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    USE OF AN EFFICACY MARKER FOR OPTIMIZING THERAPEUTIC EFFICACY OF AN ANTI-HUMAN PD-1 ANTIBODY ON CANCERS
    3.
    发明申请
    USE OF AN EFFICACY MARKER FOR OPTIMIZING THERAPEUTIC EFFICACY OF AN ANTI-HUMAN PD-1 ANTIBODY ON CANCERS 有权
    使用有效标记来优化抗人PD-1抗体对癌症的治疗效果

    公开(公告)号：US20110123550A1

    公开(公告)日：2011-05-26

    申请号：US13001875

    申请日：2009-07-03

    申请人： Shiro Shibayama ,  Takao Yoshida ,  Tamon Hayashi ,  Akio Hayashi ,  Jun Murai

    发明人： Shiro Shibayama ,  Takao Yoshida ,  Tamon Hayashi ,  Akio Hayashi ,  Jun Murai

    IPC分类号： A61K39/395 ,  G01N33/53 ,  G01N33/50 ,  A61P35/00

    CPC分类号： C07K16/2818 ,  A61K2039/505 ,  G01N2800/52

    摘要： A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing therapeutic efficacy thereof, and further an efficacy marker that can be used in methods thereof. The present invention enables selection of the cancer patient in whom the therapeutic efficacy of the anti-human PD-1 antibody can be expected in future, by measuring the change which is more than a certain level of several kinds of efficacy markers in blood after administering the initial dose or doses of the anti-human PD-1 antibody compared to that prior to administering the initial dose, and provides a new prescription of the anti-human PD-1 antibody for anti-cancer therapy.

    摘要翻译： 本发明的目的是提供一种能够更有效地制备用于抗癌治疗的抗人PD-1抗体的方法，用于估计或优化其治疗功效的方法，以及可用于 方法。 本发明能够通过测量在施用后多于血液中的几种功效标记物的一定水平的变化来选择将来能够预期抗人PD-1抗体的治疗功效的癌症患者的选择 与施用初始剂量之前的抗人PD-1抗体的初始剂量或剂量相比较，并且提供了用于抗癌治疗的抗人PD-1抗体的新处方。

    BAGLIKE CONTAINER FOR CENTRIFUGATION AND METHOD OF GENE TRANSFER USING THE SAME
    5.
    发明申请
    BAGLIKE CONTAINER FOR CENTRIFUGATION AND METHOD OF GENE TRANSFER USING THE SAME 失效
    用于离心的巴格莱集装箱和使用该方法的基因转移方法

    公开(公告)号：US20100136680A1

    公开(公告)日：2010-06-03

    申请号：US12377234

    申请日：2006-08-23

    申请人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

    发明人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

    IPC分类号： C12N5/10 ,  B04B7/12

    CPC分类号： A61J1/10 ,  B01L3/5021 ,  B01L3/505 ,  C12M23/14 ,  C12M35/04 ,  C12N15/87

    摘要： Baglike container (1) that is fitted in a centrifuge to thereby allow centrifugation of any dispersion liquid placed therein. The baglike container for centrifugation is one comprising a main frame constituted of first container wall (3) with recess portion (6) formed so as to allow fitting in a centrifuge and with flange portion (7) provided on an open face border of the recess portion (6) and constituted of flexible second container wall (4) having its peripheral portion sealed mutually with the flange portion (7) of the first container wall (3) so as to define storing space (6′) for dispersion liquid in cooperation with the recess portion (6) and further comprising port (5) fitted to the main frame in a fashion allowing communication with the storing space (6′), wherein the recess portion (6) defining the storing space (6′) can be set in the centrifuge so that centrifugal force perpendicular to the bottom plane of the recess portion (6) applies. Moreover, there is disclosed a method of gene introduction using this baglike container.

    摘要翻译： 袋状容器（1），其装配在离心机中，从而允许离心分离任何分散液体。 用于离心的袋状容器是包括由具有凹部（6）的第一容器壁（3）构成的主框架，所述第一容器壁（3）形成为能够安装在离心机中，并且具有设置在凹部的开放面边界上的凸缘部（7） 部分（6），并且由具有与第一容器壁（3）的凸缘部分（7）相互密封的周边部分的柔性第二容器壁（4）构成，以便在合作中限定用于分散液体的储存空间（6'） 与所述凹部（6）相连并且还包括以允许与所述存放空间（6'）连通的方式装配到所述主框架的端口（5），其中限定所述存储空间（6'）的所述凹部（6）可以 设置在离心机中，使得垂直于凹部（6）的底面的离心力适用。 此外，公开了使用该袋状容器的基因导入方法。

    Information recording medium conveyer
    7.
    发明授权
    Information recording medium conveyer 失效
    信息记录介质输送机

    公开(公告)号：US06980493B2

    公开(公告)日：2005-12-27

    申请号：US10427988

    申请日：2003-05-02

    申请人： Yuichi Kimikawa ,  Nobutaka Kawakita ,  Katsunori Tamamura ,  Hiroyuki Matsumoto ,  Takao Yoshida ,  Masashi Takano

