sterile filter while flowing the purified water through the connector assembly into the sterile batch container so as to provide a sterile fluid stored therein. The connector assembly can be detached from the filling port of the sterile batch container. After the detaching, the sterile batch container can be coupled to the blood treatment system. In response to a change in the transmembrane pressure exceeding a predefined level, an alarm signal can be generated.
摘要翻译： 无菌批量容器的连接器组件的第一连接器可以是非密封的。 连接器组件可以附接到无菌批量容器的填充口，并且可以具有布置在填充口和第一连接器之间的无菌过滤器。 第一连接器可以联接以便接收产生的净化水。 可以跨越无菌过滤器监测跨膜压力，同时将净化水流过连接器组件进入无菌分批容器，以提供储存在其中的无菌流体。 连接器组件可以从无菌批量容器的填充口分离。 分离后，无菌批量容器可以与血液处理系统联接。 响应于超过预定水平的跨膜压力的变化，可以产生报警信号。
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65.发明授权公开(公告)号：US08460228B2
公开(公告)日：2013-06-11
申请号：US12912714
申请日：2010-10-26
摘要： A tubing set is disclosed including a first line having first and second ends, a bag spike at the first end configured for connection to a source of infusate, and a connector at the second end configured for connection to a blood line. The first line has a pumping portion for engagement with an infusate pump. The tubing set includes a second line having first and second ends, the first end being attached to the first line between the first line pumping portion and the first line second end and the second end being configured for connection to the first line between the first line first end and the first line pumping portion. The second line second end is configured for connection to the first line by a dual lumen spike.
摘要翻译： 公开了一种管组，其包括具有第一端和第二端的第一线，在第一端处的构造成用于连接到输注源的连接件的袋尖端，以及被配置为连接到血液线的第二端的连接器。 第一行具有用于与输液泵接合的泵送部分。 管组包括具有第一和第二端的第二线，第一端附接到第一线路抽吸部分和第一线路第二端之间的第一线路，第二端部被配置为连接到第一线路之间的第一线路 第一端和第一线抽吸部分。 第二行第二端被配置为通过双腔尖钉连接到第一线。
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66.发明申请LAST-CHANCE QUALITY CHECK AND/OR AIR/PATHOGEN FILTER FOR INFUSION SYSTEMS 审中-公开最新法治质量检查和/或空气/病毒过滤器用于输注系统公开(公告)号：US20130032537A1
公开(公告)日：2013-02-07
申请号：US13465128
申请日：2012-05-07
IPC分类号： A61M1/34
CPC分类号： A61L2/0017 , A61M1/1656 , A61M1/1658 , A61M1/1664 , A61M1/1668 , A61M1/3455 , A61M1/3458 , A61M1/3462 , A61M1/3465 , A61M2205/75 , B01D61/32
摘要： Blood treatment system and method for high rate hemofiltration ensures against pyrogenic patient reaction by providing various mechanisms for filtering replacement fluid to remove endotoxins and other safety features including detecting incorrect fluid administration.
摘要翻译： 用于高速血液滤过的血液处理系统和方法通过提供用于过滤置换液以除去内毒素和其他安全特征的各种机制（包括检测不正确的液体给药），确保了对致热原患者的反应。
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公开(公告)号：US08210049B2
公开(公告)日：2012-07-03
申请号：US12049903
申请日：2008-03-17
申请人： James M. Brugger
发明人： James M. Brugger
CPC分类号： A61M1/3626 , A61M1/3641
摘要： A pressure measurement device isolates liquid, such as blood, from an intermediate fluid, such as air, by means of a diaphragm. The diaphragm is arranged between first and second chambers of respective first and second shells of a pressure pod body. The first shell has first and second ports, which are connected to the first chamber. The second shell has a measurement port with a connector in communication with the second chamber. A pressure transducer with a mating connector is directly connected to the measurement port connector to minimize the sealed volume between the diaphragm and the pressure transducer.
摘要翻译： 压力测量装置通过隔膜将诸如血液的液体从诸如空气的中间流体分离。 隔膜布置在压力舱体的相应第一和第二壳体的第一和第二室之间。 第一壳体具有连接到第一室的第一和第二端口。 第二壳体具有测量端口，其具有与第二腔室连通的连接器。 具有配合连接器的压力传感器直接连接到测量端口连接器，以最小化隔膜和压力传感器之间的密封体积。
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68.发明授权Batch filtration system for preparation of sterile fluid for renal replacement therapy 有权用于制备用于肾替代治疗的无菌液体的分批过滤系统公开(公告)号：US08202420B2
公开(公告)日：2012-06-19
申请号：US13159045
申请日：2011-06-13
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.
