公开(公告)号：US20090177011A1

公开(公告)日：2009-07-09

申请号：US11720692

申请日：2005-12-08

申请人： Harald Walter ,  Camilla Corsi ,  Josef Ehrenfreund ,  Clemens Lamberth ,  Hans Tobler

发明人： Harald Walter ,  Camilla Corsi ,  Josef Ehrenfreund ,  Clemens Lamberth ,  Hans Tobler

IPC分类号： C07C209/06

CPC分类号： C07C209/10 ,  C07C2601/02 ,  C07C211/45

摘要： The present invention relates to a process for the preparation of compounds of formula (I) wherein R1, R2 and R3 are each independently of the others hydrogen or methyl, by reaction of compounds of formula (II) wherein R1, R2 and R3 are as defined for formula (I) and X is bromine or chlorine, with ammonia in the presence of a catalytic amount of at least one copper-containing compound.

摘要翻译： 本发明涉及式（Ⅰ）化合物的制备方法，其中R 1，R 2和R 3各自独立地为氢或甲基，其中R 1，R 2和R 3为 对于式（I）定义，X是溴或氯，与氨在催化量的至少一种含铜化合物的存在下反应。

公开(公告)号：US20080132557A1

公开(公告)日：2008-06-05

申请号：US11570796

申请日：2005-06-21

申请人： Clemens Lamberth ,  Camilla Corsi ,  Josef Ehrenfreund ,  Hans Tobler ,  Harald Walter

发明人： Clemens Lamberth ,  Camilla Corsi ,  Josef Ehrenfreund ,  Hans Tobler ,  Harald Walter

IPC分类号： A61K31/4155 ,  C07D403/12

CPC分类号： C07D403/12 ,  C07D231/40 ,  C07D333/20 ,  C07D409/12

摘要： Compounds of the formula (I), in which the substituents are as defined in claim 1 are suitable for use as microbiocides.

摘要翻译： 其中取代基如权利要求1中所定义的式（I）化合物适合用作杀微生物剂。

公开(公告)号：US07355065B2

公开(公告)日：2008-04-08

申请号：US11572053

申请日：2005-07-13

申请人： Harald Walter ,  Camilla Corsi ,  Josef Ehrenfreund ,  Clemens Lamberth ,  Hans Tobler

发明人： Harald Walter ,  Camilla Corsi ,  Josef Ehrenfreund ,  Clemens Lamberth ,  Hans Tobler

IPC分类号： C07C69/72

CPC分类号： C07C67/343 ,  C07C69/716

摘要： The present invention relates to a process for the preparation of a compound of the formula (I), wherein R is C1−12 alkyl, by the contact of a compound of the general formula (II), wherein R1 and R2 are each, independently, C1−12 alkyl; or R1 and R2 join together with the nitrogen atom to which they are attached to form an alicyclic amine ring containing 4 to 7 carbon atoms or a morpholine ring, with an acetic acid ester of the general formula (III) CH3COOR, wherein R is as defined under formula (I), in the presence of a base.

摘要翻译： 本发明涉及制备式（I）化合物的方法，其中R是C 1-12烷基，通过通式（II）的化合物与 其中R 1和R 2各自独立地为C 1-12烷基; 或R 1和R 2 2与它们所连接的氮原子一起形成含有4至7个碳原子的脂环族胺环或吗啉环，其中 （III）CH 3 COOR的乙酸酯，其中R如式（I）所定义，在碱的存在下。

