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108 条记录 (耗时 0.034 秒)

    Broadband phased array transducer with frequency controlled two dimensional aperture capability for harmonic imaging
    62.
    发明授权
    Broadband phased array transducer with frequency controlled two dimensional aperture capability for harmonic imaging 失效
    宽带相控阵传感器，具有频率控制二维孔径能力，用于谐波成像

    公开(公告)号：US5971925A

    公开(公告)日：1999-10-26

    申请号：US93422

    申请日：1998-06-08

    申请人： John A. Hossack ,  Amin M. Hanafy

    发明人： John A. Hossack ,  Amin M. Hanafy

    IPC分类号： A61B8/00 ,  G01S7/52 ,  G01S15/89

    CPC分类号： A61B8/4281 ,  G01S15/8909 ,  G01S15/8952 ,  G01S7/52038

    摘要： An ultrasonic transducer array for harmonic imaging including an ultrasonic transducer array having a plurality of transducer elements, each of said transducer elements having a first surface and a second surface opposite of said first surface, said second surface being non-planar in an elevation direction and said second surface facing away from a region of examination when the transducer is in use. Transmit circuitry is coupled to the transducer array and is operative to cause the transducer array to emit a signal having a bandwidth controlled such that substantially no harmonic energy is transmitted. Receive circuitry is coupled to the transducer array and selectively responsive to harmonic echo information.

    摘要翻译： 一种用于谐波成像的超声换能器阵列，包括具有多个换能器元件的超声换能器阵列，每个所述换能器元件具有与所述第一表面相对的第一表面和第二表面，所述第二表面在高度方向上是非平面的， 当换能器在使用时，所述第二表面背离检查区域。 发射电路耦合到换能器阵列并且可操作地使得换能器阵列发射具有被控制的带宽的信号，从而基本上不传输谐波能量。 接收电路耦合到换能器阵列并且选择性地响应谐波回波信息。

    Flexible ultrasonic transducers and related systems
    65.
    发明授权
    Flexible ultrasonic transducers and related systems 失效
    灵活的超声换能器及相关系统

    公开(公告)号：US5680863A

    公开(公告)日：1997-10-28

    申请号：US657646

    申请日：1996-05-30

    申请人： John A. Hossack ,  John W. Eaton ,  Thomas G. Cooper ,  Michael H. Ikeda ,  David J. Rosa

    发明人： John A. Hossack ,  John W. Eaton ,  Thomas G. Cooper ,  Michael H. Ikeda ,  David J. Rosa

    IPC分类号： A61B8/00 ,  A61B8/12 ,  G01S15/89 ,  G10K11/32 ,  G10K11/34

    CPC分类号： A61B8/4281 ,  A61B8/12 ,  G10K11/32 ,  G10K11/341 ,  A61B8/445 ,  G01S15/892

    摘要： A phased array transducer for an ultrasonic imaging system includes a flexible support element which supports an array of piezoelectric transducer elements. Shape transducers such as strain gauges or capacitive transducers are coupled to the support element to generate a signal indicative of the instantaneously prevailing curvature of the array. A user-controlled actuator is coupled to the support element to flex the support element between at least first and second configurations, wherein the support element has separate curvatures along the axis of the transducer in each of the first and second configurations. In some applications the transducer elements are positioned for separate scan formats in the first and second configurations. The support element can be provided with first and second alternating regions which differ in flexibility, in order to concentrate flexing of the support element in the second regions. In some applications the support element may have a cross-sectional dimension of less than about ten millimeters to facilitate insertion of the transducer into a tortuous vessel of a living subject.

    摘要翻译： 用于超声成像系统的相控阵转换器包括支撑压电换能器元件阵列的柔性支撑元件。 诸如应变仪或电容式换能器的形状换能器耦合到支撑元件以产生指示阵列瞬时占据的曲率的信号。 用户控制的致动器联接到支撑元件以在至少第一和第二配置之间弯曲支撑元件，其中支撑元件在第一和第二构造中的每一个中沿着换能器的轴线具有单独的曲率。 在一些应用中，换能器元件被定位成在第一和第二配置中分开的扫描格式。 支撑元件可以设置有不同柔性的第一和第二交替区域，以便集中在第二区域中的支撑元件的弯曲。 在一些应用中，支撑元件可以具有小于约十毫米的横截面尺寸，以便于将换能器插入活体的曲折血管。

    METHODS AND APPARATUS FOR CELL TRACKING AND MOLECULAR IMAGING
    66.
    发明申请
    METHODS AND APPARATUS FOR CELL TRACKING AND MOLECULAR IMAGING 审中-公开

