公开(公告)号：US20060131977A1

公开(公告)日：2006-06-22

申请号：US11312983

申请日：2005-12-19

申请人： Niels Weihrauch ,  Peter Andersen

发明人： Niels Weihrauch ,  Peter Andersen

IPC分类号： H02K21/12 ,  H02K1/06

CPC分类号： H02K21/46

摘要： The invention provides a rotor for an electrical motor. The rotor comprises both a squirrel cage and a number of magnets and can be inserted e.g. in a line-start motor. To secure the magnets in cavities in a core of the rotor, an end plate is attached to one axial end face by rivet means, and to simplify manufacturing of the rotor, the rivet means forms part of at least one of the short circuit rings of the squirrel cage.

公开(公告)号：US20060115847A1

公开(公告)日：2006-06-01

申请号：US11268959

申请日：2005-11-08

申请人： Peter Andersen ,  Inger Brock ,  Karin Weldingh

发明人： Peter Andersen ,  Inger Brock ,  Karin Weldingh

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： G01N33/6812 ,  C07K14/35 ,  G01N33/505 ,  G01N33/5695

摘要： The currently used method for immunological diagnosis of tuberculosis infection, the tuberculin skin test, is problematic for a number of reasons; it has low specificity in BCG vaccinated individuals, a high interobserver variance and requires skill to be read and interpreted. Furthermore it requires an extra visit to the clinic to have the test read. Both people vaccinated with BCG and those exposed to non-tuberculosis mycobacteria give a positive skin test result similar to that seen in a TB infected individual. This also applies for purified protein derivative (PPD) when used in a blood cell based test. The present invention discloses the development of an immunological TB diagnostic tool based on a combination of epitopes from proteins encoded by regions of the M. Tuberculosis (M. tub.) genome, that are not present in the BCG vaccine strain or in the most common non-tuberculosis mycobacteria. Four recently characterized proteins with this diagnostic potential were selected. Peptides from these proteins were tested one by one with peripheral blood mononuclear cells from microscopy or culture confirmed TB patients as well as from healthy BCG vaccinated controls. Some combinations of peptides showed a sensitivity level comparable to the level seen with the two wellknown M. tuberculosisspecific proteins ESAT 6 and CFP 10. An epitope combination with these peptides combined with ESAT 6 and CFP 10 gave a sensitivity of 93%, representing a raise in sensitivity of about 26-33% compared to using ESAT6 or CFP 10 alone. The results from a panel of TB patients, using a collection of the new specific epitopes clearly demonstrates, that addition of other specific epitopes to the already known specific antigens, increases the sensitivity of a diagnostic assay based on cell mediated immune response.

摘要翻译： 目前使用的结核菌感染免疫诊断方法，结核菌素皮肤试验，有其原因有问题; 它在BCG接种个体中具有低特异性，具有高的观察者间差异，并且需要阅读和解释技能。 此外，还需要额外访问诊所以进行测试。 接种BCG的人和暴露于非结核分枝杆菌的两个人都能获得与TB感染个体相似的阳性皮肤试验结果。 当用于基于血细胞的试验中时，这也适用于纯化的蛋白质衍生物（PPD）。 本发明公开了一种免疫结核病诊断工具的开发，该工具基于由结核分枝杆菌（M. tub。）（M. tub。）基因组区域编码的蛋白质的表位的组合，其不存在于BCG疫苗株中或最常见 非结核分枝杆菌。 选择了具有该诊断潜力的四种最近鉴定的蛋白质。 使用来自显微镜或培养物确认的TB患者以及来自健康的BCG接种对照的外周血单核细胞逐个测试来自这些蛋白质的肽。 肽的一些组合显示出与两种已知的结核分枝杆菌特异性蛋白质ESAT 6和CFP 10所见的水平相当的灵敏度水平。与这些肽结合ESAT 6和CFP 10的表位结合产生93％的灵敏度，表示升高 与单独使用ESAT6或CFP 10相比，灵敏度约为26-33％。 使用新的特异性表位的一组结核病患者的结果清楚地表明，已知的特异性抗原的其他特异性表位的添加增加了基于细胞介导的免疫应答的诊断测定的灵敏度。

公开(公告)号：US20060008519A1

公开(公告)日：2006-01-12

申请号：US11174955

申请日：2005-07-05

申请人： Jesper Davidsen ,  Peter Andersen ,  Ida Rosenkrands

发明人： Jesper Davidsen ,  Peter Andersen ,  Ida Rosenkrands

IPC分类号： A61K9/127 ,  A61K39/395

CPC分类号： A61K9/1272 ,  A61K39/04 ,  A61K47/186 ,  A61K47/26 ,  A61K2039/55555 ,  Y02A50/412

摘要： The present invention relates to liposome formulations that are physically stable. In particular the present invention relates to steric stabilization of cationic liposomes by incorporating glycolipids into the liposomes. The stabilized liposomes can be used either as an adjuvant for antigenic components or as a drug delivery system. In particular the invention relates to vaccines with adjuvants in aqueous media for immunization, where the final product is stable.