公开(公告)号：US20060276434A1

公开(公告)日：2006-12-07

申请号：US10554336

申请日：2004-04-21

申请人： Josef Ehrenfreund ,  Harald Walter ,  Hans Tobler ,  Clemens Lamberth

发明人： Josef Ehrenfreund ,  Harald Walter ,  Hans Tobler ,  Clemens Lamberth

IPC分类号： C07F7/02 ,  A01N43/54 ,  A01N43/40

CPC分类号： C07D409/12 ,  A01N55/00 ,  C07D333/28 ,  C07D333/36 ,  C07D411/12 ,  C07D413/12 ,  C07D417/12

摘要： The invention also relates to novel compounds of formula (I) where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by one to three groups R4; R1 is hydrogen, optionally substituted (C1-4)alkyl, formyl, optionally substituted (C1-4)alkylC(═O), optionally substituted (C1-4)alkylC(═O)O, optionally substituted (C1-4)alkoxy(C1-4)alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; each R2 is, independently, halogen, optionally substitute (C1-4)alkyl, optionally substituted (C1-4)alkoxy or optionally substituted (C1-4)alkoxy(C1-4)alkyl; R3 is either position 2 or at position 4 of the thiophene ring and is an organic group containing three to thirteen carbon atoms and al least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and is optionally substituted by one to four independently selected halogen atoms; each R4 is, independently, halogen, C1-3 alkyl, C1-3 haloalkyl, C1-3alkoxy(C1-3)alkyl or cyano; r is 0, 1 or 2; and X is O or S; or an N-oxide thereof, to novel intermediates used in the preparation of these compounds, to agrochemical compositions which comprise at least one of the novel compounds as an active ingredient and to the use of the active ingredients or compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.

公开(公告)号：US20130324544A1

公开(公告)日：2013-12-05

申请号：US13989797

申请日：2011-11-25

申请人： Sarah Sulzer-Mosse ,  Clemens Lamberth ,  Mathias Stephan Respondek ,  Laura Quaranta ,  Fredrik Cederbaum ,  Guillaume Berthon

发明人： Sarah Sulzer-Mosse ,  Clemens Lamberth ,  Mathias Stephan Respondek ,  Laura Quaranta ,  Fredrik Cederbaum ,  Guillaume Berthon

IPC分类号： A01N43/82 ,  A01N43/80 ,  A01N43/60

CPC分类号： A01N43/82 ,  A01N43/60 ,  A01N43/80 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D513/04

摘要： Compounds of the formula I Formula (I) wherein the substituents are as defined in claim 1, are useful as active ingredients, which have microbiocidal activity, in particular fungicidal activity.

摘要翻译： 其中取代基如权利要求1中所定义的式I化学式（I）的化合物可用作具有杀微生物活性，特别是杀真菌活性的活性成分。

公开(公告)号：US20130281467A1

公开(公告)日：2013-10-24

申请号：US13881648

申请日：2011-10-28

申请人： Stephan Trah ,  Laura Quaranta ,  Clemens Lamberth ,  Martin Pouliot

发明人： Stephan Trah ,  Laura Quaranta ,  Clemens Lamberth ,  Martin Pouliot

IPC分类号： A01N43/54 ,  A01N43/90

CPC分类号： A01N43/54 ,  A01N43/90 ,  C07D401/04 ,  C07D491/04 ,  C07D491/10

摘要： Compounds of formula (I), wherein G represents together with the two carbon atoms of the pyrimidine ring to which it is attached, a 5- to 7-membered aliphatic carbocyclic or heterocyclic ring system which contain 0 to 2 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; and wherein said 5- to 7-membered aliphatic carbocyclic or heterocyclic ring system can be mono-, di- or trisubstituted by substituents selected from the group consisting of halogen, keto, C1-C6alkyl, C1-C6alkoxy, C1-C6alkyloximino and C1-C6alkylendioxy; and wherein the other substituents R1, R2, R3, R4, R5 and R6 are as defined in claim 1, and their use as microbicides.

摘要翻译： 式（I）化合物，其中G代表与其连接的嘧啶环的两个碳原子一起，含有0至2个选自以下的杂原子的5-至7-元脂族碳环或杂环系： 的氮，氧和硫; 并且其中所述5-至7-元脂族碳环或杂环系统可以被选自卤素，酮，C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷氧基肟基和C 1 -C 6烷氧基的取代基单，二或三取代， C6烷基二氧基; 并且其中其它取代基R 1，R 2，R 3，R 4，R 5和R 6如权利要求1中所定义，及其作为杀微生物剂的用途。