    公开(公告)号：US20180099059A1

    公开(公告)日：2018-04-12

    申请号：US15729164

    申请日：2017-10-10

    申请人： John A. Hossack ,  Adam Joseph Dixon ,  Edwin Lu

    发明人： John A. Hossack ,  Adam Joseph Dixon ,  Edwin Lu

    IPC分类号： A61K49/22

    CPC分类号： A61K49/223 ,  A61K49/225 ,  A61K49/227

    摘要： A composition for cell tracking and molecular imaging containing perfluorocarbon (“PFC”) droplets having a liquid PFC core enclosed within a stabilizing shell and embedded with solid nanoparticles. The solid nanoparticles act as nucleating agents for reducing the activation pressure of the liquid PFC core required to transition the liquid PFC core to a gaseous microbubble thereby permitting the use of more body-temperature stable longer chain PFCs in the liquid PFC core. The improved stability of the PFC droplets with a reduced or limited increase in the activation pressure required due to the nucleating nanoparticles improves the efficacy of using the PFC droplets as phase-change contrast agents.

    SYSTEM AND METHOD FOR BINDING DYNAMICS OF TARGETED MICROBUBBLES
    68.
    发明申请
    SYSTEM AND METHOD FOR BINDING DYNAMICS OF TARGETED MICROBUBBLES 有权
    用于绑定微量元素动力学的系统和方法

    公开(公告)号：US20150150534A1

    公开(公告)日：2015-06-04

    申请号：US14559422

    申请日：2014-12-03

    申请人： F. William Mauldin, JR. ,  Shiying Wang ,  John A. Hossack ,  Alexander L. Klibanov

    发明人： F. William Mauldin, JR. ,  Shiying Wang ,  John A. Hossack ,  Alexander L. Klibanov

    IPC分类号： A61B8/08 ,  A61B8/00

    CPC分类号： A61B8/481 ,  A61B8/0891 ,  A61B8/587 ,  G06T7/0016 ,  G06T2207/10132 ,  G06T2207/30104

    摘要： An ultrasound system and method that can include: a receive beamformer configured to receive signals from a transducer; a processor coupled to the receive beamformer, the processor configured to: analyze echo data reflected from a region of interest, the echo data elicited by a transmitted pulse sequence; using the echo data, determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest; determine a time series of the signal magnitude; using the time series, determine an initial signal magnitude parameter; obtain a saturated signal parameter and a residual signal parameter using the time series; and determine a relative indication of information indicative of the residual signal magnitude versus the saturated signal magnitude.

    摘要翻译： 一种超声系统和方法，其可以包括：接收波束形成器，被配置为从换能器接收信号; 耦合到所述接收波束形成器的处理器，所述处理器被配置为：分析从感兴趣区域反射的回波数据，所述回波数据由所发射的脉冲序列引起; 使用回波数据，确定在感兴趣区域内随时间的粘附微泡区域的信号幅度的集中趋势; 确定信号幅度的时间序列; 使用时间序列，确定初始信号幅度参数; 使用时间序列获得饱和信号参数和残差信号参数; 并确定指示残留信号幅度与饱和信号幅度相关的信息的相对指示。

    Specialized, high performance, ultrasound transducer substrates and related method thereof
    69.
    发明授权
    Specialized, high performance, ultrasound transducer substrates and related method thereof 有权
    专用，高性能，超声换能器基板及其相关方法

    公开(公告)号：US08093782B1

    公开(公告)日：2012-01-10

    申请号：US12191839

    申请日：2008-08-14

    申请人： John A. Hossack

    发明人： John A. Hossack

    IPC分类号： A61B18/00

    CPC分类号： G10K11/002

    摘要： Backing substrates for reducing parasitic echoes produced within a ultrasonic transducer are provided comprising a polymeric material, for example, an epoxy having a glass transition temperature (Tg) ranging from about 10 to 50° C.; or an epoxy having an acoustical attenuation that increases by at least about 2 dB/mm at 5 MHz in a temperature range of about 5° C. to 40° C. Transducer assemblies comprising the backing substrates and methods for producing the assemblies are also provided.

    摘要翻译： 提供用于减少在超声波换能器内产生的寄生回波的背衬基底，其包括聚合物材料，例如玻璃化转变温度（Tg）为约10至50℃的环氧树脂; 或在约5℃至40℃的温度范围内具有在5MHz下增加至少约2dB / mm的声学衰减的环氧树脂。还提供了包括背衬基板的传感器组件以及用于制造组件的方法 。