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公开(公告)号：US20130018444A1
公开(公告)日：2013-01-17
申请号：US13068866
申请日：2011-07-11
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61B5/0422 , A61B5/6862 , A61N1/057
摘要： An intravascular electrode device for use in neuromodulation includes an anchor expandable from a radially compressed position to a radially expanded position. A lead extends from the anchor and has at least one conductor extending through it. A flex circuit is coupled to the anchor and comprises a flexible insulative substrate, a plurality of electrodes carried by the substrate, and a plurality of conductive traces carried by the substrate, each trace electrically coupled to an electrode and a conductor. Expansion of the anchor within a blood vessel biases the electrodes into contact with the surrounding blood vessel wall.
摘要翻译： 用于神经调节的血管内电极装置包括可从径向压缩位置扩展到径向扩张位置的锚。 引线从锚固体延伸并且具有延伸穿过其的至少一个导体。 柔性电路耦合到锚固件并且包括柔性绝缘衬底，由衬底承载的多个电极和由衬底承载的多个导电迹线，每个迹线电耦合到电极和导体。 在血管内锚固体的膨胀将电极偏置成与周围的血管壁接触。
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公开(公告)号：US07899554B2
公开(公告)日：2011-03-01
申请号：US11980006
申请日：2007-10-30
IPC分类号： A61N1/02
CPC分类号： A61N1/057 , A61N1/37205 , A61N1/375
摘要： The present application describes an intravascular implantable pacing and/or defibrillation system. The described system includes a pulse generator that is implantable within a blood vessel and proportioned to blood flow through the blood vessel, and at least one electrode attachable to the pulse generator. During implantation, the pulse generator is introduced into a patient's vasculature, advanced to a desired vessel and anchored in place within the vessel. The electrode or electrodes are placed within the heart or surrounding vessels as needed to deliver electrical pulses to the appropriate location.
摘要翻译： 本申请描述了血管内可植入起搏和/或除颤系统。 所描述的系统包括脉冲发生器，该脉冲发生器可植入血管内并与通过血管的血液流动成比例，以及至少一个可附着到脉冲发生器的电极。 在植入期间，将脉冲发生器引入患者的脉管系统中，前进到期望的血管并锚定在血管内的适当位置。 根据需要将电极或电极放置在心脏或周围血管内，以将电脉冲传递到适当的位置。
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63.发明申请公开(公告)号：US20090281521A1
公开(公告)日：2009-11-12
申请号：US12506232
申请日：2009-07-20
CPC分类号： A61N1/057 , A61N1/37205 , A61N1/375
摘要： The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.
摘要翻译： 本申请描述了用于将医疗装置锚定在脉管系统内的保持装置。 该装置可以包括联接到血管内医疗装置并且成比例地用于在容器内接收的可扩张构件。 可膨胀构件的至少一部分可扩张以径向接合容器壁并由此将医疗装置保持在容器内。 该系统适用于各种血管内装置，包括但不限于ICD，起搏器和血管内药物输送系统。
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64.发明申请Polymeric endoprostheses with enhanced strength and flexibility and methods of manufacture 审中-公开具有增强强度和柔韧性的聚合体内用假体和制造方法公开(公告)号：US20090096137A1
公开(公告)日：2009-04-16
申请号：US12231504
申请日：2008-09-02
IPC分类号： B29C47/88
CPC分类号： A61F2/82 , A61L29/126 , A61L29/18 , A61L31/128 , A61L31/18
摘要： Improved polymeric endoprostheses and methods of manufacturing endoprostheses are disclosed herein. The endoprostheses may comprise one or more polymers wherein the polymer chains are substantially aligned circumferentially, and comprising increased radial strength and flexibility. An endoprosthesis according to the invention may comprise a smooth surface. Endoprostheses disclosed herein may be used in the treatment of strictures in lumens of the body. Alternatively, endoprostheses disclosed herein may be used as anchors to secure medical devices within lumens of the body. The endoprostheses disclosed herein may comprise one or more erodible polymer.
