公开(公告)号：US08187475B2

公开(公告)日：2012-05-29

申请号：US12399048

申请日：2009-03-06

申请人： Barry F. Hecker ,  Michael D. Leach

发明人： Barry F. Hecker ,  Michael D. Leach

IPC分类号： B01D33/15 ,  G03C1/85

CPC分类号： C12N9/6429 ,  C07K1/34 ,  C12Y304/21005

摘要： A device for isolating a component of a multi-component composition. The device includes a housing, a chamber, and a withdrawal port. The chamber is rotatably mounted within the housing. The chamber includes a chamber base and a sidewall. The side wall extends from the chamber base. At least a portion of the sidewall is defined by a filter that permits passage of a first component of the multi-component composition out of the chamber through the filter and to the housing base. The filter restricts passage of a second component of the multi-component composition through the filter. The withdrawal port extends from a position proximate to the housing base to an exterior of the device. The withdrawal port permits the withdrawal of the first component from the housing base to an exterior of the device.

摘要翻译： 用于隔离多组分组合物的组分的装置。 该装置包括壳体，腔室和取出口。 腔室可旋转地安装在壳体内。 腔室包括腔室底座和侧壁。 侧壁从腔室底部延伸。 侧壁的至少一部分由过滤器限定，该过滤器允许多组分组合物的第一组分通过过滤器并通过壳体底座。 过滤器限制多组分组合物的第二组分通过过滤器。 取出口从靠近壳体底座的位置延伸到设备的外部。 提取端口允许第一部件从壳体基座撤回到装置的外部。

公开(公告)号：US08048320B2

公开(公告)日：2011-11-01

申请号：US12817814

申请日：2010-06-17

申请人： Michael D. Leach ,  James M. McKale

发明人： Michael D. Leach ,  James M. McKale

IPC分类号： B01D17/038 ,  B01D21/26 ,  B04B1/02

CPC分类号： B01L3/50215 ,  B01L2200/026 ,  B01L2400/0478 ,  B01L2400/0633 ,  Y10T436/25375

摘要： A method and apparatus for separating and concentrating a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.

摘要翻译： 一种用于从多组分材料中分离和浓缩选定组分的方法和装置。 多组分材料可以包括整个样品，例如脂肪组织，全血等。 该装置通常包括位于分离容器内的可移动活塞和可操作以与收集容器的远端相互作用通过活塞的抽出管。 材料可以通过提取管取出。

公开(公告)号：US20100274206A1

公开(公告)日：2010-10-28

申请号：US12832293

申请日：2010-07-08

申请人： Michael D. Leach ,  Barry F. Hecker

发明人： Michael D. Leach ,  Barry F. Hecker

IPC分类号： A61M35/00 ,  A61M37/00

CPC分类号： A61M11/00 ,  A61M1/02 ,  A61M1/3693 ,  A61M11/06 ,  B05B11/00416 ,  B05B11/3011 ,  B05B11/3084 ,  B65D83/28 ,  B65D83/68 ,  B65D83/682 ,  B65D83/685

摘要： A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

摘要翻译： 用于分离，浓缩和/或施用生物或生物工程化流体的方法和装置。 通常，流体施加装置包括能够施加流体的喷雾器主体和适于使流体分离成至少第一部件和第二部件的容器。 容器可释放地联接到喷嘴。 喷嘴适于在流体分离之后从容器中抽出第一部件或第二部件中的至少一个，以将流体施加到选定的部位。

公开(公告)号：US20100256595A1

公开(公告)日：2010-10-07

申请号：US12417789

申请日：2009-04-03

申请人： Michael D. Leach ,  Jason Chavarria

发明人： Michael D. Leach ,  Jason Chavarria

IPC分类号： A61M5/31 ,  A61M35/00 ,  B01D17/00 ,  B01D17/12

CPC分类号： B01D17/12 ,  A61M1/029 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2202/0464 ,  A61M2202/10 ,  B01L3/0217 ,  B01L3/50215 ,  B01L2400/0409 ,  G01N33/491 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A separation device including a first buoy, a second buoy, a first valve, and a second valve. The first buoy is mounted to a buoy guide post and slidably mounted within a separation chamber. The second buoy is slidably mounted to the guide post and movable between a first position and a second position. The second buoy closes the first valve and opens the second valve when in the first position. The second buoy opens the first valve and closes the second valve when in the second position. The second buoy has a density such that after spinning the device for a suitable period of time a first component of the composition is isolated between the first buoy and the second buoy and a second component of the composition is isolated between the second buoy and the end of the separation chamber that is opposite to a port.

