公开(公告)号：US09283597B2

公开(公告)日：2016-03-15

申请号：US11516269

申请日：2006-09-06

Applicant: Sivaramakrishnan Krishnamoorthy ,  Guiren Wang ,  Jianjun Feng ,  Yi Wang

Inventor： Sivaramakrishnan Krishnamoorthy ,  Guiren Wang ,  Jianjun Feng ,  Yi Wang

IPC: G01N30/00 ,  B08B7/00 ,  B01F13/00 ,  B08B9/00 ,  F04B19/00 ,  F04B19/24 ,  B01L99/00 ,  B01L3/00

CPC classification number: A61M5/14244 ,  A61M2205/0244 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B01L2400/0496 ,  B08B7/0064 ,  B08B9/00 ,  F04B19/006 ,  F04B19/24 ,  G01N2030/0035 ,  G01N2030/0065

Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.

Abstract translation: 描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。 微型泵应用于微流体系统，如生物芯片。 自调节输液泵可用于向患者施用大量和小体积的液体如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。

公开(公告)号：US08535536B1

公开(公告)日：2013-09-17

申请号：US12830104

申请日：2010-07-02

Applicant: Bruce K. Gale ,  Himanshu Sant ,  Venu Madhav ,  Srinivas Merugu

Inventor： Bruce K. Gale ,  Himanshu Sant ,  Venu Madhav ,  Srinivas Merugu

IPC: B01D61/28

CPC classification number: B01D57/00 ,  G01N30/0005 ,  G01N2030/0035

Abstract: A split thin-flow separations device can include a fluid channel having an inlet zone, an outlet zone, and a transport region between the inlet zone and outlet zone. The inlet zone includes a sample inlet and a carrier fluid inlet which are fluidly separated by an inlet splitter to minimize mixing of fluids from respective inlets in the inlet zone. The transport region can be a substantially open channel. Similar to the inlet zone, the outlet zone can include a sample outlet and a carrier outlet which are fluidly separated by an outlet splitter to segregate portions of a fluid into each of the two outlets as the fluid enters the outlet zone. A plurality of cross-flow inducers can also be oriented along a wall of the fluid channel in the transport region. The cross-flow inducers are oriented to form a cross-flow field across the transport region.

Abstract translation: 分流薄流分离装置可以包括具有入口区域，出口区域和入口区域和出口区域之间的输送区域的流体通道。 入口区域包括样品入口和载体流体入口，其通过入口分离器流体分隔，以最小化来自入口区域中相应入口的流体的混合。 运输区域可以是基本上开放的通道。 与入口区类似，出口区可以包括样品出口和载体出口，其通过出口分流器流体分离，以在流体进入出口区时将流体的一部分分离成两个出口中的每一个。 多个横流诱导器也可沿输送区域中的流体通道的壁定向。 横流诱导剂被定向成跨越传输区域形成交叉流场。

公开(公告)号：US07615354B2

公开(公告)日：2009-11-10

申请号：US10275041

申请日：2001-05-04

Applicant: Michel D. Faupel ,  Hubert H. Girault ,  Frederic Reymond ,  Alexandra Ros ,  Joel Stephane Rossier

Inventor： Michel D. Faupel ,  Hubert H. Girault ,  Frederic Reymond ,  Alexandra Ros ,  Joel Stephane Rossier

IPC: G01N33/53

CPC classification number: G01N27/44795 ,  G01N27/44769 ,  G01N2030/0035 ,  G01N2030/285

Abstract: A device, method and kit for the electrophoretic separation and purification of charged and neutral compounds in an analyte solution. The device comprises a chamber (1), at least one wall of which is composed of a chemical buffering system (4). A potential difference is applied across the buffering system, resulting in the charged and neutral compounds being differentially separated by extraction of the charged compounds into the buffering system. The device also comprises means for collecting the separated compounds, preferably in ampholyte-free or buffer-free solution and optionally means for recycling the separated fractions.

