公开(公告)号：US07532936B2

公开(公告)日：2009-05-12

申请号：US11109835

申请日：2005-04-19

申请人： John H. Erickson ,  Anthony J. Varrichio

发明人： John H. Erickson ,  Anthony J. Varrichio

IPC分类号： A61N1/08

CPC分类号： A61N1/36185 ,  A61N1/3686

摘要： A device and method for generating electrical stimulation. The implantable device includes a programmable switching device or array that receives at least one pulse generator output coupled through at least one coupling capacitor. The switching device selectively connects at least one pulse generator output to a plurality of electrode terminals via at least one coupling capacitor. Electrical stimulation signals may be applied directly from the electrode terminals, or are applied through a lead or lead extension having corresponding electrodes electrically connected to the electrode terminals.

摘要翻译： 一种用于产生电刺激的装置和方法。 可植入装置包括可编程开关装置或阵列，其接收通过至少一个耦合电容耦合的至少一个脉冲发生器输出。 开关装置经由至少一个耦合电容器选择性地将至少一个脉冲发生器输出连接到多个电极端子。 电刺激信号可以直接从电极端子施加，或者通过电连接到电极端子的具有相应电极的引线延伸部分施加。

公开(公告)号：US20080269831A1

公开(公告)日：2008-10-30

申请号：US12109866

申请日：2008-04-25

申请人： John H. Erickson

发明人： John H. Erickson

IPC分类号： A61N1/375

CPC分类号： A61N1/37 ,  A61N1/086 ,  A61N1/3718

摘要： In one embodiment, a pulse generator for generating electrical stimulation for delivery to a patient, comprises: a hermetically sealed housing containing pulse generating circuitry; a header coupled to the housing for receiving one or more stimulation leads, wherein feedthrough wires are provided to conduct electrical pulses from the pulse generating circuitry to the header; the header comprising a plurality of connectors for electrically connecting to each terminal of the one or more stimulation leads, wherein an inductive winding is disposed around or adjacent to each of the connector structures and is electrically connected between the respective connector structure and a corresponding feedthrough wire to limit MRI induced heating of a respective electrode of the one or more stimulation leads.

摘要翻译： 在一个实施例中，用于产生用于递送给患者的电刺激的脉冲发生器包括：包含脉冲发生电路的密封外壳; 连接到所述壳体以用于接收一个或多个刺激引线的头部，其中提供穿通线以将电脉冲从所述脉冲发生电路传导到所述头部; 所述头部包括用于电连接到所述一个或多个刺激引线的每个端子的多个连接器，其中感应绕组设置在每个所述连接器结构的周围或附近，并且电连接在相应的连接器结构和相应的馈通线 以限制一个或多个刺激引线的相应电极的MRI诱导加热。

公开(公告)号：US07047084B2

公开(公告)日：2006-05-16

申请号：US10300434

申请日：2002-11-20

申请人： John H. Erickson ,  Terry D. Daglow

发明人： John H. Erickson ,  Terry D. Daglow

IPC分类号： A61N1/04

CPC分类号： A61N1/0534 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/36071

摘要： This invention relates to an apparatus and method for making such apparatus for providing controlled and directional stimulation patterns for tissue stimulation. The apparatus may be useful in stimulation nervous tissue in the brain, about the spinal cord, on nerve roots, about peripheral nerves, and in muscles, among others. The apparatus includes a implantable pulse generator connected to a lead. The lead has electrodes placed about a perimeter. In addition, the lead may include electrodes placed longitudinally along the axis of the lead. By applying charge differences between circumferentially distributed electrodes, a smaller stimulation field may be established. In addition, by stimulating between electrodes distributed longitudinally on the same side, a directional flow field may be established. Such leads are especially useful in deep brain stimulation as the region in which a stimulation field is strong enough to produce tissue stimulation is directional and minimized.

摘要翻译： 本发明涉及一种用于制造这种用于提供用于组织刺激的受控和定向刺激图案的装置的装置和方法。 该装置可用于刺激脑中的神经组织，关于脊髓，神经根，周围神经和肌肉等。 该装置包括连接到引线的可植入脉冲发生器。 铅带有围绕周边的电极。 此外，引线可以包括沿引线的轴线纵向放置的电极。 通过在周向分布的电极之间施加电荷差异，可以建立较小的刺激场。 此外，通过在同一侧纵向分布的电极之间进行刺激，可以建立定向流场。 这种引线在深部脑刺激中特别有用，因为其中刺激场足够强以产生组织刺激的区域是定向的并且最小化。

公开(公告)号：US06620151B2

公开(公告)日：2003-09-16

申请号：US09796969

申请日：2001-03-01

申请人： Brian Blischak ,  John H. Erickson ,  Terry Daglow ,  Sandra Marie Hooper ,  Bruce David Wigness

发明人： Brian Blischak ,  John H. Erickson ,  Terry Daglow ,  Sandra Marie Hooper ,  Bruce David Wigness

