摘要:
Aryl 119 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
摘要:
A switchable resistive device has a multi-layer thin film structure interposed between an upper conductive electrode and a lower conductive electrode. The multi-layer thin film structure comprises a perovskite layer with one buffer layer on one side of the perovskite layer, or a perovskite layer with buffer layers on both sides of the perovskite layer. Reversible resistance changes are induced in the device under applied electrical pulses. The resistance changes of the device are retained after applied electric pulses. The functions of the buffer layer(s) added to the device include magnification of the resistance switching region, reduction of the pulse voltage needed to switch the device, protection of the device from being damaged by a large pulse shock, improvement of the temperature and radiation properties, and increased stability of the device allowing for multivalued memory applications.
摘要:
Systems, devices, features, and methods for detecting geographic features in images, such as, for example, to develop a navigation database are disclosed. For example, a method of detecting a path marking from collected images includes collecting a plurality of images of geographic areas along a path. An image of the plurality of images is selected. Components that represent an object on the path in the selected image are determined. In one embodiment, the determined components are independent or invariant to scale of the object. The determined components are compared to reference components in a data library. If the determined components substantially meet a matching threshold with the reference components, the object in the selected image is identified to be a path marking corresponding to the reference components in the data library.
摘要:
Systems, devices, features, and methods for detecting geographic features in images, such as, for example, to develop a navigation database are disclosed. For example, a method of detecting text from collected images includes collecting a plurality of images of geographic areas along a road or path. An image of the plurality of images is selected. Components that represent a feature about the road or path in the selected image are determined. In one embodiment, the components are independent or invariant to scale of the feature. The determined components are compared to reference components in a data library. If the determined components substantially match with the reference components, the feature in the selected image is identified to be a text character (e.g., of a road sign) corresponding to at least some of the reference components in the data library.
摘要:
Systems, devices, features, and methods for determining a geometric parameter from an image are disclosed. For example, one method for determining the geometric parameter is used to develop a navigation database. The method comprises determining calibration values corresponding to a camera mounted on a vehicle or a pedestrian. A plurality of images of geographic features are captured by the camera. A single image from the plurality of images is identified or selected. A geometric parameter of a region in the single image is determined based on the determined calibration values. For example, the geometric parameter is a real-world distance, such as a real-world length or width.
摘要:
A compound of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X, Y, and Z are as defined herein. Also disclosed is a method for inhibiting actively of fibroblast activation protein or for treating cancer or inflammation conditions with such a compound.
摘要:
A large-mode-area (LMA) optical fiber (10) that operates as a single-mode optical fiber. The optical fiber includes a core region (20) surrounded by an inner cladding (32), which in turn is surrounded by an outer cladding (40). The inner cladding includes at least one up-doped ring region (32R1). The ring region is configured to form a large attenuation differential between the higher-order modes and the fundamental mode so only that the fundamental mode remains traveling in the optical fiber. If necessary, the optical fiber can include a bend (10B) having a select “resonant” bend diameter (DB) that increases the relative attenuation of the fundamental and higher-order modes. The optical fiber supports an effective mode field diameter (MFD) of up to 40 μm to 50 μm. As a result, detrimental non-linear effects are suppressed, which allows the optical fiber to carry substantially more optical power than conventional LMA optical fibers. The LMA optical fiber is thus eminently suited for a number of optical-fiber-based applications calling for high optical power, such as fiber lasers and pump sources for wavelength conversion.
摘要:
The present invention relates generally to ophthamological drugs. More specifically, the invention relates to a method of modifying (derivatizing) ophthamological drugs so as to increase their penetration through the cornea. The invention also relates to drugs modified (derivatized) in accordance with the instant method and to the use of same in treating conditions associated with elevated intraocular pressure, particularly, glaucoma.
摘要:
Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, x and y are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes, including obesity, diabetes, modulation of feeding behavior and related metabolic syndrome.