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公开(公告)号：US07033760B2
公开(公告)日：2006-04-25
申请号：US09921645
申请日：2001-08-03
申请人： Thomas J. Meade , Jon F. Kayyem
发明人： Thomas J. Meade , Jon F. Kayyem
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00 , G01N33/566 , C07H19/00
CPC分类号： C12Q1/6818 , B82Y30/00 , C07H21/00 , C07H23/00 , C12Q1/6825 , C12Q2563/137 , C12Q2563/113 , C12Q2565/607 , C12Q2565/101 , C12Q2565/1015 , C12Q2565/401
摘要： The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.
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62.发明授权公开(公告)号：US07029655B2
公开(公告)日：2006-04-18
申请号：US09972302
申请日：2001-10-04
IPC分类号： A61B5/055
CPC分类号： A61K49/10 , A61K49/085 , A61K49/122 , A61K49/1833 , B82Y5/00
摘要： The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic resonance images of amyloid deposits associated with Alzheimer's disease.
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公开(公告)号：US06977151B2
公开(公告)日：2005-12-20
申请号：US10081936
申请日：2002-02-20
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
摘要翻译： 本发明涉及通过导电低聚物共价偶联到电极上的核酸。 更具体地，本发明涉及具有电子转移部分和电极的核酸的位点选择性修饰以产生新类别的生物材料，以及制备和使用它们的方法。
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公开(公告)号：US06258545B1
公开(公告)日：2001-07-10
申请号：US09545227
申请日：2000-04-07
IPC分类号： C12Q168
CPC分类号： C12Q1/6825 , C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q2563/113 , C12Q2565/101
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06248229B1
公开(公告)日：2001-06-19
申请号：US09417988
申请日：1999-10-13
申请人： Thomas J. Meade
发明人： Thomas J. Meade
IPC分类号： C12Q100
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, &lgr;, of an electron transfer process.
摘要翻译： 本发明涉及使用电子转移过程的核重组能量羔羊检测分析物的新方法和组合物。
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公开(公告)号：US6013459A
公开(公告)日：2000-01-11
申请号：US873977
申请日：1997-06-12
申请人： Thomas J. Meade
发明人： Thomas J. Meade
IPC分类号： G01N27/416 , G01N27/327 , G01N33/543 , G01N33/53 , C12Q1/00 , G01F1/64 , G01N33/573
CPC分类号： B82Y30/00 , B82Y15/00 , B82Y5/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, .lambda., of an electron transfer process.
摘要翻译： 本发明涉及使用电子转移方法的核重组能量λ检测分析物的新方法和组合物。
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公开(公告)号：US5880149A
公开(公告)日：1999-03-09
申请号：US721872
申请日：1996-09-27
IPC分类号： A61K31/555 , A61K31/00 , A61K31/665 , A61K31/67 , A61K31/675 , A61K31/69 , A61P29/00 , A61P43/00 , C07C251/24 , C07F1/00 , C07F1/08 , C07F1/12 , C07F15/00 , C07F15/04 , A61K31/28 , C07H23/00
CPC分类号： C07F1/005 , C07C251/24 , C07F15/0066 , C07F15/0093 , C07F15/045
摘要： The invention relates to metal complexes used to bind proteins and enzymes.
摘要翻译： 本发明涉及用于结合蛋白质和酶的金属络合物。
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公开(公告)号：US5824473A
公开(公告)日：1998-10-20
申请号：US475051
申请日：1995-06-07
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , C07H21/02 , C07H21/04 , C12Q1/70
CPC分类号： C12Q1/6818 , B82Y30/00 , C07H21/00 , C07H23/00 , C12Q1/6825
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US5770369A
公开(公告)日：1998-06-23
申请号：US660534
申请日：1996-06-07
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , C07H21/04 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/6818 , B82Y30/00 , C07H21/00 , C07H23/00 , C12Q1/6825
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US5705348A
公开(公告)日：1998-01-06
申请号：US709265
申请日：1996-09-06
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , C07H21/02 , C07H21/04 , C12Q1/70
CPC分类号： C07H23/00 , C07H21/00 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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