公开(公告)号：US20120037506A1

公开(公告)日：2012-02-16

申请号：US13279787

申请日：2011-10-24

申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

IPC分类号： G01N27/327 ,  G01N33/50

CPC分类号： G01N27/3274

摘要： The present invention provides a method of electrochemically measuring a hematocrit (Hct) value using a sensor, capable of achieving excellent measurement accuracy and reliability and also provides a sensor used in the method. The method of electrochemically measuring a hematocrit (Hct) value of blood include: providing an electrode system having a working electrode (11) and a counter electrode (12), in which a redox substance is provided on the counter electrode (12) but not on the working electrode (11); supplying blood to the electrode system; applying a voltage to the electrode system in this state to cause an oxidation current or a reduction current to flow between the working electrode (11) and the counter electrode (12); detecting the oxidation current or the reduction current; and determining a Hct value based on a value of the detected current.

摘要翻译： 本发明提供一种使用传感器电化学测量血细胞比容（Hct）值的方法，其能够实现优异的测量精度和可靠性，并且还提供了该方法中使用的传感器。 电化学测量血液血细胞比容（Hct）值的方法包括：提供具有工作电极（11）和对电极（12）的电极系统，其中在对电极（12）上设置氧化还原物质 在工作电极（11）上; 向电极系统供应血液; 在该状态下向电极系统施加电压，使得氧化电流或还原电流在工作电极（11）和对电极（12）之间流动。 检测氧化电流或还原电流; 以及基于检测到的电流的值确定Hct值。

公开(公告)号：US20100261935A1

公开(公告)日：2010-10-14

申请号：US12742873

申请日：2008-11-14

申请人： Tetsuya Ooyama ,  Takashi Onozawa ,  Shin Ikeda ,  Yoshinobu Suzuki

发明人： Tetsuya Ooyama ,  Takashi Onozawa ,  Shin Ikeda ,  Yoshinobu Suzuki

IPC分类号： C07C45/61

CPC分类号： C07C45/80 ,  C07C2602/08 ,  C07C49/67

摘要： [Problems to be Solved] The present invention aims to provide a method for efficiently producing a high-purity alkoxyindanone derivative while maintaining an industrially superior volumetric efficiency.[Solution] Provided is a method for producing an alkoxyindanone derivative represented by a general formula in FIG. 2 (wherein R represents an alkoxy group containing 1 to 6 carbon atoms and n represents an integer of 1 to 4), comprising reacting an alkoxyphenylpropionic acid derivative represented by a general formula in FIG. 1 (wherein R and n are as defined above) with a condensing agent, adding an organic solvent to the resulting reaction mixture, and subsequently decomposing the condensing agent with an aqueous alkaline solution.

摘要翻译： [待解决的问题]本发明的目的在于提供一种有效地制造高纯度烷氧基茚满酮衍生物的方法，同时保持了工业上优异的体积效率。 [解决方案]提供一种制备图1中通式所示的烷氧基茚满酮衍生物的方法。 2（其中R表示含有1至6个碳原子的烷氧基，n表示1至4的整数），包括使由图1中的通式表示的烷氧基苯基丙酸衍生物反应。 1（其中R和n如上定义）与缩合剂反应，向所得反应混合物中加入有机溶剂，随后用碱性水溶液分解缩合剂。

公开(公告)号：US07238160B2

公开(公告)日：2007-07-03

申请号：US10512939

申请日：2004-01-16

申请人： Yuko Taniike ,  Mariko Miyashita ,  Shin Ikeda ,  Toshihiko Yoshioka

发明人： Yuko Taniike ,  Mariko Miyashita ,  Shin Ikeda ,  Toshihiko Yoshioka

IPC分类号： A61B5/00

CPC分类号： A61B5/6843 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150259 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150748 ,  A61B5/150954 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/157 ,  A61B5/417

摘要： The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus. The puncture mechanism includes a puncture needle, and a cap which is detachably engaged with a body of the apparatus, wherein the cap has a skin contact surface which is brought into contact with the skin for puncturing. The skin contact surface having an opening through which the puncture needle moves to puncture the skin, and is shaped so as to fit a surface shape of the skin to be punctured. The set includes a plurality of different caps each corresponding to a different sample collection site so that a plurality of different sample collection sites can be selected.

摘要翻译： 生物成分测定装置技术领域本发明涉及一种生物成分测定装置，其特征在于，将生物体测定装置与被检体的皮肤刺穿用于收集血样的穿刺机构一体化。 穿刺机构包括穿刺针和与装置的主体可拆卸地接合的帽，其中，所述帽具有与皮肤接触以进行穿刺的皮肤接触表面。 皮肤接触表面具有穿刺针穿过的穿刺孔，并且被成形为适合要刺穿的皮肤的表面形状。 该集合包括多个不同的盖，每个不同的盖对应于不同的采样站点，从而可以选择多个不同的样本采集站点。

