利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

95 条记录 (耗时 0.073 秒)

    Electronic writing systems and methods
    63.
    发明授权
    Electronic writing systems and methods 有权
    电子书写系统和方法

    公开(公告)号：US07342575B1

    公开(公告)日：2008-03-11

    申请号：US10818599

    申请日：2004-04-06

    申请人： Peter G. Hartwell ,  Steven Rosenberg ,  Steven L Naberhuis

    发明人： Peter G. Hartwell ,  Steven Rosenberg ,  Steven L Naberhuis

    IPC分类号： G09G5/00

    CPC分类号： G06F3/038 ,  G06F3/0317 ,  G06F3/03545

    摘要： Electronic writing systems and methods are described. In one aspect, an electronic writing system includes an elongated housing, an inertial sensor, an optical sensor, and a tracking module. The elongated housing has an optical input. The inertial sensor is attached to the housing and is operable to generate data indicative of movement of the housing relative to an inertial reference frame. The optical sensor is attached to the housing and is operable to generate data from light received through the optical input. The tracking module is operable to compute relative displacement data from inertial movement data corresponding to data generated by the inertial sensor. The tracking module also is operable to detect at least one calibrated position from calibration data encoded in optical data generated from light received by the optical sensor.

    摘要翻译： 描述了电子书写系统和方法。 在一个方面，电子书写系统包括细长壳体，惯性传感器，光学传感器和跟踪模块。 细长壳体具有光学输入。 惯性传感器附接到壳体并且可操作以产生指示壳体相对于惯性参考系的运动的数据。 光学传感器附接到壳体并且可操作以从通过光学输入接收的光产生数据。 跟踪模块可操作以从对应于由惯性传感器产生的数据的惯性运动数据计算相对位移数据。 跟踪模块还可操作以从由光学传感器接收的光产生的光学数据中编码的校准数据中检测至少一个校准位置。

    Adoptive Immunotherapy with Enhanced T Lymphocyte Survival
    64.
    发明申请
    Adoptive Immunotherapy with Enhanced T Lymphocyte Survival 有权
    采用增强型T淋巴细胞存活的免疫治疗

    公开(公告)号：US20080050341A1

    公开(公告)日：2008-02-28

    申请号：US11576621

    申请日：2005-10-07

    申请人： Richard Morgan ,  Steven Rosenberg ,  Cary Hsu

    发明人： Richard Morgan ,  Steven Rosenberg ,  Cary Hsu

    IPC分类号： A61K48/00 ,  A61P35/00 ,  C12N5/10

    CPC分类号： C12N5/0636 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/55527

    摘要： The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a cytokine that enhances T lymphocyte survival during the contraction phase of an immune response. The invention further provides an isolated T lymphocyte, or population thereof, expressing at least one recombinant polynucleotide encoding the cytokine, wherein the polynucleotide comprises a non-native coding sequence encoding the cytokine. Also provided is the use of such compositions and T lymphocytes, or populations thereof, for the treatment or prevention of a medical condition e.g., cancer. A method of preparing the a T lymphocyte with enhanced T cell survival is further provided herein.

    摘要翻译： 本发明提供包含T淋巴细胞或其群体的组合物，例如表达至少一种编码细胞因子的重组多核苷酸的组合物，其在免疫应答的收缩阶段增强T淋巴细胞存活。 本发明进一步提供分离的T淋巴细胞或其群体，其表达至少一种编码细胞因子的重组多核苷酸，其中所述多核苷酸包含编码细胞因子的非天然编码序列。 还提供了这种组合物和T淋巴细胞或其群体用于治疗或预防医学病症例如癌症的用途。 本文进一步提供了具有增强的T细胞存活的T淋巴细胞的制备方法。

    Peptide ligands of the urokinase receptor
    66.
    发明授权
    Peptide ligands of the urokinase receptor 失效
    尿激酶受体的肽配体

    公开(公告)号：US07094752B2

    公开(公告)日：2006-08-22

    申请号：US10821544

    申请日：2004-04-09

    申请人： Steven Rosenberg ,  Michael V. Doyle ,  Harold A. Chapman

    发明人： Steven Rosenberg ,  Michael V. Doyle ,  Harold A. Chapman

    IPC分类号： A61K38/04 ,  C07K7/04

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08

    摘要： Novel peptides that are capable of binding to uPAR and inhibiting the binding of an integrin and vitronectin are described. Also provided are nucleic acid sequences encoding the novel peptides. Methods for screening for small molecules, other peptides, or peptoids that mimic the antagonistic function of the peptides of the invention are described. The invention has applications in design of therapeutics for treating disorders characterized by upregulation of uPA and uPAR, and cancer and chronic inflammation, cell migration or uPAR: integrin binding interactions, and diagnostical applications to such disorders.

