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30 条记录 (耗时 0.051 秒)

    HIGH AFFINITY ANTIBODIES AGAINST HMGB1 AND METHODS OF USE THEREOF
    1.
    发明申请
    HIGH AFFINITY ANTIBODIES AGAINST HMGB1 AND METHODS OF USE THEREOF 失效
    HMGB1的高亲和力抗体及其使用方法

    公开(公告)号：US20090169546A1

    公开(公告)日：2009-07-02

    申请号：US12094447

    申请日：2006-11-27

    申请人： Herren Wu ,  Changshou Gao ,  Ling-Ling An ,  Peter Kiener ,  Su-Yau Mao ,  Anthony Coyle ,  Jane Tian ,  Theresa O'Keefe ,  Shixin Qin

    发明人： Herren Wu ,  Changshou Gao ,  Ling-Ling An ,  Peter Kiener ,  Su-Yau Mao ,  Anthony Coyle ,  Jane Tian ,  Theresa O'Keefe ,  Shixin Qin

    IPC分类号： A61K39/395 ,  C07K16/00 ,  G01N33/53 ,  C12Q1/68 ,  A61P37/06

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/32

    摘要： Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

    摘要翻译： 公开了用于抑制促炎细胞因子从脊椎动物细胞中释放并抑制患者炎性细胞因子级联的组合物和方法。 组合物包含例如特异性结合HMG1的高亲和力抗体及其抗原性片段。 本发明的高亲和力抗体和包含其的药物组合物可用于许多目的，例如作为针对广泛范围的炎性疾病和病症的治疗剂，例如败血症，类风湿性关节炎，腹膜炎，克罗恩病，再灌注损伤， 败血症，内毒素性休克，囊性纤维化，心内膜炎，牛皮癣，牛皮癣关节炎，关节炎，过敏性休克，器官缺血，再灌注损伤和同种异体移植排斥。 此外，本发明的高亲和力抗体可用作诊断抗体。

    ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS
    4.
    发明申请
    ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS 审中-公开
    抗GCC抗体分子及相关组合物及方法

    公开(公告)号：US20140322233A1

    公开(公告)日：2014-10-30

    申请号：US14293802

    申请日：2014-06-02

    申请人： Samuel S. Nam ,  Edward A. Greenfield ,  John S. Babcook ,  Theresa O'Keefe ,  Shixin Qin

    发明人： Samuel S. Nam ,  Edward A. Greenfield ,  John S. Babcook ,  Theresa O'Keefe ,  Shixin Qin

    IPC分类号： C07K16/40 ,  G01N33/573 ,  A61K39/395 ,  A61K47/48

    摘要： Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

    摘要翻译： 公开了结合GCC的抗体和抗原结合片段。 抗体结合GCC的细胞外结构域并可以内化。 在一些实施方案中，抗体是人源化的，嵌合的或人的。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了利用本文提供的抗体和抗原结合片段的治疗和诊断方法。

    RAGE protein derivatives
    5.
    发明申请
    RAGE protein derivatives 失效
    RAGE蛋白衍生物

    公开(公告)号：US20060057679A1

    公开(公告)日：2006-03-16

    申请号：US11186422

    申请日：2005-07-20

    申请人： Theresa O'Keefe ,  Peter Luciano ,  Shixin Qin

    发明人： Theresa O'Keefe ,  Peter Luciano ,  Shixin Qin

    IPC分类号： C07K16/46 ,  C07K14/705 ,  C07H21/04 ,  C12P21/04 ,  C12N5/06

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/30 ,  C07K2319/32

    摘要： The present invention is drawn to fusion proteins comprising a Receptor for Advanced Glycation Endproducts (RAGE) and an immunoglobulin element. The invention also encompasses methods of treating a condition characterized by activation of an inflammatory cytokine cascade comprising administering such fusion proteins. The invention is also drawn to nucleic acids encoding the fusion proteins, as well as vectors and cells comprising such nucleic acids.

    摘要翻译： 本发明涉及包含高级糖基化终产物（RAGE）受体和免疫球蛋白元件的融合蛋白。 本发明还包括治疗特征为激活炎性细胞因子级联的病症的方法，包括施用这种融合蛋白。 本发明还涉及编码融合蛋白的核酸，以及包含这种核酸的载体和细胞。

    RAGE protein derivatives
    6.
    发明授权
    RAGE protein derivatives 失效
    RAGE蛋白衍生物

    公开(公告)号：US07470521B2

    公开(公告)日：2008-12-30

    申请号：US11186422

    申请日：2005-07-20

    申请人： Theresa O'Keefe ,  Peter Luciano ,  Shixin Qin

    发明人： Theresa O'Keefe ,  Peter Luciano ,  Shixin Qin

    IPC分类号： C12P21/06 ,  A61K39/00 ,  C07H21/04 ,  C12P21/04 ,  C12N5/00 ,  C12N5/16 ,  C12N15/64 ,  C12N1/20

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/30 ,  C07K2319/32

    摘要： The present invention is drawn to fusion proteins comprising a Receptor for Advanced Glycation Endproducts (RAGE) and an immunoglobulin element. The invention also encompasses methods of treating a condition characterized by activation of an inflammatory cytokine cascade comprising administering such fusion proteins. The invention is also drawn to nucleic acids encoding the fusion proteins, as well as vectors and cells comprising such nucleic acids.

    摘要翻译： 本发明涉及包含高级糖基化终产物（RAGE）受体和免疫球蛋白元件的融合蛋白。 本发明还包括治疗特征为激活炎性细胞因子级联的病症的方法，包括施用这种融合蛋白。 本发明还涉及编码融合蛋白的核酸，以及包含这种核酸的载体和细胞。

    Rage protein derivatives
    7.
    发明申请
    Rage protein derivatives 审中-公开
    愤怒蛋白衍生物

    公开(公告)号：US20090202542A1

    公开(公告)日：2009-08-13

    申请号：US12313504

    申请日：2008-11-19

    申请人： Theresa O'Keefe ,  Peter Luciano ,  Shixin Qin

    发明人： Theresa O'Keefe ,  Peter Luciano ,  Shixin Qin

    IPC分类号： A61K39/395 ,  A61K38/16

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/30 ,  C07K2319/32

    摘要： The present invention is drawn to fusion proteins comprising a Receptor for Advanced Glycation Endproducts (RAGE) and an immunoglobulin element. The invention also encompasses methods of treating a condition characterized by activation of an inflammatory cytokine cascade comprising administering such fusion proteins. The invention is also drawn to nucleic acids encoding the fusion proteins, as well as vectors and cells comprising such nucleic acids.

    摘要翻译： 本发明涉及包含高级糖基化终产物（RAGE）受体和免疫球蛋白元件的融合蛋白。 本发明还包括治疗特征为激活炎性细胞因子级联的病症的方法，包括施用这种融合蛋白。 本发明还涉及编码融合蛋白的核酸，以及包含这种核酸的载体和细胞。