公开(公告)号：US20110287023A1

公开(公告)日：2011-11-24

申请号：US13051327

申请日：2011-03-18

申请人： Herren Wu ,  Changshou Gao ,  Ling-Ling An ,  Peter Kiener ,  Su-Yau Mao ,  Anthony Coyle ,  Jane Tian ,  Theresa O'Keefe ,  Shixin Qin

发明人： Herren Wu ,  Changshou Gao ,  Ling-Ling An ,  Peter Kiener ,  Su-Yau Mao ,  Anthony Coyle ,  Jane Tian ,  Theresa O'Keefe ,  Shixin Qin

IPC分类号： A61K39/395 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  A61P3/00 ,  A61P3/02 ,  A61K38/19 ,  A61P5/18

CPC分类号： C07K16/24 ,  A61K38/1709 ,  A61K39/39 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  A61K2300/00

摘要： Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

摘要翻译： 公开了用于抑制促炎细胞因子从脊椎动物细胞中释放并抑制患者炎性细胞因子级联的组合物和方法。 组合物包含例如特异性结合HMG1的高亲和力抗体及其抗原性片段。 本发明的高亲和力抗体和包含其的药物组合物可用于许多目的，例如作为针对广泛范围的炎性疾病和病症的治疗剂，例如败血症，类风湿性关节炎，腹膜炎，克罗恩病，再灌注损伤，败血症 内毒素性休克，囊性纤维化，心内膜炎，牛皮癣，牛皮癣关节炎，关节炎，过敏性休克，器官缺血，再灌注损伤和同种异体移植排斥。 此外，本发明的高亲和力抗体可用作诊断抗体。

公开(公告)号：US20110123528A1

公开(公告)日：2011-05-26

申请号：US13007142

申请日：2011-01-14

申请人： Ling-Ling An ,  Sek Chung Fung ,  Robert F. Kelley ,  Henry B. Lowman ,  Sanjaya Singh ,  Herren Wu

发明人： Ling-Ling An ,  Sek Chung Fung ,  Robert F. Kelley ,  Henry B. Lowman ,  Sanjaya Singh ,  Herren Wu

IPC分类号： A61K39/395 ,  C07K16/40 ,  A61P27/02 ,  A61P31/00 ,  A61P29/00 ,  A61P37/06

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/50 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

公开(公告)号：US20110064725A1

公开(公告)日：2011-03-17

申请号：US12413014

申请日：2009-03-27

申请人： Sanjaya Singh ,  Herren Wu ,  Catherine Foster

发明人： Sanjaya Singh ,  Herren Wu ,  Catherine Foster

IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/02 ,  C12N5/10 ,  C12N15/63 ,  C07K16/42 ,  C07H21/00 ,  A61P37/08 ,  A61P11/06 ,  A61P17/00

CPC分类号： C07K16/18 ,  C07K16/005 ,  C07K16/4291 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  G01N33/6854 ,  G01N2800/24 ,  Y10S435/81

摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

摘要翻译： 本发明涉及高亲和力的人单克隆抗体，特别是针对免疫球蛋白E（IgE）的同种型决定簇的那些，以及这些抗体的直接等同物和衍生物。 这些抗体以比原始亲本抗体大至少100倍的亲和力结合到它们各自的靶。 这些抗体可用于疾病的诊断，预防和治疗。

公开(公告)号：US20110059078A1

公开(公告)日：2011-03-10

申请号：US12866579

申请日：2009-02-06

申请人： Anthony Coyle ,  Peter Kiener ,  Herren Wu ,  Ricardo Cibotti

发明人： Anthony Coyle ,  Peter Kiener ,  Herren Wu ,  Ricardo Cibotti

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07H21/00 ,  C12N5/10 ,  A61P37/02 ,  A61P37/06

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The invention provides anti-IFNAR1 antibodies with reduced affinity for Fc receptors and/or ligands and methods of making and using such antibodies.

摘要翻译： 本发明提供对Fc受体和/或配体具有降低的亲和力的抗-IFNAR1抗体以及制备和使用这些抗体的方法。

公开(公告)号：US07847082B2

公开(公告)日：2010-12-07

申请号：US12476183

申请日：2009-06-01

申请人： James F. Young ,  Scott Koenig ,  Leslie S. Johnson ,  William D. Huse ,  Jeffrey D. Watkins ,  Herren Wu

发明人： James F. Young ,  Scott Koenig ,  Leslie S. Johnson ,  William D. Huse ,  Jeffrey D. Watkins ,  Herren Wu

IPC分类号： C07H21/04 ,  A61K39/42 ,  A61K39/155

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection.

摘要翻译： 本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段，以及包含所述抗体和抗体片段的组合物。 本发明包括预防人类呼吸道合胞病毒（RSV）感染的方法，包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定的血清滴度为 所述抗体或抗体片段在所述人受试者中实现。 本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法，包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定 所述抗体或抗体片段的血清滴度在所述人受试者中实现。 本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物，以及使用所述组合物检测或诊断RSV感染的方法。

公开(公告)号：US20100266614A1

公开(公告)日：2010-10-21

申请号：US12777814

申请日：2010-05-11

申请人： James F. YOUNG ,  Leslie S. Johnson ,  William D. Huse ,  Herren Wu ,  Jeffry D. Watkins

发明人： James F. YOUNG ,  Leslie S. Johnson ,  William D. Huse ,  Herren Wu ,  Jeffry D. Watkins

IPC分类号： A61K39/42 ,  C07K16/08 ,  A61P31/12

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

摘要： Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.

