摘要:
A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein A is —(NR4)—, —(CR5R6)— or —O—, B is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively.
摘要:
A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein A is —(NR4)—, —(CR5R6)— or —O—, B is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively.
摘要:
A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.
摘要:
To provide a driver for driving piezoelectric actuators with drastically reduced drive currents during on/off switch control, thereby reducing the power consumption of an overall device. Each of the plural piezoelectric actuators 1a to 1h is composed of a plate and piezoelectric sheets attached to the opposed surfaces of the plate. A positive feeder line 19 or a negative feeder line 21 is connected to the opposite side of each piezoelectric sheet to the side attached to the plate. The controller 27 on-controls the piezoelectric sheets of each of the piezoelectric actuators 1a to 1h by selectively applying a positive or negative drive voltage thereto. Thereafter, the controller 27 turns off the drive voltage applied to the piezoelectric sheets subjected to on-control and simultaneously with this, turns on a drive voltage to the piezoelectric sheets of any other one the piezoelectric electric actuators 1a to 1h to be driven next.
摘要:
A method for forming a glass optical element by press forming a thermally softened glass material with a preheated forming mold composed of an upper and a lower die. The glass material, the upper die and the lower die are heated within respectively prescribed temperature ranges, the preheating temperature of the upper die being below the preheating temperature of the lower die. The thermally softened glass material is pressed in the preheated forming mold, and the forming surfaces of the upper and the lower dies are cooled simultaneously with the start of the initial pressing, during the process of the initial pressing, or after the completion of the initial pressing.
摘要:
2,4-Diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine and pharmaceutically acceptable acid addition salts thereof in finely pulverized form so that the average particle diameter is 20 microns or less have been found to be particularly useful for the treatment of peptic ulcers.
摘要:
2-Hydroxymethyl-3,4,5-trihydroxypiperidines bearing a quaternary ammonium-substituted cinnamyl group on the piperidine nitrogen atom and their acid addition salts are antihyperglycemic agents. A typical example is 1-(4-trimethylammoniumcinnamyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine chloride.
摘要:
4-(3-Aryloxy-2-hydroxypropyl)piperazines bearing a carbamyl, N-alkyl or N,N-dialkylcarbamyl group in the 1-position are .beta.-adrenergic blockers. A typical example is 1-carbamyl-4-(3-phenoxy-2-hydroxypropyl)piperazine.
摘要:
New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.
摘要:
2-Hydroxymethyl-3,4,5-trihydroxypiperidine is obtained from the mulberry plant through extraction, optionally with further purification through ion exchange or chromatographic treatment.