IPC分类号： A61K922

CPC分类号： A61M5/14276 ,  A61M5/1452 ,  A61M5/16881 ,  A61M2005/14264 ,  A61M2005/14506 ,  A61M2205/33 ,  A61M2205/3372

摘要： The present invention relates to an implantable infusion pump having a refillable infusate reservoir in fluid communication with a delivery site via a flow path. This flow path includes a flow resistance. The infusion pump includes a sensing device(s), positioned relative to the flow path, to provide data regarding a flow rate along the flow path. The infusion pump effects a division of a total flow period into at least a plurality of unit dose periods, each unit dose period effecting delivery of a unit dose of infusate. The cumulative effect of delivering the total number of unit dose periods is the delivery of a desired dose over the total flow period. The present invention permits a reservoir pressure to vary over any portion of total flow period but effects a constant-pressure state over each unit dose cycle.

公开(公告)号：US6027456A

公开(公告)日：2000-02-22

申请号：US113390

申请日：1998-07-10

申请人： Claudio A. Feler ,  John H. Erickson ,  Steven P. Rhines

发明人： Claudio A. Feler ,  John H. Erickson ,  Steven P. Rhines

IPC分类号： A61N1/34 ,  A61B5/05

CPC分类号： A61N1/36021 ,  A61N1/0553 ,  A61N1/36017

摘要： An apparatus for assisting in the placement of a spinal cord stimulation lead with respect to the dorsal column of a patient. The apparatus detects evoked potentials which result from the controlled stimulation of spinal nerves and provides information to an operator to allow a stimulation lead to be positioned relative to a physiological midline and/or positioned along the dorsal column in a longitudinal direction.

摘要翻译： 一种用于辅助脊髓刺激引线相对于患者的背侧柱放置的装置。 该装置检测由受控的脊髓神经刺激引起的诱发电位，并向操作者提供信息，以允许刺激引线相对于生理中线定位和/或沿纵向方向沿背侧柱定位。

公开(公告)号：US5565005A

公开(公告)日：1996-10-15

申请号：US18944

申请日：1993-02-17

申请人： John H. Erickson ,  John C. Tepper ,  Ike C. Thacker ,  Greg Turi ,  Anthony J. Varrichio ,  Arthur A. Pilla ,  Mark A. Bettin ,  William C. Brosche

发明人： John H. Erickson ,  John C. Tepper ,  Ike C. Thacker ,  Greg Turi ,  Anthony J. Varrichio ,  Arthur A. Pilla ,  Mark A. Bettin ,  William C. Brosche

IPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/18 ,  A61N1/32 ,  A61N1/36

CPC分类号： A61N1/3605 ,  A61N1/05 ,  A61N1/08 ,  A61N1/326 ,  Y10S128/903

摘要： A hand-held programmer/monitor (500) for programming and monitoring an implantable tissue growth stimulator (10) is provided. The stimulator (10) includes circuitry (46) for implementing selected operations in response to a down-link signal transmitted by the programmer/monitor (500). The stimulator (10) also includes circuitry (46) for transmitting up-link signals to the programmer/monitor (500). The programmer/monitor (500) includes a control circuit (518) for generating the down-link signal. The control circuit (518) also processes the up-link signal to monitor the status of the implantable tissue growth stimulator (10). The programmer/monitor (500) also includes a transmit/receive circuit (514) for transmitting the down-link signal to and for receiving the up-link signal from the implantable tissue growth stimulator (10). The transmit/receive circuit (514) also couples the up-link signal to the control circuit (518).

摘要翻译： 提供了一种用于编程和监测植入式组织生长刺激器（10）的手持编程器/监视器（500）。 刺激器（10）包括用于响应于由编程器/监视器（500）发送的下行链路信号来实现所选择的操作的电路（46）。 刺激器（10）还包括用于向编程器/监视器（500）发送上行链路信号的电路（46）。 编程器/监视器（500）包括用于产生下行链路信号的控制电路（518）。 控制电路（518）还处理上行链路信号以监视可植入组织生长刺激器（10）的状态。 编程器/监视器（500）还包括发送/接收电路（514），用于将下行链路信号发送到可植入组织生长刺激器（10）并用于从可植入组织生长刺激器（10）接收上行链路信号。 发射/接收电路（514）还将上行链路信号耦合到控制电路（518）。

公开(公告)号：US5441527A

公开(公告)日：1995-08-15

申请号：US186230

申请日：1994-01-24

申请人： John H. Erickson ,  John C. Tepper ,  Ike C. Thacker ,  Gregg Turi ,  Anthony J. Varrichio ,  Arthur A. Pilla

发明人： John H. Erickson ,  John C. Tepper ,  Ike C. Thacker ,  Gregg Turi ,  Anthony J. Varrichio ,  Arthur A. Pilla

IPC分类号： A61N1/05 ,  A61N1/18 ,  A61N1/32 ,  A61N1/36

CPC分类号： A61N1/3605 ,  A61N1/05 ,  A61N1/326 ,  A61N1/37211

摘要： A method for the therapeutic stimulation of bone growth of a bone site is disclosed comprising the steps of implanting first and second electrodes into the tissue near the base site. The electrodes are coupled to a bone growth stimulator which generates an alternating current.

