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    Novel N-hydroxyalkylated dicarboxylic acid bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), as X-ray contrast media
    64.
    发明授权
    Novel N-hydroxyalkylated dicarboxylic acid bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), as X-ray contrast media 失效
    新型N-羟烷基化二羧酸双（3,5-二氨基甲酰基-2,4,6-三碘苯胺）作为X射线造影剂

    公开(公告)号：US4426371A

    公开(公告)日：1984-01-17

    申请号：US292115

    申请日：1981-08-12

    申请人： Heinrich Pfeiffer ,  Ulrich Speck

    发明人： Heinrich Pfeiffer ,  Ulrich Speck

    IPC分类号： A61K49/04 ,  C07C231/00 ,  C07C231/08 ,  C07C233/00 ,  C07C237/46 ,  A61K31/165

    CPC分类号： C07C233/00

    摘要： Novel N-hydroxyalkylated dicarboxylic acid bis(3,5-dicarbamoyl-2,4,6-triiodoanilides) have Formula I ##STR1## wherein R.sup.1 is a lower, linear or branched mono- or polyhydroxyalkyl residue,R.sup.2 is hydrogen, lower alkyl, or R.sup.1,R.sup.3 is lower mono- or dihydroxyalkyl, andX is a direct bond or linear or branched alkylene, which can be interrupted by one or more oxygen atoms or substituted by hydroxy or alkoxy groups.The novel dimeric compounds of Formula I possess good pharmacological and physicochemical properties making them very advantageous as radiopaque agents in all fields of application for water-soluble, iodine-containing X-ray contrast media.

    摘要翻译： 新的N-羟烷基化二羧酸双（3,5-二氨基甲酰基-2,4,6-三碘苯胺）具有式I（I）其中R 1是低级，直链或支链的单 - 或多羟基烷基残基，R 2是氢， 低级烷基或R 1，R 3为低级单或二羟基烷基，X为直链或直链或支链亚烷基，其可被一个或多个氧原子中断或被羟基或烷氧基取代。 式I的新型二聚化合物具有良好的药理学和物理化学性质，使得它们在用于水溶性的含碘X射线造影剂的所有领域中作为不透射线剂非常有利。

    Novel iodized isophthalamic acid compounds
    66.
    发明授权
    Novel iodized isophthalamic acid compounds 失效
    新型碘化间苯二甲酸化合物

    公开(公告)号：US4132731A

    公开(公告)日：1979-01-02

    申请号：US806383

    申请日：1977-06-14

    申请人： Erich Klieger ,  Ulrich Speck

    发明人： Erich Klieger ,  Ulrich Speck

    IPC分类号： A61K31/195 ,  A61K20060101 ,  A61K49/04 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C237/46 ,  C07C63/12 ,  A61K29/02

    CPC分类号： A61K49/0447

    摘要： Iodized isophthalamic acid compounds of the formula ##STR1## wherein R.sub.1 is straight-chain or branched lower hydroxyalkyl;R.sub.2 is hydroxymethyl or a lower, straight-chain or branched alkyl of at least 2 carbon atoms, which can be interrupted by one or more oxygen atoms, or is ##STR2## wherein Z is a carbon-to-carbon bond or a straight-chain or branched hydrocarbon which can be interrupted by one or more oxygen atoms, or when R.sub.1 is other than --CH.sub.2 --CH.sub.2 --OH, is methyl; and the salts thereof with physiologically acceptable inorganic or organic bases, are x-ray contrast agents.

    摘要翻译： 其中R1是直链或支链低级羟基烷基的式（I）的碘化间苯二甲酰胺酸化合物; R2是至少2个碳原子的羟甲基或低级直链或支链烷基，其可以被一个或多个氧原子间隔，或者是Z是碳 - 碳键或直链 - 可被一个或多个氧原子中断的链或支链烃，或当R1不是-CH2-CH2-OH时，是甲基; 及其与生理上可接受的无机或有机碱的盐是x射线造影剂。

    Limus-coated medical devices
    67.
    发明授权
    Limus-coated medical devices 有权

    公开(公告)号：US09629942B2

    公开(公告)日：2017-04-25

    申请号：US13641490

    申请日：2011-04-19

    申请人： Ulrich Speck

    发明人： Ulrich Speck

    IPC分类号： A61F2/00 ,  A61L29/16 ,  A61L31/16

    CPC分类号： A61L29/16 ,  A61L31/16

    摘要： The present invention is related to a medical device carrying at least on a portion of its surface a Limus drug or Limus drug preparation and butylated hydroxytoluene at a ratio of 3-100% by weight of butylated hydroxytoluene in relation to 100% by weight of the Limus drug.

    LIMUS-COATED MEDICAL DEVICES
    68.
    发明申请
    LIMUS-COATED MEDICAL DEVICES 有权
    LIMUS涂层医疗器械

    公开(公告)号：US20130041315A1

    公开(公告)日：2013-02-14

    申请号：US13641490

    申请日：2010-04-19

    申请人： Ulrich Speck

    发明人： Ulrich Speck

    IPC分类号： A61M25/10

    CPC分类号： A61L29/16 ,  A61L31/16

    摘要： The present invention is related to a medical device carrying at least on a portion of its surface a Limus drug or Limus drug preparation and butylated hydroxytoluene at a ratio of 3-100% by weight of butylated hydroxytoluene in relation to 100% by weight of the Limus drug.

    摘要翻译： 本发明涉及至少在其一部分表面上携带Limus药物或Limus药物制剂和丁基化羟基甲苯的丁基化羟基甲苯的比例相对于100重量％的丁基化羟基甲苯的比例为3-100重量％ 利马药

    PREPARATION FOR RESTENOSIS PREVENTION
    70.
    发明申请
    PREPARATION FOR RESTENOSIS PREVENTION 有权
    预防预防的准备

    公开(公告)号：US20100278744A1

    公开(公告)日：2010-11-04

    申请号：US12835414

    申请日：2010-07-13

    申请人： Ulrich Speck ,  Bruno Scheller

    发明人： Ulrich Speck ,  Bruno Scheller

    IPC分类号： A61K49/06 ,  A61K49/00 ,  A61K49/04

    CPC分类号： A61L29/08 ,  A61K9/0019 ,  A61K9/5094 ,  A61K31/095 ,  A61K31/165 ,  A61K31/337 ,  A61K45/06 ,  A61K49/0433 ,  A61K49/0438 ,  A61K49/0447 ,  A61K49/0452 ,  A61K49/105 ,  A61K49/106 ,  A61K49/18 ,  A61L29/16 ,  A61L29/18 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

    摘要： The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.

    摘要翻译： 本发明涉及预防再狭窄的制剂。 已知的再狭窄预防制剂在血管壁的受影响部分中不能达到足够的活性剂浓度，因为较高剂量引起不期望的副作用。 本发明是一种具有至少一种具有丁醇与水分配比例的抗高血压药物的制剂。 亲脂性活性剂被血管壁快速且足够的量吸收。 该制剂可以是可以通过毛细血管并且可以含有造影剂的液体，使得活性剂在没有任何额外的努力的同时转移到血管壁中，而通常需要的对比度放射照相。 该制剂也可以应用于导管。