公开(公告)号：US06734307B2

公开(公告)日：2004-05-11

申请号：US09906215

申请日：2001-07-16

申请人： Anita Mehta ,  Arora K. Sudershan ,  Biswajit Das ,  Abhijit Ray ,  Sonali Rudra ,  Ashok Rattan

发明人： Anita Mehta ,  Arora K. Sudershan ,  Biswajit Das ,  Abhijit Ray ,  Sonali Rudra ,  Ashok Rattan

IPC分类号： C07D41314

CPC分类号： C07D413/10 ,  C07D413/12 ,  C07D413/14

摘要： The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

摘要翻译： 本发明涉及某些取代的苯基恶唑烷酮及其合成方法。 本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。 这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌以及厌氧生物如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

公开(公告)号：US20120004201A1

公开(公告)日：2012-01-05

申请号：US13060832

申请日：2009-09-19

申请人： Sonali Rudra ,  Nidhi Gupta ,  Kakade Ganesh Chandrakant ,  Tarun Jain ,  Sreedhara Rao Voleti ,  Abhijit Ray ,  Sunanda G. Dastidar ,  Lalitha Vijaykrishnan

发明人： Sonali Rudra ,  Nidhi Gupta ,  Kakade Ganesh Chandrakant ,  Tarun Jain ,  Sreedhara Rao Voleti ,  Abhijit Ray ,  Sunanda G. Dastidar ,  Lalitha Vijaykrishnan

IPC分类号： A61K31/56 ,  C07D519/00 ,  A61K31/437 ,  A61P29/00 ,  A61P25/00 ,  A61P37/06 ,  A61P37/00 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P11/02 ,  A61P17/06 ,  A61P17/00 ,  A61P43/00 ,  A61P27/02 ,  A61P19/02 ,  A61P1/00 ,  A61P35/00 ,  A61P1/18 ,  C07D471/04

CPC分类号： C07D471/04 ,  C07D519/00

摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.

摘要翻译： 本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。 本文公开的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性 结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。 提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

公开(公告)号：US07750735B1

公开(公告)日：2010-07-06

申请号：US12171906

申请日：2008-07-11

申请人： Abhijit Ray

发明人： Abhijit Ray

IPC分类号： H03F3/45

CPC分类号： H03F3/45183 ,  H03F2203/45244 ,  H03F2203/45466

摘要： A voltage-level translator includes an input node, a differential amplifier, first and second output transistors, and a constant current source. The input node receives an input signal. The differential amplifier produces a voltage swing at an amplifier node based at least in part on a difference between the input signal and a voltage supply. The first output transistor provides a substantially constant current to the output node. The voltage swing produced by the differential amplifier prevents forward biasing of the second output transistor. The constant current source provides a substantially constant current both to the differential amplifier and through the first output transistor. The translator outputs a first voltage in an output voltage range at the output node when the input signal is at a high voltage, and outputs a second voltage in the output voltage range at the output node when the input signal is at a low voltage.

摘要翻译： 电压电平转换器包括输入节点，差分放大器，第一和第二输出晶体管以及恒流源。 输入节点接收输入信号。 差分放大器至少部分地基于输入信号和电压源之间的差异在放大器节点处产生电压摆​​幅。 第一输出晶体管向输出节点提供基本恒定的电流。 由差动放大器产生的电压摆动阻止了第二输出晶体管的正向偏置。 恒流源向差分放大器和第一输出晶体管提供基本恒定的电流。 当输入信号处于高电压时，转换器在输出节点的输出电压范围内输出第一电压，并且当输入信号处于低电压时，输出输出节点的输出电压范围内的第二电压。

公开(公告)号：US07747425B1

公开(公告)日：2010-06-29

申请号：US11593729

申请日：2006-11-07

申请人： Vipin Kumar Tiwari ,  Manish Bhatia ,  Abhijit Ray

发明人： Vipin Kumar Tiwari ,  Manish Bhatia ,  Abhijit Ray

IPC分类号： G06F17/50

CPC分类号： G06F17/5036

摘要： A peak current modeling method and system for modeling peak current demand of an integrated circuit (IC) block such as, e.g., a compilable memory instance. A current demand curve associated with the IC for a particular IC block event is obtained via simulation, for example. A defined time region associated with the particular IC block event is divided into multiple time segments, whereupon at least a first current value and a second current value for each time segment is obtained based on the current demand curve. Thereafter, the current demand curve is approximated, on a segment-by-segment basis, using a select approximate waveform depending on a relationship between the first and second current values.

摘要翻译： 用于建模集成电路（IC）块的峰值电流需求的峰值电流建模方法和系统，例如可编译存储器实例。 例如，通过模拟获得与特定IC块事件的IC相关联的电流需求曲线。 与特定IC块事件相关联的定义的时间区域被划分为多个时间段，因此基于当前需求曲线获得每个时间段的至少第一当前值和第二电流值。 此后，根据第一和第二电流值之间的关系，使用选择近似波形，逐段地逐次地近似当前需求曲线。

公开(公告)号：US20100099644A1

公开(公告)日：2010-04-22

申请号：US12575276

申请日：2009-10-07

申请人： Young B. Lee ,  Deog J. Kim ,  Chang H. Ahn ,  Anjan Nan ,  Hamidreza Ghandehari ,  Abhijit Ray

发明人： Young B. Lee ,  Deog J. Kim ,  Chang H. Ahn ,  Anjan Nan ,  Hamidreza Ghandehari ,  Abhijit Ray

IPC分类号： A61K47/48

CPC分类号： B82Y5/00 ,  A61K47/551 ,  A61K47/58 ,  A61K47/64 ,  A61K47/65

摘要： Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.

