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    Vaccines comprising TB10.4
    2.
    发明授权
    Vaccines comprising TB10.4 有权
    疫苗包含TB10.4

    公开(公告)号：US08557258B2

    公开(公告)日：2013-10-15

    申请号：US13221211

    申请日：2011-08-30

    申请人： Jes Dietrich ,  Claus Aagaard ,  Peter Andersen

    发明人： Jes Dietrich ,  Claus Aagaard ,  Peter Andersen

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/04

    CPC分类号： A61K39/04 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/55561

    摘要： Vaccination with the combination of Ag85B-TB10.4 and IC31® adjuvant generated a high amount of polyfunctional CD4+T cells expressing high levels of IFN-γ, TNF-α, and IL-2. This in turn led to significant protection against infection with M. tuberculosis in the mouse aerosol challenge model of tuberculosis. Both the immunogenicity of the vaccine and its ability to protect against TB infection was highly dependent on the antigen dose. Thus, whereas the standard antigen dose of 5 μg, as well as 15 μg, did not induce significant protection against M. tuberculosis, reducing the dose to 0.5 μg increased both the immunogenicity of the vaccine as well as its protective efficacy to a level comparable to that observed in BCG vaccinated mice. Thus, the IC31® adjuvant, with the specified antigen dose, can induce a strong protective Th1 response against M. tuberculosis.

    摘要翻译： 使用Ag85B-TB10.4和IC31®佐剂的组合进行疫苗接种，产生大量表达高水平IFN-γ，TNF-α和IL-2的多功能CD4 + T细胞。 这反过来又导致了结核病小鼠气溶胶攻击模型中结核分枝杆菌感染的重大保护。 疫苗的免疫原性及其抗TB感染的能力都高度依赖于抗原剂量。 因此，尽管5杯以及15杯的标准抗原剂量没有诱导对结核分枝杆菌的显着保护，但将剂量降低至0.5杯可将疫苗的免疫原性以及其保护功效提高到可比水平 到BCG接种的小鼠中观察到的。 因此，具有特定抗原剂量的IC31®佐剂可以诱导针对结核分枝杆菌的强烈的保护性Th1应答。

    Adjuvant combinations of liposomes and mycobacterial lipids for immunization compositions and vaccines
    3.
    发明授权
    Adjuvant combinations of liposomes and mycobacterial lipids for immunization compositions and vaccines 有权
    用于免疫组合物和疫苗的脂质体和分枝杆菌脂质的佐剂组合

    公开(公告)号：US08241610B2

    公开(公告)日：2012-08-14

    申请号：US13083385

    申请日：2011-04-08

    申请人： Else Marie Agger ,  Peter Andersen ,  Anja Olsen ,  Ida Rosenkrands

    发明人： Else Marie Agger ,  Peter Andersen ,  Anja Olsen ,  Ida Rosenkrands

    IPC分类号： A61K9/127 ,  A61B5/055

    CPC分类号： A61K39/04 ,  A61K2039/55555 ,  A61K2039/55594

    摘要： The present invention provides a vaccine adjuvant consisting of a combination of a surfactant i.e. dimethyldeoctadecylammonium-bromide/chloride (DDA) and a lipid extract from Mycobacterium bovis BCG. The total lipid extract contains both apolar lipids, polar lipids, and lipids of intermediate polarity of which the apolar lipids were found to induce the most powerful immune responses. The total lipids may be extracted with chloroform/methanol and re-dissolved in water before the addition of surfactant. This preparation may be used to induce prominent cell-mediated immune responses in a mammal in order to combat pathogens, or as a treatment for cancer.

    摘要翻译： 本发明提供了由表面活性剂，即二甲基十八烷基溴化铵/氯化物（DDA）和牛分枝杆菌BCG的脂质提取物的组合组成的疫苗佐剂。 总脂质提取物包含非极性脂质，极性脂质和具有中性极性的脂质，其中发现非极性脂质诱导最强大的免疫应答。 总脂质可以用氯仿/甲醇萃取，并在加入表面活性剂之前再溶解在水中。 该制剂可用于诱导哺乳动物中突出的细胞介导的免疫应答以抵抗病原体，或用作癌症治疗。

    Device and a method for fixing a carcass
    5.
    发明授权
    Device and a method for fixing a carcass 失效
    用于固定胎体的装置和方法

    公开(公告)号：US07625267B2

    公开(公告)日：2009-12-01

    申请号：US12043826

    申请日：2008-03-06

    申请人： Peter Andersen

    发明人： Peter Andersen

    IPC分类号： A22B3/10

    CPC分类号： A22B5/0005

    摘要： The invention relates to a fixation device (1) and a method for fixating a carcass, e.g. during processing the carcass at a slaughterhouse, such as a carcass hanging head-down from a gambrel, wherein the device (1) comprises mouth-engaging fixation means.

    摘要翻译： 本发明涉及一种固定装置（1）和一种用于固定胎体的方法，例如， 在屠宰场处理过程中，例如从野蛮人向下悬挂的屠体，其中所述装置（1）包括口接合固定装置。

    METHOD AND APPARATUS FOR LOOSENING A PLUCKS SET
    7.
    发明申请
    METHOD AND APPARATUS FOR LOOSENING A PLUCKS SET 审中-公开
    用于放松一个塑料套的方法和装置

    公开(公告)号：US20080220705A1

    公开(公告)日：2008-09-11

    申请号：US12043791

    申请日：2008-03-06

    申请人： Peter Andersen ,  Kjeld N. Andersen ,  Carsten Jensen

    发明人： Peter Andersen ,  Kjeld N. Andersen ,  Carsten Jensen

    IPC分类号： A22B5/00

    CPC分类号： A22B5/0005

    摘要： The disclosure relates to a method and aspects of an apparatus for loosening a plucks set (3) including tongue (28), heart and lungs from a suspended carcass (1). The carcass (1) may be fixed by means of mouth-engaging fixing means (10). The plucks set of the carcass (1) is cut loose by cutting means (15) that are introduced through the mouth (2) of the carcass (1), mouth-engaging fixing means (10) possibly cooperating with the cutting means (15) to ensure that e.g. the tonsils (27) or tongue (28) are not damaged. Subsequently, the tongue (28) may be loosened from the mandible (14) by scraping.

    摘要翻译： 本公开涉及一种用于松开包括舌状物（28），从悬挂的胎体（1）的心脏和肺部的拔毛器（3）的装置的方法和方面。 胎体（1）可以通过口接合固定装置（10）固定。 通过从胎体（1）的口部（2）引入的切割装置（15），使胎体（1）的拔除组件松开，可能与切割装置（15）配合的接口固定装置 ）以确保例如 扁桃体（27）或舌头（28）不被损坏。 随后，舌部（28）可以通过刮擦从下颌骨（14）松开。