公开(公告)号：US20090274637A1

公开(公告)日：2009-11-05

申请号：US11919253

申请日：2006-04-27

Applicant: Philippe Msika ,  Nathalie Piccardi

Inventor： Philippe Msika ,  Nathalie Piccardi

IPC: A61K8/49 ,  A61K31/421 ,  C07D263/12

CPC classification number: A61K8/49 ,  A61Q19/02

Abstract: The invention relates to the cosmetic use of at least one oxazolin as a depigmenting active ingredient in a depigmenting composition, and to the associated cosmetic treatment method. The invention also relates to the use of at least one oxazolin for preparing an active medicament as a depigmenting agent, and to a depigmenting cosmetic composition comprising at least one oxazolin as a depigmenting active ingredient.

Abstract translation: 本发明涉及至少一种恶唑啉在脱色组合物中作为脱色素活性成分的美容应用，以及相关的美容治疗方法。 本发明还涉及至少一种恶唑啉用于制备活性药物作为脱色剂的用途，以及涉及包含至少一种恶唑啉作为脱色素活性成分的脱色处理化妆品组合物的用途。

公开(公告)号：US20080081837A1

公开(公告)日：2008-04-03

申请号：US11597635

申请日：2005-05-27

Applicant: Antoine Piccirilli ,  Philippe Msika ,  Nathalie Piccardi

Inventor： Antoine Piccirilli ,  Philippe Msika ,  Nathalie Piccardi

IPC: A61K31/341 ,  A61P3/04 ,  A61P3/08

CPC classification number: A61K31/341

Abstract: The invention relates to using one or several synthetic or natural furan alkyls for preparing a drug for preventing and/or treating diabetes and insulin resistance, thereby preventing the risks of cardiovascular, nervous, cutaneous, renal, ocular and infectious diseases. The use of one or several synthetic or natural furan alkyls for cosmetically treating diabetes related skin disorders is also disclosed.

Abstract translation: 本发明涉及使用一种或多种合成或天然呋喃烷基酯制备用于预防和/或治疗糖尿病和胰岛素抵抗的药物，从而防止心血管，神经，皮肤，肾脏，眼睛和感染性疾病的风险。 还公开了使用一种或几种合成或天然呋喃烷基化妆品来治疗糖尿病相关的皮肤病。

公开(公告)号：US20070281994A1

公开(公告)日：2007-12-06

申请号：US11597636

申请日：2005-05-27

Applicant: Antoine Piccirilli ,  Philippe Msika ,  Nathalie Piccardi

Inventor： Antoine Piccirilli ,  Philippe Msika ,  Nathalie Piccardi

IPC: A61K31/34 ,  A61P43/00

CPC classification number: A61K8/4973 ,  A61Q19/06

Abstract: The invention relates to the use of one or several synthetic or natural furan alkyls for cosmetically treating cellulite. Said furan alkyls preferably correspond to formula (I), wherein identical or different R1, R2, R3 et R4 are independently of each other a hydrogen atom, a C1-C35alkyl radical, C1-C35 alcenyl radical or a C1-C35 alcynyl radical, preferably C10-C22, wherein said alkyl, alcenyl and alcynyl radicals are substitutable and R1, R2, R3 are preferably a hydrogen atom.

Abstract translation: 本发明涉及一种或多种合成或天然呋喃烷基酯用于化妆处理脂肪团的用途。 所述呋喃烷基优选对应于式（I），其中相同或不同的R 1，R 2，R 3和R 4 氢原子，C 1 -C 3烷基，C 1 -C 3烷基，C 1 -C 3烷基， 丙烯基或C 1 -C 35烷基，优选C 10 -C 22亚烷基，优选C 10 -C 22亚烷基 >，其中所述烷基，烯基和烷酰基是可取代的，并且R 1，R 2，R 3优选为氢原子。

公开(公告)号：US07029713B2

公开(公告)日：2006-04-18

申请号：US10678884

申请日：2003-10-03

Applicant: Philippe Msika ,  Antoine Piccirilli ,  François Paul

Inventor： Philippe Msika ,  Antoine Piccirilli ,  François Paul

IPC: A61K35/78 ,  A61K38/00

CPC classification number: C07K14/415 ,  A61K8/645 ,  A61K36/48 ,  A61K2800/782 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: The invention concerns a peptide extract of lupine (lupinus) characterised in that it has a metalloprotease inhibiting activity, in particular collagenase and gelatinase. The invention also concerns a pharmaceutical, cosmetic or nutritional composition comprising a peptide extract, optionally an inert carrier, in particular for treating humans or mammals suffering from a condition or disease related to excessive degeneration of support by a metalloprotease.