Abstract translation: 用于在分析物溶液中电荷分离和纯化带电和中性化合物的装置，方法和试剂盒。 该装置包括室（1），其至少一个壁由化学缓冲系统（4）组成。 在缓冲系统上施加电位差，导致带电和中性化合物通过将带电荷的化合物萃取到缓冲系统中而被差异地分离。 该装置还包括用于收集分离的化合物的装置，优选以不含两性电解质或不含缓冲液的溶液和用于再循环分离的级分的方法。

公开(公告)号：US07583382B2

公开(公告)日：2009-09-01

申请号：US10594528

申请日：2005-03-29

Applicant: Takakazu Yano ,  Kenji Matsumoto ,  Tadahiro Fukuda ,  Miharu Sugiura

Inventor： Takakazu Yano ,  Kenji Matsumoto ,  Tadahiro Fukuda ,  Miharu Sugiura

IPC: G01N21/00 ,  G01N3/00 ,  C02F1/461

CPC classification number: G01N30/96 ,  B01J39/07 ,  B01J41/07 ,  B01J47/04 ,  B01J49/08 ,  B01J49/30 ,  B01J49/53 ,  B01J49/57 ,  G01N21/21 ,  G01N30/74 ,  G01N2030/746 ,  G01N2030/0035

Abstract: An object of the present invention is to provide an optical measurement apparatus equipped with an ion-exchange resin for pretreating a sample, thereby enabling the concentration of component in the sample to be measured with higher accuracy. The optical measurement apparatus of the present invention includes, in addition to the ion-exchange resin, an optical measurement section for measuring, based on the optical characteristics of the component, the concentration of the component in the sample after the sample is passed through the ion-exchange resin.

Abstract translation: 本发明的目的是提供一种配备有用于对样品进行预处理的离子交换树脂的光学测量装置，从而能够以更高的精度测量样品中的组分的浓度。 本发明的光学测量装置除了离子交换树脂之外还包括光学测量部分，用于基于部件的光学特性，测量样品在样品通过之后的浓度 离子交换树脂。

公开(公告)号：US20070110625A1

公开(公告)日：2007-05-17

申请号：US11516269

申请日：2006-09-06

Applicant: Sivaramakrishnan Krishnamoorthy ,  Guiren Wang ,  Jianjun Feng ,  Yi Wang

Inventor： Sivaramakrishnan Krishnamoorthy ,  Guiren Wang ,  Jianjun Feng ,  Yi Wang

IPC: B01L3/00

CPC classification number: A61M5/14244 ,  A61M2205/0244 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B01L2400/0496 ,  B08B7/0064 ,  B08B9/00 ,  F04B19/006 ,  F04B19/24 ,  G01N2030/0035 ,  G01N2030/0065

Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.

Abstract translation: 描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。 微型泵应用于微流体系统，如生物芯片。 自调节输液泵可用于向患者施用大量和小体积的液体如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。

公开(公告)号：US06635226B1

公开(公告)日：2003-10-21

申请号：US09502593

申请日：2000-02-11

Applicant: Jacqueline Tso ,  Sally A. Swedberg ,  Paul K Wolber

Inventor： Jacqueline Tso ,  Sally A. Swedberg ,  Paul K Wolber

IPC: B01J1000

CPC classification number: G01N30/6095 ,  B01L3/5027 ,  B01L3/502707 ,  B01L7/52 ,  B01L7/54 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/163 ,  B01L2300/1805 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0481 ,  B01L2400/0487 ,  B29C66/549 ,  G01N27/44721 ,  G01N27/44773 ,  G01N27/44791 ,  G01N30/02 ,  G01N30/60 ,  G01N30/6052 ,  G01N30/606 ,  G01N2030/285 ,  G01N2030/0035 ,  B29C65/00

Abstract: A microanalytical device is provided for conducting chemical processes using small amounts of fluid. The devices include microstructures, e.g., microcavities, microchannels and the like, that are laser ablated or otherwise formed in a support substrate, and can be used in a variety of chemical and biochemical methods, including chromatographic, electrophoretic and electrochromatographic separations, screening and diagnostics, and chemical and biochemical synthesis. The devices are formed from a material that is thermally and chemically stable and resistant to biofouling, significantly reducing electroosmotic flow and unwanted adsorption of solute. Preferred materials are polymeric.

