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公开(公告)号：US08252284B2
公开(公告)日：2012-08-28
申请号：US12413014
申请日：2009-03-27
申请人： Sanjaya Singh , Herren Wu , Catherine Foster
发明人： Sanjaya Singh , Herren Wu , Catherine Foster
CPC分类号： C07K16/18 , C07K16/005 , C07K16/4291 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N2800/24 , Y10S435/81
摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及高亲和力的人单克隆抗体，特别是针对免疫球蛋白E（IgE）的同种型决定簇的那些，以及这些抗体的直接等同物和衍生物。 这些抗体以比原始亲本抗体大至少100倍的亲和力结合到它们各自的靶。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US07531169B2
公开(公告)日：2009-05-12
申请号：US10544056
申请日：2004-02-02
申请人： Sanjaya Singh , Catherine Foster , Herren Wu
发明人： Sanjaya Singh , Catherine Foster , Herren Wu
CPC分类号： C07K16/18 , C07K16/005 , C07K16/4291 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N2800/24 , Y10S435/81
摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及高亲和力的人单克隆抗体，特别是针对免疫球蛋白E（IgE）的同种型决定簇的那些，以及这些抗体的直接等同物和衍生物。 这些抗体以比原始亲本抗体大至少100倍的亲和力结合到它们各自的靶。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US20060251644A1
公开(公告)日：2006-11-09
申请号：US10544056
申请日：2004-02-02
申请人： Herren Wu , Sanjaya Singh , Catherine Foster
发明人： Herren Wu , Sanjaya Singh , Catherine Foster
CPC分类号： C07K16/18 , C07K16/005 , C07K16/4291 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N2800/24 , Y10S435/81
摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及高亲和力的人单克隆抗体，特别是针对免疫球蛋白E（IgE）的同种型决定簇的那些，以及这些抗体的直接等同物和衍生物。 这些抗体以比原始亲本抗体大至少100倍的亲和力结合到它们各自的靶。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US20130052202A1
公开(公告)日：2013-02-28
申请号：US13559938
申请日：2012-07-27
申请人： Sanjaya Singh , Herren Wu , Catherine Foster
发明人： Sanjaya Singh , Herren Wu , Catherine Foster
IPC分类号： C07K16/42 , G01N33/566 , C12P21/02 , C12N15/63 , C12N5/16 , A61K39/395 , C12N15/13
CPC分类号： C07K16/18 , C07K16/005 , C07K16/4291 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N2800/24 , Y10S435/81
摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及高亲和力的人单克隆抗体，特别是针对免疫球蛋白E（IgE）的同种型决定簇的那些，以及这些抗体的直接等同物和衍生物。 这些抗体以比原始亲本抗体大至少100倍的亲和力结合到它们各自的靶。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US20110064725A1
公开(公告)日：2011-03-17
申请号：US12413014
申请日：2009-03-27
申请人： Sanjaya Singh , Herren Wu , Catherine Foster
发明人： Sanjaya Singh , Herren Wu , Catherine Foster
IPC分类号： A61K39/395 , G01N33/53 , C12P21/02 , C12N5/10 , C12N15/63 , C07K16/42 , C07H21/00 , A61P37/08 , A61P11/06 , A61P17/00
CPC分类号： C07K16/18 , C07K16/005 , C07K16/4291 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N2800/24 , Y10S435/81
摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及高亲和力的人单克隆抗体，特别是针对免疫球蛋白E（IgE）的同种型决定簇的那些，以及这些抗体的直接等同物和衍生物。 这些抗体以比原始亲本抗体大至少100倍的亲和力结合到它们各自的靶。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US20060234296A1
公开(公告)日：2006-10-19
申请号：US10544057
申请日：2004-02-02
申请人： Sanjaya Singh , Catherine Foster , Herren Wu
发明人： Sanjaya Singh , Catherine Foster , Herren Wu
CPC分类号： C07K16/4291 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及高亲和力的人单克隆抗体，特别是针对免疫球蛋白E（IgE）的同种型决定簇的那些，以及这些抗体的直接等同物和衍生物。 这些抗体以比原始亲本抗体大至少100倍的亲和力结合到它们各自的靶。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US08604171B2
公开(公告)日：2013-12-10
申请号：US13559938
申请日：2012-07-27
申请人： Sanjaya Singh , Herren Wu , Catherine Foster
发明人： Sanjaya Singh , Herren Wu , Catherine Foster
CPC分类号： C07K16/18 , C07K16/005 , C07K16/4291 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N2800/24 , Y10S435/81
摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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公开(公告)号：US08067002B2
公开(公告)日：2011-11-29
申请号：US11931060
申请日：2007-10-31
申请人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
发明人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
IPC分类号： A61K39/395 , C07K16/36
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US08372403B2
公开(公告)日：2013-02-12
申请号：US13461253
申请日：2012-05-01
申请人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
发明人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US20110123528A1
公开(公告)日：2011-05-26
申请号：US13007142
申请日：2011-01-14
申请人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
发明人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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