摘要翻译： 本文公开了改进的聚合物内用假体和制造内用假体的方法。 内用假体可以包含一种或多种聚合物，其中聚合物链基本上对齐地对准，并且包括增加的径向强度和柔性。 根据本发明的内用假体可以包括光滑表面。 本文公开的内假体可以用于治疗身体内腔的狭窄。 或者，本文公开的假体可以用作锚固件以将身体内腔内的医疗装置固定。 本文公开的内用假体可以包含一种或多种可侵蚀的聚合物。
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公开(公告)号：US07163554B2
公开(公告)日：2007-01-16
申请号：US10984112
申请日：2004-11-08
申请人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
发明人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2250/0014
摘要： A woven tubular endoprosthesis comprising means for locking the endoprosthesis in a deployed configuration is disclosed. The means for locking the endoprosthesis may comprise locking protrusions, notches, a chemical bond, a curable bond, or other mechanism. The woven fibers comprising the endoprosthesis may be hollow and comprise circumferentially oriented polymeric chains, and may be filled with a curable material. A method of treatment using an endoprosthesis according to the invention is also disclosed.
摘要翻译： 公开了一种编织管状内假体，其包括用于将内置假体锁定在展开构造中的装置。 用于锁定内假体的装置可以包括锁定突起，凹口，化学键，可固化键或其它机构。 包含内用假体的编织纤维可以是中空的并且包括周向取向的聚合物链，并且可以用可固化材料填充。 还公开了使用根据本发明的内置假体的治疗方法。
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公开(公告)号：US20130018247A1
公开(公告)日：2013-01-17
申请号：US13281399
申请日：2011-10-25
CPC分类号： A61N1/05 , A61B5/0422 , A61B5/6862 , A61N1/057
摘要： An intravascular electrode device for use in neuromodulation includes an anchor expandable from a radially compressed position to a radially expanded position. A lead extends from the anchor and has at least one conductor extending through it. A flex circuit is coupled to the anchor and comprises a flexible insulative substrate, a plurality of electrodes carried by the substrate, and a plurality of conductive traces carried by the substrate, each trace electrically coupled to an electrode and a conductor. Expansion of the anchor within a blood vessel biases the electrodes into contact with the surrounding blood vessel wall. An exemplary anchor includes a first portion having expansion forces sufficient to bias the electrodes against the vessel wall for mapping and chronic stimulation, and a second portion having greater radial expansion forces sufficient to chronically engage the vessel wall once an optimal electrode location has been selected.
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67.发明申请公开(公告)号：US20110054555A1
公开(公告)日：2011-03-03
申请号：US12908086
申请日：2010-10-20
CPC分类号： A61N1/057 , A61N1/37205 , A61N1/375
摘要： The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.
摘要翻译： 本申请描述了用于将医疗装置锚定在脉管系统内的保持装置。 该装置可以包括联接到血管内医疗装置并且成比例地用于在容器内接收的可扩张构件。 可膨胀构件的至少一部分可扩张以径向接合容器壁并由此将医疗装置保持在容器内。 该系统适用于各种血管内装置，包括但不限于ICD，起搏器和血管内药物递送系统。
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公开(公告)号：US07857748B2
公开(公告)日：2010-12-28
申请号：US11584784
申请日：2006-10-19
申请人： Michael S. Williams , Kevin D. Holbrook , Richard A. Glenn , Jeffrey A. Smith , Joseph M. DeSimone
发明人： Michael S. Williams , Kevin D. Holbrook , Richard A. Glenn , Jeffrey A. Smith , Joseph M. DeSimone
CPC分类号： A61F2/958 , A61F2002/30583 , A61F2210/0085 , B29C35/0266 , B29C71/04 , B29C2035/0827 , B29L2031/7532
摘要： Methods of manufacture of endoprostheses comprising one or more photocurable materials are disclosed. The endoprostheses may comprise regions wherein the photocurable materials are selectively disposed about the endoprosthesis and are cured according to desired parameters to achieve varying desired properties. Photolithographic masking material may be selectively disposed about an inflatable balloon and exposed to a radiation emitting catheter.