Abstract translation: 提供了一种微量分析装置，用于使用少量流体进行化学过程。 这些器件包括在支撑衬底中激光烧蚀或以其他方式形成的微结构，例如微腔，微通道等，并且可以用于各种化学和生物化学方法，包括色谱，电泳和电色谱分离，筛选和诊断 ，以及化学和生物化学合成。 这些装置由热和化学稳定的材料形成，并且能抵抗生物污损，显着减少电渗流和不想要的溶质吸附。 优选的材料是聚合物。

公开(公告)号：US06596144B1

公开(公告)日：2003-07-22

申请号：US09699674

申请日：2000-10-30

Applicant: Fred E. Regnier ,  Bing He

Inventor： Fred E. Regnier ,  Bing He

IPC: G01N27447

CPC classification number: B01J20/281 ,  B01J2220/54 ,  G01N27/44791 ,  G01N30/16 ,  G01N30/60 ,  G01N30/6017 ,  G01N30/6043 ,  G01N30/6095 ,  Y10S366/03 ,  G01N30/02 ,  G01N2030/0035 ,  G01N30/466

Abstract: A separation column for use in a separation process such as chromatography, electrochromatography and electrophoresis is described. The separation column includes multiple collocated monolith support structures and interconnected channels defined by the support structures. The monolith support structures and interconnected channels are created on a substrate using an isotropic etching. The separation column also includes a cover plate disposed on the etched surface of the substrate, creating an enclosed separation column.

Abstract translation: 描述了用于分离过程如色谱，电色谱和电泳的分离柱。 分离柱包括由支撑结构限定的多个并置整料支撑结构和互连通道。 使用各向同性蚀刻在基板上形成整体支撑结构和互连通道。 分离柱还包括设置在基板的蚀刻表面上的盖板，形成封闭的分离柱。

公开(公告)号：US20020023842A1

公开(公告)日：2002-02-28

申请号：US09978997

申请日：2001-10-16

Inventor： David Ogle

IPC: B01D061/42 ,  G01N027/26 ,  B01D061/00 ,  G01N027/447

CPC classification number: B01D57/02 ,  B01D61/425 ,  B01D61/44 ,  G01N27/44704 ,  G01N27/44769 ,  G01N30/0005 ,  G01N2030/0035

Abstract: An electrophoresis apparatus, comprises a cartridge configured to be removably mounted in the apparatus, and a separation membrane positioned in the cartridge. The separation membrane has a first side along which a first flow path defined in a first grid element and a second side along which a second flow path defined in a second grid element is provided. Restriction membranes separate buffer flow from the first flow path and the second flow path. The apparatus includes connection blocks which house electrodes and inlets and outlets for buffer flow and sample flows. The cartridge is removable from the connection blocks for replacement with another cartridge.

Abstract translation: 一种电泳装置，包括被配置为可移除地安装在该装置中的盒，以及定位在盒中的分离膜。 分离膜具有第一侧，沿着第一侧限定第一流路，该第一流路限定在第一栅格元件中，第二侧设置有限定在第二栅格元件中的第二流路。 限制膜将缓冲液流从第一流动路径和第二流动路径分离。 该装置包括连接块，其容纳用于缓冲液流和样品流的电极和入口和出口。 墨盒可从连接块中取出，以便更换其他墨盒。

公开(公告)号：US06328869B1

公开(公告)日：2001-12-11

申请号：US09390565

申请日：1999-09-03

Applicant: David Ogle

Inventor： David Ogle

IPC: G02N2726

CPC classification number: B01D57/02 ,  B01D61/425 ,  B01D61/44 ,  G01N27/44704 ,  G01N27/44769 ,  G01N30/0005 ,  G01N2030/0035

Abstract: An electrophoresis apparatus, comprises a cartridge configured to be removably mounted in the apparatus, and a separation membrane positioned in the cartridge. The separation membrane has a first side along which a first flow path defined in a first grid element and a second side along which a second flow path defined in a second grid element is provided. Restriction membranes separate buffer flow from the first flow path and the second flow path. The apparatus includes connection blocks which house electrodes and inlets and outlets for buffer flow and sample flows. The cartridge is removable from the connection blocks for replacement with another cartridge.

