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149 条记录 (耗时 0.055 秒)

    Applied estimation of eigenvectors and eigenvalues
    62.
    发明申请
    Applied estimation of eigenvectors and eigenvalues 审中-公开
    特征向量和特征值的应用估计

    公开(公告)号：US20050021577A1

    公开(公告)日：2005-01-27

    申请号：US10855174

    申请日：2004-05-27

    申请人： Nagabhushana Prabhu ,  Wei He

    发明人： Nagabhushana Prabhu ,  Wei He

    IPC分类号： G06F20060101 ,  G06F7/00 ,  G06F17/16 ,  G06K9/62

    CPC分类号： G06F17/16 ,  G06K9/6232

    摘要： Various applications are presented of a vector field method of computing one or more eigenvalues and eigenvectors of a symmetric matrix. The vector field method computes an eigenvector by computing a discrete approximation to the integral curve of a special tangent vector field on the unit sphere. The optimization problems embedded in each iteration of the vector field algorithms admit closed-form solutions making the vector field approach relatively efficient. Among the several vector fields discussed is a family of vector fields called the recursive vector fields. Numerical results are presented that suggest that in some embodiments the recursive vector field method yields implementations that are faster than those based on the QR method. Further, the vector field method preserves, and hence can fully exploit the sparseness on the given matrix to speed up computation even further. Preprocessing that contracts the spectral radius of the given matrix further accelerates the systems.

    摘要翻译： 呈现了用于计算对称矩阵的一个或多个特征值和特征向量的矢量场方法的各种应用。 矢量场方法通过计算单位球上特殊切线矢量场的积分曲线的离散近似来计算特征向量。 嵌入在矢量场算法的每次迭代中的优化问题承认封闭形式的解决方案，使得矢量场方法相对有效。 在讨论的几个矢量场中，有一系列称为递归矢量场的矢量场。 提出了数值结果，表明在一些实施例中，递归矢量场方法产生比基于QR方法的实现更快的实现。 此外，矢量场方法保留，因此可以充分利用给定矩阵上的稀疏度，进一步加速计算。 收缩给定矩阵的光谱半径的预处理进一步加速了系统。

    Method and apparatus for petroleum and gas exploration
    63.
    发明授权
    Method and apparatus for petroleum and gas exploration 失效
    石油和天然气勘探方法和装置

    公开(公告)号：US5311484A

    公开(公告)日：1994-05-10

    申请号：US736682

    申请日：1991-07-26

    申请人： Roger N. Anderson ,  Wei He

    发明人： Roger N. Anderson ,  Wei He

    IPC分类号： G01V1/28 ,  G01V9/00 ,  G01V1/00

    CPC分类号： G01V9/005 ,  G01V1/28 ,  G01V2210/51

    摘要： In the exploration for petroleum or natural gas, drilling targets are identified by locating local maxima of horizontal gradient in the top-of-geopressure surface of a region of exploration. The probability of finding hydrocarbon deposits is significantly improved where the drilling targets are local maxima of the horizontal gradient in the top-of-geopressure surface which coincide with local maxima of subsurface heat flow in the region of exploration, particularly where the local maxima in the horizontal gradient of the top-of-geopressured surface is concentrated across major fault offsets and are parallel to the predominant strike directions of the faults. The top-of-geopressure surface may be remotely sensed by performing complex trace analysis on reflection seismic traces gathered for the region of exploration to derive corresponding reflection strength attribute traces. The corresponding reflection strength traces are first smoothed and then subject to further complex trace analysis to derive the envelope amplitudes of the smoothed reflection strength traces, which are referred to as second reflection strength traces. The second reflection strength traces are then analyzed to locate an uppermost distinct subsurface boundary between high and low amplitude components thereof. Such a distinct boundary is then identified as the top-of-geopressure surface for the region of exploration.

    摘要翻译： 在勘探石油或天然气时，通过在勘探区域顶部地质压力表面定位局部最大水平梯度来确定钻井目标。 发现碳氢化合物沉积物的概率显着改善，其中钻井目标是地质压力表面中的水平梯度的局部最大值，其与勘探区域中的地下热流的局部最大值一致，特别是在 顶层地表压实表面的水平梯度集中在主要的断层偏移上，并且与断层的主要冲击方向平行。 可以通过对为探索区域收集的反射地震迹线执行复杂的轨迹分析来导出相应的反射强度属性轨迹，来远程感测地顶压力表面。 首先平滑对应的反射强度迹线，然后进行进一步的复杂轨迹分析，得到平滑的反射强度迹线的包络幅度，这被称为第二反射强度迹线。 然后分析第二反射强度迹线以在其高和低幅度分量之间定位最上面的不同的地下边界。 然后，将这样一个明确的边界确定为勘探区域的地顶压力表面。

    POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS
    64.
    发明申请
    POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS 有权
    作为BRUTON酪氨酸激酶抑制剂的多氟化合物

    公开(公告)号：US20160200730A1

    公开(公告)日：2016-07-14

    申请号：US15075033

    申请日：2016-03-18

    申请人： Wei He

    发明人： Wei He

    IPC分类号： C07D487/04

    CPC分类号： A61K31/519 ,  C07C303/38 ,  C07C311/08 ,  C07D487/04 ,  C07D519/00 ,  C07F5/025 ,  C07F5/04

    摘要： Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

    摘要翻译： 本文描述了一系列新的多氟取代的吡唑并嘧啶化合物或其盐。 这些化合物是Bruton的酪氨酸激酶（BTK）抑制剂。 这些化合物可具有更好的BTK抑制选择性和药代动力学性质。 本文公开了这些化合物的合成方法。 本文公开了多氟取代的二苯甲酮和取代的苯氧基苯的新型合成方法。 还公开了包含本文所述的BTK抑制剂的药物组合物。 本发明还涉及包含本文所述的化合物作为活性成分的药物制剂。 本发明还包括通过施用BTK抑制剂及其制剂来治疗和抑制自身免疫性疾病，超敏反应性疾病，炎性疾病和癌症的治疗方法。

    Fairing for a truck cab-trailer gap
    65.
    发明授权
    Fairing for a truck cab-trailer gap 有权
    一个卡车驾驶室 - 拖车间隙的整流罩

    公开(公告)号：US08960769B2

    公开(公告)日：2015-02-24

    申请号：US14348087

    申请日：2011-10-12

    申请人： Wei He ,  Mathew Frederick Heinecke

    发明人： Wei He ,  Mathew Frederick Heinecke

    IPC分类号： B62D35/00

    CPC分类号： B62D35/001

    摘要： A truck for pulling a semi-trailer includes an operator cab positioned on a frame and a fifth wheel mounted on the frame for receiving an underside of the semi-trailer. The trailer when attached to the truck defines a gap between a forward most portion of the semi-trailer and rearward most portion of the operator cab. A fairing can be located on the frame, aft of the operator cab and forward of at least a portion of the fifth wheel. The fairing can block at least a portion of the air flow attempting to enter the gap from below the frame.

    摘要翻译： 用于牵引半挂车的卡车包括位于框架上的操作者驾驶室和安装在框架上的用于接收半挂车下侧的第五轮。 拖车当连接到卡车时，定义了半挂车的最前部分和驾驶室后方最大部分之间的间隙。 整流罩可以位于框架上，操作员驾驶室的后部和第五轮的至少一部分的前方。 整流罩可以阻挡试图从框架下方进入间隙的空气流的至少一部分。

    Compounds and Compositions for Nucleic Acid Formulation and Delivery
    68.
    发明申请
    Compounds and Compositions for Nucleic Acid Formulation and Delivery 审中-公开
    用于核酸配方和递送的化合物和组合物

    公开(公告)号：US20130072543A1

    公开(公告)日：2013-03-21

    申请号：US13541891

    申请日：2012-07-05

    申请人： John Frederick Boylan ,  Wei He

    发明人： Michael J. Bennett ,  John Frederick Boylan ,  Wei He

    IPC分类号： A61K47/22

    CPC分类号： A61K47/22 ,  A61K9/1271 ,  A61K9/5123 ,  A61K31/7105 ,  C12N15/88 ,  Y10S977/773

    摘要： The invention relates to compositions containing compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, and n are defined in the detailed description and claims. In addition, the present invention relates to novel formulations containing compounds of formula I for improved delivery of nucleic acids such as siRNA to the cytoplasm of target cells. In particular embodiments these formulations comprise compounds of formula I, phospholipids, cholesterol, and pegylated lipids. The present invention also relates to methods of manufacturing and using such compounds and compositions.

    摘要翻译： 本发明涉及包含式I化合物及其药学上可接受的盐的组合物，其中R，R 1，R 2，R 3和n在详细描述和权利要求书中定义。 此外，本发明涉及含有式I化合物的新型制剂，用于将核酸如siRNA转移至靶细胞的细胞质。 在具体实施方案中，这些制剂包含式I化合物，磷脂，胆固醇和聚乙二醇化脂质。 本发明还涉及制备和使用这些化合物和组合物的方法。