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公开(公告)号：US08952323B2
公开(公告)日：2015-02-10
申请号：US12092601
申请日：2006-11-10
CPC分类号： H01J49/004 , G01N27/622 , H01J49/0031 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a first ion trap or ion guide (2), a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).
摘要翻译： 公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器 ）。 在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。
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公开(公告)号：US08704164B2
公开(公告)日：2014-04-22
申请号：US13109585
申请日：2011-05-17
IPC分类号： H01J49/40
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Capture Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Capture Dissociation fragmentation device.
摘要翻译： 用于分析组分混合物的方法包括通过使组分在一段时间内顺序洗脱的方式分离或部分分离样品混合物的组分，从洗脱液中的组分形成前体离子，重复切换， 在高分裂模式和低碎裂模式之间来回地改变或改变电子俘获解离破碎装置，以在高分裂模式中交替地从前体离子产生产物离子，并在低分散模式中产生基本上更少的产物离子， 并且从从电子俘获解离破碎装置接收的前体和产物离子的时间段内获得质谱。
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公开(公告)号：US20110210242A1
公开(公告)日：2011-09-01
申请号：US13054171
申请日：2009-07-16
CPC分类号： H01J49/147 , H01J27/02 , H01J49/0077
摘要： An ion source is disclosed wherein a sample is introduced into the sample chamber (1) of the ion source in the gas phase via a sample introduction capillary tube (2). The sample is directed onto a heated surface (6) coated with an oxidising reagent such as copper oxide. Carbon in the sample is oxidised to form carbon dioxide. The resulting carbon dioxide molecules are then ionised by electron impact ionisation with an electron beam (3) and the resulting ions are passed to a mass analyser for mass analysis.
摘要翻译： 公开了一种离子源，其中将样品通过样品导入毛细管（2）引入到气相中的离子源的样品室（1）中。 样品被引导到涂覆有氧化剂如氧化铜的加热表面（6）上。 样品中的碳被氧化形成二氧化碳。 然后用电子束（3）通过电子轰击电离将所得二氧化碳分子电离，并将所得离子通过质量分析器进行质量分析。
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公开(公告)号：US20110095175A1
公开(公告)日：2011-04-28
申请号：US11568167
申请日：2005-04-20
CPC分类号： G01N27/624 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a FAIMS device comprising two parallel electrodes (9a, 9b) in series with an ion mobility separator (12) forming part of a mass spectrometer. Ions are separated in the FAIMS device (9a, 9b) according to their rate of change of ion mobility with electric field strength. The ions which are onwardly transmitted from the FAIMS device (9a, 9b) are then passed to an ion separator device (12) comprising a plurality of electrodes (12) and an optional ion trapping region (33). Ions are radially confined with the ion separator by application of an AC or RF voltage to the electrodes (12) and ions are separated according to their ion mobility by applying an axial DC voltage gradient which may remain constant as a function of time or which may vary with time.
摘要翻译： 公开了一种质谱仪，其包括FAIMS装置，其包括与形成质谱仪的一部分的离子迁移率分离器（12）串联的两个平行电极（9a，9b）。 根据其离子迁移率随电场强度的变化率，在FAIMS装置（9a，9b）中分离离子。 然后将从FAIMS装置（9a，9b）向前传播的离子传送到包括多个电极（12）和任选的离子捕获区域（33）的离子分离装置（12）。 离子通过向电极（12）施加AC或RF电压而与离子分离器径向地限制，并且通过施加可以保持恒定的时间的函数的轴向DC电压梯度，其离子根据其离子迁移率而分离，或者可以 随时间变化。
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公开(公告)号：US20110042565A1
公开(公告)日：2011-02-24
申请号：US12917720
申请日：2010-11-02
IPC分类号： H01J49/40
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator 4 and an ion guide 6 arranged downstream of the ion mobility spectrometer or separator 4. A plurality of axial potential wells are created in the ion guide 6 so that ions received from the ion mobility spectrometer or separator 4 become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator 4. The potential wells are translated along the length of the ion guide 6.
