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    Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
    63.
    发明授权
    Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation 失效
    使用常规介电电泳和场流分馏的分级方法和设备

    公开(公告)号：US5993630A

    公开(公告)日：1999-11-30

    申请号：US604779

    申请日：1996-01-31

    申请人： Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    发明人： Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    IPC分类号： B03C5/02 ,  G01N30/00 ,  G01N27/26 ,  G01N27/447

    CPC分类号： B03C5/028 ,  G01N30/0005 ,  G01N2030/0035 ,  G01N2030/0065

    摘要： The present disclosure is directed to a novel apparatus and novel methods for the separtion, characterization, and manipulation of matter. In particular, the invention combines the use of frequency-dependent dielectric and conductive properties of particulate matter and solubilized matter with the properties of the suspending and transporting medium to discriminate and separate such matter. The apparatus includes a chamber having at least one electrode element and at least one inlet and one output port into which cells are introduced and removed from the chamber. Matter carried through the chamber in a fluid stream is then displaced within the fluid by a dielectrophoretic (DEP) force caused by the energized electrode. Following displacement within the fluid, matter travels through the chamber at velocities according to the velocity profile of the chamber. After the matter has transitted through the chamber, it exits at the opposite end of the chamber at a characteristic position. Methods according to the invention involve using the apparatus for discriminating and separating matter for research, diagnosis of a condition, and therapeutic purposes. Examples of such methods may include separation of mixtures of cells, such as cancer cells from normal cells, separation of parasitized erythrocytes from normal erythrocytes, separation of nucleic acids, and others.

    摘要翻译： 本公开涉及用于分离，表征和操纵物质的新型装置和新颖方法。 特别地，本发明结合了使用频率依赖的电介质和颗粒物质和溶解物质的导电性质与悬浮和输送介质的性质，以区分和分离这种物质。 该装置包括具有至少一个电极元件和至少一个入口和一个输出端口的腔室，细胞从腔室中被引入和移出。 然后通过流体流中的腔室进行的物质由通电电极引起的介电电泳（DEP）力在流体内移动。 在流体内移动之后，物质按照腔室的速度分布以速度行进通过腔室。 在物体经过腔室之后，它在特定位置处在腔室的相对端处离开。 根据本发明的方法涉及使用该装置来鉴别和分离用于研究，病症诊断和治疗目的的物质。 这些方法的实例可以包括分离细胞混合物，例如来自正常细胞的癌细胞，从正常红细胞分离寄生的红细胞，分离核酸等。

    Decision support system for the management of an agile supply chain
    64.
    发明授权
    Decision support system for the management of an agile supply chain 失效
    敏捷供应链管理决策支持系统

    公开(公告)号：US5953707A

    公开(公告)日：1999-09-14

    申请号：US802961

    申请日：1997-02-21

    申请人： Ying Huang ,  Ramakrishna Desiraju ,  Christophe Begue ,  Omer Bakkalbasi ,  Lap Mui Ann Chan ,  Krishnakumar Bhaskaran ,  Awi Federgruen ,  Raymond J. Krasinski ,  Peter Boey

    发明人： Ying Huang ,  Ramakrishna Desiraju ,  Christophe Begue ,  Omer Bakkalbasi ,  Lap Mui Ann Chan ,  Krishnakumar Bhaskaran ,  Awi Federgruen ,  Raymond J. Krasinski ,  Peter Boey

    IPC分类号： G06Q10/00 ,  G06F17/60

    CPC分类号： G06Q10/06 ,  G06Q10/06315 ,  G06Q10/0637 ,  G06Q30/0202 ,  Y10S706/925

    摘要： A decision support system for the management of an agile supply chain that provides an architecture including a server side and a client side. The server side includes a decision support system database that interfaces with a model engine that performs analysis of the data to support planning decisions. The server side includes a server manager that coordinates requests for service and information. The client side includes decision frames that present the various view points available in the system to the users. A frame manager coordinates the requests from decision support frames to access the needed data and models. The decision support frames provide a view into the supply chain and integrate analytical models responsive to the view point of a business process such as demand management. The frames include a supply management frame, a demand management frame, a vendor managed replenishment frame, a Planning, Sales and Inventory planning frame, and a distribution network design frame. The frame manager includes a system integrator and a functional integrator. A database management system manages the supply and maintenance of information needed by the modeling processes through the frame manager. A domain management process limits data available to saidl frame responsive to a user selection. The system also includes a demand and supply reconciliation process; a capacity planning process; a vendor managed replenishment process; and a scenario management process.

    摘要翻译： 用于管理敏捷供应链的决策支持系统，其提供包括服务器端和客户端的架构。 服务器端包括与执行数据分析以支持规划决策的模型引擎接口的决策支持系统数据库。 服务器端包括一个协调服务和信息请求的服务器管理器。 客户端包括向用户呈现系统中可用的各种观点的决策帧。 帧管理器协调来自决策支持帧的请求以访问所需的数据和模型。 决策支持框架提供了对供应链的观点，并针对业务流程（如需求管理）的观点来整合分析模型。 框架包括供应管理框架，需求管理框架，供应商管理的补货框架，规划，销售和库存计划框架以及分销网络设计框架。 帧管理器包括系统集成商和功能集成商。 数据库管理系统通过框架管理器管理建模过程所需的信息的供应和维护。 响应于用户选择，域管理过程限制可用于所述帧的数据。 该系统还包括需求和供应调节过程; 能力规划过程; 供应商管理补货流程; 和场景管理过程。