公开(公告)号：US20070138026A1

公开(公告)日：2007-06-21

申请号：US10598001

申请日：2005-04-18

申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

IPC分类号： C12Q1/00 ,  G01N33/487

CPC分类号： G01N27/3272 ,  A61B5/14546 ,  A61B5/1486 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3274 ,  G01N27/3277 ,  G01N27/413 ,  G01N33/49

摘要： The present invention provides a method of measuring a component in blood, by which the amounts of blood cells and an interfering substance can be measured with high accuracy and high reliability and the amount of the component can be corrected accurately based on the amounts of the blood cells and the interfering substance. In a sensor for measuring a blood component, a first working electrode 13 measures a current that flows during a redox reaction of a blood component, a second working electrode 17 measures the amount of blood cells, and a third working electrode 12 measures the amount of an interfering substance. Next, based on the measurement results, the amount of the blood component to be measured is corrected. Thus, more accurate and precise measurement of the amount of the blood component can be realized.

摘要翻译： 本发明提供一种测定血液成分的方法，通过该方法能够以高精度，高可靠性测定血细胞量和干扰物质的量，并且能够根据血液的量准确地校正成分的量 细胞和干扰物质。 在用于测量血液成分的传感器中，第一工作电极13测量在血液成分的氧化还原反应期间流动的电流，第二工作电极17测量血细胞的量，第三工作电极12测量 干扰物质。 接下来，基于测定结果，校正被测量的血液成分的量。 因此，可以实现对血液成分量的更准确和精确的测量。

公开(公告)号：US20070131565A1

公开(公告)日：2007-06-14

申请号：US10578275

申请日：2004-12-03

申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

IPC分类号： C12Q1/00

CPC分类号： G01N27/3274 ,  C12Q1/001 ,  C12Q1/006 ,  G01N33/66 ,  G01N33/728

摘要： The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The sensor for measuring a component in blood has a first analysis portion and a second analysis portion. The first analysis portion has a first electrode system (11,12) and a reagent layer (14), and the reagent layer (14) has an oxidoreductase that acts on the component and a mediator. In the first analysis portion, the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and detecting a redox current caused when a voltage is applied by the first electrode (11,12). The second analysis portion has a working electrode and a counter electrode, and a mediator is provided on the counter electrode but not on the working electrode. In the second analysis portion, a Hct value of the blood is measured by supplying the blood to the electrode system, applying a voltage to cause a current to flow, and detecting a value of the current. Using this Hct value, the amount of the component is corrected.

摘要翻译： 本发明提供了一种测量血液中的成分的方法，通过以高精度和高可靠性测量血液的血细胞比容（Hct）值，能够精确地校正成分的量，并且还提供了该方法中使用的传感器 。 用于测量血液中成分的传感器具有第一分析部分和第二分析部分。 第一分析部分具有第一电极系统（11,12）和试剂层（14），并且试剂层（14）具有作用于组分的氧化还原酶和介体。 在第一分析部分中，通过在介体存在下引起组分与氧化还原酶的氧化还原反应并检测当通过第一电极（11,12）施加电压时引起的氧化还原电流来测量血液中的组分， 。 第二分析部分具有工作电极和对电极，并且在对电极上而不是在工作电极上设置介体。 在第二分析部分中，通过将血液供给到电极系统，施加电压以使电流流动并检测电流的值来测量血液的Hct值。 使用此Hct值，校正组件的数量。

公开(公告)号：US20050165255A1

公开(公告)日：2005-07-28

申请号：US10515974

申请日：2003-05-28

申请人： Shin Ikeda ,  Yasuhiro Takahashi

发明人： Shin Ikeda ,  Yasuhiro Takahashi

IPC分类号： C07C209/74 ,  C07C211/45 ,  C07C29/68

CPC分类号： C07C209/74 ,  C07C211/45

摘要： 2-benzylaniline can be manufactured in one-pot reaction at a substantially reduced cost by allowing 2-amino-5-halogenobenzophenone to react under a reductive condition.

摘要翻译： 2-苄基苯胺可以通过使2-氨基-5-卤代二苯甲酮在还原条件下反应，以大幅度降低的成本在一锅反应中制备。

公开(公告)号：US20050159678A1

公开(公告)日：2005-07-21

申请号：US10512939

申请日：2004-01-16

申请人： Yuko Taniike ,  Mariko Miyashita ,  Shin Ikeda ,  Toshihiko Yoshioka

发明人： Yuko Taniike ,  Mariko Miyashita ,  Shin Ikeda ,  Toshihiko Yoshioka

IPC分类号： A61B5/00 ,  A61B5/15

CPC分类号： A61B5/6843 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150259 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150748 ,  A61B5/150954 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/157 ,  A61B5/417

摘要： The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus, wherein the puncture mechanism comprises at least: a puncture needle; and a cap which is detachably engaged with a body of the apparatus, wherein the cap has a skin contact surface which is brought into contact with the skin for puncturing, the skin contact surface having an opening through which the puncture needle moves to puncture the skin, and being shaped so as to fit a surface shape of the skin to be punctured, and the set comprises a plurality of different such caps each corresponding to a different sample collection site so that a plurality of different sample collection sites can be selected.