Abstract translation: 一种电泳装置，包括被配置为可移除地安装在该装置中的盒，以及定位在盒中的分离膜。 分离膜具有第一侧，沿着第一侧限定第一流路，该第一流路限定在第一栅格元件中，第二侧设置有限定在第二栅格元件中的第二流路。 限制膜将缓冲液流从第一流动路径和第二流动路径分离。 该装置包括连接块，其容纳用于缓冲液流和样品流的电极和入口和出口。 墨盒可从连接块中取出，以便更换其他墨盒。

公开(公告)号：US06309532B1

公开(公告)日：2001-10-30

申请号：US09289876

申请日：1999-04-12

Applicant: Tri D. Tran ,  Joseph C. Farmer ,  Laura Murguia

Inventor： Tri D. Tran ,  Joseph C. Farmer ,  Laura Murguia

IPC: B01D1508

CPC classification number: C02F1/4691 ,  B01D15/36 ,  B01J47/08 ,  B01J49/30 ,  C02F1/42 ,  C02F1/46104 ,  C02F1/46109 ,  C02F2001/46119 ,  C02F2001/46123 ,  C02F2001/46128 ,  C02F2001/46138 ,  C02F2001/46152 ,  C02F2001/46161 ,  C02F2101/006 ,  C02F2201/4611 ,  C02F2201/46115 ,  C02F2201/4612 ,  C02F2201/46125 ,  C02F2201/46145 ,  C02F2201/46175 ,  C02F2209/001 ,  C02F2209/003 ,  C02F2209/02 ,  C02F2209/05 ,  C02F2209/06 ,  C02F2303/16 ,  G01N30/02 ,  G01N30/60 ,  G01N30/6095 ,  G01N30/96 ,  G01N2030/645 ,  G01N2030/8881 ,  B01D15/362 ,  B01D15/363 ,  B01D15/361 ,  G01N2030/0035

Abstract: An electrically regeneratable electrochemical cell (30) for capacitive deionization and electrochemical purification and regeneration of electrodes includes two end plates (31, 32), one at each end of the cell (30). A new regeneration method is applied to the cell (30) which includes slowing or stopping the purification cycle, electrically desorbing contaminants and removing the desorbed contaminants. The cell (30) further includes a plurality of generally identical double-sided intermediate electrodes (37-43) that are equidistally separated from each other, between the two end electrodes (35, 36). As the electrolyte enters the cell, it flows through a continuous open serpentine channel (65-71) defined by the electrodes, substantially parallel to the surfaces of the electrodes. By polarizing the cell (30), ions are removed from the electrolyte and are held in the electric double layers formed at the carbon aerogel surfaces of the electrodes. The cell (30) is regenerated electrically to desorb such previously removed ions.

Abstract translation: 用于电容去离子和电化学纯化和电极再生的可再生电化学电池（30）包括两个端板（31,32），在电池的每个端部（30）中一个。 将新的再生方法应用于细胞（30），其包括减缓或停止纯化循环，电解除污染物并除去解吸的污染物。 电池（30）还包括在两个端电极（35,36）之间彼此等距离分离的多个大致相同的双面中间电极（37-43）。 当电解质进入电池时，它流过由电极限定的连续开放的蛇形通道（65-71），基本上平行于电极的表面。 通过使电池（30）极化，离子从电解质中除去并保持在形成在电极的碳气凝胶表面的电双层中。 电池（30）电解再生以解吸这种先前去除的离子。