公开(公告)号：US08462956B2

公开(公告)日：2013-06-11

申请号：US11931252

申请日：2007-10-31

申请人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

发明人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

IPC分类号： H04R29/00 ,  H04R25/02 ,  G06F17/00 ,  G01C3/08

CPC分类号： H04R1/1083 ,  A61B5/121 ,  A61B5/746 ,  A61F2011/145 ,  G01H3/14 ,  H04R29/00

摘要： A system for monitoring sound pressure levels at the ear includes an ambient sound microphone (ASM) for receiving ambient sounds and an ear canal microphone (ECM) for producing audio signals as a function of ambient sound received at the ambient sound microphone and a sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECM calculates a total SPL_Dose experienced by the ear at a time t. The total SPL_Dose is calculated by determining SPL_Dose for periods Δt as measured at the ECM. The logic circuit may select an action parameter in response to the Total SPL_Dose.

摘要翻译： 用于监测耳朵上的声压级的系统包括用于接收环境声音的环境声麦克风（ASM）和用于产生作为在环境声音麦克风​​处接收的环境声音的函数的音频信号的耳道麦克风（ECM），以及声音信号 从相关联的个人音频设备接收。 逻辑电路与ASM可操作地相关联，并且ECM在时间t计算由耳朵经历的总SPL_Dose。 通过在ECM处测量的周期Deltat确定SPL_Dose来计算总SPL_Dose。 逻辑电路可以响应于总SPL_Dose来选择动作参数。

公开(公告)号：US08194864B2

公开(公告)日：2012-06-05

申请号：US11928290

申请日：2007-10-30

申请人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

发明人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

IPC分类号： H04R29/00 ,  A61F11/06 ,  A61B5/12

CPC分类号： A61B5/6817 ,  A61B5/121 ,  G01H3/14

摘要： Methods of operating an audio device are provided. A method includes calculating estimated sound pressure levels (SPLs) for drive signals directed to an ear canal receiver (ECR) during a time increment Δt; calculating an estimated SPL_Dose during the time increment Δt using the estimated sound pressure levels; and calculating a total SPL_Dose at a time t of the audio device using the estimated SPL_Dose.

摘要翻译： 提供操作音频设备的方法。 一种方法包括在时间增量＆Dgr; t期间计算针对耳道接收器（ECR）的驱动信号的估计声压级（SPL）; 使用估计的声压级在时间增量＆Dgr; t期间计算估计的SPL_Dose; 以及使用估计的SPL_Dose在音频设备的时间t计算总SPL_Dose。

公开(公告)号：US07817803B2

公开(公告)日：2010-10-19

申请号：US11767181

申请日：2007-06-22

申请人： Steven W. Goldstein

发明人： Steven W. Goldstein

IPC分类号： H04R29/00

CPC分类号： H04R1/1083 ,  A61B5/0002 ,  A61B5/121 ,  G01H3/14 ,  H04R5/033 ,  H04R2420/07 ,  H04R2430/01

摘要： At least one exemplary embodiment is directed to a method of monitoring hearing health comprising: measuring a first acoustic sound pressure level due to an ambient audio signal; measuring a second acoustic sound pressure level due to an emitted audio signal from a speaker; calculating a total sound pressure level dosage, where the total sound pressure level dosage is calculated using the first acoustic sound pressure level and a first time span, and the second acoustic sound pressure level and a second time span associated, where the first time span is the time associated with the measured first acoustic sound pressure level and second time span is the time associated with the measured second acoustic sound pressure level; and sending a notification signal when total sound pressure level dosage is greater than a threshold value.

摘要翻译： 至少一个示例性实施例涉及一种监测听力健康的方法，包括：测量由于环境音频信号引起的第一声压级; 由扬声器发出的音频信号测量第二声压级; 计算总声压级剂量，其中使用第一声压级和第一时间跨度计算总声压级剂量，以及第二声压级和第二时间跨度，其中第一时间跨度为 与所测量的第一声压级和第二时间跨度相关联的时间是与所测量的第二声压级相关联的时间; 以及当总声压级别剂量大于阈值时发送通知信号。

公开(公告)号：US20080205660A1

公开(公告)日：2008-08-28

申请号：US11767181

申请日：2007-06-22

申请人： Steven W. Goldstein

发明人： Steven W. Goldstein

IPC分类号： H04R29/00

CPC分类号： H04R1/1083 ,  A61B5/0002 ,  A61B5/121 ,  G01H3/14 ,  H04R5/033 ,  H04R2420/07 ,  H04R2430/01

摘要： At least one exemplary embodiment is directed to a method of monitoring hearing health comprising: measuring a first acoustic sound pressure level due to an ambient audio signal; measuring a second acoustic sound pressure level due to an emitted audio signal from a speaker; calculating a total sound pressure level dosage, where the total sound pressure level dosage is calculated using the first acoustic sound pressure level and a first time span, and the second acoustic sound pressure level and a second time span associated, where the first time span is the time associated with the measured first acoustic sound pressure level and second time span is the time associated with the measured second acoustic sound pressure level; and sending a notification signal when total sound pressure level dosage is greater than a threshold value.

