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68 条记录 (耗时 0.055 秒)

    MEDICAL DEVICE TO PROVIDE BREATHING THERAPY
    62.
    发明申请
    MEDICAL DEVICE TO PROVIDE BREATHING THERAPY 有权
    医疗设备提供呼吸治疗

    公开(公告)号：US20150045848A1

    公开(公告)日：2015-02-12

    申请号：US13961963

    申请日：2013-08-08

    申请人： Yong K. Cho ,  Shaileshkumar V. Musley ,  Avram Scheiner

    发明人： Yong K. Cho ,  Shaileshkumar V. Musley ,  Avram Scheiner

    IPC分类号： A61N1/36 ,  A61N1/365

    CPC分类号： A61N1/3601 ,  A61B5/0205 ,  A61B5/02405 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/6869 ,  A61B5/6877 ,  A61N1/36521 ,  A61N1/36585

    摘要： Medical devices and methods for providing breathing therapy (e.g., for treating heart failure, hypertension, etc.) may determine at least the inspiration phase of one or more breathing cycles based on the monitored physiological parameters and control delivery of a plurality of breathing therapy sessions (e.g., each of the breathing therapy sessions may be provided during a defined time period). Further, each of the plurality of breathing therapy sessions may include delivering stimulation after the start of the inspiration phase of each of a plurality of breathing cycles to prolong diaphragm contraction during the breathing cycle.

    摘要翻译： 用于提供呼吸治疗（例如，用于治疗心力衰竭，高血压等）的医疗装置和方法可以基于所监测的生理参数和多个呼吸治疗会话的控制递送来至少确定一个或多个呼吸周期的吸气阶段 （例如，可以在限定的时间段内提供每个呼吸治疗会话）。 此外，多个呼吸治疗会话中的每一个可以包括在多个呼吸周期中的每一个呼吸循环的启动阶段开始之后递送刺激，以在呼吸循环期间延长膜片收缩。

    Medical device to provide breathing therapy
    63.
    发明授权
    Medical device to provide breathing therapy 有权
    医疗器械提供呼吸治疗

    公开(公告)号：US08509902B2

    公开(公告)日：2013-08-13

    申请号：US13192914

    申请日：2011-07-28

    申请人： Yong K. Cho ,  Shaileshkumar Musley ,  Avram Scheiner

    发明人： Yong K. Cho ,  Shaileshkumar Musley ,  Avram Scheiner

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3655 ,  A61N1/3601 ,  A61N1/3611 ,  A61N1/36521

    摘要： Medical devices and methods for providing breathing therapy (e.g., for treating heart failure, hypertension, etc.) may determine at least the inspiration phase of one or more breathing cycles based on the monitored physiological parameters and control delivery of a plurality of breathing therapy sessions (e.g., each of the breathing therapy sessions may be provided during a defined time period). Further, each of the plurality of breathing therapy sessions may include delivering stimulation after the start of the inspiration phase of each of a plurality of breathing cycles to prolong diaphragm contraction during the breathing cycle.

    摘要翻译： 用于提供呼吸治疗（例如，用于治疗心力衰竭，高血压等）的医疗装置和方法可以基于所监测的生理参数和多个呼吸治疗会话的控制递送来至少确定一个或多个呼吸周期的吸气阶段 （例如，可以在限定的时间段内提供每个呼吸治疗会话）。 此外，多个呼吸治疗会话中的每一个可以包括在多个呼吸周期中的每一个呼吸循环的启动阶段开始之后递送刺激，以在呼吸循环期间延长膜片收缩。

    ALGORITHM FOR THE AUTOMATIC DETERMINATION OF OPTIMAL AV AND VV INTERVALS
    64.
    发明申请
    ALGORITHM FOR THE AUTOMATIC DETERMINATION OF OPTIMAL AV AND VV INTERVALS 有权
    用于自动确定最佳AV和VV间隔的算法

    公开(公告)号：US20120150253A1

    公开(公告)日：2012-06-14

    申请号：US13400381

    申请日：2012-02-20

    申请人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

    发明人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

    摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.

    摘要翻译： 用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。 在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。 为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。 另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。 另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。 另一实施例改变VV间隔以最大化阻抗变化。

    Algorithm for the automatic determination of optimal pacing intervals
    66.
    发明授权
    Algorithm for the automatic determination of optimal pacing intervals 失效
    自动确定最佳起搏间隔的算法

    公开(公告)号：US07711423B2

    公开(公告)日：2010-05-04

    申请号：US11135921

    申请日：2005-05-24

    申请人： John E. Burnes ,  David A. Igel ,  John C. Rueter ,  Yong K. Cho ,  Luc R. Mongeon ,  Harold E. Stone ,  Jodi Zilinski

    发明人： John E. Burnes ,  David A. Igel ,  John C. Rueter ,  Yong K. Cho ,  Luc R. Mongeon ,  Harold E. Stone ,  Jodi Zilinski

    IPC分类号： A61N1/362

    CPC分类号： A61N1/36521

    摘要： Impedance, e.g. sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change. Other methods vary the AA interval to maximize impedance change over the entire cardiac cycle or during the atrial cycle.

    摘要翻译： 阻抗，例如 亚阈值阻抗是在选定心脏周期时间内心脏测量的，作为腔室扩张或收缩的量度。 为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。 另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。 另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。 另一实施例改变VV间隔以最大化阻抗变化。 其他方法改变AA间隔以最大化整个心动周期或心房周期期间的阻抗变化。

    High loading of immobilized enzymes on activated carbon supports
    68.
    发明授权
    High loading of immobilized enzymes on activated carbon supports 失效
    固定化酶在活性炭载体上的高负载量

    公开(公告)号：US4204041A

    公开(公告)日：1980-05-20

    申请号：US838544

    申请日：1977-10-03

    申请人： James E. Bailey ,  Yong K. Cho

    发明人： James E. Bailey ,  Yong K. Cho

    IPC分类号： C12N11/06 ,  C12N11/14 ,  C07G7/02

    CPC分类号： C12N11/06 ,  C12N11/14

    摘要： Enzymes are immobilized on activated carbon supports at high load levels and with high stability by a procedure whereby a carbon support is first activated with a water-soluble carbodiimide derivative which forms a highly reactive intermediate with carboxyl and other active organic radicals on the surface of the carbon support; thereafter the complex of the carbon and carbodiimide is treated with an enzyme solution whereby the enzyme displaces the carbodiimide and forms a carbon-enzyme complex wherein the enzyme is immobilized and yet the carbon retains its surface activity. Preferred immobilizing agents are quaternary ammonium forms of aminocarbodiimides or hydrochloric acid salts of water-soluble carbodiimides. The immobilization of the enzymes on activated carbon provides materials which are easily handled and which are stabilized against denaturation by hydrogen peroxide.

    摘要翻译： 酶以高负载水平固定在活性炭载体上，并具有高稳定性，其中碳载体首先用水溶性碳二亚胺衍生物活化，该衍生物在羧基和其它活性有机基团的表面上形成高反应性中间体 碳支持; 此后用酶溶液处理碳和碳二亚胺的络合物，由此酶置换碳二亚胺并形成酶固定化的碳 - 酶复合物，而碳保留其表面活性。 优选的固定剂是氨基碳二亚胺的季铵形式或水溶性碳二亚胺的盐酸盐。 将酶固定在活性炭上提供容易处理的物质，并且其被稳定以防止过氧化氢变性。