公开(公告)号：US08073627B2

公开(公告)日：2011-12-06

申请号：US10754415

申请日：2004-01-09

申请人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

发明人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

IPC分类号： G01N33/50

CPC分类号： C07H21/04 ,  C12Q1/6809 ,  C12Q1/686 ,  G06F19/16 ,  G06F19/22 ,  G06F19/28 ,  Y10T436/24 ,  C12Q2565/627 ,  C12Q2563/179

摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.

摘要翻译： 本发明一般涉及研究生物信息学领域，更具体地涉及定义数据库的二级结构。 本发明还涉及询问数据库作为已知生物标签的分子量来源的方法，用于与未知或选择的生物标签的分子量进行比较以确定所选择的生物标签的身份，和/或确定所选生物标记的来源 所选的生物标签。 生物制剂的鉴定对于在诸如生物战争的情况下确定生物制剂的适当治疗过程和/或辐照是重要的。 此外，确定所选择的生物制剂的地理起源将有助于确定潜在的犯罪认同。

公开(公告)号：US20110238316A1

公开(公告)日：2011-09-29

申请号：US10754415

申请日：2004-01-09

申请人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

发明人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

IPC分类号： G06F19/00

CPC分类号： C07H21/04 ,  C12Q1/6809 ,  C12Q1/686 ,  G06F19/16 ,  G06F19/22 ,  G06F19/28 ,  Y10T436/24 ,  C12Q2565/627 ,  C12Q2563/179

摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.

摘要翻译： 本发明一般涉及研究生物信息学领域，更具体地涉及定义数据库的二级结构。 本发明还涉及询问数据库作为已知生物标签的分子量来源的方法，用于与未知或选择的生物标签的分子量进行比较以确定所选择的生物标签的身份，和/或确定所选生物标记的来源 所选的生物标签。 生物制剂的鉴定对于在诸如生物战争的情况下确定生物制剂的适当治疗过程和/或辐照是重要的。 此外，确定所选择的生物制剂的地理起源将有助于确定潜在的犯罪认同。

公开(公告)号：US20110143358A1

公开(公告)日：2011-06-16

申请号：US12995429

申请日：2009-05-29

申请人： Rangarajan Sampath ,  David J. Ecker ,  Mark W. Eshoo ,  Heather E. Matthews ,  Christopher D. Crowder ,  Lawrence B. Blyn

发明人： Rangarajan Sampath ,  David J. Ecker ,  Mark W. Eshoo ,  Heather E. Matthews ,  Christopher D. Crowder ,  Lawrence B. Blyn

IPC分类号： C12Q1/68 ,  H01J49/26

CPC分类号： C12Q1/6876 ,  C12Q2600/16

摘要： The present invention relates generally to the field of genetic identification and quantification of tick borne pathogens and provides methods, compositions and kits useful for this purpose when combined with molecular mass or base composition analysis.

摘要翻译： 本发明一般涉及蜱传播的病原体的遗传鉴定和定量领域，并且当与分子量或碱成分分析结合时，提供可用于此目的的方法，组合物和试剂盒。

公开(公告)号：US08380442B2

公开(公告)日：2013-02-19

申请号：US11930108

申请日：2007-10-31

申请人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

发明人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

IPC分类号： G01N33/50

CPC分类号： G06F19/28 ,  G06F19/00 ,  G06F19/10 ,  G06F19/16 ,  G06F19/18 ,  G16H50/80 ,  Y02A90/24 ,  Y02A90/26

摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.

公开(公告)号：US20120142085A1

公开(公告)日：2012-06-07

申请号：US11929910

申请日：2007-10-30

申请人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

发明人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

IPC分类号： C12M1/34

CPC分类号： C12Q1/689 ,  C12Q1/686 ,  Y10T436/24 ,  C12Q2565/627

摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.

摘要翻译： 本发明提供了以下方法：鉴定来自人和动物的生物样品中的病原体，解决从人和动物获得的样品中存在的多种病原体，确定关于这种病原体或病原体的详细遗传信息，以及快速检测和鉴定生物代谢 来自环境，临床或其他样品。

公开(公告)号：US20120123685A1

公开(公告)日：2012-05-17

申请号：US11674538

申请日：2007-02-13

申请人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

发明人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil ,  Stanley T. Crooke

IPC分类号： G06F19/00 ,  G01N33/483

CPC分类号： G06F19/28 ,  G06F19/00 ,  G06F19/10 ,  G06F19/16 ,  G06F19/18 ,  G16H50/80 ,  Y02A90/24 ,  Y02A90/26

摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.

摘要翻译： 本发明一般涉及研究生物信息学领域，更具体地涉及定义数据库的二级结构。 本发明还涉及询问数据库作为已知生物标签的分子量来源的方法，用于与未知或选择的生物标签的分子量进行比较以确定所选择的生物标签的身份，和/或确定所选生物标记的来源 所选的生物标签。 生物制剂的鉴定对于在诸如生物战争的情况下确定生物制剂的适当治疗过程和/或辐照是重要的。 此外，确定所选择的生物制剂的地理起源将有助于确定潜在的犯罪认同。

公开(公告)号：US08017358B2

公开(公告)日：2011-09-13

申请号：US11331987

申请日：2006-01-13

申请人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven Hofstadler ,  John McNeil

发明人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven Hofstadler ,  John McNeil

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Q2565/627

摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.

公开(公告)号：US20110183343A1

公开(公告)日：2011-07-28

申请号：US13122352

申请日：2009-09-30

申请人： Rangarajan Sampath ,  Feng Li ,  Robert J. Lovari ,  Lawrence B. Blyn ,  David J. Ecker

发明人： Rangarajan Sampath ,  Feng Li ,  Robert J. Lovari ,  Lawrence B. Blyn ,  David J. Ecker

IPC分类号： C12Q1/68 ,  C07H21/00 ,  H01J49/26

CPC分类号： C12Q1/689

摘要： The present invention relates generally to identification of members of the bacterial class Alphaproteobacter and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.

摘要翻译： 本发明一般涉及鉴定细菌类阿尔茨海默氏菌属的成员，并且提供了当例如与分子量或碱组成分析组合时可用于此目的的方法，组合物和试剂盒。

公开(公告)号：US07741036B2

公开(公告)日：2010-06-22

申请号：US11331978

申请日：2006-01-13

申请人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven Hofstadler ,  John McNeil

发明人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven Hofstadler ,  John McNeil

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/689 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Q2565/627

摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.

摘要翻译： 通过核酸扩增和分子量测定的组合来检测和识别未知生物标签的方法，所述引物与衍生自生物制剂的核酸的保守序列区域杂交的引物以及独特的括号可变序列区域 识别生物制剂。 结果是“基本组成签名”（BCS），然后与基础组合签名的数据库进行匹配，通过该数据库识别生物标签。

公开(公告)号：US20090148836A1

公开(公告)日：2009-06-11

申请号：US11929707

申请日：2007-10-30

申请人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil

发明人： David J. Ecker ,  Richard H. Griffey ,  Rangarajan Sampath ,  Steven A. Hofstadler ,  John McNeil

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Q2565/627

摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.