摘要翻译： 生物成分测定装置技术领域本发明涉及一种生物体成分测定装置，其特征在于，将生物体成分测定装置与生物传感器测定装置一体化，其中，穿刺机构至少包括：穿刺针， 以及与所述装置的主体可拆卸地接合的帽，其中所述帽具有与皮肤接触以刺穿的皮肤接触表面，所述皮肤接触表面具有穿刺针穿过的穿孔刺穿皮肤 并且被成形为适合要刺穿的皮肤的表面形状，并且该组包括多个不同的这样的帽，每个对应于不同的样本收集位置，使得可以选择多个不同的样本收集位置。

公开(公告)号：US09212380B2

公开(公告)日：2015-12-15

申请号：US13392630

申请日：2010-08-30

申请人： Yoshifumi Takahara ,  Takahiro Nakaminami ,  Shin Ikeda

发明人： Yoshifumi Takahara ,  Takahiro Nakaminami ,  Shin Ikeda

IPC分类号： G01N27/327 ,  C12Q1/00 ,  C12Q1/32 ,  G01N21/84

CPC分类号： G01N27/3272 ,  C12Q1/006 ,  C12Q1/32 ,  G01N21/8483

摘要： A reagent layer of a sensor contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor.

摘要翻译： 传感器的试剂层含有具有亲水性官能团的醌化合物，菲醌和/或菲醌衍生物作为介体。 醌类化合物的氧化还原电位低于常规介体，因此干扰物质对该传感器的检测结果影响较小。

公开(公告)号：US20100276303A1

公开(公告)日：2010-11-04

申请号：US12377497

申请日：2007-10-17

申请人： Masaki Fujiwara ,  Takahiro Takasu ,  Shin Ikeda ,  Takahiro Nakaminami

发明人： Masaki Fujiwara ,  Takahiro Takasu ,  Shin Ikeda ,  Takahiro Nakaminami

IPC分类号： G01N33/49

CPC分类号： G01N27/3274

摘要： A voltage is applied across a counter electrode and a working electrode while an oxidant of a redox substance is in contact with the counter electrode and is not substantially in contact with the working electrode, and thereby metal that readily undergoes electrolytic oxidation forming at least part of a surface of the working electrode is oxidized while the oxidant in contact with the working electrode is reduced, such that a current produced upon the oxidation and the reduction is measured. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, a hematocrit value of a blood sample can be measured stably with satisfactory detection sensitivity. This measurement can be carried out, for example, with a sensor chip comprising a working electrode 11, a counter electrode 12, and a blood sample holder 14 in communication with a blood sample inlet 16, wherein a portion 31 of the working electrode 11 is disposed closer to the blood sample inlet 16 than a portion 32 of the counter electrode is, a surface of the portion 31 includes the metal that readily undergoes electrolytic oxidation, and a reagent 13 containing the oxidant is disposed in contact with the portion 32.

摘要翻译： 在对电极和工作电极之间施加电压，而氧化还原物质的氧化剂与对电极接触并且基本上不与工作电极接触，从而容易经历电解氧化形成的金属至少部分 工作电极的表面被氧化，而与工作电极接触的氧化剂减少，从而测量氧化和还原时产生的电流。 根据上述结构，在降低施加在工作电极和对电极两端的电压的同时，能够以良好的检测灵敏度稳定地测定血液样品的血细胞比容值。 该测定例如可以使用包含与血液检体入口16连通的工作电极11，对电极12和血液检体保持器14的传感器芯片进行，其中工作电极11的部分31为 比对置电极的部分32更靠近血液采样入口16设置，部分31的表面包括容易经历电解氧化的金属，并且含有氧化剂的试剂13设置成与部分32接触。

公开(公告)号：US20090093068A1

公开(公告)日：2009-04-09

申请号：US12330859

申请日：2008-12-09

申请人： Keiko Yugawa ,  Shinji Tanaka ,  Shin Ikeda

发明人： Keiko Yugawa ,  Shinji Tanaka ,  Shin Ikeda

IPC分类号： G01N33/53 ,  B01J19/00

CPC分类号： G01N33/536 ,  B01L3/508 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/0858 ,  B01L2400/0487 ,  G01N21/03 ,  G01N2021/0325

摘要： An immunosensor includes a base body (101) having a sample holding portion (102) which holds a test sample, a sample introducing port (103) which is communicated with the sample holding portion (102) and through which the test sample is introduced to the sample holding portion (102), a dried first reagent body (109) which contains an antibody to a material to be measured which is contained in the test sample, and a dried second reagent body (110) which contains polyethylene glycol, and in the sample holding portion (102), the first reagent body (109) is placed closer to the sample introducing port (103) than the second reagent body (110).

摘要翻译： 免疫传感器包括：具有保持试样的样品保持部（102）的基体（101），与试样保持部（102）连通的试样导入口（103），将试样插入其中 样品保持部（102），含有测试样品中包含的被测定材料的抗体的干燥的第一试剂体（109）和含有聚乙二醇的干燥后的第二试剂体（110） 样品保持部（102），第一试剂体（109）比第二试剂体（110）更靠近试样导入口（103）。