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公开(公告)号：US20060217389A1
公开(公告)日：2006-09-28
申请号：US11355922
申请日：2006-02-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4709 , A61K31/4439 , A61K31/426 , A61K31/42
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b， SUB> 2 在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US08269017B2
公开(公告)日：2012-09-18
申请号：US12883883
申请日：2010-09-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20110059893A1
公开(公告)日：2011-03-10
申请号：US12883883
申请日：2010-09-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K38/06 , A61K31/675 , A61K31/501 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/42 , C07K5/08 , C07F9/09 , C07D261/08 , C07D413/10 , C07D413/04 , A61K31/422 , A61P35/00 , A61P7/00 , A61P27/02
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20120289483A1
公开(公告)日：2012-11-15
申请号：US13558886
申请日：2012-07-26
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K31/42 , C07D261/08 , C07F9/653 , C07D413/04 , A61P35/00 , A61K31/4439 , A61K31/4725 , A61K31/4709 , A61K31/422 , A61K31/675 , C07D413/10
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US20110195094A1
公开(公告)日：2011-08-11
申请号：US12673254
申请日：2008-08-13
申请人： Weiwen Ying , Lijun Sun , Keizo Koya , Dinesh U. Chimmanamada , Shijie Zhang , Teresa Kowalcyzk Przewloka , Hao Li
发明人： Weiwen Ying , Lijun Sun , Keizo Koya , Dinesh U. Chimmanamada , Shijie Zhang , Teresa Kowalcyzk Przewloka , Hao Li
IPC分类号： A61K31/675 , C07F9/12 , C07D413/14 , A61P35/00 , A61P29/00 , C12N5/071 , A61P31/10 , A61P33/00 , A61P31/12 , A61P31/04 , A61P37/06 , A61P37/02
CPC分类号： A61K31/675 , C07D209/04 , C07D249/08 , C07D403/04 , C07F9/6518 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US06616959B2
公开(公告)日：2003-09-09
申请号：US10006326
申请日：2001-11-13
申请人： Mitsunori Ono , Keizo Koya , Noriaki Tatsuta , Naoto Yamaguchi , Lan Bo Chen
发明人： Mitsunori Ono , Keizo Koya , Noriaki Tatsuta , Naoto Yamaguchi , Lan Bo Chen
IPC分类号： A23L120
CPC分类号： A23L33/105 , A23V2002/00 , A23V2250/2116
摘要： This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also shown is a method of preparing such a water-soluble bean-based extract.
摘要翻译： 本发明涉及包含一种或多种异黄酮糖苷的水溶性豆类提取物。 还示出了制备这种水溶性豆类提取物的方法。
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公开(公告)号：US20100093828A1
公开(公告)日：2010-04-15
申请号：US12310303
申请日：2007-08-20
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Jun Jiang
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Jun Jiang
IPC分类号： A61K31/165 , C07C327/56 , C07D333/24 , C07D307/54 , A61K31/381 , A61K31/341 , A61P35/00 , A61P25/16 , A61P25/28
CPC分类号： C07C327/56 , C07C337/08 , C07C2601/14 , C07C2601/18 , C07D211/84 , C07D213/53 , C07D239/04 , C07D263/10 , C07D271/10 , C07D307/52 , C07D317/28 , C07D333/22 , C07D339/08 , C07D413/14
摘要： Disclosed are compounds of formula (IA), formula (IV) or formula (V), and pharmaceutical compositions containing them which are useful for treating a subject with a proliferative disorder, such as cancer. The disclosed compounds and pharmaceutical compositions are also useful for treating disorders responsive to Hsp70 induction and/or natural killer induction.
摘要翻译： 公开了式（IA），式（IV）或式（V）的化合物和含有它们的药物组合物，其可用于治疗患有增殖性疾病如癌症的受试者。 所公开的化合物和药物组合物还可用于治疗对Hsp70诱导和/或天然杀伤诱导反应的病症。
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公开(公告)号：US20090270353A1
公开(公告)日：2009-10-29
申请号：US12496902
申请日：2009-07-02
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/427 , A61K31/425 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/675
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20090023736A1
公开(公告)日：2009-01-22
申请号：US12150445
申请日：2008-04-28
申请人： Keizo Koya , Weiwen Ying , Teresa Przewloka , Lijun Sun
发明人： Keizo Koya , Weiwen Ying , Teresa Przewloka , Lijun Sun
IPC分类号： C07D265/30 , C07C243/12 , C07C243/22 , A61P35/00 , A61K31/15 , A61K31/5375
CPC分类号： C07C391/00 , A61K31/165 , A61K31/18 , A61K45/06 , C07C259/20 , C07C2601/02
摘要： Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
摘要翻译： 公开了使用本发明化合物治疗患有增殖性疾病如癌症的受试者的化合物和方法，以及用于治疗响应于Hsp70诱导和/或自然杀伤诱导的病症的方法。 此外，公开了包含本发明化合物和药学上可接受的载体的药物组合物。
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公开(公告)号：US20070179159A1
公开(公告)日：2007-08-02
申请号：US11601590
申请日：2006-11-17
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/425 , C07F9/06 , C07F9/6512 , C07D417/02
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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