    摘要翻译： 描述了能够结合uPAR并抑制整联蛋白和玻连蛋白结合的新型肽。 还提供了编码新肽的核酸序列。 描述了筛选模拟本发明的肽的拮抗功能的小分子，其他肽或拟肽的方法。 本发明在用于治疗以uPA和uPAR上调为特征的疾病以及癌症和慢性炎症，细胞迁移或uPAR：整联蛋白结合相互作用以及诊断应用于此类疾病的治疗剂的设计中具有应用。

    Apparatus and methods of printing on an electrically writable medium
    68.
    发明授权
    Apparatus and methods of printing on an electrically writable medium 失效
    在电可写介质上打印的设备和方法

    公开(公告)号：US06707479B1

    公开(公告)日：2004-03-16

    申请号：US10341630

    申请日：2003-01-14

    申请人： Alfred I-Tsung Pan ,  Steven Rosenberg

    发明人： Alfred I-Tsung Pan ,  Steven Rosenberg

    IPC分类号： B41J222

    CPC分类号： B41J2/22

    摘要： Apparatus and methods of printing on an electrically writable medium are disclosed. In one aspect, a printer for printing on an electrically writable medium includes a print head and a biasing system. The print head has multiple solenoid-actuated print wires that are operable to reciprocate toward and away from the medium. The biasing system is coupled to the print head and is operable to apply through print wires extended toward the medium an electric field greater than a threshold electric field needed to reorient switchable display elements in a localized region of the medium.

    摘要翻译： 公开了在电可写介质上印刷的装置和方法。 一方面，用于在电可写介质上打印的打印机包括打印头和偏压系统。 打印头具有多个电磁致动打印线，其可操作以朝向和远离介质往复运动。 偏置系统耦合到打印头，并且可操作以通过向介质延伸的印刷线施加大于重新定向介质的局部区域中的可切换显示元件所需的阈值电场的电场。

    Process for making cellulose ethers having reduced yellowing and discoloration
    69.
    发明授权
    Process for making cellulose ethers having reduced yellowing and discoloration 有权
    制备纤维素醚的方法，其具有减少的变黄和变色

    公开(公告)号：US06306333B1

    公开(公告)日：2001-10-23

    申请号：US09416783

    申请日：1999-10-13

    申请人： Steven Rosenberg ,  Michael V. Spencer ,  Gary J. Schulz

    发明人： Steven Rosenberg ,  Michael V. Spencer ,  Gary J. Schulz

    IPC分类号： B29C4114

    CPC分类号： C08B11/00 ,  C08B11/20

    摘要： A process for making a low molecular weight cellulose ether has the following steps: a) providing a high molecular weight cellulose ether; b) contacting it with acid to partially depolymerize it to a cellulose ether of a viscosity of about 100 cP or less; c) neutralizing the acid; d) repeating steps a)-c) to produce two or more discrete product batches of low molecular weight cellulose ether and produce at least one discrete product batch which is partially neutralized; and e) blending the two or more discrete product batches to form a combined product batch of low molecular weight cellulose ether of a pH of 4 to 6.8. The process provides a cellulose ether with reduced yellowing and discoloration.

    摘要翻译： 制备低分子量纤维素醚的方法具有以下步骤：a）提供高分子量纤维素醚; b）使其与酸接触以将其部分解聚为粘度为约100cP或更低的纤维素醚; c）中和酸; d）重复步骤a）-c）以产生两个或更多个分散的低分子量纤维素醚的分批产物，并产生部分中和的至少一个离散产物批料; 和e）混合两个或更多个离散的产物批次以形成pH为4至6.8的低分子量纤维素醚的组合产品批料。 该方法提供了具有减少黄变和变色的纤维素醚。