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120 条记录 (耗时 0.048 秒)

    Method for correcting motion-induced errors in MR imaging
    61.
    发明授权
    Method for correcting motion-induced errors in MR imaging 失效
    用于校正MR成像中运动诱发误差的方法

    公开(公告)号：US6057685A

    公开(公告)日：2000-05-02

    申请号：US987594

    申请日：1997-12-09

    申请人： Xiaohong Zhou

    发明人： Xiaohong Zhou

    IPC分类号： G01R33/567 ,  G01V3/00

    CPC分类号： G01R33/56509 ,  G01R33/5676

    摘要： In a method for providing an MR image of a section taken through an object, wherein the section is acquired in the presence of in-plane translational motion of the object, an MR system is operated to acquire a set of imaging data points from the section, the set of imaging data points being contaminated by phase errors resulting from the motion. The MR system is further operated to acquire a plurality of correction data point sets, each correction data point in one of said sets being acquired along an alignment line or other trajectory and at a location coinciding with the location of one of the imaging data points. The imaging data points respectively coinciding with the correction data points comprise, collectively, a subset of the imaging data points. The phase difference between each correction data point set and its corresponding subset of imaging data points is determined, and then used to remove the phase errors from the set of imaging data points.

    摘要翻译： 在用于提供通过对象拍摄的部分的MR图像的方法中，其中在存在对象的平面内平移运动的情况下获取该部分，操作MR系统以从该部分获取一组成像数据点 ，该组成像数据点被运动产生的相位误差污染。 进一步操作MR系统以获取多个校正数据点集合，其中一个组中的每个校正数据点沿着对准线或其他轨迹以及与一个成像数据点的位置重合的位置获取。 分别与校正数据点一致的成像数据点总共包括成像数据点的子集。 确定每个校正数据点集合及其对应的成像数据点子集之间的相位差，然后用于从成像数据点集合中去除相位误差。

    Method and apparatus for induced T-wave alternans assessment
    67.
    发明授权
    Method and apparatus for induced T-wave alternans assessment 有权
    诱导T波交替评估的方法和装置

    公开(公告)号：US08437837B2

    公开(公告)日：2013-05-07

    申请号：US11536946

    申请日：2006-09-29

    申请人： Xiaohong Zhou

    发明人： Xiaohong Zhou

    IPC分类号： A61B5/04 ,  A61N1/00

    CPC分类号： A61B5/0456 ,  A61B5/0452 ,  A61N1/365 ,  G16H40/63

    摘要： An implantable medical device and associated method assesses T-wave alternans. The method includes sensing a cardiac signal from implanted electrodes subsequent to a premature contraction; measuring a T-wave parameter from the sensed cardiac signal for a plurality of cardiac cycles; and determining a T-wave alternans metric corresponding to the measured T-wave parameter.

    摘要翻译： 可植入医疗器械和相关方法评估T波交替。 该方法包括在过早收缩之后感测来自植入电极的心脏信号; 从感测的心脏信号中测量多个心动周期的T波参数; 以及确定对应于所测量的T波参数的T波交替量度。

    Implantable medical device having optical fiber for sensing electrical activity
    68.
    发明授权
    Implantable medical device having optical fiber for sensing electrical activity 有权
    具有用于感测电活动的光纤的可植入医疗装置

    公开(公告)号：US08396539B2

    公开(公告)日：2013-03-12

    申请号：US11676128

    申请日：2007-02-16

    申请人： Vinod Sharma ,  Xiaohong Zhou

    发明人： Vinod Sharma ,  Xiaohong Zhou

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

    摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

    摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

    Delivery of a sympatholytic cardiovascular agent to the central nervous system
    69.
    发明授权
    Delivery of a sympatholytic cardiovascular agent to the central nervous system 有权
    交配性心血管药物向中枢神经系统递送

    公开(公告)号：US08348884B2

    公开(公告)日：2013-01-08

    申请号：US12128046

    申请日：2008-05-28

    申请人： Keith R. Hildebrand ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

    发明人： Keith R. Hildebrand ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

    IPC分类号： A61M31/00

    CPC分类号： A61M5/142 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3523 ,  A61M2230/00 ,  A61M2230/04 ,  A61M2230/63 ,  A61N1/3962

    摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).

    摘要翻译： 由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。 药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。 患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。 交感神经心血管药物是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西汀，脱甲基丸，美托咪定和 右美托咪定）。