摘要翻译： 至少一个示例性实施例涉及一种监测听力健康的方法，包括：测量由于环境音频信号引起的第一声压级; 由扬声器发出的音频信号测量第二声压级; 计算总声压级剂量，其中使用第一声压级和第一时间跨度计算总声压级剂量，以及第二声压级和第二时间跨度，其中第一时间跨度为 与所测量的第一声压级和第二时间跨度相关联的时间是与所测量的第二声压级相关联的时间; 以及当总声压级别剂量大于阈值时发送通知信号。

公开(公告)号：US20080144842A1

公开(公告)日：2008-06-19

申请号：US11931252

申请日：2007-10-31

申请人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

发明人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

IPC分类号： H04R29/00

CPC分类号： H04R1/1083 ,  A61B5/121 ,  A61B5/746 ,  A61F2011/145 ,  G01H3/14 ,  H04R29/00

摘要： A system for monitoring sound pressure levels at the ear includes an ambient sound microphone (ASM) for receiving ambient sounds and an ear canal microphone (ECM) for producing audio signals as a function of ambient sound received at the ambient sound microphone and sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECM calculates a total SPL_Dose experienced by the ear at a time t. In one exemplary embodiment, the total SPL_Dose is calculated by determining SPL_Dose for periods Δt as measured at the ECM. The logic circuit then may then select an action parameter in response to the Total SPL_Dose.

摘要翻译： 用于监测耳朵声压级的系统包括用于接收环境声音的环境声麦克风（ASM）和用于产生作为在环境声音麦克风​​处接收的环境声音的功能的音频信号和接收的声音信号的耳道麦克风（ECM） 来自相关联的个人音频设备。 逻辑电路与ASM可操作地相关联，并且ECM在时间t计算由耳朵经历的总SPL_Dose。 在一个示例性实施例中，通过在ECM处测量的周期Deltat确定SPL_Dose来计算总SPL_Dose。 然后逻辑电路可以响应于总SPL_Dose来选择动作参数。

公开(公告)号：US06576632B1

公开(公告)日：2003-06-10

申请号：US09548460

申请日：2000-04-13

申请人： Steven W. Goldstein ,  Kelly P. Longo ,  James F. Blake ,  Mohamed M. A. Awad ,  Kenneth P. Raiche ,  Kevin W. Kramer

发明人： Steven W. Goldstein ,  Kelly P. Longo ,  James F. Blake ,  Mohamed M. A. Awad ,  Kenneth P. Raiche ,  Kevin W. Kramer

IPC分类号： C07C23305

CPC分类号： C07C233/51 ,  C07C233/11 ,  C07C233/83 ,  C07C311/51 ,  C07C2601/14 ,  C07C2602/10

摘要： The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b, m, n, p and v are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and methods of treating hyperproliferative disorders in mammals by administering the above compounds.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，水合物和前药，其中R1，R2，R3，R4，R5，R10，R11，b，m，n，p和v如本文所定义。 本发明还涉及含有上述化合物的药物组合物和通过施用上述化合物治疗哺乳动物中过度增殖性疾病的方法。

公开(公告)号：US06541495B1

公开(公告)日：2003-04-01

申请号：US09548937

申请日：2000-04-13

申请人： Steven W. Goldstein ,  Kelly P. Longo ,  Bernard Hulin

发明人： Steven W. Goldstein ,  Kelly P. Longo ,  Bernard Hulin

IPC分类号： A61K3142

CPC分类号： A61K31/343

摘要： A method of treating hyperproliferation diseases in mammals in need of such treatment, which method includes administering to said mammal a therapeutically effective amount of a compound of the formula: or a pharmaceutically acceptable salt, hydrate or prodrug thereof, wherein R1, R2, R3, R4, W, X, Y, Z and t are as defined herein.

摘要翻译： 一种在需要这种治疗的哺乳动物中治疗过度增生疾病的方法，该方法包括向所述哺乳动物施用治疗有效量的下式化合物或其药学上可接受的盐，水合物或前药，其中R1，R2，R3， R4，W，X，Y，Z和t如本文所定义。

