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公开(公告)号：US20110143358A1
公开(公告)日：2011-06-16
申请号：US12995429
申请日：2009-05-29
申请人： Rangarajan Sampath , David J. Ecker , Mark W. Eshoo , Heather E. Matthews , Christopher D. Crowder , Lawrence B. Blyn
发明人： Rangarajan Sampath , David J. Ecker , Mark W. Eshoo , Heather E. Matthews , Christopher D. Crowder , Lawrence B. Blyn
CPC分类号： C12Q1/6876 , C12Q2600/16
摘要： The present invention relates generally to the field of genetic identification and quantification of tick borne pathogens and provides methods, compositions and kits useful for this purpose when combined with molecular mass or base composition analysis.
摘要翻译： 本发明一般涉及蜱传播的病原体的遗传鉴定和定量领域，并且当与分子量或碱成分分析结合时，提供可用于此目的的方法，组合物和试剂盒。
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公开(公告)号：US09393564B2
公开(公告)日：2016-07-19
申请号：US13259350
申请日：2010-03-30
申请人： David J. Ecker , Steven A. Hofstadler , Rangarajan Sampath , Lawrence B. Blyn , Thomas A. Hall , Mark W. Eshoo
发明人： David J. Ecker , Steven A. Hofstadler , Rangarajan Sampath , Lawrence B. Blyn , Thomas A. Hall , Mark W. Eshoo
CPC分类号： B01L3/502761 , B01L3/5027 , B01L3/52 , B01L7/52 , B01L2200/028 , B01L2200/10 , B01L2300/027 , B01L2400/0415 , H01J49/0022
摘要： The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.
摘要翻译： 本发明涉及用于检测生物代理的便携式系统和装置及相应的方法。 特别地，本发明提供利用样品制备组分，采用宽范围引物的样品分析组分和样品检测组分中的一种或多种的系统，装置和方法。
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3.发明申请Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 审中-公开线粒体DNA的快速法医分析系统和线粒体DNA异质性的表征公开(公告)号：US20100145626A1
公开(公告)日：2010-06-10
申请号：US12605628
申请日：2009-10-26
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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4.发明授权Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权线粒体DNA快速法医分析方法及线粒体DNA异质性表征公开(公告)号：US07666588B2
公开(公告)日：2010-02-23
申请号：US10660998
申请日：2003-09-12
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neil White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neil White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US20090239224A1
公开(公告)日：2009-09-24
申请号：US12326800
申请日：2008-12-02
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US20120064523A1
公开(公告)日：2012-03-15
申请号：US13259350
申请日：2010-03-30
申请人： David J. Ecker , Steven A. Hofstadler , Rangarajan Sampath , Lawrence B. Blyn , Thomas A. Hall , Mark W. Eshoo
发明人： David J. Ecker , Steven A. Hofstadler , Rangarajan Sampath , Lawrence B. Blyn , Thomas A. Hall , Mark W. Eshoo
CPC分类号： B01L3/502761 , B01L3/5027 , B01L3/52 , B01L7/52 , B01L2200/028 , B01L2200/10 , B01L2300/027 , B01L2400/0415 , H01J49/0022
摘要： The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.
摘要翻译： 本发明涉及用于检测生物代理的便携式系统和装置及相应的方法。 特别地，本发明提供利用样品制备组分，采用宽范围引物的样品分析组分和样品检测组分中的一种或多种的系统，装置和方法。
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公开(公告)号：US08268565B2
公开(公告)日：2012-09-18
申请号：US12326800
申请日：2008-12-02
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Stephen A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Stephen A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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8.发明申请公开(公告)号：US20110166040A1
公开(公告)日：2011-07-07
申请号：US12995425
申请日：2009-05-28
申请人： James C. Hannis , Feng Li , Rangarajan Sampath , Lawrence B. Blyn , Steven A. Hofstadler , David J. Ecker , Mark W. Eshoo
发明人： James C. Hannis , Feng Li , Rangarajan Sampath , Lawrence B. Blyn , Steven A. Hofstadler , David J. Ecker , Mark W. Eshoo
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： The present invention relates generally to strain typing of Escherichia coli O157:H7, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
摘要翻译： 本发明一般涉及大肠杆菌O157：H7的菌株分型，并且提供了用于此目的的方法，组合物和试剂盒，例如当与分子量或碱组成分析组合时。
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公开(公告)号：US08407010B2
公开(公告)日：2013-03-26
申请号：US12049949
申请日：2008-03-17
申请人： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
发明人： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
IPC分类号： G06F7/00
CPC分类号： G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G06F19/28 , C12Q2565/627 , C12Q2521/301
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
摘要翻译： 本发明提供了通过扩增含有限制性位点的线粒体DNA片段，用限制酶消化线粒体DNA片段，确定限制性片段的分子量并将分子量与分子量进行比较的线粒体DNA的快速法医分析方法 已知线粒体DNA序列的理论限制性消化存储在数据库中。
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公开(公告)号：US20130337452A1
公开(公告)日：2013-12-19
申请号：US13850683
申请日：2013-03-26
申请人： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
发明人： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
IPC分类号： G01N27/62
CPC分类号： G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G16B50/00 , C12Q2565/627 , C12Q2521/301
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
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