Process for the Preparation of 4,4-Difluoro-3-Oxobutanoic Acid Esters
    2.
    发明申请
    Process for the Preparation of 4,4-Difluoro-3-Oxobutanoic Acid Esters 有权
    制备4,4-二氟-3-氧代丁酸酯的方法

    公开(公告)号:US20080004465A1

    公开(公告)日:2008-01-03

    申请号:US11572053

    申请日:2005-07-13

    IPC分类号: C07C69/66

    CPC分类号: C07C67/343 C07C69/716

    摘要: The present invention relates to a process for the preparation of a compound of the formula (I), wherein R is C1-12 alkyl, by the contact of a compound of the general formula (II), wherein R1 and R2 are each, independently, C1-12 alkyl; or R1 and R2 join together with the nitrogen atom to which they are attached to form an alicyclic amine ring containing 4 to 7 carbon atoms or a morpholine ring, with an acetic acid ester of the general formula (III) CH3COOR, wherein R is as defined under formula (I), in the presence of a base.

    摘要翻译: 本发明涉及制备式(I)化合物的方法,其中R是C 1-12烷基,通过通式(II)的化合物与 其中R 1和R 2各自独立地为C 1-12烷基; 或R 1和R 2 2与它们所连接的氮原子一起形成含有4至7个碳原子的脂环族胺环或吗啉环,其中 (III)CH 3 COOR的乙酸酯,其中R如式(I)所定义,在碱的存在下。