摘要翻译： 本发明涉及物理稳定的脂质体制剂。 特别地，本发明涉及通过将糖脂掺入到脂质体中的阳离子脂质体的空间稳定化。 稳定的脂质体可以用作抗原成分的佐剂或用作药物递送系统。 特别地，本发明涉及用于免疫的水性介质中的佐剂的疫苗，其中最终产物是稳定的。

公开(公告)号：US20050191308A1

公开(公告)日：2005-09-01

申请号：US10654720

申请日：2003-09-03

申请人： Erik Lindblad ,  Martin Elhay ,  Peter Andersen ,  Lise Brandt

发明人： Erik Lindblad ,  Martin Elhay ,  Peter Andersen ,  Lise Brandt

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K39/04 ,  A61K39/39 ,  C12Q1/68 ,  A61K39/00 ,  A61K39/38

CPC分类号： A61K39/39 ,  A61K9/127 ,  A61K39/04 ,  Y10S435/822

摘要： An adjuvant combination and a kit useful for immunization is provided. The kit contains an antigenic substance and an adjuvant combination of dimethyl dioctadecyl ammonium bromide (DDA-Br or DDA-Cl) with a monophosphoryl lipid.

摘要翻译： 提供佐剂组合和用于免疫的试剂盒。 试剂盒含有抗原物质和二甲基双十八烷基溴化铵（DDA-Br或DDA-Cl）与单磷酰脂质的佐剂组合。

公开(公告)号：US06893304B1

公开(公告)日：2005-05-17

申请号：US10049069

申请日：2000-05-10

申请人： Peter Andersen ,  Bjoern A. Henriksen ,  Kay Tigges

发明人： Peter Andersen ,  Bjoern A. Henriksen ,  Kay Tigges

IPC分类号： B63B1/04 ,  B63B1/08 ,  B63H1/12 ,  B63H5/08 ,  B63H5/10 ,  B63H5/125 ,  B63H5/16 ,  B63H21/22 ,  B63H23/24 ,  B63H1/28

CPC分类号： B63H1/12 ,  B63B1/042 ,  B63B1/08 ,  B63H5/08 ,  B63H5/10 ,  B63H5/125 ,  B63H5/16 ,  B63H21/22 ,  B63H23/24 ,  B63H2005/1258 ,  Y02T70/128

摘要： A course-holding, high-speed, sea-going vessel having a hull which is intended to hold payloads or passengers and at least one rotatable, preferably electric, rudder propeller (POD) which is arranged gondola-like under the hull of the vessel and has, to supply it with power, at least one motor/generator unit which is arranged in the hull of the vessel, the hull of the vessel having at least in part a bottom which rises somewhat toward the two sides of the hull, and in that the front part of the hull is designed so as to stabilize the course and movement of the vessel and ending under water, in particular in a relatively slender bow with a bulb, and in that a flow-guiding element (skegg) is arranged upstream of each rudder propeller in order both to optimize the handling characteristics and to achieve an optimized flow against the rudder propeller, which has a displacement volume for the water flowing against the respective rudder propeller.

摘要翻译： 具有用于保持有效载荷或乘客的船体和至少一个可旋转的，优选电动的方向舵推进器（POD）的跑道，高速，海上船只，其在船体的船体下方布置 并且具有向其供电的至少一个电动机/发电机单元，该电动机/发电机单元布置在容器的船体中，所述容器的船体至少部分地具有朝向船体的两侧上升的底部，并且 因为船体的前部被设计成稳定船舶的航向和运动并且在水下结束，特别是在具有灯泡的相对细长的弓中，并且布置有导流元件（skegg） 以便优化处理特性并且实现针对舵螺旋桨的优化流动，其具有流向相应舵螺旋桨的水的排量。

公开(公告)号：US06645016B1

公开(公告)日：2003-11-11

申请号：US10019554

申请日：2002-05-16

申请人： Peter Andersen ,  Wolfgang Rzadki ,  Hannes Schulze Horn ,  Hans van Mameren

发明人： Peter Andersen ,  Wolfgang Rzadki ,  Hannes Schulze Horn ,  Hans van Mameren

IPC分类号： B63B300

CPC分类号： B63B1/042 ,  B63H1/12 ,  B63H5/10 ,  B63H5/16 ,  B63H23/24

摘要： A ship includes a ship's hull which is intended for accommodating cargo and/or people, and at least one rotatable steering propeller as a propulsion unit. The rotatable steering propeller is arranged in a connection unit in the form of a box in the stem of the ship's hull. Electrical and mechanical components for supplying power to and controlling the steering propeller and its electric motor are at least partially combined in functional modules which are in the form of a transport container. The container is designed such that it can be functionally tested, can be accepted at its point of manufacture, and can be installed in this form at any desired location in the ship based upon the container base structure.