摘要翻译： 公开了具有1010M-1甚至1011M-1范围内的结合亲和力的超高亲和力抗体。 此类抗体包括具有新型高亲和力互补决定区（CDR）的抗体，特别是具有来自人或小鼠的骨架和恒定区的抗体。 还公开了制备和筛选这些抗体的方法，以及使用它们来预防和/或治疗疾病，特别是病毒诱导的疾病的方法。

公开(公告)号：US20080311122A1

公开(公告)日：2008-12-18

申请号：US12094449

申请日：2006-11-27

申请人： Herren Wu ,  Ling-Ling An ,  Peter Kiener ,  Anthony Coyle ,  Jane Tian ,  Changsou Gao

发明人： Herren Wu ,  Ling-Ling An ,  Peter Kiener ,  Anthony Coyle ,  Jane Tian ,  Changsou Gao

IPC分类号： A61K39/395 ,  A61K31/7105 ,  A61P37/02

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/32

摘要： Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, lupus, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

摘要翻译： 公开了用于抑制促炎细胞因子从脊椎动物细胞中释放并抑制患者炎性细胞因子级联的组合物和方法。 组合物包含例如特异性结合HMG1的高亲和力抗体及其抗原性片段。 本发明的高亲和力抗体和包含其的药物组合物可用于许多目的，例如作为针对广泛范围的炎性疾病和病症的治疗剂，例如败血症，类风湿性关节炎，腹膜炎，克罗恩病，再灌注损伤， 败血病，内毒素性休克，囊性纤维化，心内膜炎，狼疮，牛皮癣，牛皮癣关节炎，关节炎，过敏性休克，器官缺血，再灌注损伤和同种异体移植排斥。 此外，本发明的高亲和力抗体可用作诊断抗体。

公开(公告)号：US20080138336A1

公开(公告)日：2008-06-12

申请号：US11852106

申请日：2007-09-07

申请人： Melissa Damschroder ,  Peter Kiener ,  Herren Wu ,  William Dall'Acqua ,  Ronald Herbst ,  Anthony Coyle

发明人： Melissa Damschroder ,  Peter Kiener ,  Herren Wu ,  William Dall'Acqua ,  Ronald Herbst ,  Anthony Coyle

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  A61P37/00 ,  C12N5/06

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention provides chimeric and humanized versions of anti-CD19 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human CD19 antigen and that may mediate ADCC, CDC, and/or apoptosis for the treatment of B cell diseases and disorders, such as, but not limited to, B cell malignancies, for the treatment and prevention of autoimmune disease, and for the treatment and prevention of graft-versus-host disease (GVHD), humoral rejection, and post-transplantation lymphoproliferative disorder in human transplant recipients.

摘要翻译： 本发明提供抗CD19小鼠单克隆抗体的嵌合和人源化形式。 本发明进一步涉及药物组合物，免疫治疗组合物和使用结合人CD19抗原并且可介导ADCC，CDC和/或细胞凋亡以治疗B细胞疾病和病症的治疗性抗体的方法，例如但不 限于B细胞恶性肿瘤，用于治疗和预防自身免疫疾病，以及用于治疗和预防人类移植受体中移植物抗宿主病（GVHD），体液排斥和移植后淋巴增殖性疾病。

公开(公告)号：US20080118506A1

公开(公告)日：2008-05-22

申请号：US11931060

申请日：2007-10-31

申请人： Ling-Ling An ,  Sek Chung Fung ,  Robert F. Kelley ,  Henry B. Lowman ,  Sanjaya Singh ,  Herren Wu

发明人： Ling-Ling An ,  Sek Chung Fung ,  Robert F. Kelley ,  Henry B. Lowman ,  Sanjaya Singh ,  Herren Wu

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K14/00 ,  A61P43/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/50 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

摘要翻译： 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。

公开(公告)号：US07323172B2

公开(公告)日：2008-01-29

申请号：US10962285

申请日：2004-10-08

申请人： James F. Young ,  Scott Koenig ,  Leslie S. Johnson ,  William D. Huse ,  Jeffrey D. Watkins ,  Herren Wu

发明人： James F. Young ,  Scott Koenig ,  Leslie S. Johnson ,  William D. Huse ,  Jeffrey D. Watkins ,  Herren Wu

IPC分类号： A61K39/42 ,  A61K39/155

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection.

摘要翻译： 本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段，以及包含所述抗体和抗体片段的组合物。 本发明包括预防人类呼吸道合胞病毒（RSV）感染的方法，包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定的血清滴度为 所述抗体或抗体片段在所述人受试者中实现。 本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法，包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定 所述抗体或抗体片段的血清滴度在所述人受试者中实现。 本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物，以及使用所述组合物检测或诊断RSV感染的方法。