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117 条记录 (耗时 0.035 秒)

    Process for augmenting or enhancing the aroma or taste of a peppermint oil based oral hygiene flavor by adding thereto methyl substituted oxobicyclo-4,4,0-decane derivatives
    64.
    发明授权
    Process for augmenting or enhancing the aroma or taste of a peppermint oil based oral hygiene flavor by adding thereto methyl substituted oxobicyclo-4,4,0-decane derivatives 失效
    通过加入甲基取代的氧代二环-4,4,0癸烷衍生物来增强或增强薄荷油基口腔卫生香精的香气或味道的方法

    公开(公告)号：US4431680A

    公开(公告)日：1984-02-14

    申请号：US313992

    申请日：1981-10-22

    申请人： Takao Yoshida

    发明人： Takao Yoshida

    IPC分类号： C07C29/17 ,  C07C29/40 ,  C07C29/68 ,  C07C35/36 ,  C07F3/02 ,  C11B9/00 ,  A23L1/226

    CPC分类号： C07C29/172 ,  C07C29/40 ,  C07C29/68 ,  C07C35/36 ,  C07F3/02 ,  C11B9/0053 ,  C07B2200/09 ,  C07C2102/28

    摘要： Described is the use of compounds defined according to the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein X represents the moieties: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or methyl with the proviso that (i) at least three of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen and (ii) when the dashed line is a carbon-carbon single bond and X is: ##STR3## then one of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is methyl and the other represents hydrogen; wherein R.sub.5 represents hydrogen, and uses thereof for their organoleptic properties in augmenting or enhancing the aroma or taste of peppermint oil based oral hygiene flavors.

    摘要翻译： 描述了根据通用结构定义的化合物的用途：其中虚线表示碳 - 碳单键或碳 - 碳双键; 其中X表示部分：其中R 1，R 2，R 3和R 4表示氢或甲基，条件是（i）R 1，R 2，R 3和R 4中的至少3个表示氢，和（ii）当虚线为 碳 - 碳单键，X是：其中R1，R2，R3或R4之一是甲基，另一个代表氢; 其中R5代表氢，以及其用于增强或增强基于薄荷油的口腔卫生香精的香味或味道的感官特性。

    Process for producing solanone, norsolanadione and intermediates therefor
    65.
    发明授权
    Process for producing solanone, norsolanadione and intermediates therefor 失效
    制备索罗酮，二酰甘油和其中间体的方法

    公开(公告)号：US4412083A

    公开(公告)日：1983-10-25

    申请号：US357158

    申请日：1982-03-11

    申请人： Kenneth K. Light ,  William L. Schreiber ,  Joseph A. McGhie ,  Ronald P. Schreck ,  Takao Yoshida ,  Loren B. Schreiber ,  Ranya Muralidhara

    发明人： Kenneth K. Light ,  William L. Schreiber ,  Joseph A. McGhie ,  Ronald P. Schreck ,  Takao Yoshida ,  Loren B. Schreiber ,  Ranya Muralidhara

    IPC分类号： A23L27/20 ,  A24B15/32 ,  C07C45/42 ,  C07C45/51 ,  C07C45/59 ,  C07C45/66 ,  C07D295/02 ,  C07D295/03 ,  C07D295/145 ,  C07D295/155 ,  C07D309/28 ,  C07D317/30 ,  C07C119/12

    CPC分类号： C07D295/03 ,  A23L27/2024 ,  A24B15/32 ,  C07C255/00 ,  C07C45/42 ,  C07C45/516 ,  C07C45/59 ,  C07C45/66 ,  C07D295/145 ,  C07D295/155 ,  C07D309/28 ,  C07D317/30

    摘要： Described is a process for preparing solanone and norsolanadione using chemical intermediates defined according to the generic structure: ##STR1## wherein X is one of the moieties: ##STR2## wherein R represents hydrogen or methyl; wherein Y represents one of the structures: ##STR3## wherein one of the dashed lines represents a carbon-carbon single bond and the other of the dashed lines represents a carbon-carbon double bond; with the provisos that:(i) when Y is the moiety having the structure: ##STR4## then X is the moiety having the structure: ##STR5## (ii) when X is the moiety having the structure: ##STR6## then Y is the moiety having the structure:--C.tbd.N]In preparing solanone, the compound having the structure: ##STR7## or a mixture of compounds defined according to the structure: ##STR8## is reacted with methyl lithium and the resulting intermediate is hydrolyzed and the resulting compound is dehydrated. In producing the norsolanadione, the compound having the structure: ##STR9## or a mixture of compounds according to the structure: ##STR10## is reacted with ethylene glycol or propylene glycol thereby forming a ketal and the resulting ketal is reacted with methyl lithium and the resulting intermediate is then hydrolyzed in the presence of acid.