摘要翻译： 公开了一种治疗性刺激骨骼部位骨生长的方法，包括将第一和第二电极植入基部附近的组织中的步骤。 电极耦合到产生交流电的骨生长刺激器。

公开(公告)号：US5351389A

公开(公告)日：1994-10-04

申请号：US973681

申请日：1992-11-09

申请人： John H. Erickson ,  John C. Tepper

发明人： John H. Erickson ,  John C. Tepper

IPC分类号： A61N2/02 ,  A61N2/04 ,  H01F7/06 ,  A61N2/00

CPC分类号： A61N2/02 ,  Y10T29/49071

摘要： Fabricating a transducer system (FIGS. 1a-1b) for providing electromagnetic therapeutic stimulation to a target area of a patient's body includes forming a primary winding (71) having a selected number of turns. The primary winding (71) and any other windings (72, 73) are bonded together to form a winding bundle (32). The winding bundle (32) is encapsulated in a malleable shell (34) that is substantially triangular in shape. Control electronics (16, 40, 94) are coupled to the shell-encapsulated winding bundle (30, 70, 90) for selectively generating electromagnetic fields, and thus implementing a prescribed electromagnetic therapy.

摘要翻译： 制造用于向患者身体的目标区域提供电磁治疗刺激的换能器系统（图1a-1b）包括形成具有所选匝数的初级绕组（71）。 初级绕组（71）和任何其它绕组（72,73）结合在一起以形成绕组（32）。 缠绕束（32）被封装在基本上为三角形形状的可延展的壳体（34）中。 控制电子器件（16,40,94）耦合到壳体封装的绕组束（30,70,90），用于选择性地产生电磁场，从而实现规定的电磁疗法。

公开(公告)号：US5195941A

公开(公告)日：1993-03-23

申请号：US638219

申请日：1991-01-07

申请人： John H. Erickson ,  John C. Tepper

发明人： John H. Erickson ,  John C. Tepper

IPC分类号： A61N2/02 ,  A61N2/04

CPC分类号： A61N2/02 ,  Y10T29/49071

摘要： A PEMF contoured triangular transducer system (FIGS. 1a-1b) used for PEMF therapy (such as after spinal fusion) uses a two-transducer configuration for generating fluxaided electromagnetic fields. The semi-rigid transducers (12, 14) are conformable to a selected anatomical contour, and incorporated with an adjustable belt (16) to provide bracing. The belt includes compartments for a drive electronics module (22), and a rechargeable battery pack (24), making the system portable. The drive electronics (FIG. 3) includes a PEMF processor (41) that executes a PEMF program for providing pulsing current to the front and back transducers at predetermined intervals, thereby activating the electromagnetic field according to a prescribed PEMF regimen.

摘要翻译： 用于PEMF治疗（例如在脊柱融合之后）的PEMF轮廓三角换能器系统（图1a-1b）使用双换能器配置来产生自动电磁场。 半刚性换能器（12,14）符合选定的解剖轮廓，并结合有可调节带（16）以提供支撑。 带包括用于驱动电子模块（22）的隔间和可再充电电池组（24），使系统可移动。 驱动电子装置（图3）包括PEMF处理器（41），该PEMF处理器执行PEMF程序，用于以预定的间隔向前后的换能器提供脉冲电流，从而根据规定的PEMF方案激活电磁场。

公开(公告)号：US5181902A

公开(公告)日：1993-01-26

申请号：US586505

申请日：1990-09-21

申请人： John H. Erickson ,  John C. Tepper

发明人： John H. Erickson ,  John C. Tepper

IPC分类号： A61N2/02 ,  A61N2/04

CPC分类号： A61N2/02

摘要： A PEMF double-transducer system (FIG. 1) used for PEMF therapy (such as after spinal fusion) uses a two-transducer configuration for generating flux-aided electromagnetic fields. The semi-rigid transducers (12, 14) are comformable, anatomically contoured and flat-wound to enhance patient comfort, and incorporated with an adjustable belt (16) to provide bracing. The belt includes compartments for a drive electronic module (22), and a rechargeable battery pack (24), making the system portable. The drive electronics (FIG. 3) includes a PEMF processor (41) that executes a PEMF program for providing pulsing current to the front and back transducers at predetermined intervals, thereby activating the electromagnetic field according to a prescribed PEMF regimen.

摘要翻译： 用于PEMF治疗（如脊柱融合术后）的PEMF双换能器系统（图1）使用双换能器配置来产生助焊电磁场。 半刚性换能器（12,14）是可变形的，解剖学轮廓和平面缠绕以增强患者的舒适度，并且结合有可调节带（16）以提供支撑。 皮带包括用于驱动电子模块（22）的隔间和可再充电电池组（24），使系统可移动。 驱动电子装置（图3）包括PEMF处理器（41），该PEMF处理器执行PEMF程序，用于以预定的间隔向前后的换能器提供脉冲电流，从而根据规定的PEMF方案激活电磁场。