摘要翻译： 一种分离装置，包括第一浮标，第二浮标，第一阀和第二阀。 第一浮标安装在浮标导向柱上并可滑动地安装在分离室内。 第二浮标可滑动地安装到引导柱上，并可在第一位置和第二位置之间移动。 第二个浮标关闭第一个阀，并在第一个位置打开第二个阀。 第二个浮标打开第一个阀，并在第二个位置关闭第二个阀。 第二浮标具有密度，使得在将装置旋转适当的时间段之后，组合物的第一组分在第一浮标和第二浮标之间分离，并且组合物的第二组分在第二浮标和末端之间被隔离 与分离室相对。

公开(公告)号：US08551344B2

公开(公告)日：2013-10-08

申请号：US12757492

申请日：2010-04-09

申请人： Matthew Swift ,  Barry F. Hecker ,  Michael D. Leach

发明人： Matthew Swift ,  Barry F. Hecker ,  Michael D. Leach

IPC分类号： B01D37/00 ,  B01D61/00 ,  C02F1/00

CPC分类号： A61M1/3679 ,  A61M2202/0427 ,  B01D15/00 ,  B01D17/0202 ,  B01D17/0217 ,  B01D17/10 ,  B01J20/046 ,  B01J20/10 ,  B01J20/26 ,  B01J20/261 ,  B01J20/262 ,  B01J2220/46

摘要： A method and apparatus for obtaining various components of a multi-component material. Generally, a component of a whole blood sample may be concentrated from a patient and re-introduced to the same patient. For example, a clotting component, such as thrombin, from a whole blood sample may be extracted and concentrated in an apparatus and collection to be reapplied or reintroduced into a patient.

公开(公告)号：US08512575B2

公开(公告)日：2013-08-20

申请号：US13567755

申请日：2012-08-06

申请人： Michael D. Leach ,  James M. McKale

发明人： Michael D. Leach ,  James M. McKale

IPC分类号： B01D21/26 ,  B01D17/038 ,  B04B5/02 ,  B04B7/12

CPC分类号： B01L3/50215 ,  B01L2200/026 ,  B01L2300/046 ,  B01L2400/0478 ,  B01L2400/0633

摘要： A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.

摘要翻译： 一种方法和装置可以从多组分材料中分离和集中所选择的组分。 多组分材料可以包括整个样品，例如脂肪组织，全血等。 该装置通常包括位于分离容器内的可移动活塞和可操作以与收集容器的远端相互作用通过活塞的抽出管。 材料可以通过提取管取出。

公开(公告)号：US20120301957A1

公开(公告)日：2012-11-29

申请号：US13567755

申请日：2012-08-06

申请人： Michael D. Leach ,  James M. McKale

发明人： Michael D. Leach ,  James M. McKale

IPC分类号： B01D43/00 ,  C12N5/077

CPC分类号： B01L3/50215 ,  B01L2200/026 ,  B01L2300/046 ,  B01L2400/0478 ,  B01L2400/0633

摘要： A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.

公开(公告)号：US20120045823A1

公开(公告)日：2012-02-23

申请号：US13285436

申请日：2011-10-31

申请人： Michael D. Leach ,  James M. McKale

发明人： Michael D. Leach ,  James M. McKale

IPC分类号： C12M1/12

CPC分类号： B01L3/50215 ,  B01L2200/026 ,  B01L2300/046 ,  B01L2400/0478 ,  B01L2400/0633

摘要： A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.

摘要翻译： 一种方法和装置可以从多组分材料中分离和集中所选择的组分。 多组分材料可以包括整个样品，例如脂肪组织，全血等。 该装置通常包括位于分离容器内的可移动活塞和可操作以与收集容器的远端相互作用通过活塞的抽出管。 材料可以通过提取管取出。

公开(公告)号：US20120015796A1

公开(公告)日：2012-01-19

申请号：US13239962

申请日：2011-09-22

申请人： Michael D. Leach ,  Joel C. Higgins

发明人： Michael D. Leach ,  Joel C. Higgins

IPC分类号： B01D21/26 ,  B01L3/00

CPC分类号： B01D17/12 ,  B01D17/0217 ,  B01D21/262 ,  B01L3/50215 ,  B01L9/54 ,  B01L2200/026 ,  B01L2400/0409 ,  B01L2400/0478 ,  G01N33/491

摘要： Disclosed is an apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.

摘要翻译： 公开了允许分离和收集样品的一部分的装置。 该设备在与离心机一起使用时允许在设备中以各种分数的形式产生。 可以使用可包括第一浮标部分和可操作地连接的第二部件的浮标系统，以在基本上单独的离心过程期间从样品形成至少三个部分。 因此，各种馏分的分离可以基本上快速有效。 也可以将来自样品的选择的部分单独或作为混合物的一部分施用于患者。

公开(公告)号：US20110251041A1

公开(公告)日：2011-10-13

申请号：US12758127

申请日：2010-04-12

申请人： Jason Chavarria ,  Michael D. Leach

发明人： Jason Chavarria ,  Michael D. Leach

IPC分类号： B04B7/00 ,  B04B1/08 ,  B04B5/02 ,  B04B1/16

CPC分类号： A61M1/3693 ,  A61M1/3695 ,  B01D17/0217 ,  B01D21/262 ,  B01D21/307 ,  B01D2221/10 ,  B01L3/5021

摘要： A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side.

摘要翻译： 一种用于将多组分材料分离成至少两个级分的分离系统。 分离系统包括具有第一端，与第一端相对的第二端以及在第一端和第二端之间延伸以限定具有内部容积的分离室的侧壁的分离装置。 所述系统还包括可在打开位置和关闭位置之间移动的阀，所述阀安装在所述分离室内的固定位置处，该位置比所述第一端更靠近所述第二端并与所述第二端分隔开 所述阀可操作以将所述阀的第一侧上具有第一密度的所述多组分材料的第一部分与所述阀的与所述第一侧相对的第二侧上具有第二密度的第二部分隔离。