    发明人： Yuichi Kimikawa ,  Nobutaka Kawakita ,  Katsunori Tamamura ,  Hiroyuki Matsumoto ,  Takao Yoshida ,  Masashi Takano

    IPC分类号： G11B17/26 ,  G11B17/04 ,  G11B17/22 ,  G11B7/085

    CPC分类号： G11B17/051 ,  G11B17/021 ,  G11B17/0404

    摘要： An information recording medium conveyer is provided, which provides countermeasures against power interruptions with high reliability. When a power interruption occurs during a loading operation with a conveying roller, the first unloading operation is initiated. When the outputs from detection sensors satisfy a predetermined condition during the first unloading operation, the process is initialized to cause the conveying roller to initiate a re-loading operation, thereby loading an information recording medium into a tray. On the other hand, when the outputs from the detection sensors do not change in accordance with a predetermined sequence during the re-loading operation, the process initiates the second unloading operation. When the detection sensors have detected the information recording medium during the second unloading operation and then the outputs from the detection sensors satisfy the predetermined condition, the process is initialized to cause the conveying roller to initiate another loading operation, thereby loading the information recording medium into the tray. Even when a power interruption occurs during an unloading operation, the same processing is performed to eject the information recording medium.

    摘要翻译： 提供了一种信息记录介质输送机，提供了高可靠性的电力中断对策。 当在与输送辊的装载操作期间发生电力中断时，开始第一卸载操作。 当检测传感器的输出在第一卸载操作期间满足预定条件时，初始化处理以使输送辊开始重新加载操作，从而将信息记录介质装载到托盘中。 另一方面，当检测传感器的输出在重新加载操作期间根据预定顺序不改变时，处理开始第二卸载操作。 当检测传感器在第二卸载操作期间检测到信息记录介质，然后检测传感器的输出满足预定条件时，初始化处理以使输送辊开始另一加载操作，从而将信息记录介质装入 托盘。 即使在卸载操作期间发生电源中断时，也执行相同的处理以弹出信息记录介质。

    Filled and sealed, self-contained mixing container
    8.
    发明授权
    Filled and sealed, self-contained mixing container 失效
    填充和密封，自包含混合容器

    公开(公告)号：US5114004A

    公开(公告)日：1992-05-19

    申请号：US654037

    申请日：1991-02-12

    申请人： Keinosuke Isono ,  Takao Yoshida ,  Tatsuo Suzuki

    发明人： Keinosuke Isono ,  Takao Yoshida ,  Tatsuo Suzuki

    IPC分类号： A61J1/00 ,  A61J1/20 ,  B65D81/32

    CPC分类号： A61J1/2093 ,  B65D81/3266 ,  A61J1/201 ,  A61J1/2027 ,  A61M2207/00

    摘要： Disclosed herein is a filled and sealed, self-contained mixing container. The container has compartments which are isolated from each other. Plural substances which contain components susceptible to mutual reaction unless isolated from each other are contained in the respective compartments. In use, these compartments are communicated together so that the individual contents can be mixed within the container. A flow passage or passages, each of which has an isolator for the contents and is adapted to communicate the compartments with each other, and is formed by a side channel provided on an outer surface of a wall of the container. Mixing of the contents without exposure to the external atmosphere can be realized by irreversible destruction of the isolator upon use. The container is suited particularly for a closed therapy system.

    Disc brake apparatus
    10.
    发明授权
    Disc brake apparatus 失效
    盘式制动装置

    公开(公告)号：US4732241A

    公开(公告)日：1988-03-22

    申请号：US873968

    申请日：1986-06-13

    申请人： Takao Yoshida

    发明人： Takao Yoshida

    IPC分类号： B62L1/00 ,  F16D55/228

    CPC分类号： B62L1/00 ,  F16D55/228

    摘要： In a disc brake apparatus mounted to a vehicle wheel supported by a fork member, a caliper body is disposed within a space formed inwardly of the fork member and to one side of the vehicle wheel. The caliper member straddles the brake disc from the internal periphery of the brake disc. A bracket integrally formed with the caliper body extends inwardly therefrom in a radial direction to the axle of the wheel where it is pivotally supported. The caliper body is also coupled by a removable pin with the fork member to prevent rotation about the axle. The caliper body is formed with an opening for permitting removal and replacement of the friction pads through the bottom wall portion thereof and the bracket is also formed with an opening for permitting the pads to be fully removed from the vehicle.

    摘要翻译： 在安装在由叉构件支撑的车轮上的盘式制动装置中，卡钳体设置在形成在叉构件内侧的空间和车轮的一侧。 制动器构件从制动盘的内周边跨越制动盘。 与卡钳主体一体形成的托架在径向方向上从其向内延伸到轮的枢轴，其中枢轴支撑。 卡钳体还通过可拆卸的销与叉构件联接，以防止绕轴旋转。 卡钳体形成有用于允许摩擦垫通过其底壁部分移除和更换的开口，并且托架还形成有用于允许将垫从车辆中完全移除的开口。