摘要翻译： 公开了通过将吉西他滨或多西他赛与诸如N-2-羟丙基甲基丙烯酰胺（HPMA）的水溶性聚合物缀合而形成的吉西他滨和多西紫杉醇的水溶性组合物。 还公开了使用本发明的组合物治疗癌症的方法。

公开(公告)号：US07688111B1

公开(公告)日：2010-03-30

申请号：US12195725

申请日：2008-08-21

申请人： Abhijit Ray

发明人： Abhijit Ray

IPC分类号： H03K19/082 ,  H03K19/0175

CPC分类号： H03K19/017509

摘要： A level-shifting circuit includes an input node, a first output transistor, a second output transistor, a pull-up transistor, and an output node. The input node receives an input signal. The first output transistor turns on when the input signal is at a first voltage level and couples an output node to a positive supply voltage when turned on. The second output transistor, a bipolar junction transistor (BJT), couples the output node to a negative supply voltage when turned on. The pull-up transistor turns on when the input signal is at a second voltage level and generates a voltage at a base terminal of the second output transistor that turns the second output transistor on. Additionally, the level-shifting circuit generates, at the output node, an output signal with a voltage swing that includes a positive voltage range and a negative voltage range.

摘要翻译： 电平移动电路包括输入节点，第一输出晶体管，第二输出晶体管，上拉晶体管和输出节点。 输入节点接收输入信号。 当输入信号处于第一电压电平时，第一输出晶体管导通，并且当导通时将输出节点耦合到正电源电压。 第二输出晶体管，双极结型晶体管（BJT）在导通时将输出节点耦合到负电源电压。 当输入信号处于第二电压电平时，上拉晶体管导通，并在第二输出晶体管的基极端产生电压，使第二输出晶体管导通。 此外，电平移动电路在输出节点产生具有包括正电压范围和负电压范围的电压摆幅的输出信号。

公开(公告)号：US20100056496A1

公开(公告)日：2010-03-04

申请号：US12439771

申请日：2007-09-04

申请人： Naresh Kumar ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

发明人： Naresh Kumar ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

IPC分类号： A61K31/55 ,  C07D223/14 ,  A61P1/00 ,  A61P11/00 ,  A61P3/00

CPC分类号： C07D221/24 ,  C07D209/12 ,  C07D209/14

摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The present invention also relates to processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors. Formula (I) or a pharmaceutically accepted salt, pharmaceutically acceptable solvate, enantiomers, diastereomer, polymorph or N-oxide thereof, wherein X is.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备本文所述化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。 式（I）或其药学上可接受的盐，药学上可接受的溶剂合物，对映异构体，非对映体，多晶型物或N-氧化物，其中X为。

公开(公告)号：US20090221664A1

公开(公告)日：2009-09-03

申请号：US12090805

申请日：2006-10-19

申请人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Shivani Malhotra

发明人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Shivani Malhotra

IPC分类号： A61K31/403

CPC分类号： A61K31/401

摘要： Provided herein are pharmaceutical compositions comprising one or more muscarinic receptor antagonists (“MRA”), and at least one additional active ingredients selected from one or more β2-agonists, p38 MAP kinase inhibitors, PDE-IV inhibitors, corticosteroids or a mixture thereof and optionally one or more pharmaceutically acceptable carriers, excipients or diluents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.

摘要翻译： 本文提供包含一种或多种毒蕈碱受体拮抗剂（“MRA”）和至少一种选自一种或多种β-激动剂，p38MAP激酶抑制剂，PDE-IV抑制剂，皮质类固醇或其混合物的另外的活性成分的药物组合物， 任选的一种或多种药学上可接受的载体，赋形剂或稀释剂。 此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

公开(公告)号：US20090054382A1

公开(公告)日：2009-02-26

申请号：US12090798

申请日：2006-10-19

申请人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Suman Gupta

发明人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Suman Gupta

IPC分类号： A61K31/573 ,  A61K31/407 ,  A61K31/424

CPC分类号： A61K31/41

摘要： Provided herein are pharmaceutical compositions comprising one or more phosphodiesterase inhibitors of type IV (“PDE-IV”), and at least one other active ingredients selected from muscarinic receptor antagonists (MRA), β2-agonists, p38 MAP Kinase inhibitors, and corticosteroids and optionally one or more pharmaceutically acceptable excipients and/or other therapeutic agents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.

摘要翻译： 本文提供了包含一种或多种IV型磷酸二酯酶抑制剂（“PDE-IV”）和至少一种选自毒蕈碱受体拮抗剂（MRA），β2-激动剂，p38 MAP激酶抑制剂和皮质类固醇的其它活性成分的药物组合物，以及 任选地一种或多种药学上可接受的赋形剂和/或其它治疗剂。 此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

公开(公告)号：US20080021080A1

公开(公告)日：2008-01-24

申请号：US11685892

申请日：2007-03-14

申请人： Ashwani Verma ,  Sanjay Malhotra ,  Abhijit Ray ,  Shirumalla Kumar

发明人： Ashwani Verma ,  Sanjay Malhotra ,  Abhijit Ray ,  Shirumalla Kumar

IPC分类号： A61K31/41 ,  A61P11/00 ,  C07D249/00

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D413/14

摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.

摘要翻译： 本发明涉及5-脂氧合酶抑制剂。 本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性 皮炎，过敏性鼻炎，其他炎性和自身免疫性疾病。 还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。