公开(公告)号：US08198215B2

公开(公告)日：2012-06-12

申请号：US11573411

申请日：2005-08-11

申请人： Harald Walter ,  Ronald Zeun ,  Josef Ehrenfreund ,  Hans Tobler ,  Camilla Corsi ,  Clemens Lamberth

发明人： Harald Walter ,  Ronald Zeun ,  Josef Ehrenfreund ,  Hans Tobler ,  Camilla Corsi ,  Clemens Lamberth

IPC分类号： A01N43/56 ,  A01P3/00

CPC分类号： A01N43/56

摘要： A method of controlling phytopathogenic diseases on useful plants or plant propagation material thereof, which comprises applying to said plant propagation material a fungicidally effective amount of a compound of formula (I) wherein R1 is trifluoromethyl or difluoromethyl and R2 is hydrogen or methyl, or a tautomer of such a compound, is particularly effective in controlling or preventing fungal diseases of crop plants.

摘要翻译： 一种控制有用植物或其植物繁殖材料上的植物病原性疾病的方法，其包括向所述植物繁殖材料施用杀真菌有效量的式（I）化合物，其中R 1为三氟甲基或二氟甲基且R 2为氢或甲基，或 这种化合物的互变异构体在控制或预防作物植物的真菌病害中特别有效。

公开(公告)号：US20120142698A1

公开(公告)日：2012-06-07

申请号：US13390023

申请日：2010-08-06

申请人： Sarah Sulzer-Mosse ,  Clemens Lamberth ,  Laura Quaranta ,  Mathias Stephan Respondek

发明人： Sarah Sulzer-Mosse ,  Clemens Lamberth ,  Laura Quaranta ,  Mathias Stephan Respondek

IPC分类号： A01N43/60 ,  C07D207/09 ,  C07D207/48 ,  C07D401/14 ,  C07D401/04 ,  A01P3/00 ,  C07D403/04 ,  A01N43/56 ,  A01N43/36 ,  A01N43/40 ,  A01N43/54 ,  C07D403/06 ,  C07D403/14

CPC分类号： C07D401/14 ,  C07D231/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12

摘要： The present invention relates to heterocyclic compounds of formula I which have microbiocidal activity, in particular fungicidal activity as well as methods of using the compounds of formula (I) to control microbes: wherein A is x-C(R10R11)—C(═O)—, x-C(R12R13)—C(═S)—, x-O—C(═O)—, x-O—C(═S)—, x-N(R14)—C(═O)—, x-N(R15)—C(═S)—, x-C(R16R17)—SO2— or X—N═C(R30)—, in each case x indicates the bond that is connected to R1; T is CR18 or N; Y1, Y2, Y3, and Y4 are independently CR19 or N; Q is O or S; n is 1 or 2; p is 1 or 2, providing that when n is 2, p is 1. R1 is phenyl, pyridyl, imidazolyl, or pyrazolyl; wherein the phenyl, pyridyl, imidazolyl and pyrazolyl are each optionally substituted by 1 to 3 substituents independently selected from C1-C4 alkyl, C1-C4 haloalkyl, halogen, cyano, hydroxy and amino; R2, R3, R4, R5, R6, R7, R10, R11, R12, R13, R16, R17, R18, R19 and R30 each independently are hydrogen, halogen, cyano, C1-C4alkyl, or C1-C4haloalkyl; R8, R14 and R15 each independently are hydrogen or C1-C4alkyl; and R9 is phenyl, benzyl or group (a): wherein the phenyl, benzyl and group (a) are each optionally substituted with 1 to 3 substituents independently selected from C1-C4 alkyl, C1-C4 haloalkyl, halogen, cyano, hydroxy and amino; or a salt or a N-oxide thereof.

