公开(公告)号：US20050119587A1

公开(公告)日：2005-06-02

申请号：US10944518

申请日：2004-09-17

申请人： Blake Roessler ,  Michael Morris ,  Steven Goldstein ,  Abigail Smukler ,  Nicole Crane ,  Barbara McCreadie ,  Tso-Ching Chen

发明人： Blake Roessler ,  Michael Morris ,  Steven Goldstein ,  Abigail Smukler ,  Nicole Crane ,  Barbara McCreadie ,  Tso-Ching Chen

IPC分类号： A61B5/00 ,  A61B5/103 ,  G01N21/35 ,  G01N21/65 ,  A61B10/00

CPC分类号： A61B5/0059 ,  A61B5/4504 ,  A61B5/4509 ,  A61B5/4514 ,  A61B5/4523 ,  A61B5/4533 ,  G01N21/35 ,  G01N21/65 ,  G01N2021/656

摘要： In a method for evaluating a connective tissue condition of a patient, an indicator of the supporting tissue condition may be generated. A portion of connective tissue of the patient is irradiated using a light source. The connective tissue may be irradiated in vivo through the skin or via an incision, for example. Alternatively, a biopsy of the connective tissue may be irradiated. Then, spectral content information for light scattered, reflected, or transmitted by the connective tissue is determined. The spectral content information is used, at least in part, to generate the indicator. The indicator may assist a physician in diagnosing or ruling out the connective tissue condition, determining a risk of developing a disease, monitoring the progression of a disease, monitoring a response to treatment, etc.

摘要翻译： 在用于评估患者的结缔组织状况的方法中，可以产生支撑组织状况的指示符。 使用光源照射患者的一部分结缔组织。 结缔组织可以通过皮肤或通过切口体内照射。 或者，可以照射结缔组织的活组织检查。 然后，确定由结缔组织散射，反射或透射的光的光谱含量信息。 使用频谱内容信息，至少部分地用于生成指示符。 指示器可以帮助医生诊断或排除结缔组织状况，确定发展疾病的风险，监测疾病的进展，监测治疗反应等。

公开(公告)号：US06866686B2

公开(公告)日：2005-03-15

申请号：US09769769

申请日：2001-01-26

申请人： Jeremy D. Ollerenshaw ,  Steven Goldstein ,  Kirby S. Black

发明人： Jeremy D. Ollerenshaw ,  Steven Goldstein ,  Kirby S. Black

IPC分类号： C12N5/06 ,  A61F2/04 ,  A61F2/06 ,  A61F2/10 ,  A61L27/00 ,  A61L27/36 ,  A61L27/38 ,  A61L31/00 ,  A61F2/36

CPC分类号： A61L31/005 ,  A61F2/04 ,  A61F2/06 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L2430/40

摘要： The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.

摘要翻译： 本发明涉及一种制备组织移植材料的方法。 本发明还涉及一种多功能组织移植物材料以及使用其作为血管和非血管组织替代物的方法。

公开(公告)号：US5843182A

公开(公告)日：1998-12-01

申请号：US791450

申请日：1997-01-27

申请人： Steven Goldstein

发明人： Steven Goldstein

IPC分类号： C12N5/06 ,  A61F2/24 ,  A61L27/00 ,  A61L27/36 ,  A61L27/38

CPC分类号： A61L27/3687 ,  A61L27/3604 ,  A61L27/3625 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3895 ,  A61L2430/40 ,  Y10S623/92 ,  Y10S623/921

摘要： This disclosure includes a method for generating a functional hybrid bioprosthesis. Tissue formed naturally of interstitial collagens is treated to kill native cells and remove potentially immunologically active soluble molecules. Then it may be treated sequentially with extracellular matrix adhesion factor, extracellular matrix glycosaminoglycan, and growth factor appropriate to the cell type required to function within the matrix, and incubating the transplant tissue matrix with cells that are either allogeneic or autologous for the recipient thereby imparting to the matrix the characteristics of the cell type and tissue selected. Tissues with a variety of functional bioactivities can thus be formed in vitro prior to graft transplantation or implantation which will exhibit reduced or no stimulation of an immunological response in the recipient.