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113 条记录 (耗时 0.054 秒)

    Monoclonal antibody to human Mx protein MxA
    64.
    发明授权
    Monoclonal antibody to human Mx protein MxA 有权
    人Mx蛋白MxA的单克隆抗体

    公开(公告)号：US06180102B2

    公开(公告)日：2001-01-30

    申请号：US09165798

    申请日：1998-10-02

    申请人： Nobuo Hanai ,  Kyosuke Nagata ,  Akiko Furuya ,  Akira Kusano ,  Noboru Taniguchi

    发明人： Nobuo Hanai ,  Kyosuke Nagata ,  Akiko Furuya ,  Akira Kusano ,  Noboru Taniguchi

    IPC分类号： A61K39395

    CPC分类号： C07K16/18 ,  Y10S530/809

    摘要： This invention provides a monoclonal antibody which recognizes an epitope corresponding to amino acids 10 to 220, amino acids 221 to 297, or amino acids 469 to 662, counting from the N-terminus of a human Mx protein MxA, and specifically reacts with the human Mx protein by western blotting, immunoprecipitation or immunocyte staining, and a hybridoma which produces the antibody. The human Mx protein MxA monoclonal antibody of this invention can be used, for example, in the diagnosis of viral infection.

    摘要翻译： 本发明提供一种单克隆抗体，其识别对应于人Mx蛋白MxA的N末端计数的氨基酸10至220，氨基酸221至297或氨基酸469至662的表位，并与人类特异性反应 Mx蛋白通过Western印迹，免疫沉淀或免疫细胞染色，以及产生抗体的杂交瘤。 本发明的人Mx蛋白MxA单克隆抗体可用于例如病毒感染的诊断。

    Anti-DCC gene product specific monoclonal antibody
    66.
    发明授权
    Anti-DCC gene product specific monoclonal antibody 失效
    抗DCC基因产物特异性单克隆抗体

    公开(公告)号：US5445938A

    公开(公告)日：1995-08-29

    申请号：US80809

    申请日：1993-06-24

    申请人： Nobuo Hanai ,  Shozo Baba ,  Tadachika Ozawa

    发明人： Nobuo Hanai ,  Shozo Baba ,  Tadachika Ozawa

    IPC分类号： C07K16/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/28 ,  C07K16/30 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12P21/08 ,  C12R1/91 ,  G01N33/574 ,  G01N33/577

    CPC分类号： C07K14/4703 ,  C07K14/70503 ,  C07K16/2803 ,  C07K16/30 ,  Y10S436/813

    摘要： This invention relates to monoclonal antibodies capable of specifically reacting with a peptide encoded by tumor suppressor gene DCC gene and to hybridomas capable of producing such monoclonal antibodies. In particular, the invention relates to mouse monoclonal antibody KM890 belonging to the IgG3 subclass, which is specifically reactive with a DCC gene DCC-2, and to a hybridoma KM890 capable of producing the monoclonal antibody KM890.The monoclonal antibodies of this invention which are specifically reactive with DCC gene products can be used in immunohistochemical staining, quantitative determination of DCC gene products and the like, as well as in cancer diagnosis.

    摘要翻译： 本发明涉及能够与由肿瘤抑制基因DCC基因编码的肽特异性反应的单克隆抗体以及能够产生这种单克隆抗体的杂交瘤。 特别地，本发明涉及属于与DCC基因DCC-2特异性反应的IgG3亚类的小鼠单克隆抗体KM890以及能产生单克隆抗体KM890的杂交瘤KM890。 与DCC基因产物特异性反应的本发明的单克隆抗体可用于免疫组织化学染色，DCC基因产物的定量测定等，以及癌症诊断。