摘要翻译： 船舶包括用于容纳货物和/或人的船体，以及至少一个可旋转转向螺旋桨作为推进单元。 可旋转的转向螺旋桨以船体形式的箱形式的连接单元布置。 用于向转向螺旋桨及其电动机供电和控制的电气和机械部件至少部分地组合在运输容器形式的功能模块中。 容器被设计成使得其可以在功能上被测试，可以在其制造点被接受，并且可以基于容器基座结构以这种形式安装在船舶的任何期望位置。

公开(公告)号：US06274004B1

公开(公告)日：2001-08-14

申请号：US09355632

申请日：1999-08-02

申请人： Peter Andersen

发明人： Peter Andersen

IPC分类号： B01D302

CPC分类号： C02F1/14 ,  C02F1/008 ,  C02F2103/08 ,  C02F2209/42 ,  Y02A20/128 ,  Y02A20/129 ,  Y02A20/142 ,  Y02A20/211 ,  Y02A20/212 ,  Y10S159/21 ,  Y10S159/903 ,  Y10S203/01 ,  Y10S203/11 ,  Y10S203/18

摘要： A water purification and/or desalination plant for producing drinking water from a polluted water source or sea water with the aid of sunlight, which plant includes an evaporator (1) having a roof part (2) made of a light-penetrable material, and an underlying basin part (3) containing the water that is to be purified, which basin part (3) includes channels (17) for collecting water vapor that has been condensed on the inside of the roof part (2), and a reservoir (10) for purified water. The plant also includes a device for removing moist air or vapor from the evaporator and a device for condensation of the moist air or vapor outside the evaporator.

摘要翻译： 一种用于借助于阳光从污染水源或海水生产饮用水的净水和/或脱盐设备，所述设备包括具有由透光材料制成的屋顶部分（2）的蒸发器（1），以及 包含要净化的水的下面盆地部分（3），所述盆部分（3）包括用于收集已被冷凝在屋顶部分（2）内部的水蒸汽的通道（17）和储存器 10）净化水。 该设备还包括用于从蒸发器除去湿空气或蒸汽的装置以及用于冷凝蒸发器外部的潮湿空气或蒸气的装置。

公开(公告)号：US5955077A

公开(公告)日：1999-09-21

申请号：US465640

申请日：1995-06-05

申请人： Peter Andersen ,  .ANG.se Bengaard Andersen ,  Kaare Haslov ,  Anne Lund Sorensen

发明人： Peter Andersen ,  .ANG.se Bengaard Andersen ,  Kaare Haslov ,  Anne Lund Sorensen

IPC分类号： A61K39/04 ,  A61P31/06 ,  C07K14/35 ,  A61K39/00 ,  C07K1/00 ,  C12P21/06

CPC分类号： A61K39/04 ,  C07K14/35 ,  C12R1/19 ,  A61K2039/523 ,  A61K2039/53

摘要： The invention relates to novel secreted antigens from mycobacteria capable of evoking early (within 4 days) immunological responses from T-helper cells in the form of gamma-interferon release in memory immune animals after rechallenge infection with mycobacteria of the tuberculosis complex. The antigens are present in short term filtrates (ST-CF) from cultured mycobacteria belonging to the tuberculosis complex. One of these antigens, a polypeptide with an apparent molecular weight of 6 kDa, has been identified, and the DNA encoding the polypeptide has been cloned and sequenced. The antigens of the invention are believed useful especially in vaccines, but also in diagnostic compositions, especially for diagnosing infection with virulent mycobacteria. Also disclosed are nucleic acid fragments encoding the antigens as well as methods of immunizing animals/humans and methods of diagnosing tuberculosis.

摘要翻译： 本发明涉及能够以结核分枝杆菌复合体分枝杆菌感染后的记忆免疫动物中早期（4天内）诱发来自T-辅助细胞的免疫反应以γ-干扰素释放的形式的分枝杆菌的新型分泌型抗原。 抗原存在于来自属于结核病复合体的培养的分枝杆菌的短期滤液（ST-CF）中。 已经鉴定了这些抗原中的一种，表观分子量为6kDa的多肽，并且已经克隆并测序了编码该多肽的DNA。 认为本发明的抗原特别用于疫苗，而且在诊断组合物中尤其是用于诊断有毒分枝杆菌的感染是有用的。 还公开了编码抗原的核酸片段以及免疫动物/人的方法和诊断结核病的方法。