公开(公告)号：USD280930S

公开(公告)日：1985-10-08

申请号：US448746

申请日：1982-12-10

申请人： Vernon L. Speicher ,  Mir Imran

设计人： Vernon L. Speicher ,  Mir Imran

公开(公告)号：US09861683B2

公开(公告)日：2018-01-09

申请号：US13538793

申请日：2012-06-29

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61K38/27 ,  A61M25/10 ,  A61K9/00 ,  A61K9/48 ,  A61L27/54 ,  A61M31/00

CPC分类号： A61K38/27 ,  A61K9/0053 ,  A61K9/4808 ,  A61L27/54 ,  A61M25/10 ,  A61M31/002

摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

公开(公告)号：US09763977B2

公开(公告)日：2017-09-19

申请号：US12316809

申请日：2008-12-12

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： C07K14/00 ,  A61K31/785 ,  A61L27/22 ,  C07K14/78

CPC分类号： A61K31/785 ,  A61L27/227 ,  C07K14/001 ,  C07K14/78

摘要： Embodiments of the invention provide bio-reactor circuits for in vitro research applications. One embodiment provides a bio-reactor circuit comprising at least one bio-reactor and a pump fluidically coupled to the at-least-one bio-reactor. The bio-reactor comprises a housing having inlet and outlet ports and first and second chambers. The chambers are separated by a porous membrane with the first chamber providing a flow path for a fluid. The membrane includes a coating having a cell binding affinity for the attachment and proliferation of cells to cover the surface of the membrane. The second chamber provides a volume for maintaining the viability of cells disposed in the chamber. The cells can be selected to produce a biochemical compound. The membrane is configured to allow for diffusion of the compound from the second chamber into the flow path as well as allow for diffusion of gases, nutrients and other biochemical compounds.

公开(公告)号：US09610398B2

公开(公告)日：2017-04-04

申请号：US13681261

申请日：2012-11-19

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61M5/14 ,  A61M5/142 ,  A61M5/168

CPC分类号： A61M5/1409 ,  A61M5/14276 ,  A61M5/16804 ,  A61M5/16827 ,  A61M39/0208 ,  A61M2039/0238 ,  A61M2205/0244 ,  A61M2205/50

摘要： Embodiments provide apparatus and methods for delivering liquid form medication within the body wherein the medication is stored in solid form and then mixed with a liquid in an apparatus implanted within the body. One embodiment provides an implantable apparatus for in vivo delivery of medication comprising a housing including a reservoir, a store of solid form medication (SSM) and a pump. An SSM element is added to the reservoir along with fluid to form a medication solution comprising at least one drug. The medication solution is then delivered to a delivery site using a pumping means to pump solution from the reservoir through a delivery member such as catheter to a delivery site. Embodiments of the invention are particularly useful for delivering medication to a patient to treat a medical condition over an extended period of time without requiring the patient to take external medication.

公开(公告)号：US09320877B2

公开(公告)日：2016-04-26

申请号：US13138764

申请日：2010-03-22

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61M31/00 ,  A61M37/00 ,  A61M25/00

CPC分类号： A61K9/0009 ,  A61K9/2072 ,  A61K9/2813 ,  A61K31/635 ,  A61K38/28 ,  A61M25/00 ,  A61M31/002 ,  A61M37/0069 ,  A61M37/0092

摘要： Embodiments provide apparatus and methods for delivering solid form medications such as pellets to various locations in the body. One embodiment provides an apparatus for in vivo delivery of medication pellets comprising a first chamber including an opening; a second chamber substantially surrounding the first chamber, a carriage disposed in the first chamber, a mechanism for transferring the medication pellets from the first chamber to the second chamber and a pusher plate. The carriage can hold and dispense a plurality of medication pellets. Each pellet contains a selected dose of drug to treat a medical condition. A catheter is positioned in the second chamber. The catheter has a lumen sized for the pellet, a proximal end inside the chamber and a distal end extending through chamber opening to deliver the pellet to a delivery site. The pusher plate engages and advances the pellet though the catheter to the delivery site.