摘要翻译： 公开了包含一种或多种光固化材料的内用假体的制造方法。 内假体可以包括其中可光固化材料围绕内假体选择性地设置并根据期望参数固化以实现变化的所需性质的区域。 光刻掩模材料可以选择性地围绕可膨胀气囊设置并且暴露于辐射放射导管。
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公开(公告)号：US20080177392A1
公开(公告)日：2008-07-24
申请号：US12004322
申请日：2007-12-19
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61B2017/00871 , A61F2/442 , A61F2/4611 , A61F2002/30092 , A61F2002/30242 , A61F2002/30448 , A61F2002/30451 , A61F2002/30583 , A61F2002/30584 , A61F2002/30586 , A61F2002/30588 , A61F2002/3067 , A61F2002/30971 , A61F2002/444 , A61F2002/4627 , A61F2210/0014 , A61F2210/0085 , A61F2220/005 , A61F2220/0058 , A61F2230/0071 , A61F2250/0002 , A61F2310/00407 , A61F2310/00431 , A61F2310/00562
摘要： An artificial intervertebral disc and disc nucleus are described herein having chambers and dampening members. The dampening members may be within or outside of the main body of the device. The chambers may be filled with a suitable liquid, gas, or both, and separated by valves to regulate flow of fluid between chambers, within a dampening member, between the main body and dampening member, or all of the above. Chambers may be filled with responsive hydrogels, EPAM, or other suitable materials, and the device may have activation plates or members, a strain gauge, a pressure sensor, or other means for detecting changes in the materials and/or triggering desired changes in the materials in order to mimic the behavior of a healthy native disc or disc nucleus. A control system may be in communication with the device for receiving feedback and delivering stimuli to initiate desired changes in the fluids or other materials. Membranes may be of variable permeability and may be metallized to ensure as low permeability as possible. Dampening members may be filled during manufacture with carbon dioxide or other suitable gas which may be in a supercritical state and allowed to return to ambient temperature and gaseous state or by other means. Methods of manufacture, delivery of the artificial disc and related structures, and methods of treatment are also described.
摘要翻译： 本文描述了人造椎间盘和椎间盘细胞，其具有腔室和阻尼构件。 阻尼构件可以在装置的主体内或外部。 这些室可以填充合适的液体，气体或两者，并由阀隔开以调节腔室之间，阻尼构件内部，主体和阻尼构件之间的流体流动，或全部上述流体。 腔室可以填充有响应性水凝胶，EPAM或其它合适的材料，并且该装置可以具有活化板或构件，应变计，压力传感器或用于检测材料变化和/或触发材料中的所需变化的其它装置 材料，以模仿健康的本地盘或盘核的行为。 控制系统可以与装置通信，用于接收反馈和递送刺激以启动流体或其它材料中的期望变化。 膜可以具有可变的渗透性并且可以被金属化以确保尽可能低的渗透性。 阻尼构件可以在制造期间用可能处于超临界状态的二氧化碳或其它合适的气体填充并允许其返回到环境温度和气态或通过其他方式。 还描述了制造，输送人造盘和相关结构的方法，以及处理方法。
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公开(公告)号：US20150328021A1
公开(公告)日：2015-11-19
申请号：US14120397
申请日：2014-05-16
申请人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
发明人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
IPC分类号： A61F2/82
CPC分类号： A61F2/945 , A61F2/82 , A61F2/90 , A61F2210/0085 , A61F2220/0033 , A61F2250/0019 , A61F2250/0036 , A61F2250/0057
摘要： A woven tubular endoprosthesis comprising means for locking the endoprosthesis in a deployed configuration is disclosed. The means for locking the endoprosthesis may comprise locking protrusions, notches, a chemical bond, a curable bond, or other mechanism. The woven fibers comprising the endoprosthesis may be hollow and comprise circumferentially oriented polymeric chains, and may be filled with a curable material. A method of treatment using an endoprosthesis according to the invention is also disclosed.
摘要翻译： 公开了一种编织管状内假体，其包括用于将内置假体锁定在展开构造中的装置。 用于锁定内假体的装置可以包括锁定突起，凹口，化学键，可固化键或其它机构。 包含内用假体的编织纤维可以是中空的并且包括周向取向的聚合物链，并且可以用可固化材料填充。 还公开了使用根据本发明的内置假体的治疗方法。
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