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公开(公告)号:US5948641A
公开(公告)日:1999-09-07
申请号:US864804
申请日:1997-05-29
申请人: Preeti Lal , Purvi Shah , Neil C. Corley
发明人: Preeti Lal , Purvi Shah , Neil C. Corley
CPC分类号: C07K14/4702 , C07K14/825
摘要: The present invention provides a metal response element binding protein (MERESP) and polynucleotides which identify and encode MERESP. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of MERESP.
摘要翻译: 本发明提供了金属响应元件结合蛋白(MERESP)和识别和编码MERESP的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与MERESP表达相关的疾病的方法。
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公开(公告)号:US5948625A
公开(公告)日:1999-09-07
申请号:US94080
申请日:1998-06-09
申请人: Jennifer L. Hillman , Surya K. Goli
发明人: Jennifer L. Hillman , Surya K. Goli
摘要: The present invention provides a human ATP synthase d subunit (ASYSD) and polynucleotides which encode ASYSD. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYSD and for treating disorders associated with expression of ASYSD.
摘要翻译: 本发明提供了人ATP合成酶d亚基(ASYSD)和编码ASYSD的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,反义分子,抗体或拮抗剂。 本发明还提供了用于产生ASYSD和用于治疗与ASYSD表达相关的疾病的方法。
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公开(公告)号:US5945306A
公开(公告)日:1999-08-31
申请号:US991946
申请日:1997-12-16
摘要: The invention provides two human Ras proteins, referred to collectively as "RAPR" and individually as "RAPR-1" and "RAPR-2", and polynucleotides which identify and encode RAPR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of RAPR.
摘要翻译: 本发明提供两种人类Ras蛋白质,统称为“RAPR”,分别称为“RAPR-1”和“RAPR-2”,以及鉴定和编码RAPR的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了预防和治疗与RAPR表达相关的疾病的方法。
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公开(公告)号:US5942399A
公开(公告)日:1999-08-24
申请号:US73362
申请日:1998-05-06
申请人: Jennifer L. Hillman , Henry Yue , Neil C. Corley
发明人: Jennifer L. Hillman , Henry Yue , Neil C. Corley
CPC分类号: C07K14/705 , A61K38/00
摘要: The invention provides a human amino acid permease homolog (AAPH) and polynucleotides which identify and encode AAPH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of AAPH.
摘要翻译: 本发明提供了人氨基酸通透酶同源物(AAPH)和识别和编码AAPH的多核苷酸。 本发明还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 本发明还提供用于诊断,治疗或预防与AAPH表达相关的紊乱的方法。
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公开(公告)号:US5935931A
公开(公告)日:1999-08-10
申请号:US094212
申请日:1998-06-09
申请人: Jennifer L. Hillman , Surya K. Goli
发明人: Jennifer L. Hillman , Surya K. Goli
IPC分类号: G01N33/53 , A61K38/00 , A61K45/00 , A61P1/00 , A61P1/16 , A61P9/10 , A61P13/12 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/14 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , A61K38/04 , A61K38/17 , C07K7/00
CPC分类号: C07K14/4747 , C07K14/4702 , A61K38/00
摘要: The present invention provides a human apoptosis-related calcium-binding protein (HARC) and polynucleotides which identify and encode HARC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HARC and a method for producing HARC. The invention also provides for agonists, antibodies, or antagonists specifically binding HARC, and their use, in the prevention and treatment of diseases associated with expression of HARC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HARC for the treatment of diseases associated with the expression of HARC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HARC.
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公开(公告)号:US5932443A
公开(公告)日:1999-08-03
申请号:US937972
申请日:1997-09-26
申请人: Preeti Lal , Olga Bandman , Neil C. Corley , Purvi Shah
发明人: Preeti Lal , Olga Bandman , Neil C. Corley , Purvi Shah
CPC分类号: C07K14/4713 , C07K14/47 , A61K38/00
摘要: The invention provides two human antigens (ANTS) and polynucleotides which identify and encode ANTS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of ANTS.
摘要翻译: 本发明提供两种识别和编码ANTS的人抗原(ANTS)和多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与ANTS表达相关的疾病的方法。
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公开(公告)号:US5932420A
公开(公告)日:1999-08-03
申请号:US892690
申请日:1997-07-14
申请人: Olga Bandman , Preeti Lal , Purvi Shah
发明人: Olga Bandman , Preeti Lal , Purvi Shah
摘要: The invention provides a new human integral membrane protein (NIMPH) and polynucleotides which identify and encode NIMPH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NIMPH.
摘要翻译: 本发明提供了一种新的人内膜蛋白(NIMPH)和识别和编码NIMPH的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与NIMPH表达相关的疾病的方法。
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公开(公告)号:US5929210A
公开(公告)日:1999-07-27
申请号:US997040
申请日:1997-12-23
IPC分类号: C12N15/09 , A61K38/00 , A61K38/55 , A61P25/28 , C07K14/81 , C07K16/38 , C12N1/21 , C12N5/10 , C12N15/15 , C12Q1/68 , G01N33/53
CPC分类号: C07K14/8121 , A61K38/00
摘要: The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of Cape, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
摘要翻译: 本发明提供鉴定和编码在人下丘脑中表达的新型serpin(CAPE)的核苷酸和氨基酸序列。 本发明还提供编码CAPE的核苷酸序列的反义分子,用于产生纯化的CAPE的表达载体,能够特异性结合CAPE的抗体,用于检测编码CAPE的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主 用于表达Cape的细胞,含有生物活性CAPE的药物组合物,基于CAPE编码核酸分子的诊断试验,以及包含施用生物活性CAPE的治疗方法。
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公开(公告)号:US5928923A
公开(公告)日:1999-07-27
申请号:US19216
申请日:1998-02-05
申请人: Preeti Lal , Neil C. Corley
发明人: Preeti Lal , Neil C. Corley
摘要: The invention provides a human short-chain dehydrogenase (HSCD) and polynucleotides which identify and encode HSCD. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HSCD.
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公开(公告)号:US5928874A
公开(公告)日:1999-07-27
申请号:US49671
申请日:1998-03-27
申请人: Olga Bandman , Neil C. Corley , Karl J. Guegler , Mariah Baughn
发明人: Olga Bandman , Neil C. Corley , Karl J. Guegler , Mariah Baughn
IPC分类号: C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61P15/00 , A61P35/00 , A61P37/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/68 , C07H21/02 , C12N15/00
CPC分类号: C12N9/1205 , A61K38/00
摘要: The invention provides a human Nek1-related protein kinase (NRPK) and polynucleotides which identify and encode NRPK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NRPK.
摘要翻译: 本发明提供了人Nek1相关蛋白激酶(NRPK)和识别和编码NRPK的多核苷酸。 本发明还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 本发明还提供了用于诊断,治疗或预防与NRPK表达相关的紊乱的方法。
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