摘要翻译： 用于血液处理的方法和装置，其使用诸如透析液和替代液的流体用于肾替代治疗。 在一个实施例中，流体通过泵或被动地通过重力进料通过微孔灭菌过滤器从流体源传递到替换流体容器。 后者形成可在治疗期间使用的批次。 在处理之前形成批次的优点是过滤速率与处理过程中的消耗速率不一致。 结果，灭菌过滤器可以具有小容量。 在另一个实施方案中，过滤器被立即放置在无菌流体被处理过程消耗的点之前。 后者可以与前一个实施方案组合使用，作为不育的最后机会保证和/或流体没有气泡。 它也可以用作无菌过滤的主要手段。
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69.发明申请公开(公告)号：US20110106047A1
公开(公告)日：2011-05-05
申请号：US12912714
申请日：2010-10-26
IPC分类号： A61M5/162
摘要： A tubing set is disclosed that includes a first line having first and second ends, a bag spike at the first end configured for connection to a source of infusate, and a connector at the second end configured for connection to a blood line. The first line can have a pumping portion for engagement with an infusate pump. The tubing set can also include a second line having first and second ends, the second line first end being attached to the first line between the first line pumping portion and the first line second end and the second line second end being configured for connection to the first line between the first line first end and the first line pumping portion. The tubing set can further include a check valve located in the second line, the check valve having a predetermined cracking pressure of at least 200 mm Hg. The second line second end can be configured for connection to the first line by a dual lumen spike such that when a container is connected to the dual lumen spike, a bypass loop is formed that permits a flow from a second end side of the pumping portion to the first end side of the pumping portion. The first line can include a spike septum at the first end thereof.
摘要翻译： 公开了一种管组，其包括具有第一端和第二端的第一线，在第一端处构造成用于连接到输注源的连接器的第一端，以及被配置为连接到血液线的第二端的连接器。 第一行可以具有用于与输液泵接合的泵送部分。 管组还可以包括具有第一和第二端的第二线，第二线第一端附接到第一线路抽吸部分和第一线路第二端之间的第一线路，而第二线路第二端部被配置为连接到 第一线第一端和第一线抽吸部之间的第一线。 管组可进一步包括位于第二管线中的止回阀，止回阀具有至少200mm Hg的预定开启压力。 第二行第二端可以被配置为通过双腔尖钉连接到第一线，使得当容器连接到双腔尖钉时，形成旁路回路，其允许从泵送部分的第二端侧流动 到泵送部的第一端侧。 第一行可以在其第一端包括穗状隔膜。
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70.发明授权Systems and methods for handling air and/or flushing fluids in a fluid circuit 有权用于在流体回路中处理空气和/或冲洗流体的系统和方法公开(公告)号：US07790043B2
公开(公告)日：2010-09-07
申请号：US12508900
申请日：2009-07-24
申请人： James M. Brugger , Dennis M. Treu
发明人： James M. Brugger , Dennis M. Treu
CPC分类号： A61M1/3643 , A61M1/288 , A61M1/3462 , A61M1/3468 , A61M1/3644 , A61M1/3646
摘要： Systems and methods handle air and rinsing fluid during fluid processing. The systems and methods eliminate air from a fluid processing system prior to, during, and after use. The systems and methods provide a connector assembly for establishing fluid flow from a fluid source. The connector assembly has discrete first and second passages that prevent communication between the fluid in first passage and the fluid in the second passage. Prior to system use, the connector assembly may be utilized in a priming function to remove residual air from a fluid circuit prior to use. The connector assembly may also be utilized after use to perform a rinse-back function.
摘要翻译： 系统和方法在流体处理过程中处理空气和冲洗液。 系统和方法在使用之前，期间和之后都从流体处理系统中排除空气。 这些系统和方法提供了用于建立来自流体源的流体流动的连接器组件。 连接器组件具有分离的第一和第二通道，其防止第一通道中的流体和第二通道中的流体之间的连通。 在系统使用之前，连接器组件可用于起动功能，以在使用之前从流体回路中除去残余空气。 连接器组件也可以在使用之后用于执行冲洗功能。
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