    TARGETED LIPOSOMES IN CANCER THERAPY
    68.
    发明申请
    TARGETED LIPOSOMES IN CANCER THERAPY 有权
    癌症治疗中的目标药物

    公开(公告)号：US20150157571A1

    公开(公告)日：2015-06-11

    申请号：US14240753

    申请日：2012-09-10

    申请人： Maria Polikandritou Lambros ,  Ying Huang

    发明人： Maria Polikandritou Lambros ,  Ying Huang

    IPC分类号： A61K9/127 ,  A61K31/704

    CPC分类号： A61K9/1271 ,  A61K31/704 ,  A61K47/6911

    摘要： The invention provides pharmaceutical compositions containing a vehicle for the targeted delivery of therapeutic and diagnostic agents for the treatment of hyperproliferative diseases. The targeting component of the vehicle is a cystine molecule that is coupled to the cargo component, which can be either a therapeutic or diagnostic agent or to a nanoparticle composition that contains the therapeutic agent or diagnostic. The invention also provides methods of treating hyperproliferative disorders by targeting hyperproliferative disease cells for the targeted delivery of a therapeutic or diagnostic agent.

    摘要翻译： 本发明提供含有用于靶向递送用于治疗过度增殖性疾病的治疗和诊断剂的载体的药物组合物。 载体的靶向组分是与货物组分偶联的胱氨酸分子，其可以是治疗剂或诊断剂或含有治疗剂或诊断剂的纳米颗粒组合物。 本发明还提供了通过靶向过度增殖性疾病细胞来治疗过度增殖性疾病用于靶向递送治疗剂或诊断剂的方法。

    Method and apparatus for non-access stratum message processing during handover in evolved network
    69.
    发明授权
    Method and apparatus for non-access stratum message processing during handover in evolved network 有权
    在进化网络中切换期间的非接入层消息处理的方法和装置

    公开(公告)号：US08665820B2

    公开(公告)日：2014-03-04

    申请号：US12704906

    申请日：2010-02-12

    申请人： Hongzhuo Zhang ,  Yong Qiu ,  Ying Huang ,  Qiang Wang

    发明人： Hongzhuo Zhang ,  Yong Qiu ,  Ying Huang ,  Qiang Wang

    IPC分类号： H04W4/00

    CPC分类号： H04W36/0005 ,  H04W36/02 ,  H04W92/12 ,  H04W92/20

    摘要： A method and an apparatus for non-access stratum (NAS) message processing during handover in an evolved network are provided. The method includes the following steps. An evolved packet core (EPC) receives a message which indicates that a UE is being handed over sent by a source evolved NodeB (S-eNB), and stops sending an NAS message to the UE temporarily. The EPC receives a message which indicates that the UE returns to an S-eNB service area sent by the S-eNB. The EPC sends the NAS message to the UE through the S-eNB, if needed. With the method and the apparatus, the EPC can acquire a location of the UE in time in the case of a handover failure of the UE, a time limit of a retransmission timer is set precisely, and a specific implementation for forwarding an NAS message through an X2 interface is provided.

    摘要翻译： 提供了一种用于演进网络中的切换期间的非接入层（NAS）消息处理的方法和装置。 该方法包括以下步骤。 演进的分组核心（EPC）接收指示由源演进的节点B（S-eNB）发送的UE正在切换的消息，并且暂时向UE发送NAS消息。 EPC接收到指示UE返回由S-eNB发送的S-eNB服务区域的消息。 如果需要，EPC通过S-eNB向NAS发送NAS消息。 利用该方法和装置，EPC可以在UE的切换失败的情况下及时获取UE的位置，精确地设置重发定时器的时间限制，以及用于转发NAS消息的特定实现 提供X2接口。

    Methods, cells and systems for incorporating non-canonical amino acids into proteins
    70.
    发明授权
    Methods, cells and systems for incorporating non-canonical amino acids into proteins 有权
    用于将非标准氨基酸掺入蛋白质的方法，细胞和系统

    公开(公告)号：US08658394B2

    公开(公告)日：2014-02-25

    申请号：US13353106

    申请日：2012-01-18

    申请人： Ying Huang ,  Wenshe Liu

    发明人： Ying Huang ,  Wenshe Liu

    IPC分类号： C12P21/00 ,  C12N1/21 ,  C12N15/63 ,  C12N1/00

    CPC分类号： C12N15/67

    摘要： The present disclosure pertains to methods of incorporating one or more non-canonical amino acids into a protein during a translation of the protein in bacterial cells. The present disclosure also pertains to methods of incorporating one or more non-canonical amino acids into a protein during an in vitro translation of the protein. In additional embodiments, the present disclosure pertains to isolated bacterial cells and in vitro translation systems (e.g., cell-free extract systems) for incorporating one or more non-canonical amino acids into a protein during a translation of the protein.

    摘要翻译： 本公开涉及在蛋白质在细菌细胞中翻译期间将一种或多种非标准氨基酸掺入蛋白质的方法。 本公开还涉及在体外翻译蛋白质期间将一种或多种非标准氨基酸掺入蛋白质的方法。 在另外的实施方案中，本公开涉及在翻译蛋白质期间将一种或多种非标准氨基酸掺入到蛋白质中的分离的细菌细胞和体外翻译系统（例如，无细胞提取系统）。