    摘要翻译： 描述了使用根据以下通用结构定义的化学中间体制备索罗酮和尼考兰那酮的方法：其中X是部分之一：其中R表示氢或甲基; 其中Y表示以下结构之一：其中一条虚线表示碳 - 碳单键，另一条虚线表示碳 - 碳双键; 条件是：（i）当Y是具有以下结构的部分时：X是具有以下结构的部分：（ⅱ）当X是具有以下结构的部分时，则Y是 具有以下结构的部分：-C 3 N N]在制备solone的过程中，将具有以下结构的化合物：IMAGE或根据结构定义的化合物的混合物与甲基锂反应，并将所得中间体水解， 所得化合物脱水。 在制备硝酰甘油的过程中，将具有以下结构的化合物：IMAGE或根据以下结构的化合物的混合物与乙二醇或丙二醇反应，从而形成缩酮，得到的缩酮与甲基锂反应， 得到的中间体然后在酸的存在下水解。

    Methyl substituted oxobicyclo-4,4,0-decane derivatives and organoleptic uses thereof
    66.
    发明授权
    Methyl substituted oxobicyclo-4,4,0-decane derivatives and organoleptic uses thereof 失效
    甲基取代的氧代二环-4,4,0癸烷衍生物及其感官用途

    公开(公告)号：US4387048A

    公开(公告)日：1983-06-07

    申请号：US372398

    申请日：1982-04-26

    申请人： Takao Yoshida

    发明人： Takao Yoshida

    IPC分类号： C07C29/143 ,  C07C29/17 ,  C07C29/40 ,  C07C29/68 ,  C07C35/36 ,  C07F3/02 ,  C11B9/00 ,  A61K7/46

    CPC分类号： C07C29/40 ,  C07C29/143 ,  C07C29/172 ,  C07C29/68 ,  C07C35/36 ,  C07F3/02 ,  C11B9/0053 ,  C07C2102/28 ,  C07C2103/60

    摘要： Described are compounds having the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein X represents the moieties: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.8 and R.sub.9 represent hydrogen or methyl with the proviso that (i) at least three of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen and (ii) when the dashed line is a carbon-carbon single bond and X is: ##STR3## then one of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is methyl and the other represents hydrogen; wherein R.sub.5 represents hydrogen, MgZ or Li; wherein Z represents chloro, bromo or iodo and wherein R.sub.6 represents hydrogen or methyl; and uses thereof as chemical reaction intermediates and/or for their organoleptic properties in augmenting or enhancing the aromas or tastes of perfumes, perfumed articles, foodstuffs, chewing gums, smoking tobaccos, toothpastes, medicinal products, chewing tobaccos and smoking tobacco articles, as well as processes for preparing same.

    摘要翻译： 描述的是具有通用结构的化合物：其中虚线表示碳 - 碳单键或碳 - 碳双键; 其中X表示部分：其中R 1，R 2，R 3，R 4，R 8和R 9表示氢或甲基，条件是（i）R 1，R 2，R 3和R 4中的至少3个表示氢，和（ii） 虚线是碳 - 碳单键，X是：其中R1，R2，R3或R4之一是甲基，另一个代表氢; 其中R5表示氢，MgZ或Li; 其中Z表示氯，溴或碘，并且其中R6表示氢或甲基; 以及其用作化学反应中间体和/或其感官特性以增强或增强香料，香料制品，食品，口香糖，吸烟烟草，牙膏，药用产品，咀嚼烟草和烟草制品的香味或味道，以及 作为制备方法。

    Methyl substituted oxobicyclo-4,4,0-decane derivatives, process for preparing same and organoleptic uses thereof
    67.
    发明授权
    Methyl substituted oxobicyclo-4,4,0-decane derivatives, process for preparing same and organoleptic uses thereof 失效
    甲基取代的氧代二环-4,4,0癸烷衍生物，其制备方法和感官用途