摘要翻译： 实施例提供了用于将诸如颗粒的固体形式药物递送到身体中的各个位置的装置和方法。 一个实施方案提供用于体内递送药丸的装置，其包括包括开口的第一室; 基本上围绕第一室的第二室，设置在第一室中的托架，用于将药丸从第一室转移到第二室的机构和推动板。 托架可以容纳和分配多个药丸。 每个丸剂含有一定剂量的药物以治疗医疗状况。 导管位于第二腔室中。 导管具有针对颗粒尺寸的内腔，腔室内的近端和延伸穿过腔室开口的远端，以将颗粒输送到递送部位。 推动板通过导管接合和推进颗粒到输送部位。

公开(公告)号：US09320431B2

公开(公告)日：2016-04-26

申请号：US13237912

申请日：2011-09-20

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/0205 ,  B63C11/02 ,  B63C11/26 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  B63B22/00 ,  B63B35/00

CPC分类号： A61B5/14551 ,  A61B5/0002 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/0816 ,  A61B5/6826 ,  A61B5/6831 ,  A61B5/7228 ,  A61B5/7278 ,  A61B5/7296 ,  A61B5/7405 ,  A61B5/746 ,  A61B2560/0214 ,  A61B2560/0242 ,  A61B2560/0247 ,  A61B2560/0252 ,  A61B2562/18 ,  B63B22/00 ,  B63B35/00 ,  B63B2035/007 ,  B63C11/02 ,  B63C11/26

摘要： A system and method for monitoring biometric data of a diver and signaling those data from a first communication device to other communication devices, e.g., those of other divers, on a ship or buoy. A signal generated from a device of the diver can generate a diver identifier, an indication of a stress state of the diver and the diver's location.

摘要翻译： 一种用于监测潜水员的生物特征数据并将这些数据从第一通信设备发送到其他通信设备（例如其他潜水员在船舶或浮标上的通信设备）的系统和方法。 从潜水员的装置产生的信号可以产生潜水员标识符，潜水员的应力状态和潜水者位置的指示。

公开(公告)号：US09072877B2

公开(公告)日：2015-07-07

申请号：US13645344

申请日：2012-10-04

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61M37/00

CPC分类号： A61K31/635 ,  A61M5/14276 ,  A61M37/0069 ,  A61M2205/04

摘要： Embodiments provide apparatus and methods for delivering solid form medications such as pellets to various locations in the body. One embodiment provides an apparatus for in vivo delivery of medication pellets comprising a housing including a port, a pellet-containing belt disposed in the housing, and a mechanism for transferring the pellets from the belt to a delivery site (DS) outside the housing. Each pellet contains a dose of drug to treat a medical condition. An elongate member is coupled to the housing and includes a lumen for pellet delivery, a proximal end coupled to the port and a distal end positioned at the DS. The pellet can be delivered to the DS at regular intervals or responsive to a detected biological event. Embodiments of the invention are particularly useful for delivering medication to treat a medical condition over an extended period without requiring a patient to take external medication.

摘要翻译： 实施例提供了用于将诸如颗粒的固体形式药物递送到身体中的各个位置的装置和方法。 一个实施方案提供用于体内递送药物丸粒的装置，其包括壳体，该壳体包括端口，设置在壳体中的包含粒料的带以及用于将粒料从带传送到壳体外部的输送部位（DS）的机构。 每个丸剂含有一定剂量的药物以治疗病情。 细长构件联接到壳体并且包括用于颗粒递送的内腔，联接到端口的近端和位于DS处的远端。 颗粒可以定期递送到DS，或响应于检测到的生物事件。 本发明的实施方案特别可用于递送药物以在长时间内治疗医疗状况，而不需要患者服用外部药物。

公开(公告)号：US08980822B2

公开(公告)日：2015-03-17

申请号：US13538783

申请日：2012-06-29

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61K38/00 ,  A61P3/10 ,  A61K38/22 ,  A61M25/10 ,  A61M5/00 ,  A61K38/26 ,  A61K31/155 ,  A61M31/00

CPC分类号： A61K38/22 ,  A61K9/0065 ,  A61K9/48 ,  A61K9/4808 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/4891 ,  A61K31/155 ,  A61K38/26 ,  A61K38/28 ,  A61M5/00 ,  A61M25/10 ,  A61M31/002 ,  A61M31/007

摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

摘要翻译： 本发明的实施方案提供了可在胃肠道内递送药物和其它治疗剂的吞咽装置，制剂和方法。 许多实施例提供了用于递送药剂的吞咽装置。 具体实施方案提供了可吞咽的装置，例如用于将药物输送到肠壁或其它胃肠腔中的胶囊。 实施方案还提供了各种药物制剂，其被配置为容纳在胶囊内，从胶囊进入肠壁并降解以将药物释放到血流中以产生治疗效果。 制剂可以可操作地偶联到具有第一构型的输送装置，其中制剂被包含在胶囊中，并且第二配置将制剂从胶囊中推出到肠壁中。 本发明的实施方案对于递送胃肠道内吸收不良，耐受和/或降解的药物特别有用。

公开(公告)号：US08934976B2

公开(公告)日：2015-01-13

申请号：US13250757

申请日：2011-09-30

申请人： Ken Wong ,  John C. Potosky ,  Rose Province ,  Charles R. Brynelsen ,  Mir Imran

发明人： Ken Wong ,  John C. Potosky ,  Rose Province ,  Charles R. Brynelsen ,  Mir Imran

IPC分类号： A61N1/00 ,  A61F5/00

CPC分类号： A61F5/0059 ,  A61F5/0026 ,  A61F5/003 ,  A61F5/0036 ,  A61F5/005 ,  A61F5/0056 ,  A61F5/0069 ,  A61F2005/002 ,  A61F2005/0023

摘要： Feedback systems and methods enhance obstructive and other obesity treatments by presenting feedback regarding patients' actual eating. An ingestion restricting implant body can be deployed along the gastrointestinal tract. In some embodiments, ingestion alters the implant body, which, in turn, generates signals. The generated signals can be used to inhibit unhealthy ingestion by the patient. In other embodiments, the implant body can be altered by signals so as to selectable change the restriction imposed on the gastrointestinal tract, optionally in response to ingestion events, an eating schedule, or the like. The implant body may comprise a gastric band. Sensor signals may be processed to identify ingestion and/or characterize ingestion material, and the results may be displayed on a screen for a patient or coach to view.

摘要翻译： 反馈系统和方法通过呈现关于患者实际饮食的反馈来增强阻塞性和其他肥胖症治疗。 可以沿着胃肠道部署限制植入体的摄入。 在一些实施例中，摄入改变植入物本体，其又产生信号。 产生的信号可以用于抑制患者的不健康摄取。 在其他实施例中，可以通过信号来改变植入物本体，以便可选地响应于摄取事件，进食时间表等而选择性地改变施加在胃肠道上的限制。 植入体可以包括胃带。 可以处理传感器信号以识别摄取和/或表征摄取材料，并且将结果显示在用于患者或教练观看的屏幕上。

公开(公告)号：US08731662B2

公开(公告)日：2014-05-20

申请号：US12757865

申请日：2010-04-09

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61N1/00 ,  A61B5/02 ,  A61B5/04

CPC分类号： A61N1/36514 ,  A61B5/046 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/395

摘要： Embodiments of the invention provide methods for the detection and treatment of atrial fibrillation (AF) and related conditions. One embodiment provides a method comprising measuring electrical activity of the heart using electrodes arranged on the heart surface to define an area for detecting aberrant electrical activity (AEA) and then using the measured electrical activity (MEA) to detect foci of AEA causing AF. A pacing signal may then be sent to the foci to prevent AF onset. Atrial wall motion characteristics (WMC) may be sensed using an accelerometer placed on the heart and used with MEA to detect AF. The WMC may be used to monitor effectiveness of the pacing signal in preventing AF and/or returning the heart to normal sinus rhythm (NSR). Also, upon AF detection, a cardioversion signal may be sent to the atria using the electrodes to depolorize an atrial area causing AF and return the heart to NSR.

摘要翻译： 本发明的实施方案提供了用于检测和治疗心房颤动（AF）和相关病症的方法。 一个实施例提供了一种方法，其包括使用布置在心脏表面上的电极来测量心脏的电活动，以限定用于检测异常电活动（AEA）的区域，然后使用测量的电活动（MEA）来检测导致AF的AEA的焦点。 然后可以将起搏信号发送到病灶以防止AF发作。 可以使用放置在心脏上的加速度计来感测心房壁运动特征（WMC），并与MEA一起使用以检测AF。 WMC可用于监测起搏信号在预防AF和/或使心脏恢复正常窦性心律（NSR）方面的有效性。 此外，在AF检测时，可以使用电极将心脏复律信号发送到心房，以使引起AF的心房区域脱色并将心脏返回到NSR。