公开(公告)号：US06242461B1

公开(公告)日：2001-06-05

申请号：US09578655

申请日：2000-05-25

申请人： Steven W. Goldstein ,  William G. Stirtan ,  Brian A. Sherer

发明人： Steven W. Goldstein ,  William G. Stirtan ,  Brian A. Sherer

IPC分类号： A61K31435

CPC分类号： A61K31/444 ,  A61K31/437 ,  A61K45/06

摘要： This invention relates to novel aryl substituted azabenzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof wherein n is an integer from 1 to 4 X is CH or N; R1 is H, (C1-C6)alkyl or (C1-C6) alkoxy; R2 is H, (C1-C6)alkyl or (C1-C6) alkoxy; each R3 is independently selected from H, (C1-C6)alkyl (C1-C6) alkyloxy, (C1-C6) alkylthio, halo, nitro, cyano, ethynyl, hydroxy and trifluoromethyl; R4 is H, (C1-C6)alkyl or (C1-C6) alkoxy; R5 is H, (C1-C6)alkyl or (C1-C6) alkyloxy, trifluoromethyl; and W is N or C; Y is N (R4), N, S or O Z is R4, NR4H, O, or OH; Provided that when Y═NR4, W═C, Z═O, there is a single bond between YW and a double bond between WZ; and when Y=O or S, W═C, Z═O, there is a single bond between YW and a double bond between WZ; and when Y═N, W═N, there is a double bond between YW and Z does not exist. when Y═N, W═C, Z═R4 or NHR4, there is a double bond between YW and a single bond between WZ; The methods of preparing these compounds and their use in the treatment of HIV, AIDS, and AIDS related diseases and in slowing the progression of HIV infection into AIDS is also disclosed.

摘要翻译： 本发明涉及式（I）的新的芳基取代的氮杂苯并咪唑及其药学上可接受的盐。或其药学上可接受的盐，其中n是1至4X的整数是CH或N; R 1是H，（C 1 -C 6）烷基或（ C1-C6）烷氧基; R2是H，（C1-C6）烷基或（C1-C6）烷氧基;每个R3独立地选自H，（C1-C6）烷基（C1-C6）烷氧基，（C1-C6） R4是H，（C1-C6）烷基或（C1-C6）烷氧基; R5是H，（C1-C6）烷基或（C1-C6）烷氧基， 三氟甲基 并且W为N或C; Y为N（R4），N，S或OZ为R4，NR4H，O或OH;条件是当Y = NR4时，W = C，Z = O，YW 和WZ之间的双键; 当Y = O或S时，W = C，Z = O，WW之间的YW与双键之间存在单键; 当Y = N，W = N时，YW和Z之间不存在双键。当Y = N，W = C，Z = R4或NHR4时，YW与WZ之间的单键存在双键 ; 还公开了制备这些化合物及其用于治疗艾滋病毒，艾滋病和艾滋病相关疾病以及将艾滋病毒感染进一步减缓为艾滋病的方法。

公开(公告)号：US6020335A

公开(公告)日：2000-02-01

申请号：US963852

申请日：1997-11-04

申请人： Arthur A. Nagel ,  Steven W. Goldstein ,  Stanley Jung ,  Peter H. Dorff

发明人： Arthur A. Nagel ,  Steven W. Goldstein ,  Stanley Jung ,  Peter H. Dorff

IPC分类号： C07D401/12 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/501 ,  A61P1/00 ,  A61P3/04 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P25/34 ,  C07D401/06 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D213/62 ,  C07D213/36 ,  C07D213/44 ,  C07D213/79

CPC分类号： C07D401/06 ,  C07D417/06 ,  C07D471/04

摘要： An (N-(pyridinylmethyl)-heterocyclic)ylideneamine compound of the formula ##STR1## wherein R.sup.3, A, and B are as described below, and its pharmaceutically acceptable salts and prodrugs. Compounds of the formula I and their pharmaceutically acceptable salts and prodrugs are useful in the treatment of addictive disorders, such as the use of tobacco or other nicotine containing products, neurological and mental disorders such as senile dementia of the Alzheimer's type, Parkinson's disease, attentional hyperactivity disorder, anxiety, obesity, Tourette's Syndrome and ulcerative colitis.

摘要翻译： 具有下式的（N-（吡啶基甲基） - 杂环）亚基胺化合物及其药学上可接受的盐和前药其中R 3，A和B如下所述。 式I化合物及其药学上可接受的盐和前药可用于治疗成瘾性疾病，例如使用烟草或其他含有尼古丁的产品，神经和精神障碍，例如老年痴呆型老年痴呆，帕金森病，注意 多动障碍，焦虑症，肥胖，Tourette综合征和溃疡性结肠炎。

公开(公告)号：US5463070A

公开(公告)日：1995-10-31

申请号：US391308

申请日：1995-02-17

申请人： Steven W. Goldstein ,  Ruth E. McDermott

发明人： Steven W. Goldstein ,  Ruth E. McDermott

IPC分类号： A61K31/42 ,  A61K31/421 ,  A61P3/06 ,  A61P3/08 ,  C07D20060101 ,  C07D213/12 ,  C07D213/14 ,  C07D263/32 ,  C07D263/34 ,  C07D263/38 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14

CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

摘要： Certain 1-(benzyl or 5-benzofuranylmethyl)-1-hydroxyurea derivatives are useful as hypoglycemic and hypocholesterolemic agents.

摘要翻译： 某些1-（苄基或5-苯并呋喃基甲基）-1-羟基脲衍生物可用作低血糖和低胆固醇血症药。