摘要翻译： 本发明涉及具有杀微生物活性，特别是杀真菌活性的式I的杂环化合物以及使用式（I）化合物来控制微生物的方法：其中A是xC（R10R11）-C（= O） - ，xC（R12R13）-C（= S） - ，xO-C（= O） - ，xO-C（= S） - ，xN（R14）-C（= O） - ，xN（R15）-C （X）（R 16 R 17）-SO 2 - 或X-N = C（R 30） - ，在各种情况下，x表示与R1连接的键; T为CR18或N; Y1，Y2，Y3和Y4独立地为CR19或N; Q是O或S; n为1或2; p为1或2，条件是当n为2时，p为1. R1为苯基，吡啶基，咪唑基或吡唑基; 其中苯基，吡啶基，咪唑基和吡唑基各自任选被1至3个独立地选自C 1 -C 4烷基，C 1 -C 4卤代烷基，卤素，氰基，羟基和氨基的取代基取代; R2，R3，R4，R5，R6，R7，R10，R11，R12，R13，R16，R17，R18，R19和R30各自独立地为氢，卤素，氰基，C1-C4烷基或C1-C4卤代烷基; R8，R14和R15各自独立地为氢或C1-C4烷基; 并且R 9为苯基，苄基或基团（a）：其中苯基，苄基和基团（a）各自任选被1至3个独立地选自C 1 -C 4烷基，C 1 -C 4卤代烷基，卤素，氰基，羟基和 氨基; 或其盐或N-氧化物。

公开(公告)号：US20120129875A1

公开(公告)日：2012-05-24

申请号：US13322949

申请日：2010-05-26

申请人： Laura Quaranta ,  Clemens Lamberth ,  David Guillaume Claude François Lefranc ,  Jayant Umarye ,  Peter Renold ,  Andrew Edmunds ,  Martin Pouliot

发明人： Laura Quaranta ,  Clemens Lamberth ,  David Guillaume Claude François Lefranc ,  Jayant Umarye ,  Peter Renold ,  Andrew Edmunds ,  Martin Pouliot

IPC分类号： A01N43/54 ,  C07D401/14 ,  A01P3/00 ,  C07D401/04

CPC分类号： C07D401/04 ,  A01N43/54

摘要： The present invention relates to a compound of formula (I) wherein the substituents have the definitions as defined in claim 1 or a salt or a N-oxide thereof, their use and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.

摘要翻译： 本发明涉及式（I）化合物，其中取代基具有如权利要求1所定义的定义或其盐或N-氧化物，其用途和控制和/或预防微生物感染的方法，特别是真菌 感染，在植物中以及制备这些化合物的方法。

公开(公告)号：US08124567B2

公开(公告)日：2012-02-28

申请号：US11696908

申请日：2007-04-05

申请人： Harald Walter ,  Camilla Corsi ,  Josef Ehrenfreund ,  Clemens Lamberth ,  Hans Tobler

发明人： Harald Walter ,  Camilla Corsi ,  Josef Ehrenfreund ,  Clemens Lamberth ,  Hans Tobler

IPC分类号： A01N43/64 ,  A01N43/00

CPC分类号： A01N43/56 ,  A01N45/02 ,  A01N37/34 ,  A01N37/38 ,  A01N43/36 ,  A01N43/40 ,  A01N43/54 ,  A01N43/653 ,  A01N43/84 ,  A01N43/90 ,  A01N47/24 ,  A01N61/00 ,  A01N2300/00

摘要： A method of controlling phytopathogenic diseases on useful plants or on propagation material thereof, which comprises applying to the useful plants, the locus thereof or propagation material thereof a combination of components A) and B) in a synergistically effective amount, whereincomponent A) is a compound of formula I wherein R1 is difluoromethyl or trifluoromethyl; Y is —CHR2— or and R2 is hydrogen or C1-C6alkyl; or a tautomer of such a compound; and component B) is a compound selected from compounds known for their fungicidal and/or insecticidal activity, is particularly effective in controlling or preventing fungal diseases of useful plants.

摘要翻译： 一种在有用植物或繁殖材料上控制植物病原性疾病的方法，其包括以协同有效量施用于有用植物，其基因座或繁殖材料的组合物A）和B）的组合，其中组分A）为 式Ⅰ化合物，其中R 1是二氟甲基或三氟甲基; Y是-CHR2-或R2是氢或C1-C6烷基; 或这种化合物的互变异构体; 和组分B）是选自其杀真菌和/或杀虫活性已知的化合物的化合物，在控制或预防有用植物的真菌疾病方面特别有效。