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公开(公告)号：US07189566B2
公开(公告)日：2007-03-13
申请号：US09944896
申请日：2001-08-31
申请人： David Botstein , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Margaret Ann Roy , William Wood
发明人： David Botstein , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Margaret Ann Roy , William Wood
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： The present invention is directed to novel polypeptides having homology to cysteine-rich secretory protein-3 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cell comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与富含半胱氨酸的分泌蛋白-3和编码这些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20070031901A1
公开(公告)日：2007-02-08
申请号：US11457750
申请日：2006-07-14
申请人： Avi Ashkenazi , Audrey Goddard , Paul Godowski , Austin Gurney , Paul Polakis , P. Williams , William Wood , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Audrey Goddard , Paul Godowski , Austin Gurney , Paul Polakis , P. Williams , William Wood , Thomas Wu , Zemin Zhang
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20070003935A1
公开(公告)日：2007-01-04
申请号：US11102284
申请日：2005-04-07
申请人： Dan Eaton , Ellen Filvaroff , Mary Gerrilsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
发明人： Dan Eaton , Ellen Filvaroff , Mary Gerrilsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20060257971A1
公开(公告)日：2006-11-16
申请号：US10131833
申请日：2002-04-24
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20060257897A1
公开(公告)日：2006-11-16
申请号：US11367172
申请日：2006-03-02
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C12Q1/68 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060216270A1
公开(公告)日：2006-09-28
申请号：US11353441
申请日：2006-02-14
申请人： Avi Ashkenazi , Kevin Baker , Paul Godowski , Austin Gurney , Melanie Mark , Scot Marsters , Robert Pitti
发明人： Avi Ashkenazi , Kevin Baker , Paul Godowski , Austin Gurney , Melanie Mark , Scot Marsters , Robert Pitti
CPC分类号： C07K14/525 , A61K38/00 , C07K2319/02
摘要： A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.
摘要翻译： 提供了鉴定为DNA19355的肿瘤坏死因子同源物。 DNA19355多肽在哺乳动物癌细胞中具有凋亡活性，可能参与促炎反应。 还提供了编码DNA19355的核酸分子，嵌合分子和DNA19355的抗体。
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公开(公告)号：US20060188914A1
公开(公告)日：2006-08-24
申请号：US11369228
申请日：2006-03-02
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060177441A1
公开(公告)日：2006-08-10
申请号：US11402010
申请日：2006-04-12
申请人： Camellia Adams , Austin Gurney
发明人： Camellia Adams , Austin Gurney
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2866 , C07K16/40 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/74 , C07K2317/75 , C07K2317/92
摘要： Various forms of c-mpl agonist antibodies are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.
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公开(公告)号：US20060167231A1
公开(公告)日：2006-07-27
申请号：US11258349
申请日：2005-10-24
申请人： Audrey Goddard , Paul Godowski , Austin Gurney , Victoria Smith , William Wood
发明人： Audrey Goddard , Paul Godowski , Austin Gurney , Victoria Smith , William Wood
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/28 , C07K2319/30 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/00 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07074592B2
公开(公告)日：2006-07-11
申请号：US09909320
申请日：2001-07-18
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jenni P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jenni P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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