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    Inhibitors of bacterial two component signal transduction system and uses thereof
    61.
    发明授权
    Inhibitors of bacterial two component signal transduction system and uses thereof 有权

    公开(公告)号：US10894037B2

    公开(公告)日：2021-01-19

    申请号：US16233280

    申请日：2018-12-27

    Applicant: Academia Sinica

    Inventor： Chinpan Chen ,  Tien-Sheng Tseng ,  Keng-Chang Tsai

    IPC: A61K31/422 ,  A61K45/06 ,  A61K31/385

    Abstract: Disclosed herein are novel uses of a compound of formula (I) as an inhibitor of bacterial two component signal transduction system (TCS), A-L-B-L-A  (I) wherein, A is a moiety having a negative charge; L is —(C2H5—O)n—CH2— or a moiety consists of a carbocyclyl and a heterocyclyl respectively having 5 to 10 ring atoms and coupling together, in which n is 0 or 1; and B is a 5 to 10-membered carbocyclyl or heterocyclyl. The compound of formula (I) may suppress or inhibit the growth of bacteria, including the notorious multi-drug resistant bacteria.

    GLYCOCONJUGATE VACCINES, PREPARATION METHOD AND USES THEREOF
    64.
    发明申请
    GLYCOCONJUGATE VACCINES, PREPARATION METHOD AND USES THEREOF 审中-公开

    公开(公告)号：US20200179503A1

    公开(公告)日：2020-06-11

    申请号：US16442334

    申请日：2019-06-14

    Applicant: Academia Sinica

    Inventor： Shih-Hsiung Wu ,  Chung-Yi Wu ,  I-Ming Lee ,  Feng-Ling Yang

    IPC: A61K39/05 ,  A61P31/04 ,  A61K45/06

    Abstract: Disclosed herein is a glycocojugate vaccine conferring protection against a Gram negative pathogen infection, a method of manufacturing the glycoconjugate vaccine, and use of the glycocojugate vaccine for treating bacterial infection. The glycocojugate vaccine of the present disclosure has the structure of formula (I), wherein, L is a maleimide-type linker, which is connected to the carrier protein via a maleimide bond formed therebetween; and n and m are respectively an integral or a non-integral number between 2 and 20.

    Transit peptide from Arabidopsis chloroplast chaperonin 10-2 and methods of use
    65.
    发明授权
    Transit peptide from Arabidopsis chloroplast chaperonin 10-2 and methods of use 有权

    公开(公告)号：US10577620B2

    公开(公告)日：2020-03-03

    申请号：US16178702

    申请日：2018-11-02

    Applicant: ACADEMIA SINICA

    Inventor： Hsou-Min Li ,  Chiung-Chih Chu

    IPC: C12N15/82

    Abstract: The present invention provides a recombinant DNA molecule encoding a fusion protein, comprising a first DNA sequence encoding a high-efficiency transit peptide operably linked to a second DNA sequence encoding a passenger protein, wherein the high-efficiency transit peptide is selected from the group consisting of transit peptides of the precursors of translocon at the inner envelope membrane of chloroplasts 40 kD (prTic40), chaperonin 10-2 (prCpn10-2), Fibrillin 1B (prFibrillin), ATP sulfurylase 1 (prAPS1), ATP sulfurylase 3 (prAPS3), 5′-adenylylsulfate reductase 3 (prAPR3), stromal ascorbate peroxidase (prsAPX), prTic40-E2A (a prTic40 variant), prCpn10-1-ΔC7C37S (a chaperonin 10-1 variant), a functional fragment of any of the transit peptides and an equivalent thereof. And the present invention also provides a method of high efficiency delivery of a protein into plastids using the high-efficiency transit peptides.

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