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公开(公告)号：US08653270B2
公开(公告)日：2014-02-18
申请号：US13300537
申请日：2011-11-18
IPC分类号： C07D405/04 , C07D405/10 , C07D405/14 , C07D409/10
CPC分类号： C07F9/655345 , C07D307/42 , C07D307/52 , C07D333/12 , C07D333/20 , C07F9/6506 , C07F9/65515 , C07F9/65744
摘要： The present invention relates to novel derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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公开(公告)号：US08653062B2
公开(公告)日：2014-02-18
申请号：US12951317
申请日：2010-11-22
IPC分类号： A61K31/397 , A61K31/421 , A61K31/4155 , A61K31/426 , A61K31/427 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D333/06
CPC分类号： C07F9/65586 , C07D205/04 , C07D333/16 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07F9/58 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655345
摘要： The present invention relates to novel cyclic amine and cycloalkyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译： 本发明涉及新的环胺和环烷基衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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公开(公告)号：US20110212925A1
公开(公告)日：2011-09-01
申请号：US12951504
申请日：2011-05-20
IPC分类号： A61K31/675 , C07F9/38 , A61K31/662 , A61P27/02 , A61P3/10 , A61P29/00 , A61P11/00 , A61P1/00 , A61P37/00 , A61P9/00 , A61P17/02 , A61P25/00
CPC分类号： C07F9/65586 , C07D205/04 , C07D333/16 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07F9/58 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655345
摘要： The present invention relates to novel amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译： 本发明涉及新的胺衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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公开(公告)号：US08440644B2
公开(公告)日：2013-05-14
申请号：US12951504
申请日：2011-05-20
IPC分类号： A61K31/675 , A61K31/662 , C07F9/38 , A61P27/02 , A61P3/10 , A61P29/00 , A61P11/00 , A61P1/00 , A61P37/00 , A61P9/00 , A61P17/02 , A61P25/00
CPC分类号： C07F9/65586 , C07D205/04 , C07D333/16 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07F9/58 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655345
摘要： The present invention relates to novel amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译： 本发明涉及新的胺衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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公开(公告)号：US20120129813A1
公开(公告)日：2012-05-24
申请号：US13300537
申请日：2011-11-18
IPC分类号： A61K31/67 , C07F9/655 , C07F9/6558 , A61K31/665 , A61K31/675 , A61K31/443 , A61K31/4439 , A61P27/02 , A61P27/06 , A61P25/00 , A61P29/00 , A61P35/04 , A61P11/00 , A61P9/10 , A61P19/02 , A61P17/06 , A61P37/06 , A61P37/00 , A61P1/00 , A61P11/06 , A61P19/10 , A61P37/08 , A61P17/18 , A61P17/02 , A61P25/28 , C07D405/04 , C07D405/14 , A61P19/08 , A61P19/04 , C07D409/10 , A61K31/4178 , C07D405/10 , C07F9/6553
CPC分类号： C07F9/655345 , C07D307/42 , C07D307/52 , C07D333/12 , C07D333/20 , C07F9/6506 , C07F9/65515 , C07F9/65744
摘要： The present invention relates to novel derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译： 本发明涉及新型衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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公开(公告)号：US5354611A
公开(公告)日：1994-10-11
申请号：US71345
申请日：1993-05-28
申请人： David J. Arthur , Gwo S. Swei , Phong X. Nguyen
发明人： David J. Arthur , Gwo S. Swei , Phong X. Nguyen
CPC分类号： H05K1/0373 , C08K7/28 , C08K9/04 , H05K1/034 , H05K2201/0116 , H05K2201/015 , H05K2201/0209 , H05K2201/0239 , H05K2201/0254 , Y10T428/252 , Y10T428/259 , Y10T428/2982 , Y10T428/2995 , Y10T428/2996 , Y10T428/3154 , Y10T428/31544
摘要： A composite material is disclosed. The material comprises a polymeric matrix and from about 20 volume percent to about 70 volume percent inorganic particles distributed throughout the matrix. Suitable inorganic particles include hollow inorganic microspheres and porous inorganic particles. The inorganic particles are coated with a surface coating. The composite material of the present invention exhibits a dielectric constant of less than about 2.5 and a thermal coefficient of expansion of less than about 70 ppm/.degree.C.
摘要翻译： 公开了一种复合材料。 该材料包括聚合物基质和分布在整个基质中的约20体积％至约70体积％的无机颗粒。 合适的无机颗粒包括中空无机微球和多孔无机颗粒。 无机颗粒用表面涂层涂覆。 本发明的复合材料的介电常数小于约2.5，热膨胀系数小于约70ppm /℃。
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