    公开(公告)号：US4320772A

    公开(公告)日：1982-03-23

    申请号：US182451

    申请日：1980-08-29

    申请人： Takao Yoshida

    发明人： Takao Yoshida

    IPC分类号： A23L27/20 ,  A61K8/34 ,  A61K8/35 ,  A61Q13/00 ,  C07C27/00 ,  C07C29/143 ,  C07C29/145 ,  C07C29/17 ,  C07C29/40 ,  C07C29/68 ,  C07C35/36 ,  C07C35/46 ,  C07C45/00 ,  C07C49/447 ,  C07C49/637 ,  C07C67/00 ,  C07F3/02 ,  C11B9/00

    CPC分类号： C11B9/0053 ,  C07C29/17 ,  C07C29/40 ,  C07C29/68 ,  C07C35/36 ,  C07F3/02 ,  C07C2102/28

    摘要： Described are compounds having the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein X represents the moieties: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or methyl with the proviso that (i) at least three of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen and (ii) when the dashed line is a carbon-carbon single bond and X is: ##STR3## then one of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is methyl and the other represents hydrogen; wherein R.sub.5 represents hydrogen, MgX, MgR.sub.7, CdR.sub.7, ZnR.sub.7, Na, K or Li; wherein X represents Chloro, Bromo or Iodo; wherein R.sub.6 represents hydrogen or methyl; and wherein R.sub.7 represents lower alkyl; and uses thereof for their organoleptic properties in augmenting or enhancing or enhancing the aromas or tastes of perfumes, perfumed articles, foodstuffs, chewing gums, smoking tobaccos, toothpastes, medicinal products, chewing tobacco and smoking tobacco articles, as well as processes for preparing same.

    摘要翻译： 描述的是具有通用结构的化合物：其中虚线表示碳 - 碳单键或碳 - 碳双键; 其中X表示部分：其中R 1，R 2，R 3和R 4表示氢或甲基，条件是（i）R 1，R 2，R 3和R 4中的至少3个表示氢，和（ii） 虚线是碳 - 碳单键，X是：其中R1，R2，R3或R4之一是甲基，另一个代表氢; 其中R5表示氢，MgX，MgR7，CdR7，ZnR7，Na，K或Li; 其中X表示氯，溴或碘; 其中R6表示氢或甲基; 并且其中R 7表示低级烷基; 以及其用于增强或增强香料，香料，食品，口香糖，吸烟烟草，牙膏，药用产品，咀嚼烟草和烟草制品的香气或口味的感官特性，以及其制备方法 。

    Use of an efficacy marker for optimizing therapeutic efficacy of an anti-human PD-1 antibody on cancers
    69.
    发明授权
    Use of an efficacy marker for optimizing therapeutic efficacy of an anti-human PD-1 antibody on cancers 有权
    使用功效标记来优化抗人PD-1抗体对癌症的治疗功效

    公开(公告)号：US08460886B2

    公开(公告)日：2013-06-11

    申请号：US13001875

    申请日：2009-07-03

    申请人： Shiro Shibayama ,  Takao Yoshida ,  Tamon Hayashi ,  Akio Hayashi ,  Jun Murai

    发明人： Shiro Shibayama ,  Takao Yoshida ,  Tamon Hayashi ,  Akio Hayashi ,  Jun Murai

    IPC分类号： G01N33/53 ,  A61K39/395

    CPC分类号： C07K16/2818 ,  A61K2039/505 ,  G01N2800/52

    摘要： A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing therapeutic efficacy thereof, and further an efficacy marker that can be used in methods thereof. The present invention enables selection of the cancer patient in whom the therapeutic efficacy of the anti-human PD-1 antibody can be expected in future, by measuring the change which is more than a certain level of several kinds of efficacy markers in blood, after administering the initial dose or doses of the anti-human PD-1 antibody compared to that prior to administering the initial dose, and provides a new prescription of the anti-human PD-1 antibody for anti-cancer therapy.

    摘要翻译： 本发明的目的是提供一种能够更有效地制备用于抗癌治疗的抗人PD-1抗体的方法，用于估计或优化其治疗功效的方法，以及可用于 方法。 本发明能够通过在血液中测定超过一定水平的几种功效标志物的变化，能够选择将来能够预期抗人PD-1抗体的治疗功效的癌症患者 与施用初始剂量之前相比，施用抗人PD-1抗体的初始剂量或剂量，并且提供了用于抗癌治疗的抗人PD-1抗体的新处方。