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪或分离器4和布置在离子迁移谱仪或分离器4下游的离子导向器6.在离子导向器6中产生多个轴向势阱，使得从离子迁移率 光谱仪或分离器4被限制在单独的轴向势阱中。 势阱保持从离子迁移谱仪或分离器4接收的离子的保真度和/或组成。势阱沿离子导向器6的长度平移。
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公开(公告)号：US07829841B2
公开(公告)日：2010-11-09
申请号：US11718213
申请日：2005-11-03
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (4) and an ion guide (6) arranged downstream of the ion mobility spectrometer or separator (4). A plurality of axial potential wells are created in the ion guide (6) so that ions received from the ion mobility spectrometer or separator (4) become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator (4). The potential wells are translated along the length of the ion guide (6).
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪或分离器（4）和布置在离子迁移谱仪或分离器（4）的下游的离子导向器（6）。 在离子导向器（6）中产生多个轴向势阱，使得从离子迁移谱仪或分离器（4）接收的离子被限制在单独的轴向势阱中。 潜在的孔维持从离子迁移谱仪或分离器（4）接收的离子的保真度和/或组成。 潜在的井沿离子导向件（6）的长度平移。
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公开(公告)号：US20100065737A1
公开(公告)日：2010-03-18
申请号：US11721260
申请日：2005-12-08
申请人： Robert Harold Bateman , Kevin Giles , Jeffrey Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Jeffrey Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser (4) arranged upstream of an ion guide (6). Ions are scanned out of the mass selective ion trap or mass analyser (4) and are received in one or more axial potential wells created or formed within the ion guide (6). One or more transient DC voltages or potentials are preferably applied to the ion guide (6) in order to create a plurality of axial potential wells which are translated along the length of the ion guide (6). Ions are released in packets from the exit of the ion guide (6) and are orthogonally accelerated into a drift or flight region of an orthogonal acceleration Time of Flight mass analyser (13) with a relatively high duty cycle.
摘要翻译： 公开了一种质谱仪，其包括布置在离子导向器（6）上游的质量选择性离子阱或质量分析器（4）。 从质量选择性离子阱或质量分析器（4）中扫描离子，并将其接收在离子导向器（6）内产生或形成的一个或多个轴向势阱中。 优选地将一个或多个瞬态DC电压或电位施加到离子导向器（6），以便产生沿离子导向件（6）的长度平移的多个轴向势阱。 从离子导向器（6）的出口以分组的形式释放离子，并以相对较高的占空比正交加速到正交加速时间飞行质量分析器（13）的漂移或飞行区域。
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公开(公告)号：US20100001180A1
公开(公告)日：2010-01-07
申请号：US12302168
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译： 公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。 来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。 如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。
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公开(公告)号：US20080135746A1
公开(公告)日：2008-06-12
申请号：US11574554
申请日：2005-09-14
IPC分类号： B01D59/44
CPC分类号： H01J49/005
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (3). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (3) is increased substantially linearly with time in order to optimise the fragmentation energy of ions as they enter the collision or fragmentation cell (5).
摘要翻译： 公开了一种质谱仪，其包括设置在碰撞或破碎电池（5）的上游的离子迁移谱仪或分离器（3）。 离子在离子迁移谱仪或分离器（3）内根据其离子迁移率分离。 离子离子迁移谱仪或分离器（3）离子的动能随时间呈线性增加，以优化离子进入碰撞或破碎电池（5）时的碎裂能。
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公开(公告)号：US20080121796A1
公开(公告)日：2008-05-29
申请号：US11568347
申请日：2005-04-26
IPC分类号： H01J49/02
CPC分类号： H01J43/246 , H01J49/025
摘要： An ion detector for a mass spectrometer is provided wherein a mask (10) is provided between a first microchannel plate (2a) and a second microchannel plate (2b). The mask (10) prevents ion arrival events causing a cloud of secondary electrons to be from the second microchannel plate (2b) which would illuminate two collection anodes (5,6) at substantially the same time. The mask (10) also prevents electron clouds emitted which would otherwise vary significantly in intensity.
摘要翻译： 提供了一种用于质谱仪的离子检测器，其中在第一微通道板（2a）和第二微通道板（2b）之间设置有掩模（10）。 掩模（10）防止导致二次电子云的离子到达事件来自第二微通道板（2b），其将基本上同时照射两个收集阳极（5,6）。 掩模（10）还防止了否则在强度上会显着变化的电子云。
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