Abstract translation: 本发明涉及羽扇豆（Lupinus）的肽提取物，其特征在于其具有金属蛋白酶抑制活性，特别是胶原酶和明胶酶。 本发明还涉及包含肽提取物，任选的惰性载体的药物，化妆品或营养组合物，特别是用于治疗患有与金属蛋白酶过度退化的病症或疾病有关的人或哺乳动物。

公开(公告)号：US5939054A

公开(公告)日：1999-08-17

申请号：US913428

申请日：1997-09-15

Applicant: Philippe Msika ,  Francis Carriere ,  Jean-Pierre Fabre ,  France Boyer

Inventor： Philippe Msika ,  Francis Carriere ,  Jean-Pierre Fabre ,  France Boyer

IPC: A61K8/00 ,  A61K8/27 ,  A61K8/29 ,  A61K8/34 ,  A61K8/37 ,  A61K8/89 ,  A61K8/891 ,  A61K8/92 ,  A61K31/315 ,  A61K33/24 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q17/04 ,  C09C1/04 ,  C09C1/36 ,  A61K7/42 ,  A61K7/00

CPC classification number: A61Q17/04 ,  A61K8/27 ,  A61K8/29 ,  A61K2800/59

Abstract: A sunscreen composition containing a synergic mixture of titanium and/or zinc oxide particles, characterized in that said particles are incorporated in paste-forming oils and/or esters and/or fatty alcohols and/or ethers selected so as to provide a wetting point of the incorporated titanium oxide particles and of the incorporated zinc oxide particles lower than about 5 and a flow point of said incorporatedparticles lower than about 30. The invention also provides a method for preparing said composition and the use thereof for protecting the skin against ultraviolet radiation and for maintaining the monocrystalline dispersion of minerals in the formulation and on the skin.

Abstract translation: PCT No.PCT / FR96 / 00393 Sec。 371日期：1997年9月15日 102（e）1997年9月15日PCT 1996年3月14日PCT公布。 公开号WO96 / 28136 日期1996年9月19日一种含有钛和/或氧化锌颗粒的协同混合物的防晒组合物，其特征在于所述颗粒掺入成膏油和/或酯和/或脂肪醇和/或醚中， 提供掺入的氧化钛颗粒和掺入的氧化锌颗粒的润湿点低于约5，所加入的颗粒的流动点低于约30.本发明还提供了制备所述组合物的方法及其用于保护 皮肤抵抗紫外线辐射，并保持矿物质在制剂和皮肤上的单晶分散。

公开(公告)号：US09089576B2

公开(公告)日：2015-07-28

申请号：US12539970

申请日：2009-08-12

Applicant: Antoine Piccirilli ,  Nathalie Piccardi ,  Philippe Msika ,  François Paul ,  Stéphanie Bredif

Inventor： Antoine Piccirilli ,  Nathalie Piccardi ,  Philippe Msika ,  François Paul ,  Stéphanie Bredif

IPC: A61K36/00 ,  A61K36/54 ,  A61K31/198

CPC classification number: A61K36/54 ,  A61K31/198 ,  A61K2300/00

Abstract: The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose an/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.

Abstract translation: 本发明涉及一种药物，其包含鳄梨的肽提取物，并且还可以包含含有D-甘露庚酮糖和/或去糖醇的组合物，例如鳄梨糖的水溶性提取物和/或羽扇豆肽提取物。 本发明的药物旨在通过增加抗微生物肽（优选hBD-2）的产生而不诱导炎症反应来治疗和/或预防与先天和/或获得性免疫的变化有关的疾病， 激怒或不宽容

公开(公告)号：US08894979B2

公开(公告)日：2014-11-25

申请号：US13516333

申请日：2010-12-15

Applicant: Caroline Baudouin ,  Philippe Msika

Inventor： Caroline Baudouin ,  Philippe Msika

IPC: A61K8/00 ,  A61K8/18 ,  A61Q3/00 ,  A61K45/06 ,  A61K9/48 ,  A61K31/7004 ,  A61K31/70 ,  A61Q7/00 ,  A61K8/60 ,  A61K8/97 ,  A61K36/54 ,  A61Q5/00

CPC classification number: A61K8/60 ,  A23L2/52 ,  A23L7/126 ,  A23V2002/00 ,  A61K8/97 ,  A61K9/4858 ,  A61K31/70 ,  A61K31/7004 ,  A61K36/54 ,  A61K45/06 ,  A61K2800/5922 ,  A61K2800/92 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q7/00 ,  A61K2300/00

Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.

Abstract translation: 本发明涉及包含至少一种C 7糖或所述糖的酯化衍生物和用于治疗脱发的药学上可接受的载体的组合物。 本发明还涉及一种美发头发和指甲的方法，所述方法旨在刺激其生长和/或减缓其损失。 根据所述方法，施用包含至少一种C 7糖或所述糖的酯化衍生物的化妆品组合物。 本发明最终涉及用于化妆品护理头发和/或睫毛和/或指甲的方法。

公开(公告)号：US08877261B2

公开(公告)日：2014-11-04

申请号：US13824699

申请日：2012-05-11

Applicant: Philippe Msika ,  Caroline Baudouin ,  Franck Menu

Inventor： Philippe Msika ,  Caroline Baudouin ,  Franck Menu

IPC: A61K36/00 ,  A61K31/74 ,  A61K8/97 ,  A61K36/48 ,  A61K8/64 ,  A61K8/34 ,  A61K8/73 ,  A61Q19/00 ,  A61Q19/10 ,  A61K38/16 ,  A61Q19/08 ,  A61Q17/04

CPC classification number: A61K8/73 ,  A61K8/347 ,  A61K8/645 ,  A61K36/48 ,  A61K38/168 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10 ,  A61K2300/00

Abstract: The present application relates to a cosmetic method for preventing and/or treating skin redness, characterized in that a composition comprising arabinogalactan is administered to a person who may form or who is displaying redness. This cosmetic composition can be administered topically or orally.

Abstract translation: 本申请涉及一种用于预防和/或治疗皮肤发红的美容方法，其特征在于将包含阿拉伯半乳聚糖的组合物施用于可能形成或正在发红的人。 该化妆品组合物可以局部或口服施用。

公开(公告)号：US20130183255A1

公开(公告)日：2013-07-18

申请号：US13824627

申请日：2011-12-22

Applicant: Alex Saunois ,  Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Sebastien Garnier ,  Philippe Msika

Inventor： Alex Saunois ,  Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Sebastien Garnier ,  Philippe Msika

IPC: A61K31/353 ,  A61Q5/12 ,  A61K8/49 ,  A61Q19/00 ,  A61Q17/04 ,  A61K45/06

CPC classification number: A61K31/353 ,  A23L19/07 ,  A23L19/09 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/498 ,  A61K8/97 ,  A61K9/0014 ,  A61K36/54 ,  A61K45/06 ,  A61K2800/92 ,  A61Q5/12 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/005 ,  A61Q19/02 ,  A61Q19/08 ,  A23V2200/318 ,  A23V2250/21

Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

Abstract translation: 本发明涉及一种富含多酚的鳄梨提取物，其含有至少10重量％的多酚，以相对于所得干提取物的没食子酸当量表示，其中所述多酚含有原花青素，咖啡酸和咖啡酸衍生物，通常为一定比例 至少70重量％，相对于总多酚含量按重量计，没食子酸当量表示。 本发明还涉及包含根据本发明的提取物作为活性剂和合适的赋形剂的组合物。 本发明还涉及用于预防或治疗皮肤，粘膜或表面体生长的病症或病理状况的组合物或这种提取物。 最后，本发明涉及一种用于皮肤，表面体生长或粘膜的美容护理方法，以改善其状况或其外观，其包括给予这种组合物或这种提取物。

公开(公告)号：US08318186B2

公开(公告)日：2012-11-27

申请号：US10181370

申请日：2001-01-18

Applicant: Philippe Msika ,  Antoine Piccirilli ,  Jacques Legrand

Inventor： Philippe Msika ,  Antoine Piccirilli ,  Jacques Legrand

IPC: A61K8/02 ,  A61K8/00 ,  A61K9/20 ,  C12P7/64

CPC classification number: A61Q19/008 ,  A23K20/158 ,  A61K8/37 ,  A61K8/922 ,  A61K9/06 ,  A61K31/23 ,  A61K31/231 ,  A61K2800/782 ,  A61Q7/00 ,  A61Q7/02 ,  A61Q19/00

Abstract: The invention concerns the use of at least a fatty ester for preparing a composition designed to inhibit 5α-reductase activity. Said use produces a remarkable inhibiting effect of 5α-reductase thereby providing a novel response for treating dermatological pathologies and/or disorders related to congenital or acquired exaggeration of 5α-reductase activity, in particular for treating prostatic hypertrophy, prostatic adenoma, acne, hyperseborrhea, alopecia and hirsutism. The invention also concerns cosmetic treatment methods, in particular for greasy skin, and the use of said fatty esters as additives in a food product for human and/or animal consumption.

Abstract translation: 本发明涉及至少一种脂肪酯用于制备抑制5α-还原酶活性的组合物的用途。 所述用途产生了5α-还原酶的显着抑制作用，从而为治疗与先天性或后遗症5α-还原酶活性相关的皮肤病学病症和/或病症，特别是用于治疗前列腺肥大，前列腺腺瘤，痤疮，过度脂肪， 脱发和多毛症。 本发明还涉及化妆品处理方法，特别是油性皮肤，以及所述脂肪酯作为食品中添加剂用于人和/或动物消费的用途。